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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Dual‑Donor‑Induced Crystallinity Modulation enables 19.23% efficiency Organic Solar Cells

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Nano-Micro Letters 2025年第3期17卷 376-388页

作者： Anhai Liang Yuqing Sun Sein Chung jiyeong Shin Kangbo Sun Chaofeng Zhu jingjing Zhao Zhenmin Zhao Yufei Zhong Guangye Zhang Kilwon cho Zhipeng Kan Center On Nanoenergy Research Institute of Science and Technology for Carbon Peak&NeutralitySchool of Physical Science&TechnologyGuangxi UniversityNanning 530004People’s Republic of China Department of Chemical engineering Pohang University of Science and TechnologyPohang 37673South Korea College of New Materials and New energies Shenzhen Technology UniversityShenzhen 518118People’s Republic of China Zhejiang engineering Research Center for Fabrication and Application of Advanced Photovoltaic Materials School of Materials Science and EngineeringNingboTech UniversityNingbo 315100People’s Republic of China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004People’s Republic of China

Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains ***, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching *** a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance *** findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

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肝细胞癌:高乙肝病毒负荷和经动脉化疗栓塞治疗病人的死亡率

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国际医学放射学杂志 2013年第4期 376-376页

作者： S.j. Yu j.H. Lee e.S. jang e.j. cho M.S. Kwak j.H. Yoon 刘春明 Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine101 Daehak-ro Jongno-gu Seoul 110-744 Republic of Korea

目的确定乙型肝炎病毒（HBV）DNA水平与经动脉化疗栓塞治疗（TACe）的肝细胞癌病人生存期之间的关系。材料与方法本研究经机构审查委员会批准,并免除病人知情同意书。连续纳入2005年1月—2007年3月间的183例HBV源性肝细胞癌病人。入组... 详细信息

目的确定乙型肝炎病毒（HBV）DNA水平与经动脉化疗栓塞治疗（TACe）的肝细胞癌病人生存期之间的关系。材料与方法本研究经机构审查委员会批准,并免除病人知情同意书。连续纳入2005年1月—2007年3月间的183例HBV源性肝细胞癌病人。入组病人均行TACe治疗,但未接受抗病毒治疗。所有病人均在行TACe治疗前检测血清HBV DNA水平,计算其从入组当天至死亡时的总体生存期。借助于独立的影像学评估,应用改良实体肿瘤反应评价标准评估肿瘤进展。结果总体生存期的中位数为19个月（95%CI:13.7;4.3）,疾病进展时间的中位数为4个月（95%CI:3.03;.97）。多因素分析显示,TACe术前的HBV DNA血浆水平高（>2000IU/L）是降低总体生存期[P=0.021;风险比（HR）,1.725]、癌症进展-相关高死亡率（P=0.014;HR,1.936）及癌症进展所致肝衰竭相关死亡率（P=0.005,HR,3.908）的独立危险因素。TACe术前HBV DNA水平对非癌症进展所致肝衰竭相关死亡率无显著影响。结论 TACe术前的HBV DNA血浆水平高与TACe术后较差的总体生存期和肝细胞癌的快速进展相关,病人死于癌症的快速进展而非肝炎的恶化。

关键词：肝细胞癌生存期 HBV 动脉化疗栓塞 TACe 病人死亡率

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Seasonal Dynamics of Turbidity Maximum in the Muthupet estuary, India

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journal of Ocean University of China 2015年第5期14卷 765-777页

作者： PRIYA K.L. jeGATHAMBAL P. jAMeS e.j. School of Civil engineering Karunya University

Results are presented of the longitudinal and vertical profiling of salinity and suspended particulate matter(SPM) at the Muthupet estuary, India, during a one year period under widely varying freshwater flow conditions. Freshwater flow was available during post-monsoon and monsoon. An up-estuary shift in the location of estuarine turbidity maxima(eTM) was observed during the transition from post-monsoon to pre-monsoon and further it shifted downstream during the transition from pre-monsoon to monsoon, thereby exhibiting a pronounced seasonal cycle. The salinity intrusion was dependent on the freshwater discharge and was expressed as a power function of freshwater flow, explaining 97% of the variance. The formation of a salt plug in Muthupet estuary and its seasonal dynamics were observed, which is not an identified feature of any of the Indian estuaries studied so far. The geographical positions of salt plug and eTM core were more or less the same during their formation. The occurrence of two eTM during the LW of post-monsoon and the absence of eTM during monsoon explains the strong seasonal variation in the formation of eTM. The primary factor affecting the formation of eTM was identified as the freshwater flow over an annual cycle; the resuspension of sediments by tidal current affecting the formation on a flood/ebb cycle was secondary. The extent of shift of eTM was found to be an inverse logarithmic function of the freshwater discharge. The separation between eTM intrusion and salinity intrusion increased two fold with the increase in eTM intrusion.

