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Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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matter and Radiation at extremes 2024年第2期9卷 12-25页

作者： J.-R.marquès L.Lancia P.Loiseau P.Forestier-Colleoni m.Tarisien e.Atukpor V.Bagnoud C.Brabetz F.Consoli J.Domange F.Hannachi P.Nicolaï m.Salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CeA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CeNBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI He.m.oltzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany eNeA Fusion and Technologies for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CeLIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agre.m.nt with the.m.chanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this be.m.are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agre.m.nt with those required for CSA.

关键词： acceleration hydrodynamic collision

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深圳市2022—2023年输入性恶性疟原虫耐药基因突变情况

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中国热带医学 2024年第4期24卷 382-387页

作者：刘小莲高世同李媛唐屹君张倩彭博阳帆张仁利黄达娜深圳市疾病预防控制中心广东深圳518055

目的分析了解深圳市输入性恶性疟原虫耐药基因突变情况,帮助评估抗疟药的疗效和指导有效用药。方法收集2022—2023年从境外输入深圳市的恶性疟荧光定量聚合酶链反应(polymerase chain reaction,PCR)阳性的样本85例,提取基因组DNA,使用巢... 详细信息

目的分析了解深圳市输入性恶性疟原虫耐药基因突变情况,帮助评估抗疟药的疗效和指导有效用药。方法收集2022—2023年从境外输入深圳市的恶性疟荧光定量聚合酶链反应(polymerase chain reaction,PCR)阳性的样本85例,提取基因组DNA,使用巢式PCR扩增耐药基因:恶性疟原虫Kelch螺旋体蛋白基因(Plasmodium falciparum Kelch 13,PfK13)、多药耐药基因1(multidrug resistance 1,Pfmdr1)、氯喹抗性转运基因(chloroquine resistance transporter,Pfcrt)、二氢叶酸还原酶基因(dihydrofolate reductase,Pfdhfr)和二氢蝶酸合成酶基因(dihydropteroate synthase,Pfdhps),并进行双向测序,使用meGA11.06软件分析这些耐药基因突变情况。结果研究发现PfK13错义突变(S549P)1例,同义突变4例。Pfmdr162.69%样本存在Y184F突变,未检测到N86Y突变体。Pfcrt基因中,未检测到72和73位点的突变,m74I、N75e和K76T突变分别占17.46%、15.87%和15.87%。Pfcrt基因野生型占主导(82.54%,52例),其次是I_(74)e_(75)T_(76)三重突变体(15.87%,10例)。Pfdhfr最常见的突变型为I_(51)R_(59)N_(108)(91.78%,67例),其次是野生型(2.74%,2例)。Pfdhps野生型占60.32%(38例),单突变K540e为最常见突变类型,检测到S436A、G437A、K540e、A581G、A613S、I431V、G556K、G579e位点突变。Pfdhfr-Pfdhps组合突变中,I_(51)R_(59)N_(108)-e540是频率最高的组合突变(11.48%),59.02%样本为Pfdhfr单独突变体。结论在本研究中,PfK13突变率低,且无报导的耐药突变,Y184F成为Pfmdr1突变主导,未发现有N86Y。Pfcrt野生型为主,其次为I_(74)e_(75)T_(76)三重突变体,Pfdhfr I_(51)R_(59)N_(108)三重突变非常普遍,本研究并未发现PfdhfrPfdhps完全抗性和超抗性突变体,但有其他的五重七重突变型。在未来的工作中,需要继续加强疟原虫耐药基因的监测,同时进一步结合体内疗效的监测来有效指导临床用药。

关键词：恶性疟原虫输入性耐药性基因突变

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贝那利珠单抗与美泊利单抗治疗嗜酸性肉芽肿性多血管炎患者的临床研究

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中国临床药理学杂志 2024年第8期40卷 1221-1221页

作者： WeCHSLeR m e 戴荣源

美国国立犹太医学中心WeCHSLeR团队开展了一项多中心、双盲、3期、随机、主动对照的非劣效性试验,以评估贝那利珠单抗与美泊利单抗治疗嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangitis,eCPA)患者的临床疗效和安... 详细信息

