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StCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： m.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.m.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.t.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.m.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng t.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.m.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.m.Duan D.epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.t.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong t.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han m.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou t.J.Hou Y.R.Hou C.Y.Hu H.m.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang m.Huang Q.Y.Huang W.Q.Huang X.t.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke m.Kenzie A.Khoukaz I.Koop e.Kravchenko A.Kuzmin Y.Lei e.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.m.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li t.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.t.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.m.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu t.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo t.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.ma P.ma Y.ma Y.m.ma F.maas S.malde D.matvienko Z.X.meng R.mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan e.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov e.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin t.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(ePFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High energy Physics Chinese Academy of SciencesBeijing 100049China Institute of modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

the superτ-charm facility(StCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BePCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the StCF,describes conceptual designs of the StCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCF detector conceptual design

Joints in unsaturated rocks:thermo-hydro-mechanical formulation and constitutive behaviour

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Journal of Rock mechanics and Geotechnical engineering 2013年第3期5卷 200-213页

作者： e.e.Alonso m.t.Zandarín S.Olivella Department of Geotechnical engineering and Geosciences UPC

A formulation for the coupled analysis of thermo-hydro-mechanical （tHm） problems in joints is first presented. the work involves the establishment of equilibrium and mass and energy balance equations. Balance equations were formulated taking into account two phases： water and air. the joint element developed was implemented in a general purpose finite element computer code for tHm analysis of porous media （Code_Bright）. the program was then used to study a number of cases ranging from laboratory tests to large scale in situ tests. A numerical simulation of coupled hydraulic shear tests of rough granite joints is first presented. the tests as well as the model show the coupling between permeability and the deformation of thejoints. the experimental investigation was focused on the effects of suction on the mechanical behaviour of rock joints. Laboratory tests were performed in a direct shear cell equipped with suction control. Suction was imposed using a vapour forced convection circuit connected to the cell and controlled by an air pump. Artificial joints of Lilla claystone were *** roughness of varying intensity was created by carving the surfaces in contact in such a manner that rock ridges of different tip angles were formed. these angles ranged from 0° （smooth joint） to 45° （very rough joint profile）. the ge.m.t.ic profiles of the two surfaces in contact were initially positioned in a ＂matching＂ situation. Several tests were performed for different values of suctions （200, 100, and 20 mPa） and for different values of vertical stresses （30, 60, and 150 kPa）. A constitutive model including the effects of suction and joint roughness is proposed to simulate the unsaturated behaviour of rock joints. the new constitutive law was incorporated in the code and experimental results were numerically simulated.

关键词： Rock joints thermo-hydro-mechanical (tHm) behaviour Finite elements Suction controlled shear tests Constitutive model Numerical simulations

Conceptual design of an experiment to study dust destruction by astrophysical shock waves

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High Power Laser Science and engineering 2018年第3期6卷 9-14页

作者： m. J.-e. manuel t. temim e. Dwek A. m. Angulo e X. Belancourt R. e Drake C. C. Kuranz m. J. macDonald B. A. Remington General Atomics 3550 General Atomics Court San Diego CA 92121 USA Space telescope Science Institute 3700 San Martin Drive Baltimore MD 21218 USA Observational Cosmology Lab Code 665 NASA Goddard Space Flight Center Greenbelt MD 20771 USA Climate and Space Science and engineering University of Michigan Ann Arbor M148109 USA Department of Physics University of California Berkeley CA 94720 USA Lawrence Livermore National Laboratory Livermore CA 94450 USA

A novel laboratory experimental design is described that will investigate the processing of dust grains in astrophysical shocks. Dust is a ubiquitous ingredient in the interstellar medium(ISm) of galaxies; however, its evolutionary cycle is still poorly understood. especially shrouded in mystery is the efficiency of grain destruction by astrophysical shocks generated by expanding supernova remnants. While the evolution of these remnants is fairly well understood, the grain destruction efficiency in these shocks is largely unknown. the experiments described herein will fill this knowledge gap by studying the dust destruction efficiencies for shock velocities in the range ～10–30 km/s(μm/ns), at which most of the grain destruction and processing in the ISm takes place. the experiments focus on the study of grain–grain collisions by accelerating small(～1 μm) dust particles into a large(～5–10 μm diameter) population; this simulates the astrophysical system well in that the more numerous, small grains impact and collide with the large population. Facilities that combine the versatility of high-power optical lasers with the diagnostic capabilities of X-ray free-electron lasers, e.g., the.m.t.er in extreme Conditions instrument at the SLAC National Accelerator Laboratory, provide an ideal laboratory environment to create and diagnose dust destruction by astrophysically relevant shocks at the micron scale.