关键词： estuarine turbidity maximum salinity intrusion suspended particulate matter salt plug Muthupet estuary, India

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A linear regression model (LRM) for groundwater chemistry in and around the Vaniyambadi industrial area, Tamil Nadu, India

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Chinese.j.urnal Of Geochemistry 2013年第1期32卷 19-26页

作者： Sajil Kumar P.j. Davis Delson P. Vernon j.G. james e.j. Brandenburg Technical University Cottbus-03046 Germany ITALCONSULT Riyadh-11421 Saudi Arabia Budapest University of Technology and economics (BMe) Budapest-Pf. 91 H-152 Hungary Water Institute Karunya UniversityCoimbatore-641114 India

A linear regression model in conjunction with cluster analysis was applied to the groundwater quality parameters for the Vaniyambadi industrial area, Tamil Nadu, India. These physico-chemical parameters were collected from 25 wells by intensive groundwater sampling conducted during january 2010. All the major ions, pH and electrical conductivity were analyzed. The abundances of cations were in the order of Na e of anions were in the order of Cl espectively. This was in agreement with the water types, Na-Cl and Na-Ca-HCO3, determined by the Piper plot. High concentrations of the ions Na, Cl and SO4 were recorded near the tanneries that operate within the study area. While the elevated concentrations of HCO3 and F were observed away from the tanneries. This peculiar hydrochemical behaviour suggests that the chemistry of water is predominantly influenced by tannery effluents and weathering of silicate minerals. Results of the linear regression model yielded 11 regression equations for the 5 most correlated parameters. A dendrogram from the cluster analysis showed 2 major clusters representing the influence of tanneries and geological formations in the study area, which confirmed the results of major ion chemistry.

关键词：线性回归模型地下水化学工业区印度 LRM 聚类分析物理化学参数研究区域

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MAGNeTIC MONOPOLeS

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Chinese Physics C 2016年第10期40卷 829-833页

作者： D. Milstead e.j. Weinberg Stockholm Univ. Columbia Univ.

The symmetry between electric and magnetic fields in the sourcefree Maxwell＇s equations naturally suggests that electric charges might have magnetic counterparts, known as magnetic monopoles. Although the greatest interest has been in the supermassive monopoles that are a firm prediction of all grand unified theories, one cannot exclude the possibility of lighter monopoles, even though there is at present no strong theoretical motivation for these.

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土木工程英语读本

土木工程英语读本

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作者： e.j.·霍尔(e.j. Hall)

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放射生物学供放射治疗、放射诊断和核医学用 1

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1987年

作者：（美）e.j.霍尔

本书主要讲了放射生物学.

ISBN: (纸本)15175·792

本书主要讲了放射生物学.

关键词：放射生物学

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Comparison between lighting performance of a virtual natural lighting solutions prototype and a real window based on computer simulation

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Frontiers of Architectural Research 2014年第4期3卷 398-412页

作者： R.A. Mangkuto S. Wang M.B.C. Aries e.j. van Loenen j.L.M. Hensen Building Physics and Services Department of the Built Environment Eindhoven University of TechnologyDen Dolech 2 5612 AZ Eindhoven the Netherlands Sustainable energy Technology Department of Mechanical Engineering Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven the Netherlands Philips Research High Tech Campus 34 5656 AE Eindhoven the Netherlands

This article discusses the measurement and simulation of a first generation prototype of Virtual Natural Lighting Solutions （VNLS）, which are systems that can artificially provide natural lighting as well as a realistic outside view, with properties comparable to those of real windows and skylights. examples of employing Radiance as a simulation tool to predict the lighting performance of such solutions are shown, for a particular case study of a VNLS prototype displaying variations of a simplified view of overcast, clear, and partly cloudy skies. Measurement and simulation were conducted to evaluate the iUuminance distribution on workptane level. The key point of this study is to show that simulations can be used to compare an actual VNLS prototype with a hypothetical real window under the same sky scenes, which was physically not possible, since the test room was not located at the building＇s facade. It is found that the investigated prototype yields a less rapidly drop iUuminance distribution and a larger average illuminance than the corresponding real window, under the overcast （52 lx compared to 28 lx） and partly cloudy （102 lx compared to 80 lx） sky scenes. Under the clear sky scene, the real window yields a larger averase illuminance （97 lx） compared to the prototype （71 lx）, due to the influence of direct sunlight.

关键词： Virtual Natural Lighting Solutions Light View Simulation Virtual window Prototype

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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