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A risk scoring system for seafood supply chain breaches and examination of freshwater fish imported to Australia

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Food Quality and Safety 2021年第3期5卷 256-270页

作者： Michelle Williams Marta Hernandez-jover Thomas Williams Shokoofeh Shamsi School of Animal and Veterinary Sciences&Graham Centre for Agricultural Innovation Charles Sturt UniversityWagga WaggaNSWAustralia

Legislative changes have altered the way imported edible seafood is inspected in *** onus of responsibility has been placed on exporting countries to provide documentary evidence of adherence to internally recognized food safety *** to global trade agreements,any additional safety tests applied to freshwater fish imported into Australia must be ***,the aim of this study was to develop a risk scoring method to provide justification for identifying countries as'Freshwater fish high risk'and to examine the seafood they export to Australia for seafood supply chain *** ng was con ducted using six predictor variables,identified in the literature as important contributors to seafood supply chain breaches,to achieve the outcome variable,Country considered'Freshwater fish high ***-seven fish fillets(9.55 kg)of the same species were examined from the third highest scoring country(Country 20)and 562(5.6 kg)whole fish from the sixth highest scoring country(Country 22).Country 20 had supply chain breaches of 28 macroscopic yellow cysts in one *** hundred and thirteen parasites and other supply chain breaches were identified in fish from Country 22,in eluding retai ned liver(91 per cent),visible mud(11 per cent),a variety of debris(16 per cent)and,depending on the commodity code,these fish were imported to Australia under full intestine(90 per cent),retained gills(89 per cent),and partial intestine(9 per cent).Three serious physical hazards were recovered from the edible portion of three'consumer-ready' fish and snails of Genus Lymnaea and Indoplanorbis were recovered from gill mud also from'consumer-readyz *** study showed variable results from the scoring system and vast differences in seafood supply chain breaches between the third and sixth highest scoring countries.

关键词： Imported seafood supply chain breaches parasites.

Illegal, unreported, and unregulated fishing: A risk scoring method for prioritizing inspection of fish imported to Australia for zoonotic parasites

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Journal of Biosafety and Biosecurity 2020年第2期2卷 81-90页

作者： Michelle Williams Marta Hernandez-jover Shokoofeh Shamsi School of Animal and Veterinary Sciences&Graham Centre for Agricultural Innovation Charles Sturt UniversityWagga WaggaNSW 2650Australia

The global burden of illegal fishing is estimated to be *** constructed trade routes introduce illegally caught fish products into the global commercial market,including *** date,no studies have investigated the potential for illegally caught fish to harbor zoonotic *** tests applied to fish imported to Australia must be scientifically justified according to international trade *** primary aim of this study was to develop a risk scoring method that provides a scientific basis for the development of protocols to examine fish imported to Australia for zoonotic *** secondary aim was to estimate and prioritize the provenance of fish,which may be high-risk areas for illegal,unreported,and unregulated(IUU)1 *** third aim was to calculate the amount of unreported catch from each of the ten highest-risk *** was conducted using seven predictor variables,which were identified in the published literature as important,within the forensics of IUU fishing,for identifying the“IUU or unreported catch risk”of each *** unreported catch(UC)2 for the highest scoring provenances(1–10)was calculated after risk *** highest and second highest scoring provenances,30 and 67,had 39.8%and 41.55%UC,respectively;Provenance 79,which had the tenth highest risk score,had 6.9%*** regression analysis showed a non-significant association between the size of the exclusive economic zone and *** of commercial *** the greatest indicator of *** analysis showed that for every unit increase in the number of different commercial ***,there was an increase of 5.28 units in the percentage of *** provenance risk scores and percentage of UC were linearly *** was a 79.4%decrease in the mean risk scores between provenances 1–5 and 6–10;a decrease was also observed in the UC between the two groups(33.7%and 15.5%,respectively).The proposed scoring method appears to be a good pre

关键词： Illegal fishing Seafood safety Parasites Australian biosecurity Seafood inspection

Serrated polyposis syndrome:Molecular,pathological and clinical aspects

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World Journal of Gastroenterology 2012年第20期18卷 2452-2461页

作者： Carla Guarinos Cristina Sánchez-Fortún María Rodríguez-Soler Cristina Alenda Artemio Payá Rodrigo jover Research Unit Hospital General Universitario de Alicante03010 AlicanteSpain Unidad de Gastroenterología Hospital General Universitario de Alicante03010 AlicanteSpain Department of Pathology Hospital General Universitario de Alicante03010 AlicanteSpain

Hyperplastic polyps have traditionally been considered not to have malignant *** pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this *** recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found thatthis pathway accounts for only approximately 70%-80% of colorectal cancer(CRC)*** majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite *** mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF *** polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the *** characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified *** with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been *** criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal *** this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome.

