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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： Bhatt D.L. Fox K.A.A. Hacke W. e.j. topol 罗亮 Department of Genetics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKGROUND: Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events. MeTHODS: We randomly assigned 15,603 patients with either clinically evident cardiovascular disease or multiple risk factors to receive clopidogrel(75 mg per day) plus low-dose aspirin(75 to 162 mg per day) or placebo plus low-dose aspirin and followed them for a median of 28 months. The primary efficacy end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes. ReSULTS: The rate of the primary efficacy end point was 6.8 percent with clopidogrel plus aspirin and 7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confidence interval, 0.83 to 1.05; P=0.22). The respective rate of the principal secondary efficacy end point, which included hospitalizations for ischemic events, was 16.7 percent and 17.9 percent(relative risk, 0.92; 95 percent confidence interval, 0.86 to 0.995; P=0.04), and the rate of severe bleeding was 1.7 percent and 1.3 percent(relative risk, 1.25; 95 percent confidence interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end point among patients with multiple risk factors was 6.6 percent with clopidogrel and 5.5 percent with placebo(relative risk, 1.2; 95 percent confidence interval, 0.91 to 1.59; P=0.20) and the rate of death from cardiovascular causes also was higher with clopidogrel(3.9 percent vs. 2.2 percent, P=0.01). In the subgroup with clinically evident atherothrombosis, the rate was 6.9 percent with clopidogrel and 7.9 percent with placebo(relative risk, 0.88; 95 percent confidence interval, 0.77 to 0.998; P=0.046). CONCLUSIONS: In this trial, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors. Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

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CHARISMA试验中缺乏氯吡格雷与他汀类药物之间相互作用的证据

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 55-56页

作者： Saw j. Brennan D.M. Steinhubl S.R. e.j. topol 刘相飞 Department of Cardiovascular Diseases Scripps Clinic La Jolla CA United States Dr.

目的:本研究旨在在一个长期随访的随机安慰剂对照试验中,评价氯吡格雷与他汀类药物间相互作用所产生的潜在影响。背景:关于主要由CYP3A4代谢的他汀类药物是否使氯吡格雷向其活性代谢物的转化减少并降低氯吡格雷的临床疗效,目前仍存有争... 详细信息

目的:本研究旨在在一个长期随访的随机安慰剂对照试验中,评价氯吡格雷与他汀类药物间相互作用所产生的潜在影响。背景:关于主要由CYP3A4代谢的他汀类药物是否使氯吡格雷向其活性代谢物的转化减少并降低氯吡格雷的临床疗效,目前仍存有争议。方法:

关键词：氯吡格雷安慰剂空白剂他汀类 CHARISMA 药物

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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An ensemble method for gene discovery based on DNA microarray data

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Science China(Life Sciences) 2004年第5期47卷 396-405页

作者： Kathy L. MOSeR eric j. topol Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simulta-neously. Current analyses of microarray data focus on precise classification of biological types, for example, tumor versus normal tissues. A further scientific challenging task is to extract dis-ease-relevant genes from the bewildering amounts of raw data, which is one of the most critical themes in the post-genomic era, but it is generally ignored due to lack of an efficient approach. In this paper, we present a novel ensemble method for gene extraction that can be tailored to fulfill multiple biological tasks including (i) precise classification of biological types; (ii) disease gene mining; and (iii) target-driven gene networking. We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensemble decision,recursive partition tree,feature gene selection.

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Application of the extended Fourier amplitude sensitivity testing(FAST)method to inflated,axial stretched,and residually stressed cylinders

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Applied Mathematics and Mechanics(english edition) 2023年第12期44卷 2139-2162页

作者： H.ASGHARI H.topol B.MARKeRT j.MeRODIO Departamento de Matemática Aplicada a las TIC ETS de Ingenier a de Sistemas InformáticosUniversidad Politécnica de MadridMadrid 28031Spain Institute of General Mechanics RWTH Aachen UniversityAachen 52062Germany

This paper is dedicated to applying the Fourier amplitude sensitivity test(FAST)method to the problem of mixed extension and inflation of a circular cylindrical tube in the presence of residual *** metafunctions and the Ishigami function are considered in the sensitivity analysis(SA).The effects of the input variables on the output variables are investigated,and the most important parameters of the system under the applied pressure and axial force such as the axial stretch and the azimuthal stretch are determined.

