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中国医疗前沿 2006年第1期 60-63页

作者： Mark e.grube 王兴栋美国Kaufman Hall & Associates咨询公司

社区医院必须当机立断,采取果断行动,从战略层面开拓出可持续发展之道,这包括如下六个方面:战略整合企划、提升运营效率、提高服务品质、调整业务内容、与医护人员建立更紧密联系和与相关机构建立战略联系。

关键词：社区医院私人诊所医疗保险支付美国美利坚合众国北美洲

GuardWire Plus远端保护下急性心肌梗死的经皮冠状动脉介入治疗

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中国介入心脏病学杂志 2003年第4期11卷 224-224页

作者： e.grube F.W.Amann S.Klugmann 申珂 Heart Center Siegburg UniversitatsSpital Zurich Niguarda Hospital

1 简介 :急性心肌梗死 (急性心梗 )的发生 ,源于粥样硬化斑块破裂 ,继而血栓形成 ,将冠状动脉 (冠脉 )血流阻塞。近期研究表明 ,早期介入治疗尤其是早期支架术治疗 ,在重建冠脉血流上优于溶栓治疗。但是 ,在心外膜中的冠脉重建的TIMI 3... 详细信息

1 简介 :急性心肌梗死 (急性心梗 )的发生 ,源于粥样硬化斑块破裂 ,继而血栓形成 ,将冠状动脉 (冠脉 )血流阻塞。近期研究表明 ,早期介入治疗尤其是早期支架术治疗 ,在重建冠脉血流上优于溶栓治疗。但是 ,在心外膜中的冠脉重建的TIMI 3级血流 ,并不意味着心肌的良好灌注。在微小血管水平 ,心肌血流灌注有可能被远端栓塞所阻断。一个定量评估微血管血流和组织灌注的指标就是心肌灌注评分 (myocar dialblushscore,MBS)。根据造影剂充盈心肌毛细血管床 (可看做血液灌注心肌 )的速率和浓度 ,可以将灌注分级为 1～3。一个近期的研究显示 ,在恢复到正常TIMI- 3级血流的病人当中 ,只有 2 8%MBS正常 ,而 30 %的MBS没有或灌注极差 ,4 2 %低于正常。较差的分数意味着组织灌注不良 ,而且已经证明会增加死亡的危险。2 研究背景 :在 3个位于欧洲的中心 ,37名 (39个病变 )急性心梗病人接受经皮冠脉介入治疗 (PCI)。GuardWire Plus被用来预防可能的远端栓塞。用TIMI血流和心肌灌注评分来评估远端保护装置是否可以增加病人的血流灌注。病人自身冠脉为 4 3...

关键词： GuardWire Plus远端保护急性心肌梗死经皮冠状动脉介入治疗心肌灌注

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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extremotolerant fungi from alpine rock lichens and their phylogenetic relationships

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Fungal Diversity 2016年第1期76卷 119-142页

作者： Lucia Muggia Antonia Fleischhacker Theodora Kopun Martin grube Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Sciences Universitàdegli Studi di TriesteVia Valerio 12/234128 TriesteItaly

Fungi other than the lichen mycobiont frequently co-occur within lichen thalli and on the same rock in harsh *** these situations dark-pigmented mycelial structures are commonly observed on lichen thalli,where they persist under the same stressful conditions as their *** we used a comprehensive sampling of lichen-associated fungi from an alpine habitat to assess their phylogenetic relationships with fungi previously known from other *** multilocus phylogenetic analyses suggest that most of the 248 isolates belong to the Chaetothyriomycetes and Dothideomycetes,while a minor fraction represents Sordariomycetes and *** many lichens also were infected by phenotypically distinct lichenicolous fungi of diverse lineages,it remains difficult to assess whether the culture isolates represent these fungi or are from additional cryptic,extremotolerant fungi within the *** of these strains represent yet undescribed lineages within Chaethothyriomycetes and Dothideomycetes,whereas other strains belong to genera of fungi,that are known as lichen colonizers,plant and human pathogens,rock-inhabiting fungi,parasites and *** symbiotic structures of the lichen thalli appear to be a shared habitat of phylogenetically diverse stress-tolerant fungi,which potentially benefit from the lichen niche in otherwise hostile habitats.