关键词： Colorectal cancer Hyperplastic polyps CpG island methylator phenotype Serrated polyposis Serrated pathway

Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells

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World Journal of Gastroenterology 2006年第36期12卷 5834-5845页

作者： Raquel Taléns-Visconti Ana Bonora Ramiro jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José Gómez-Lechón Unidad de Hepatología experimental Centro de Investigación Hospital La Fe Valencia Spain Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain. Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia Spain Centro de Transfusión de la Comunidad Valenciana Generalidad ValencianaValencia Spain Unidad de Hepatología experimental Centro de Investigación Hospital La Fe Valencia.Spain. Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain Unidad de Hepatología experi-mental Centro de Investigación Hospital La Fe Valencia Spain

AIM： To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells （ADSC） and bone marrow-derived mesenchymal stem cells （BMSC） in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC. MeTHODS： BMSCs were obtained from patients undergoing total hip arthroplasty and ADSC from human adipose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver development using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differentiation was RT-PCR-assessed and liver-marker genes were immunohistochemically ***： BMSC and ADSC exhibited a fibroblastic morphology that changed to a polygonal shape when cells differentiated. expression of stem cell marker Thyl decreased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to increased liver-enriched transcription factors （C/eBPβ and HNF4α）, as demonstrated by adenoviral expression ***： Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation capacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing.

关键词： Mesenchymal stem cells Bone marrow Adipose tissue Transdifferentiation Hepatic lineage Liver cell transplantation.

Sudden Death in Sports: Case Report and Review of an Ongoing Problem

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Health 2019年第1期11卷 67-80页

作者： María elena Caparrós-Hernández Mónica García-fernández Carla Miró-Vicedo María del Mar Ponce-Abellán Andrea Ruso-Ruso María Dolores jover-Ríos Juan Méndez-Mora Francisco Caparrós-Hernández Carmen Seguí-Pérez Marc Seguí-Pérez Pedro esteve-Atiénzar Jorge Peris-García David Bonet-Tur Pablo Roig-Rico Asunción Pérez-Fullana José Miguel Seguí-Ripoll School of Medicine Miguel Hernández University Elche (Alicante) Spain Department of Internal Medicine Hospital La Vega Baja of Orihuela (Alicante) Spain Secondary School Marist Brothers High School Alicante Spain Department of Internal Medicine University Hospital of San Juan Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche (Alicante) Spain

Background: Both competitive and recreational sports are considered a positive practice that is good for human health and quality of life, so it is difficult to understand how young, energetic and apparently healthy people can die while playing their usual sports. When these events occur in elite athletes during monitored events, they normally receive considerable media attention. Objective: To describe the case of sudden death in a young professional athlete who was successfully aided and resuscitated outside our hospital, and to review the literature about sudden death in sports. Materials and Method: We searched for Sudden Death (according to the International Classification of Diseases (ICD-9 and ICD-10)) in our hospital but found no other relevant cases. We performed a literature search on the state of the art in sudden death (Google Scholar, PubMed, LILACS, Scielo and the Revista española de Cardiología). Results: Although we observed that the prevalence of sudden death is not very high, it still represents a potentially avoidable event. An adequate medical examination prior to regular sporting practice can decrease the incidence of sudden death in athletes under the age of 35. Data available in the literature support medical check-ups that include history-taking, physical examination and electrocardiogram. The findings of this evaluation may also prompt further assessment (electrocardiograph, ergometry). Conclusions: We could not identify standard, obligatory guidelines for screening possible heart diseases causing cardiorespiratory failure and sudden death. As a measure for primary prevention, we propose a protocol for reducing the risk of sudden death in athletes.