美国国立犹太医学中心WeCHSLeR团队开展了一项多中心、双盲、3期、随机、主动对照的非劣效性试验,以评估贝那利珠单抗与美泊利单抗治疗嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangitis,eCPA)患者的临床疗效和安全性。该研究将接受标准治疗的复发或难治性嗜酸性eCPA成人患者以1:1的比例随机分配接受每4周1次皮下注射贝那利珠单抗30mg或美泊利单抗300mg,持续治疗52周。主要终点是第36和48周的缓解情况(预先设定的非劣效性边际,-25个百分点)。次要终点包括累计缓解持续时间、首次复发时间、口服糖皮质激素使用、嗜酸性粒细胞计数和安全性。

关键词：复发时间嗜酸性粒细胞计数成人患者美泊利单抗缓解情况随机分配 eCP 持续时间

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Intelligent Fractional-Order Controller for SmeS Systems in Renewable energy-Based microgrid

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Computer modeling in engineering & Sciences 2024年第8期140卷 1807-1830页

作者： Aadel m.Alatwi Abualkasim Bakeer Sherif A.Zaid Ibrahem e.Atawi Hani Albalawi Ahmed m.Kassem electrical engineering Department Faculty of EngineeringUniversity of TabukTabuk47913Saudi Arabia Industrial Innovation and Robotic Center(IIRC) University of TabukTabuk47731Saudi Arabia Department of electrical engineering Faculty of EngineeringAswan UniversityAswan81542Egypt Renewable energy and environmental Technology Centre University of TabukTabuk47913Saudi Arabia electrical engineering Department Faculty of EngineeringSohag UniversitySohag82524Egypt

An autonomous microgrid that runs on renewable energy sources is presented in this *** has a supercon-ducting magnetic energy storage(SmeS)device,wind energy-producing devices,and an energy storage ***,because such microgrids are nonlinear and the energy they create varies with time,controlling and managing the energy inside them is a difficult ***-order proportional integral(FOPI)controller is recommended for the current research to enhance a standalone.m.crogrid’s energy management and *** suggested dedicated control for the SmeS comprises two loops:the outer loop,which uses the FOPI to regulate the DC-link voltage,and the inner loop,responsible for regulating the SmeS current,is constructed using the intelligent FOPI(iFOPI).The FOPI+iFOPI parameters are best developed using the dandelion optimizer(DO)approach to achieve the optimum *** suggested FOPI+iFOPI controller’s performance is contrasted with a conventional PI controller for variations in wind speed and microgrid *** optimal FOPI+iFOPI controller manages the voltage and frequency of the *** behavior of the.m.crogrid as a reaction to step changes in load and wind speed was measured using the proposed *** simulations were used to evaluate the recommended system’s *** results of the simulations showed that throughout all interruptions,the recommended microgrid provided the load with AC power with a constant amplitude and *** addition,the required load demand was accurately ***,the.m.crogrid functioned incredibly well despite SmeS and varying wind *** obtained under identical conditions were compared with and without the best FOPI+iFOPI *** utilizing the optimal FOPI+iFOPI controller with SmeS,it was found that the.m.crogrid performed better than the.m.crogrid without SmeS.

关键词： Fractional-order proportional integral(FOPI) intelligent controller renewable energy resources superconducting magnetic energy storage optimization

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Kriging-boosted CR modeling for prompt infill drilling optimization

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Petroleum 2024年第1期10卷 39-48页

作者： elizaveta S.Gladchenko Anna e.Gubanova Denis m.Orlov Dmitry A.Koroteev Skolkovo Institute of Science and Technology Russian Federation Digital Petrole.m.LLC Russian Federation

The capacitance-resistance.m.del(CRm)has been a useful physics-based tool for obtaining production forecasts for ***,the.m.del's limitations make it difficult to work with real field cases,where a lot of various events *** events often include new well commissioning(NWC).We introduce a workflow that combines CRm concepts and kriging into a single tool to handle these types of events during history ***,it can be used for selecting a new well placement during infill *** make the workflow even more versatile,an improved version of CRm was *** takes into account wells shut-ins and performed workovers by additional adjustment of the.m.del *** preliminary re-weighing and interpolating these coefficients using kriging,the coefficients for potential wells can be *** approach was validated using both synthetic and real datasets,from which the cases of putting new wells into operation were *** workflow allows a fast assessment of future well performance with a minimal set of reservoir *** way,a lot of well placement scenarios can be considered,and the best ones could be chosen for more detailed studies.

