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比较增强彩色多普勒超声定位活检与系统性组织活检对前列腺癌检出的效能

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国际医学放射学杂志 2011年第1期34卷 95-页

作者： M.j.Mitterberger F.Aigner W.Horninger H.Ulmer S.Cavuto e.j.halpern 乔辉 Department of Urology Medical University Innsbruck

目的比较增强彩色多普勒超声(CeCD-US)定位活检与系统性组织活检(SB)在1776例男性病人中检出前列腺癌的效能。

关键词：前列腺癌前列腺活检超声对比剂

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应用超声弹性成像评价正中神经弹性来提高超声诊断腕管综合征的准确性

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国际医学放射学杂志 2014年第2期 175-175页

作者： H.Miyamoto e.j.halpern M.Kastlunger M.Gabl R.Arora R.Bellmann-Weile 尹丽 Department of Diagnostic Radiology Medical University Innsbruck Anichstrasse 35 A -6020 Innsbruck Austria

目的通过比较健康志愿者和腕管综合征(CTS)病人的正中神经(MN)弹性,评价超声弹性成像测量正中神经弹性的诊断价值。材料与方法本研究经机构审查委员会批

关键词：正中神经臂丛腕管综合征超声弹性成像弹性力学性能

腕管综合征的分叉正中神经:US横断面积测量的评估

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国际医学放射学杂志 2011年第4期 387-387页

作者： A.S.Klauser e.j.halpern R.Faschingbauer F.Guerra C.Martinoli M.F.Gabl 余华君 Department of Diagnostic Radiology Medical University Innsbruck

目的用横断面积(CSA)测量腕管水平的正中神经面积(CSAc),同时测量旋前方肌水平的较近端的正中神经面积(CSAp),评估超声(US)在分叉正中神经病人超声诊断腕管综合征(CTS)的正确性。方法本研究符合HIPAA并经当地机构审查委员会批准,口头告... 详细信息

目的用横断面积(CSA)测量腕管水平的正中神经面积(CSAc),同时测量旋前方肌水平的较近端的正中神经面积(CSAp),评估超声(US)在分叉正中神经病人超声诊断腕管综合征(CTS)的正确性。方法本研究符合HIPAA并经当地机构审查委员会批准,口头告知并签署书面知情同意。对

关键词：正中神经病人臂丛腕管综合征分叉 US

基于尸检的肘关节屈总肌腱超声弹性成像与组织学对照研究

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国际医学放射学杂志 2017年第4期 465-465页

作者： A.S.Klauser M.j.Pamminger e.j.halpern M.M.H.Abd ellah B.Moriggl M.S.Taljanovic 张鹏 Department of Radiology Medical University of Innsbruck

摘要目的基于尸检与组织学结果,探讨肘关节屈总肌腱的常规B超成像和压力性超声弹性成像相关性。材料与方法对16具尸体(共25个肘关节屈总肌腱)进行分析,其中女11例(年龄71～101岁,中位年龄85岁)、男5例(年龄70～88岁,中位年龄78岁)。所...

摘要目的基于尸检与组织学结果,探讨肘关节屈总肌腱的常规B超成像和压力性超声弹性成像相关性。材料与方法对16具尸体(共25个肘关节屈总肌腱)进行分析,其中女11例(年龄71～101岁,中位年龄85岁)、男5例(年龄70～88岁,中位年龄78岁)。所有捐献者生前均签署知情同意书。常规B超结果分级:1级,超声显示正常屈总肌腱为均质的纤维组织;2级,肌腱增厚或低回声区/钙化区小于肌腱30%;3级,肌腱增厚或低回声区/钙化区大于肌腱30%。压力

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超声横断面积测量腕管综合征病人:与神经传导研究相比增量和比值能否预测其严重程度?

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国际医学放射学杂志 2015年第5期 507-507页

作者： A.S.Klauser M.M.H.A.ellah e.j.halpern C.Siedentopf T.Auer G.eberle 罗厚丽 Department of Diagnostic Radiology Medical University Innsbruck

摘要目的通过对正中神经测量计算来预测腕管综合征(CTS)的严重程度,以评价2种不同超声检查的诊断准确性,CTS经临床和电生理证实。方法 427例病人[女325例,男102例,年龄17～90岁,平均(57.9±14.7)岁],其中643个手腕经临床和神经传导研究(... 详细信息

摘要目的通过对正中神经测量计算来预测腕管综合征(CTS)的严重程度,以评价2种不同超声检查的诊断准确性,CTS经临床和电生理证实。方法 427例病人[女325例,男102例,年龄17～90岁,平均(57.9±14.7)岁],其中643个手腕经临床和神经传导研究(NCS)诊断为CTS。在腕管水平(CSAc)和旋前方肌水平(CSAP)进行正中神经横断面积的测

关键词：腕管综合征 CTS 神经传导横断面积病人程度

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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State-of-the-Art management of knee osteoarthritis

