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硅橡胶的强力

橡胶参考资料 1972年第12期 52-57页

作者： e.kay 李润林

硅橡胶最显著的特点就是它在非常广的温度范围内能保持橡胶的性能。尤其是低温性能特别显著,虽然有些橡胶,例如氟橡胶的高温稳定性相当好,但是低温性能都无法与硅橡胶比拟,在-70℃或更低的温度下使用可以说没有一种橡胶能够比得上它。... 详细信息

硅橡胶最显著的特点就是它在非常广的温度范围内能保持橡胶的性能。尤其是低温性能特别显著,虽然有些橡胶,例如氟橡胶的高温稳定性相当好,但是低温性能都无法与硅橡胶比拟,在-70℃或更低的温度下使用可以说没有一种橡胶能够比得上它。遗憾的是,硅橡胶的结构特性使它在室温或室温以上的温度下机械强力很差,例如链的

关键词：硅橡胶白炭黑牛顿二甲基电工橡胶胶体二氧化硅补强剂二烷基撕裂强力交联密度

Structure and Functional Implications of Chaperone Chz1 Complexed with Histones H2A.Z-H2B

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Structure and Functional Implications of Chaperone Chz1 Comp...

第十二届北京分析测试学术报告会暨展览会(BCeIA 2007)

作者： Zheng Zhou Hanqiao Feng D.Flemming Hansen ed Luk Hidenori Kato Daron I.Freedberg Lewis e.kay Carl Wu Yawen Bai Department of Medical Genetics Biochemistry and Chemistry University of Toronto

The packaging of the genome into chromatin is essential for normal growth,development,and differentiation of eukaryotic *** chaperones play important roles in the assembly and disassembly of nucleosomes,the fundamental structural units of *** yeast Chz1 is a recently discovered,intrinsically-disordered histone chaperone of H2A-H2B and its variant

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聚合型防老剂

橡胶参考资料 1975年第9期 35-41页

作者： e.kay D.K.Thomas W.W.Wright 吴同锴

在某些应用上,例如高速飞机,要求橡胶另件能在高温并且经常与流体(诸如煤油、酯等液压介质)接触的条件下长期工作。特别是高温用橡胶诸如目前在飞机上广泛应用的氟胶、硅胶甚至最终也要发生老化。这种老化,在很大程度上是热氧作用的结果... 详细信息

在某些应用上,例如高速飞机,要求橡胶另件能在高温并且经常与流体(诸如煤油、酯等液压介质)接触的条件下长期工作。特别是高温用橡胶诸如目前在飞机上广泛应用的氟胶、硅胶甚至最终也要发生老化。这种老化,在很大程度上是热氧作用的结果,如果橡胶能保持在绝氧条件下应用,则可预期使用寿命明显增加。但是从系统中排除氧通常是行不通

关键词：防老剂分子网抗老剂聚合型硫化胶

Proximity-dependent protein (de)stabilization: screening the human ORFeome for protein degraders and stabilizers

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3161-3162页

作者： Thomas Hermanns kay Hofmann Institute for Genetics University of CologneCologneGermany

In a recent study published in Nature,Poirson et *** an unbiased screen for proteins that can either bring about-or prevent-the destruction of proteinaceous model substrates in a proximity-dependent *** of such protein degraders and stabilizers will be instrumental in the development of new drug classes that specifically regulate the abundance of their target proteins.

关键词： al. stabilization stabilizers

Metformin-associated lactic acidosis:A mini review of pathophysiology,diagnosis and management in critically ill patients

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World Journal of Diabetes 2024年第6期15卷 1178-1186页

作者： kay Choong See Department of Medicine National University HospitalSingapore 119228Singapore

Metformin is a common diabetes drug that may reduce lactate clearance by inhibiting mitochondrial oxidative phosphorylation,leading to metforminassociated lactic acidosis(MALA).As diabetes mellitus is a common chronic metabolic condition found in critically ill patients,pre-existing metformin use can often be found in critically ill patients admitted to the intensive care unit or the high dependency *** aim of this narrative mini review is therefore to update clinicians about MALA,and to provide a practical approach to its diagnosis and *** in critically ill patients may be suspected in a patient who has received metformin and who has a high anion gap metabolic acidosis,and confirmed when lactate exceeds 5 mmol/*** factors include those that reduce renal elimination of metformin(renal impairment from any cause,histamine-2 receptor antagonists,ribociclib)and excessive alcohol consumption(as ethanol oxidation consumes nicotinamide adenine dinucleotides that are also required for lactate metabolism).Treatment of MALA involves immediate cessation of metformin,supportive management,treating other concurrent causes of lactic acidosis like sepsis,and treating any coexisting diabetic *** MALA requires extracorporeal removal of metformin with either intermittent hemodialysis or continuous kidney replacement *** optimal time to restart metformin has not been *** is nonetheless reasonable to first ensure that lactic acidosis has resolved,and then recheck the kidney function post-recovery from critical illness,ensuring that the estimated glomerular filtration rate is 30 mL/min/1.73 m^(2) or better before restarting metformin.