关键词： Capacitance-resistance.m.del(CRm) Field development optimization Infill drilling Interwell connectivity Kriging New well commissioning(NWC)

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中国新疆生态变迁——揭示气候变化对植被动态的影响

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Journal of Geographical Sciences 2024年第6期34卷 1039-1064页

作者：郝海超姚俊强陈亚宁徐建华李稚段伟利萨达夫-伊斯梅尔王桂玲 Key Laboratory of Geographic Information Science.m.nistry of education) School of Geographic SciencesEast China Normal UniversityShanghai200241China Graduate School of Advanced Integrated Studies in Human Survivability Kyoto UniversityYoshida-Nakaadachi 1Sakyo-kuKyoto 606-8306Japan Field Scientific experiment Base of Akdala Atmospheric Background Institute of Desert MeteorologyChina Meteorological AdministrationUrumqi 830011China State Key Laboratory of Desert and Oasis ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyCASUrumqi 830011China School of Geographic Science Nantong UniversityNantong 226007JiangsuChina

For the past several decades, climate change has been driving vegetation dynamics in arid regions worldwide. This study investigates vegetation dynamics and their links to climate from 1990 to 2020 in Xinjiang, China, using data from 30-m resolution land use and cover change, remote sensing, and climate reanalysis. Our approach encompasses a range of analytical techniques, including transfer matrix analysis, modeling, correlation, regression,and trend analysis. During the study period, there were.m.jor vegetation conversions from grassland to forestland in the.m.untains, and from cropland to grassland in the plains. Climate change emerged as an important trigger of these changes, as evidenced by the increase in net primary productivity in most vegetation types, except for cropland-grassland and grassland-cropland conversions. Precipitation and soil moisture were the.m.st influential climatic factors, contributing 15.1% and 15.2%, respectively, to natural vegetation *** study also found that evapotranspiration serves as a key mechanism for moisture dissipation in the hydrological cycle of vegetation dynamics. The interplay between precipitation,soil moisture, and evapotranspiration is a critical pattern of climatic influence that shapes vegetation dynamics across zones of intersection, increase, decrease, and change. These insights are invaluable for informing vegetation conservation and development strategies in Xinjiang and other similar environments facing climate-driven ecological transitions.

关键词： climate change ecological transitions LUCC NPP efficiency vegetation dynamics Xinjiang

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Investigation of the transformation of organic matter of carbonate deposits of the Semiluksky-mendymsky horizon under hydrothe.m.l conditions

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Petroleum 2024年第2期10卷 216-223页

作者： S.m.Petrov A.I.Lakhova e.G.moiseeva A.G.Safiulina Institute of Petroleum Chemistry and NanotechnologiesKazan National Research Technological UniversityKazan420015Russia Institute of Geology and Oil and Gas Technologies Kazan Federal UniversityKazan420008Russia

The paper presents the results of studies on the transformation of the organic matter of siliceous-clayey carbonate rocks of the Semiluksko-mendymsky horizon of the Romashkino oil field in a hydrothe.m.l fluid for an hour(with a water-to-rock ratio of 33)at 340℃and 380℃and pressu res of 17 and 20 *** a result of hydrothe.m.l treatment,at 340℃and 17 mPa,based on nitrogen porosimetry and electron microscopy data,transformations of rock-forming minerals in the rock are *** lead to an increase in the volume and average diameter of mesopores in it and the formation of micropores,as well,which improve its filtration *** the same time,the amount of kerogen in the composition of the organic matter decreases and the yield of the petrole.m.hydrocarbon extract increases,in which,according to the SARA analysis,the content of asphaltenes increases and the content of resins,aromatic and saturated hydrocarbons *** the composition of aroatic hydrocarbons,the proportion of a lkyltri methyl benzenes and dibenzothiophenes increases,phenanthrene homologues appear,and in the composition of saturated hydrocarbons,the amount of iso-structure alkanes decreases relative to the content of linear *** the temperature and pressure of the hydrothe.m.l fluid to 380℃and 20 mPa increases the degree of kerogen conversion from 12.4%to 23.6%.At the same time,changes occurring in the component composition of petrole.m.hydrocarbon extracts remains similar to the experiments carried out at 340℃and 17 mPa;the content of naphthalenes decreases,the content of dibenzothiophenes increases and C_(11)-C_(17),C_(19)-C_(22)alkyltrimethylbenzenes *** to IR spectroscopy,with increasing temperature and pressure of the hydrothe.m.l fluid the intensity of the absorption bands of the aromatic ring,aliphatic fragments,and oxygen-containing groups increases in resins;the structural-group composition of asphaltenes changes little:aromaticity and the content of conde