关键词： laboratory astrophysics shock waves dust destruction

Analytical description of shape transition in nuclear alternating parity bands

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Chinese Physics C 2018年第12期42卷 112-122页

作者： e.V.mardyban t.m.Shneidman e.A.Kolganova R.V.Jolos S.-G.Zhou Bogoliubov Laboratory of theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia Dubna State University Dubna 141980Russia Kazan Federal University Kazan 420008Russia CAS Key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center of theoretical Nuclear Physics National Laboratory of Heavy Ion AcceleratorLanzhou 730000China Synergetic Innovation Center for Quantum effects and Application Hunan Normal UniversityChangsha 410081China

the angular momentum dependencies parity bands of heavy nuclei have been analyzed of parity splitting and electric dipole transitions in the alternating It is shown that these dependencies can be treated in a universal manner with a single critical angular momentum parameter, which characterizes phase transition from octupole vibrations to the stable octupole deformation. Using the simple but useful model of axially-symmetric reflection- asymmetric mode, the analytical expressions for parity splitting and electric dipole transitional moment have been obtained. the findings are in good agreement with the experimental data for various isotopes of Ra, th, U, and Pu.

关键词： octupole deformation phase transition angular momentum

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi e.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen t.Chen X.R.Chen X.t.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.e.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.t.Feng K.Fischer m.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.t.Ge Z.W.Ge C.Geng e.m.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.C.Du S.X.Du Z.H.Duan P.egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.t.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han t.t.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold t.Holtmann P.C.Hong G.Y.Hou X.t.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu t.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.t.Huang Y.P.Huang t.Hussain F.H\"olzken N.H\"usken N.in der Wiesche m.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang t.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing t.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi t.t.Lei Z.H.Lei H.Leithoff m.Lellmann t.Lenz C.Li C.Li C.H.Li Cheng Li D.m.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li t.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COmSAtS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BeSIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).the fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKm angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BeSIII D^(0)meson decays amplitude analysis CP-even fraction

Analysis of microscopic properties of radiative shock experiments performed at the Orion laser facility

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High Power Laser Science and engineering 2018年第2期6卷 189-201页

作者： R.Rodriguez G.espinosa J.m.Gil e Suzuki-Vidal t.Clayson C.Stehle e Graham IUNAt Departamento de FisicaUniversidad de Las Palmas de Gran Canaria35017 Las Palmas de Gran CanariaSpain Instituto de Fusion Nuclear Universidad Politecnica de Madrid28040 MadridSpain Blackett Laboratory Imperial CollegeLondon SW7 2AZUK LeRmA Sorbonne UniversitesUPMCObservatoire de ParisPSL Research UniversityCNRSF-75006 ParisFrance AWe AldermastonReading RG7 4PRUK

In this work we have conducted a study on the radiative and spectroscopic properties of the radiative precursor and the post-shock region from experiments with radiative shocks in xenon performed at the Orion laser facility. the study is based on post-processing of radiation-hydrodynamics simulations of the experiment. In particular, we have analyzed the thermodynamic regime of the plasma, the charge state distributions, the monochromatic opacities and emissivities, and the specific intensities for plasma conditions of both regions. the study of the intensities is a useful tool to estimate ranges of electron temperatures present in the xenon plasma in these experiments and the analysis performed of the microscopic properties commented above helps to better understand the intensity spectra. Finally, a theoretical analysis of the possibility of the onset of isobaric thermal instabilities in the post-shock has been made, concluding that the instabilities obtained in the radiative-hydrodynamic simulations could be thermal ones due to strong radiative cooling.