关键词： sensitivity analysis(SA) Fourier amplitude sensitivity test(FAST)method cylindrical inflation nonlinear elasticity

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Seasonal Dynamics of Turbidity Maximum in the Muthupet estuary, India

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journal of Ocean University of China 2015年第5期14卷 765-777页

作者： PRIYA K.L. jeGATHAMBAL P. jAMeS e.j. School of Civil engineering Karunya University

Results are presented of the longitudinal and vertical profiling of salinity and suspended particulate matter(SPM) at the Muthupet estuary, India, during a one year period under widely varying freshwater flow conditions. Freshwater flow was available during post-monsoon and monsoon. An up-estuary shift in the location of estuarine turbidity maxima(eTM) was observed during the transition from post-monsoon to pre-monsoon and further it shifted downstream during the transition from pre-monsoon to monsoon, thereby exhibiting a pronounced seasonal cycle. The salinity intrusion was dependent on the freshwater discharge and was expressed as a power function of freshwater flow, explaining 97% of the variance. The formation of a salt plug in Muthupet estuary and its seasonal dynamics were observed, which is not an identified feature of any of the Indian estuaries studied so far. The geographical positions of salt plug and eTM core were more or less the same during their formation. The occurrence of two eTM during the LW of post-monsoon and the absence of eTM during monsoon explains the strong seasonal variation in the formation of eTM. The primary factor affecting the formation of eTM was identified as the freshwater flow over an annual cycle; the resuspension of sediments by tidal current affecting the formation on a flood/ebb cycle was secondary. The extent of shift of eTM was found to be an inverse logarithmic function of the freshwater discharge. The separation between eTM intrusion and salinity intrusion increased two fold with the increase in eTM intrusion.

关键词： estuarine turbidity maximum salinity intrusion suspended particulate matter salt plug Muthupet estuary, India

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A linear regression model (LRM) for groundwater chemistry in and around the Vaniyambadi industrial area, Tamil Nadu, India

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Chinese.j.urnal Of Geochemistry 2013年第1期32卷 19-26页

作者： Sajil Kumar P.j. Davis Delson P. Vernon j.G. james e.j. Brandenburg Technical University Cottbus-03046 Germany ITALCONSULT Riyadh-11421 Saudi Arabia Budapest University of Technology and economics (BMe) Budapest-Pf. 91 H-152 Hungary Water Institute Karunya UniversityCoimbatore-641114 India

A linear regression model in conjunction with cluster analysis was applied to the groundwater quality parameters for the Vaniyambadi industrial area, Tamil Nadu, India. These physico-chemical parameters were collected from 25 wells by intensive groundwater sampling conducted during january 2010. All the major ions, pH and electrical conductivity were analyzed. The abundances of cations were in the order of Na e of anions were in the order of Cl espectively. This was in agreement with the water types, Na-Cl and Na-Ca-HCO3, determined by the Piper plot. High concentrations of the ions Na, Cl and SO4 were recorded near the tanneries that operate within the study area. While the elevated concentrations of HCO3 and F were observed away from the tanneries. This peculiar hydrochemical behaviour suggests that the chemistry of water is predominantly influenced by tannery effluents and weathering of silicate minerals. Results of the linear regression model yielded 11 regression equations for the 5 most correlated parameters. A dendrogram from the cluster analysis showed 2 major clusters representing the influence of tanneries and geological formations in the study area, which confirmed the results of major ion chemistry.

关键词：线性回归模型地下水化学工业区印度 LRM 聚类分析物理化学参数研究区域

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MAGNeTIC MONOPOLeS

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Chinese Physics C 2016年第10期40卷 829-833页

作者： D. Milstead e.j. Weinberg Stockholm Univ. Columbia Univ.

The symmetry between electric and magnetic fields in the sourcefree Maxwell＇s equations naturally suggests that electric charges might have magnetic counterparts, known as magnetic monopoles. Although the greatest interest has been in the supermassive monopoles that are a firm prediction of all grand unified theories, one cannot exclude the possibility of lighter monopoles, even though there is at present no strong theoretical motivation for these.

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土木工程英语读本

土木工程英语读本

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作者： e.j.·霍尔(e.j. Hall)

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放射生物学供放射治疗、放射诊断和核医学用 1

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1987年

作者：（美）e.j.霍尔

本书主要讲了放射生物学.

ISBN: (纸本)15175·792

本书主要讲了放射生物学.

关键词：放射生物学

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