关键词： Sudden Death Sports Athletes Cardiopulmonary Resuscitation Implantable Automatic Defibrillator

Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy

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World Journal of Gastroenterology 2016年第13期22卷 3516-3530页

作者： Oscar Murcia Miriam Juárez eva Hernández-Illán Cecilia egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo jover Unidad de Gastroenterologia Hospital General Universitario de Alicante Instituto de Investigacion Sanitaria Isabial 03010 Alicante Spain

Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer(CRC) were proposed recently based on genetic profiles that show four types of molecular alterations: BRAF gene mutations, KRAS gene mutations, microsatellite instability, and hypermethylation of Cp G islands. This review summarizes what is known about the serrated pathway of CRC, including CRC molecular and clinical features, prognosis, and response to chemotherapy.

关键词： Colorectal cancer Methylator phenotype Serrated pathway Chemotherapy CIMP

Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

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World Journal of Gastroenterology 2006年第15期12卷 2406-2411页

作者： Manuel Romero-Gómez María jover Daniel Díaz-Gómez Laura Collantes de Terán Regina Rodrigo Inés Camacho Miriam echevarría Vicente Felipo Juan D Bautista Unit for the Clinical Management of Digestive Diseases Hospital Universitario de Valme SevillaSpain Department of Biochemistry Bromatology and Toxicology Faculty of PharmacyUniversity of SevilleSpain Laboratory of Neurobiology Fundación Valenciana de Investigaciones Biomédicas ValenciaSpain Biochemistry Unit Hospital Universitario de Valme SevillaSpain Instituto de Investigaciones Biomédicas Departament of Physiology University of SevilleSpain Laboratory of Neurobiology Fundación Valenciana de Investigaciones Biomédicas ValenciaSpain

AIM： To assess whether portacaval anastomosis （PCA） in rats affects the protein expression and/or activity of glutaminase in kidneys, intestines and in three brain areas of cortex, basal ganglia and cerebellum and to explain the neurological alterations found in hepatic encephalopathy （He）. MeTHODS： Sixteen male Wistar rats weighing 250-350 g were grouped into sham-operation control （n=8） or portacaval shunt （n = 8）. Twenty-eight days after the procedure, the animals were sacrificed. The duodenum, kidney and brain were removed, homogenised and mitochondria were isolated. Ammonia was measured in brain and blood. Phosphate-activated glutaminase （PAG） activity was determined by measuring ammonia production following incubation for one hour at 37 ℃ with O-phthalaldehyde （OPA） and specific activity expressed in units per gram of protein （pkat/g of protein）. Protein expression was measured by immunoblotting. ReSULTS： Duodenal and kidney PAG activities together with protein content were significantly higher in PCA group than in control or sham-operated rats （duodenum PAG activity was 976.95±268.87μkat/g of protein in PCA rats vs 429.19±126.92.μkat/g of protein in shamoperated rats; kidneys PAG activity was 1259.18±228.79 μkat/g protein in PCA rats vs 669.67±400.8 μkat/g of protein in controls, P〈0.05; duodenal protein content： 173% in PCA vs sham-operated rats; in kidneys the content of protein was 152% in PCA vs sham-operated rats）. PAG activity and protein expression in PCA rats were higher in cortex and basal ganglia than those in shamoperated rats （cortex： 6646.6 ±1870.4 μkat/g of protein vs 3573.8± 2037.4 μkat/g of protein in control rats, P〈 0.01; basal ganglia, PAG activity was 3657.3± 1469.6 μkat/g of protein in PCA rats vs 2271.2±384 μkat/g of protein in sham operated rats, P〈0.05; In the cerebellum, the PAG activity was 2471.6±701.4 μkat/g of protein vs 1452.9 ±567.8 μkat/g of protein in the PCA and sham rats, respectively, P〈0.05; content of protein： cerebral co

关键词： Hyperammonaemia Minimal hepaticencephalopathy Glutamine Protein content Shamoperated

Colorectal cancer prognosis twenty years later

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World Journal of Gastroenterology 2010年第7期16卷 862-867页