关键词： Black fungi endolichenic Symbioses Lichenicolous.Life style Phylogeny

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Global assessment of genetic variation and phenotypic plasticity in the lichen-forming species Tephromela atra

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Fungal Diversity 2014年第1期64卷 233-251页

作者： Lucia Muggia Sergio Pérez-Ortega Alan Fryday Toby Spribille Martin grube Institute of Plant Sciences Karl-Franzens-University GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia Giorgieri 1034127 TriesteItaly Department of environmental Biology Museo Nacional de Ciencias Naturales(CSIC)C/Serrano 115-dpdoMadridSpain Department of Plant Biology Michigan State UniversityEast LansingMI 48824-1312USA Division of Biological Sciences University of MontanaMissoulaMT 59812USA

Understanding how many species exist and the processes by which they form remains a central topic of ecological and evolutionary biology,but represents a special challenge within microbial *** lichen-forming fungi represent one of the best examples in which species evolution and diversity create patterns of high phenotypic plasticity coupled with wide geographic *** sampled the lichen-forming species Tephromela atra and related species at a world-wide scale to reconstruct a phylogenetic hypothesis using three nuclear *** were also studied for morphological and chemical traits to assess how well the phenotypic relationships with species,previously segregated from ***,agrees with molecular *** used a genealogical concordance approach and identified 15 monophyletic clades,which may represent independent *** combining morphological and chemical characters,ecological preferences and geographic origin we distinguish six different *** subtle phenotypical traits are frequently used for describing previously cryptic species in fungi,the continuum of variability found in morphology and chemical patterns in *** prevents the description of new taxa with characteristic *** observed that phenotypic characters arise in parallel at local or regional scale but are not correlated with genetic ***,they are insufficient for characterizing species with broad geographic ranges within ***.

关键词： Chemistry ecology Morphology Multigene phylogeny Phylogeography Symbiosis

enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

An efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng e Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Interpreting Kuhn＇s Incommensurability-Thesis： Its Different Meanings and epistemological Consequences

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Journal of Philosophy Study 2013年第5期3卷 377-397页

作者： Dirk-Martin grube Ph.D. Full Professor of Philosophy of Religion Department of Religious Studies and Theology University of Utrecht The Netherlands

Kuhn＇s incommensurability-thesis is crucial for consequences for the pursuit of epistemology. A interpreting his views on the development of science and their commemoration of the 50th anniversary of the publication of the original version of Kuhn＇s epoch-making book The Structure of Scientific Revolutions （henceforth： SSR） should thus provide a thorough reflection on this thesis. However, this thesis is not easy to interpret. It is not only complex in itself but has also undergone a historical development--in Kuhn＇s own hands and in those of his interpreters. In this article, I sort out the different interpretations of it, in particular, in Part A. In Part B, I demonstrate their epistemological consequences. Under closer scrutiny, Kuhn＇s incommensurability-thesis contains several sub-theses Different senses of ＂incommensurability＂ thus need to be distinguished. However, the way in which those distinctions are drawn in Kuhn-scholarship differs. In paragraph I of Part A, I provide an overview of the reception of the incommensurability-thesis in Kuhn-scholarship. In Paragraph II, I trace its development in Kuhn＇s later writings： given its importance and contested nature, Kuhn later clarifies his original thesis. Those later clarifications＇ main function consists in domesticating the most radically relativistic aspects his original incommensurability-thesis had, at least, in the eyes of his interpreters. The upshot of Part A （Paragraphs I and II） is to provide a coherent interpretation of Kuhn＇s incommensurability-thesis. To that end, I distinguish in line with much of Kuhn-scholarship a semantic from a methodological sense of incommensurability. In part B, the question is raised： What sort of epistemological consequences follow from both senses of incommensurability？ In particular, what consequences follow for the issues of reference, subjectivity （objectivity）, pluralism, and realism？ The underlying question is to what extent Kuhnian incommensurability caters to a re

关键词： Sankey reference Hoyningen-Huene paradigm shift Rorty Bernstein relativism pluralism