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Ultrafast laser state active controlling based on anisotropic quasi-1D material

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light(science & Applications) 2024年第4期13卷 717-726页

作者： Zixin Yang Qiang Yu jian Wu Haiqin De.g.Yan Zhang Wenchao Wang Tianhao Xian Luyi Huang junrong Zhang shuai Yuan jinyong Le.g.li Zhan Zongfu jiang junyong Wang Kai Zhang Pu Zhou College of Advanced Interdisciplinary studies National University of Defense TechnologyChangsha 410073China. Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China. i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China. school of Applied and e.g.neering Physics Cornell UniversityIthacaNY 14853USA. state Key Laboratory of Advanced Optical Communication systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China. shanghai Key Lab of Modern Optical system University of Shanghai for Science and TechnologyShanghai 200093China

Laser state active controlling is challe.g.ng under the influence of inherent loss and other nonlinear effects in ultrafast *** an extension of degree of freedom in optical devices based on low-dimensional materials may be a way ***,the anisotropic quasi-one-dimensional layered material Ta2Pds6 was utilized as a saturable absorber to modulate the nonlinear parameters effectively in an ultrafast system by polarization-dependent *** polarization-sensitive nonlinear optical response facilitates the Ta2Pds6-based mode-lock laser to sustain two types of laser states,i.e.,conventional soliton and noise-like *** laser state was switchable in the single fiber laser with a mechanism revealed by numerical *** coding was further demonstrated in this platform by employing the laser as a codable light *** work proposed an approach for ultrafast laser state active controlling with low-dimensional material,which offers a new avenue for constructing tunable on-fiber devices.

关键词： polarization fiber controlling

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神经程序修复领域数据泄露问题的实证研究

软件学报 2024年第7期35卷 3071-3092页

作者：李卿源钟文康李传艺葛季栋骆斌计算机软件新技术国家重点实验室(南京大学) 江苏南京210023

修复软件缺陷是软件工程领域一个无法回避的重要问题,而程序自动修复技术则旨在自动、准确且高效地修复存在缺陷的程序,以缓解软件缺陷所带来的问题.近年来,随着深度学习的快速发展,程序自动修复领域兴起了一种使用深度神经网络去自动... 详细信息

修复软件缺陷是软件工程领域一个无法回避的重要问题,而程序自动修复技术则旨在自动、准确且高效地修复存在缺陷的程序,以缓解软件缺陷所带来的问题.近年来,随着深度学习的快速发展,程序自动修复领域兴起了一种使用深度神经网络去自动捕捉缺陷程序及其补丁之间关系的方法,被称为神经程序修复.从在基准测试上被正确修复的缺陷的数量上看,神经程序修复工具的修复性能已经显著超过了非学习的程序自动修复工具.然而,近期有研究发现:神经程序修复系统性能的提升可能得益于测试数据在训练数据中存在,即数据泄露.受此启发,为了进一步探究神经程序修复系统数据泄露的原因及影响,更公平地评估现有的系统:(1)对现有神经程序修复系统进行了系统的分类和总结,根据分类结果定义了神经程序修复系统的数据泄露,并为每个类别的系统设计了数据泄露的检测方法;(2)依照上一步骤中的数据泄露检测方法对现有模型展开了大规模检测,并探究了数据泄露对模型真实性能与评估性能间差异的影响以及对模型本身的影响;(3)分析现有神经程序修复系统数据集的收集和过滤策略,加以改进和补充,在现有流行的数据集上,基于改进后的策略构建了一个纯净的大规模程序修复训练数据集,并验证了该数据集避免数据泄露的有效性.由实验结果发现:调研的10个神经程序修复系统在基准测试集上均出现了数据泄露,其中,神经程序修复系统RewardRepair的数据泄露问题较为严重,在基准测试集Defects4j(v1.2.0)上的数据泄露达24处,泄露比例高达53.33%.此外,数据泄露对神经程序修复系统的鲁棒性也造成了影响,调研的5个神经程序修复系统均因数据泄露产生了鲁棒性降低的问题.由此可见,数据泄露是一个十分常见的问题,且会使神经程序修复系统得到不公平的性能评估结果以及影响系统在基准测试集上的鲁棒性.研究人员在训练神经程序修复模型时,应尽可能避免出现数据泄露,且要考虑数据泄露问题对神经程序修复系统性能评估产生的影响,尽可能更公平地评估系统.