作者： Luis Bujanda Cristina Sarasqueta elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis elorza Jose I Asensio Santiago Larburu José M enríquez-Navascués Rodrigo jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association Department of Gastroenterology Donostia HospitalUniversity of Basque CountryCentro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas(CIBEREHD)20014 San SebastiánSpain Department of epidemiology Donostia HospitalCIBERESP20014 San SebastiánSpain Department of Surgery Donostia Hospital20014 San SebastiánSpain Department of Gastroenterology General Hospital Department of Gastroenterology Clinic HospitalCIBEREHDIDIBAPS08036 BarcelonaSpain Digestive Diseases and Nutrition Secion University of IllinoisChicagoIL 60607United States Department of Gastroenterology Del Mar Hospital08003 BarcelonaSpain Department of Gastroenterology General Hospital 03010 AlicanteSpain

AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 ***:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and ***Ⅱincluded 871 patients diagnosed in ***:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,Pe difference was significant for all tumor *** surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(Pents received chemotherapy compared with 50% of GroupⅡpatients(Pectal cancer patients has doubled over the past 20 *** increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.

关键词： Colon cancer Prognosis Survival Chemotherapy Surgery

Post-Hospital Syndrome and Hyponatremia

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Health 2021年第8期13卷 846-856页

作者： José Bellod-Tonda Julio Blázquez-encinar María Dolores jover-Ríos Carmen Seguí-Pérez Juan Méndez-Mora Francisco Caparrós-Hernández Álex Méndez-jover Marc Seguí-Pérez David Baláž Leticia espinosa del Barrio Jesús Corbacho-Redondo Carles García-Cervera Juan Manuel Núñez-Cruz Isidro Hernández-Isasi Javier Guzmán-Martínez Angie Gómez-Uranga Pedro esteve-Atiénzar Jorge Peris-García Veronica Martínez-Sempere eliana Damonte-White Óscar Hernando Ruiz-Ariza Juan Carlos López-Corbalán Lourdes Lajara-Villar Andrea Riaño-Pérez Paloma Chazarra-Pérez María escamilla-espínola Maria Luisa Asensio-Tomás Miguel Ángel Auladell-Alemany Laura Serna-Torres Asunción Pérez-Fullana Amparo Gómez-Siurana Sergio Menargues-Irles José Miguel Seguí-Ripoll Internal Medicine Department University Hospital of San Juan Alicante Spain Internal Medicine Department Torrevieja University Hospital Alicante Spain Internal Medicine Department Hospital La Vega Baja of Orihuela Alicante Spain CeU Cardinal Herrera University Veterinary Hospital Valencia Spain Secondary School Marist Brothers High School Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche Spain Primary Care Medicine Benilloba Spain Sub-Delegation of the Government Alicante Spain Chemical engineering Department University of Alicante Alicante Spain

Introduction: Post-hospital syndrome (PHS) is defined as a period of vulnerability during the first 30 days after a patient is discharged from hospital, in which multiple factors come into play. Hyponatremia is the most frequent hydroelectrolytic disorder in hospitalized patients and may be related to the appearance of PHS. Objective: The objective is to estimate the prevalence of PHS that is assessed as the rate of readmissions in the first 30 days after discharge, in patients with hyponatremia. Material and Methods: It is a descriptive observational study of patients with hyponatremia who were discharged from 1 September 2010 to 2 February 2020 at the Internal Medicine Service of the Hospital University of San Juan (Alicante, Spain). Results: Of the 25 included patients, 5 (20%) were readmitted within a month of discharge, after a mean of 11.4 days (standard deviation [SD] 5.1). The overall mortality of the study was 20% (n = 5), with one case of death in the first 30 days post-hospitalization (4%). In 12 patients (48%) the origin of the hyponatremia was undetermined. The most frequently recorded etiology for the condition was pharmacological (n = 7, 28%), and there was pronounced variability in its clinical and laboratory study. The most widely used corrective measure was drug withdrawal, in 16 patients (64%). Water intake restriction was the most common treatment after discharge (5 patients, 20%), followed by urea (2 patients, 8%), while tolvaptan was not used. Conclusion: Hyponatremia may be the cause of PHS, which could increase the rate of early readmission. Hyponatremia is an underdiagnosed and undertreated entity, so it is necessary to apply an appropriate system to optimize its management and, in future studies, to assess its impact on PHS.

关键词： Hospitalization Hyponatremia Patient Readmission Inappropriate ADH Syndrome