关键词： Acid-base equilibrium Biguanides Oxidative phosphorylation Pyruvic acid Renal replacement therapy

Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1374-1383页

作者： Laura Sahyoun kay Chen Cynthia Tsay George Chen Petr Protiva Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10065United States Gastroenterology Section Jennifer Moreno VA San Diego Healthcare SystemSan DiegoCA 92161United States Division of Gastroenterology Department of MedicineUniversity of California San DiegoLa JollaCA 92093United States Department of Gastroenterology and Hepatology John Hopkins HospitalBaltimoreMD 21287United States Department of Digestive Diseases Yale New Haven HospitalNew HavenCT 06520United States Department of Gastroenterology VA Connecticut Health Care SystemWest HavenCT 06516United States

BACKGROUND Despite advances in detection and treatments,biliary tract cancers continue to have poor survival ***,there is limited data investigating the significance of socioeconomic status,race/ethnicity,and environmental factors in biliary tract cancer *** from the Surveillance,epidemiology,and end Results database for biliary and gallbladder adenocarcinomas were extracted from 1975 to ***-conomic data included smoking,poverty level,education,adjusted household income,and percentage of foreign-born persons and urban *** was calculated with Cox proportional hazards models for death in the 5-year period following *** Our study included 15883 gallbladder,11466 intrahepatic biliary,12869 extrahepatic biliary and 7268 ampulla of Vater adenocarcinoma *** analyzing county-specific demographics,patients from counties with higher incomes were associated with higher survival rates[hazard ratio(HR)=0.97,Pes with a higher percentage of patients with a college level education and counties with a higher urban population had higher 5-year survival rates(HR=0.96,P=0.002 and HR=0.97,P=0.004,respectively).CONCLUSION Worse survival outcomes were observed in lower income counties while higher income and education level were associated with higher 5-year overall survival among gallbladder and biliary malignancies.

关键词： Biliary tract cancers Survival Outcomes research Socioeconomic factors Healthcare disparities

Orchard Sports Injury and Illness Classification System (OSIICS) Version 15

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Journal of Sport and Health Science 2024年第4期13卷 599-604页

作者： John W.Orchard ebonie Rio kay M.Crossley Jessica J.Orchard Margo Mountjoy School of Public Health University of SydneySydneyNSW 2006Australia La Trobe Sport and exercise Medicine Research Centre La Trobe UniversityMelbourneVIC 3083Australia Department of Family Medicine McMaster UniversityHamilton L8S 4L8Canada

Background:Sports medicine(injury and illnesses)requires distinct coding systems because the International Classification of Diseases is insuf-ficient for sports medicine *** Orchard Sports Injury and Illness Classification System(OSIICS)is one of two sports medicine coding systems recommended by the International Olympic *** updates of coding systems are ***:For Version 15,updates for mental health conditions in athletes,sports cardiology,concussion sub-types,infectious diseases,and skin and eye conditions were considered particularly ***:Recommended codes were added from a recent International Olympic Committee consensus statement on mental health conditions in *** landmark sports cardiology papers were used to update a more comprehensive list of sports cardiology *** union protocols on head injury assessment were used to create additional concussion ***:It is planned that OSIICS Version 15 will be translated into multiple new languages in a timely fashion to facilitate international *** large number of recently published sport-specific and discipline-specific consensus statements on athlete surveillance warrant regular updating of OSIICS.

关键词： Sports cardiology Dermatology eye injuries Concussion Infectious diseases Sports injury classification

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A Multi-Channel CMOS Analog Front-end Interface IC with 157.8 d B Current Detection Dynamic Range

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Chinese Journal of electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG Man-kay LAW Li ZHOU Jie CHeN Ming CHeN Institute of Microelectronics of the Chinese Academy of Science University of Chinese Academy of Sciences Zunyi Normal University Institute of Microelectronics and Dept.of eCe FST University of Macau

A high dynamic range and low-noise CMOS(complementary metal-oxide-semiconductor transistor)front-end interface integrated circuit(IC) with multi-channel detection is presented in this paper. Two different current detection channels, composed of a trans-impedance amplifier(TIA) and an integrator-differentiator TIA, are used to boost the current detection range. A capacitance-coupled instrument amplifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigma-delta modulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective number of bits above 16 bits. The presented interface IC is implemented in 0.18-μm CMOS process with supply voltage of 3.3 V, and a proto-type electrochemical sensor platform with miniaturized sensor array is developed to verify the functionality of the interface IC. Measurement results indicate that the designed interface IC achieves 157.8 d B current detection dynamic range, and the measured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigma-delta modulation Semiconductor device measurement Voltage measurement Current measurement Noise Bandwidth

Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients:A mini review for clinicians

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World Journal of Critical Care Medicine 2024年第2期13卷 106-115页

作者： Dominic Ti Ming Tan kay Choong See Department of Medicine National University HospitalSingapore 119228Singapore

Among critically ill patients,severe pulmonary and extrapulmonary tuberculosis has high morbidity and ***,it is a diagnostic challenge given its nonspecific clinical symptoms and signs in early stages of the *** addition,management of severe pulmonary and extrapulmonary tuberculosis is complicated given the high risk of drug-drug interactions,drug-disease interactions,and adverse drug *** help clinicians acquire an up-to-date approach to severe tuberculosis,this paper will provide a narrative review of contemporary diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients.

关键词： Tuberculosis Severe tuberculosis Mycobaterium tuberculosis Critical care Intensive care Diagnosis of tuberculosis Management of tuberculosis