关键词：程序自动修复神经程序修复深度学习数据泄露程序修复数据集

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Advances in targeted therapy for malignant lymphoma

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signal Transduction and Targeted Therapy 2020年第1期5卷 2234-2279页

作者： li Wang Wei Qin Yu-jia Huo Xiao li Qing shi john e.j.Rasko Anne janin Wei-li Zhao state Key Laboratory of Medical genomics Shanghai Institute of HematologyShanghai Rui Jin HospitalShanghai Jiao Tong University School of Medicine197 Rui Jin Er RoadShanghaiChina Pôle de Recherches sino-Français en science du Vivant et génomique Laboratory of Molecular PathologyShanghaiChina gene&stem Cell Therapy Program Centenary Institute Sydney Medical SchoolUniversity of SydneyCamperdownAustralia Cell and Molecular Therapies Royal Prince Alfred HospitalCamperdownAustralia U1165 Inserm/UniversitéParis 7 Hôpital Saint LouisParisFrance

The incidence of lymphoma has gradually increased over previous decades,and it ranks among the ten most prevalent cancers *** the development of targeted therapeutic strategies,though a subset of lymphoma patients has become curable,the treatment of refractory and relapsed diseases remains *** efforts have been made to explore new targets and to develop corresponding *** addition to novel antibodies targeting surface antigens and small molecular inhibitors targeting oncogenic signaling pathways and tumor suppressors,immune checkpoint inhibitors and chimeric antigen receptor T-cells have been rapidly developed to target the tumor *** these targeted agents have shown great success in treating lymphoma patients,adverse events should be *** selection of the most suitable candidates,optimal dosage,and effective combinations warrant further *** this review,we systematically outlined the advances in targeted therapy for malignant lymphoma,providing a clinical rationale for mechanism-based lymphoma treatment in the era of precision medicine.

关键词： lymphoma targeted dosage

Cutting Characteristics of Zr-Based Bulk Metallic glass

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journal of Materials science & Technology 2015年第2期31卷 153-158页

作者： D.X.Han g.Wang j.li K.C.Chan s.To F.F.Wu Y.L.gao Q.j.Zhai Laboratory for Microstructures Shanghai University Department of Industrial and system e.g.neering The Hong Kong Polytechnic University

Cutting behavior exerts a considerable influence on the fabrication of bulk metallic glass(BMg) components. In this study,the influences of machining parameters(i.e.,depth of cutting,feed rate,and spindle rate) on the turned surface of a Zr-based BMg after observing the 3D morphologies of this surface were *** results showed that the influence of the spindle rate on the surface morphologies is more substantial as compared to the depth of cutting and the feed rate. Nanoscratch tests were conducted to further characterize the separation mechanism of the chips,which revealed that the chips are torn off the surface of a BMg because of inhomogeneous localized maximum shear stress.

关键词： Bulk metallic glass Ultra-precision machining surf

政府多工具组合优惠对企业创新行为的影响研究

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中国管理科学 2024年第2期32卷 221-230页

作者：赵凯李磊青岛大学经济学院山东青岛266075 华侨大学统计学院福建厦门361021

为提高政府创新政策运作的协调性与实施的高效性,挖掘出能够有效激励企业创新的最优政策工具“组合拳”策略,本文基于2009—2019年我国沪深A股上市企业数据,着重考察和比较直接补贴、税收优惠和政府采购这三种创新政策工具及其组合对企... 详细信息

为提高政府创新政策运作的协调性与实施的高效性,挖掘出能够有效激励企业创新的最优政策工具“组合拳”策略,本文基于2009—2019年我国沪深A股上市企业数据,着重考察和比较直接补贴、税收优惠和政府采购这三种创新政策工具及其组合对企业创新行为的影响,揭示政府多工具组合优惠策略对异质性企业创新的效果差异。结果显示,由直接补贴、税收优惠和政府采购构成的多工具组合优惠策略,无论是在激励企业创新投入还是提升企业创新质量方面,皆为政府最优的实施策略,并且该策略对于激励国有企业创新的效果尤为明显。

关键词：多工具组合优惠多水平处理效应模型政府采购税收优惠实质性创新

Fe-N-C core-shell catalysts with single low-spin Fe(Ⅱ)-N_(4)species for oxygen reduction reaction and high-performance proton exchange membrane fuel cells

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journal of ene.g. Chemistry 2024年第6期93卷 538-546,I0013页

作者： Yan Wan linhui Yu Bingxin Yang Caihong li Chen Fang Wei guo Fang-Xing Xiao Yangming lin Xiamen Key Laboratory of Rare earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021FujianChina CAs Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021FujianChina Fujian Institute of Research on the structure of Matter Chinese Academy of SciencesFuzhou 350002FujianChina College of Materials science and e.g.neering Fuzhou UniversityNew CampusMinhou 350108FujianChina College of Chemistry and Materials science Fujian Normal UniversityFuzhou 350117FujianChina