关键词： Carbonate deposits Organic matter Hydrothe.m.l fluid mobile hydrocarbons

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Combination treatment of inflammatory bowel disease:Present status and future perspectives

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World Journal of Gastroenterology 2024年第15期30卷 2068-2080页

作者： John K Triantafillidis Constantinos G Zografos manousos m Konstadoulakis Apostolos e Papalois Inflammatory Bowel Disease Unit "Metropolitan General"HospitalHolargos 15562AtticaGreece Hellenic Society for Gastrointestinal Oncology 354 Iera OdosChaidari 12461AtticaGreece The 2^(nd)Department of Surgery University of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece Unit of Surgical Research and Training The 2^(nd)Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece

The treatment of patients with inflammatory bowel disease(IBD),especially those with severe or refractory disease,represents an important challenge for the clinical *** se.m. to be no exaggeration to say that in these patients,not only the scientific background of the gastroenterologist is tested,but also the abundance of“gifts”that he should possess(insight,intuition,dete.m.ination,ability to take initiative,etc.)for the successful outcome of the *** daily clinical practice,depending on the severity of the attack,IBD is treated with one or a combination of two or more pharmaceutical *** combin-ations include not only the first-line drugs(e.g.,mesalazine,corticosteroids,antibiotics,etc)but also second-and third-line drugs(immunosuppressants and biologic agents).It is a fact that despite the significant therapeutic advances there is still a significant percentage of patients who do not satisfactorily respond to the treatment ***,a part of these patients are going to *** recent years,several small-size clinical studies,reviews,and case reports have been published combining not only biological agents with other drugs(e.g.,immunosuppressants or corticosteroids)but also the combination of two biologi-cal agents simultaneously,especially in severe *** our opinion,it is at least a strange(and largely unexplained)fact that we often use combinations of drugs in a given patient although studies comparing the simultaneous administration of two or more drugs with monotherapy are very *** mentioned above,there is a timid tendency in the literature to combine two biological agents in severe cases unresponsive to the applied treatment or patients with severe extraintestinal *** appropriate dosage,the duration of the administration,the suitable timing for checking the clinical and laboratory outcome,as well as the treatment side-effects,should be the subject of intense clinical research *** this

关键词： Biologics for immune.m.diated conditions Dual-targeted treatment Combination treatment Inflammatory bowel disease Crohn’s

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生物滞留带中轮胎磨损颗粒的理化特性

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科学技术与工程 2024年第24期24卷 10561-10568页

作者：何秋宏董荣罗玲利梁琳谭秀晴潘伟亮重庆交通大学环境水利工程重庆市工程实验室重庆400074 重庆阁林环保科技有限公司重庆400045

近年来,由于市场机动车保有量迅速提升,轮胎磨损颗粒(tire wear particles, TWP)逐渐进入人们的视野。然而,中国针对TWP的研究才刚起步,典型海绵设施生物滞留带能否有效截留TWP尚不清楚。以重庆市渝北区悦来生态城为研究区域,采集生物... 详细信息

近年来,由于市场机动车保有量迅速提升,轮胎磨损颗粒(tire wear particles, TWP)逐渐进入人们的视野。然而,中国针对TWP的研究才刚起步,典型海绵设施生物滞留带能否有效截留TWP尚不清楚。以重庆市渝北区悦来生态城为研究区域,采集生物滞留带土壤样本,提取TWP并采用扫描电子显微镜(scanning electron microscope, Sem)、能量分散X光谱仪(energy dispersive spectrometer, eDS)、红外光谱、热失重、土壤重金属测定仪和粒度仪对生物滞留带中TWP的理化特性进行分析。结果表明:TWP为不规则块状、球状及长条状。Si是TWP中含量较高的元素,Zn含量整体相对较低。表层土壤相较中层和底层土壤提取出的TWP混合物质量比较高且热失重变化较大。在100、250~400、400~550℃存在明显质量变化。TWP混合物尺寸分布在13.11~116.1μm,平均粒径为68.62μm。

关键词：生物滞留带轮胎磨损颗粒理化特性海绵设施

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Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

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Journal of Renewable.m.terials 2024年第2期12卷 369-380页

作者： m.F.elkady e.m.el-Sayed mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Technology Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt Department of Public Works engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt environmental engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt electronic materials Research Department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(FeCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(Sem),Fourier transform infrared(FTIR)and the.m.gravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current dete.m.nation at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate

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