关键词： high-power lasers laboratory experiments on radiative shocks plasma radiative properties spectroscopy

An evaluation of the Introduction of modified Cropping Practices in Yunnan Province,China,Using Surveys of Farmers’ Households

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Agricultural Sciences in China 2009年第2期8卷 188-202页

作者： m Subedi t J Hocking m A Fullen A R mcCrea e milne D J mitchell WU Bo-zhi School of Applied Sciences University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY UK the macaulay Institute Craigiebuckler Aberdeen AB15 8QH UK Yunnan Agricultural University Kunming 650201 P.R.China

Problems associated with land degradation are serious in China. Sloping land in South China has experienced a decline in crop productivity by 30-60% due to soil erosion and it has been predicted that most topsoil will be lost within the next 100 years if current erosion rates continue. Considering these situations, an agro-environmental research and development project （Sustainable Highland Agriculture in South-east Asia- SHASeA） was conducted in a catchment in Yunnan Province, China, to address the objectives of increasing crop productivity in sustainable and environmentally-friendly ways. A range of cropping practices was developed and implemented in a rural upland catchment （Wang Jia）. At the end of the project, farmers were surveyed to evaluate project effectiveness. All farmers from Wang Jia Catchment, who were involved in project implementation, were surveyed. A sample of farmers working in an adjacent catchment （not associated with the project） was surveyed for comparative purposes. Farmers had different perceptions of the cropping practices employed. Contour cultivation was preferred and likely to be adopted. Others practices such as straw mulching and intercropping were seen as less appropriate and unlikely to be adopted. Polythene mulch was recognized as effective, but likely to be adopted only if financial returns were favourable. the availability of relevant information had an important impact on the extent of technology testing by farmers and their willingness to adopt the practices in the future.

关键词： cropping practices farmers' perceptions household survey Yunnan China

Influence of processing route on microstructure and wear resistance of fly ash reinforced AZ31 magnesium matrix composites

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Journal of magnesium and Alloys 2019年第1期7卷 155-165页

作者： I.Dinaharan S.C.Vettivel m.Balakrishnan e.t.Akinlabi Department of mechanical engineering Science University of JohannesburgAuckland Park Kingsway CampusJohannesburg 2006 GautengSouth Africa Department of mechanical engineering Chandigarh College of Engineering and TechnologyChandigarh 160019India Department of mechanical engineering Nehru Institute of Engineering and TechnologyCoimbatore 641105 Tamil NaduIndia

Utilizing fly ash(FA)as reinforcement for magnesium matrix composites(mmCs)brings down the production cost and the land *** alloy AZ31 was reinforced with FA particles(10 vol.%)successfully by two different processing methods namely conventional stir casting and friction stir processing(FSP).the microstructural features were observed using optical microscope,scanning electron microscope and electron backscatter *** sliding wear behavior was tested using a pin-on-disc wear *** stir cast composite showed inhomogeneous particle dispersion and coarse grain *** of the FA particles decomposed and reacted with the.m.t.ix alloy to produce undesirable ***,FSP composite showed superior particle dispersion and fine,equiaxed grains by dynamic *** particles encountered disintegration but there was no interfacial *** composite demonstrated higher strengthening and wear resistance to that of stir cast *** morphology of the worn surface and the wear debris were studied in detail.

关键词： magnesium matrix composite Stir casting Friction stir processing Fly ash Wear

Inositol 1,4,5-trisphosphate receptor in the liver:expression and function

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World Journal of Gastroenterology 2019年第44期25卷 6483-6494页

作者： Fernanda de Oliveira Lemos Rodrigo m Florentino Antonio Carlos melo Lima filho marcone Loiola dos Santos m Fatima Leite Department of Physiology and Biophysics Universidade Federal de Minas GeraisBelo HorizonteMinas Gerais 31270-901Brazil Department of Cell Biology Universidade Federal de Minas GeraisBelo HorizonteMinas Gerais 31270-901Brazil

the liver is a complex organ that performs several functions to maintain *** functions are modulated by calcium,a second messenger that regulates several intracellular *** hepatocytes and cholangiocytes,which are the epithelial cell types in the liver,inositol 1,4,5-trisphosphate(InsP3)receptors(ItPR)are the only intracellular calcium release *** isoforms of the ItPR have been described,named type 1,type 2 and type *** ItPR isoforms are differentially expressed in liver cells where they regulate distinct physiological *** in the expression level of these receptors correlate with several liver diseases and hepatic *** this review,we highlight how the expression level,modulation,and localization of ItPR isoforms in hepatocytes and cholangiocytes play a role in hepatic homeostasis and liver pathology.

关键词： Inositol 1,4,5-trisphosphate receptor Liver Calcium signaling Hepatocytes and cholangiocytes