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World journal of Clinical Cases 2015年第2期3卷 89-101页

作者： Kenton H Fibel Howard j Hillstrom Brian C halpern Department of Medicine Primary Care Sports MedicineHospital for Special Surgery Leon Root Motion Analysis Laboratory Department of RehabilitationHospital for Special Surgery

Osteoarthritis(OA) is the most common type of arthritis found in the United States' population and is also the most common disease of joints in adults throughout the world with the knee being the most frequently affected of all joints. As the United States' population ages along with the increasing trends in obesity prevalence in other parts of the world, it is expected that the burden of OA on the population, healthcare system, and overall economy will continue to increase in the future without making major improvements in managing knee OA. Numerous therapies aim to reduce symptoms of knee OA and continued research has helped to further understand the complex pathophysiology of its disease mechanism attempting to uncover new potential targets for the treatment of OA. This review article seeks to evaluate the current practices for managing knee OA and discusses emerging therapies on the horizon. These practices include non-pharmacological treatments such as providing patient education and self-management strategies, advising weight loss, strengthening programs, and addressing biomechanical issues with bracing or foot orthoses. Oral analgesics and anti-inflammatories are pharmacologicals that are commonly used and the literature overall supports that some of these medications can be helpful for managing knee OA in the short-term but are less effective for long-term management. Additionally, more prolonged use significantly increases the risk of serious associated side effects that are not too uncommon. Diseasemodifying osteoarthritis drugs are being researched as a treatment modality to potentially halt or slow disease progression but data at this time is limited and continued studies are being conducted to further investigate their effectiveness. Intra-articular injectables are also implemented to manage knee OA ranging from corticosteroids to hyaluronans to more recently plateletrich plasma and even stem cells while several other injection therapies are presently b

关键词： Disease-modifying osteoarthritis drugs Knee osteoarthritis Disease-modifying osteoarthritis drugs Osteoarthritis management Non-steroidal antiinflammatory drugs Hyaluronic acid Arthroscopy Platelet-rich plasma Corticosteroids Stem cells

ReSPONSe OF THe eQUATORIAL WeSTeRN PACIFIC THeRMOHALINe STRUCTURe TO WIND VARIATION

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journal of Oceanology and Limnology 1986年第2期4卷 119-126页

作者：胡敦欣,David halpern Institute of Oceanology Academia Sinica NOAA Pacific Marine environmental Laboratory

During the Global Weather experiment oceanographic measurements were recorded during winter and summer in the western Pacific region 5°S-5°N,160°e-175°e. The variations of the upper ocean temperature and salinity fields were produced by the large seasonal and spatial wind fluctuations. The vertical temperature structure of the thermocline at the equator, the meridional slope of the thermocline south of the equator, and the northward penetration of high salinity water were related to the direction and intensity of the zonal wind-stress.

关键词： ReSPONSe OF THe eQUATORIAL WeSTeRN PACIFIC THeRMOHALINe STRUCTURe TO WIND VARIATION

Sperm retrieval success and testicular histopathology in idiopathic nonobstructive azoospermia

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Asian journal of Andrology 2020年第6期22卷 555-559页

作者： Arighno Das joshua A halpern Annie L Darves-Bornoz Mehul Patel james Wren Mary Kate Keeter Robert e Brannigan Department of Urology Northwestern University Feinberg School of MedicineChicagoIL 60611USA

Prior studies have investigated sperm retrieval rates in men with non obstructive azoospermia(NOA)secondary to specific etiologies,yet most cases of NOA are *** compared sperm retrieval rates and testicular histopathology in idiopathic NOA(iNOA)and nonidiopathic NOA(niNOA).We performed a retrospective review of men with NOA who underwent microdissection testicular sperm extraction(microTeSe)between 2000 and *** with no history of malignancy or cryptorchidism and negative genetic evaluation were considered *** regression determined the association between idiopathic etiology and primary outcomes of sperm retrieval and active spermatogenesis on *** 224 men,86(38.4%)were idiopathic,75(33.5%)were nonidiopathic,and 63(28.1%)did not undergo genetic *** age and serum testosterone were higher among iNOA or no testing versus *** follicle-stimulating hormone(FSH)was lower among iNOA or no testing versus niNOA.A higher proportion of iNOA or no testing versus niNOA had a clinical *** retrieval rates were similar between iNOA,niNOA,and no testing(41.8%vs 48.0%vs 55.6%,respectively;P=0.255).Active spermatogenesis was seen in a higher proportion of iNOA or no testing versus niNOA(31.4%and 27.0%vs 16.0%,P=0.073).On multivariable analysis,iNOA was not associated with sperm retrieval or spermatogenesis(P=0.430 and P=0.078,respectively).Rates of sperm retrieval and spermatogenesis on testis pathology were similar in men with iNOA and *** data will be useful to clinicians in preoperative counseling for men with NOA and negative genetic evaluation.

关键词： microdissection testicular sperm extraction nonobstructive azoospermia sperm retrieval rate