Fe-N-doped carbon materials(Fe-N-C)are promising candidates for oxygen reduction reaction(ORR)relative to Pt-based catalysts in proton exchange membrane fuel cells(PeMFCs).However,the intrinsic contributions of Fe-N_(4)moiety with different chemical/spin states(e.g.D1,D2,D3)to ORR are unclear since various states coexist *** the present work,Fe-N-C core-shell nanocatalyst with single lowspin Fe(Ⅱ)-N_(4)species(D1)is synthesized and identified with ex-situ ultralow temperature Mossbauer spectroscopy(T=1.6 K)that could essentially differentiate various Fe-N_(4)states and invisible Fe-O *** quantifying with CO-pulse chemisorption,site density and turnover frequency of Fe-N-C catalysts reach 2.4×10^(-9)site.g.(-1)and 23 e site~(-1)s^(-1)during the ORR,***-wave potential(0.915V_(RHe))of the Fe-N-C catalyst is more positive(approximately 54 mV)than that of Pt/***,we observe that the performance of PeMFCs on Fe-N-C almost achieves the 2025 target of the Us Department of ene.g. by demonstrating a current density of 1.037 A cm^(-2)combined with the peak power density of 0,685 W cm^(-2),suggesting the critical role of Fe(Ⅱ)-N_(4)site(D1).After 500 h of running,PeMFCs still deliver a power density of 1.26 W cm^(-2)at 1.0 bar H_(2)-O_(2),An unexpected rate-determining step is figured out by isotopic labelling experiment and theoretical *** work not only offers valuable insights regarding the intrinsic contribution of Fe-N_(4)with a single spin state to alkaline/acidic ORR,but also provides great opportunities for developing high-performance stable PeMFCs.

关键词： Fuel cells Oxygen reduction reaction Non-platinum group metals(PgMs) Isotopic labelling Active site TOF

基于水通道蛋白与芳香类中药相关性探讨阿尔茨海默病机制

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中国实验方剂学杂志 2024年第17期30卷 227-238页

作者：陈森林黄赛娥王志晨李艳况时祥福建中医药大学福州350122 福建省认知康复重点实验室福州350003 福建中医药大学附属康复医院福州350003 贵州中医药大学第二附属医院贵阳550003

阿尔茨海默病(AD)是一种与年龄相关的神经退行性疾病,属中医学“痴呆”范畴。中医学认为“痰、湿、瘀、毒”是其发生、发展的重要病机,应用芳香类中药清除互结之痰湿、瘀毒是中医治疗AD的重要方法。水通道蛋白(AQPs)参与中枢神经系统(C... 详细信息

阿尔茨海默病(AD)是一种与年龄相关的神经退行性疾病,属中医学“痴呆”范畴。中医学认为“痰、湿、瘀、毒”是其发生、发展的重要病机,应用芳香类中药清除互结之痰湿、瘀毒是中医治疗AD的重要方法。水通道蛋白(AQPs)参与中枢神经系统(CNs)水液代谢,在CNs的脑水平衡中起着重要作用,深度参与了AD发生发展过程。AQPs可能是大量芳香类中药的关键作用靶点之一。该文从AQPs与AD重要病机“痰、湿、瘀、毒”的内在关系出发,探讨芳香类中药治疗AD的现代医学内涵,为中医药防治AD提供思路。

关键词：阿尔茨海默病水通道蛋白芳香类中药芳香疗法痰湿瘀毒

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N-Nitrosamine formation from chloramination of two common ionic liquids

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journal of environmental sciences 2020年第1期32卷 341-348页

作者： Ian j.Vander Meulen Ping jiang Di Wu steve e.Hrudey Xing-Fang li Division of Analytical and environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of Alberta

Ionic liquids(ILs)are a class of solvents increasingly used as"green chemicals."Widespread applications of ILs have led to concerns about their accidental entry to the *** have been assessed for some environmental impacts;however,little has been done to characterize their potential impacts on drinking water if ILs accidentally enter surface *** cations are often aromatic or alkyl quaternary amines that resemble structures of previously confirmed N-nitrosamine(NA)***,this study has evaluated two common ILs,1-ethyl-3-methylimidazolium bromide(eMIm Br)and 1-ethyl-1-methylpyrrolidinium bromide(eMPyr Br),for their NA formation *** IL species was reacted with pre-formed monochloramine under various laboratory *** reaction mixtures were extracted using liquid–liquid extraction and analyzed for NAs using high performance liquid chromatography tandem mass *** low concentration of IL(250μmol/L),the yields of NAs(NMeA or NPyr)increased with increasing doses of monochloramine from both IL *** total NA yield was as high as 2.5±0.3 ng/mg from eMIm Br,and as high as 8.6±0.8 ng/mg from eMPyr *** high concentration of IL(5 mmol/L),the NA yield reached a maximum at 2.5 mmol/L NH2Cl,and then decreased with subsequent increases in the reactant concentrations,demonstrating ILs’solvent *** study re-emphasizes the importance of preventing discharge of ILs to water bodies to prevent secondary impacts on drinking water.

关键词： Ionic liquids N-nitrosamine liquid–liquid extraction HPLC–Ms/Ms DBPs

Modeling slow deformation of polygonal particles using DeM

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Particuology 2008年第6期6卷 506-514页

作者： Andrés A. Pea Pedro g. lind Hans j. Herrmann Institute for Computational Physics Universitt Stuttgart Computational Physics IfB HIF E12 ETH Hnggerberg CH-8093 Zrich Switzerland Departamento de Física Universidade Federal do Ceará

We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete element Method （DeM） when modeling the dynamics of the.g.anular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic ene.g. decay in a stress controlled test between two particles. second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time.

关键词： granular media Discrete element method slow deformation Contact forces