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Isoform-and cell-state-specific APOe homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner Anne.claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein e is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** e polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein e homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein e autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

Developing biophilic intermediate spaces for Arctic housing:Optimizing the thermal,visual,and energy performance

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Building Simulation 2024年第6期17卷 857-875页

作者： Tarlan Abazari AndréPotvin Louis Gosselin claude MH Demers GRAP(Groupe de recherche en ambiance physiques) School of ArchitectureLaval UniversityQuébecCanada Department of Mechanical engineering Faculty of Science and EngineeringLaval UniversityQuébecCanada

Connecting occupants to the outdoor environment and incorporating biophilic design principles are challenging in extreme Arctic climatic *** Arctic housing models do not provide efficient thermal and daylight transitions which are essential for the well-being and cultural needs of their *** address these challenges,this research develops free-running biophilic intermediate spaces,integrated into an existing Arctic housing *** simulation methods are employed to optimize the primary and secondary architectural design variables for 26 case studies of intermediate *** variables include volume,transparency ratio,and *** variables include materials and physical ***,Daylight Factor/Autonomy,and energy Use are evaluated as performance *** reveal that free-running intermediate spaces with 6 meters depth and a transparency ratio above 50%provide efficient indoor–outdoor transitions regarding thermal,visual,and energy *** architectural configurations contribute to an approximately 5%reduction in energy consumption within the housing unit compared to the *** side windows prevents the risk of overheating during the summer by reducing the average indoor temperature of intermediate spaces by 7°C but increases the overall energy *** a potential alternative to double-glazing,polycarbonate sheets enable efficient thermal performance by increasing the average indoor temperature of intermediate spaces by approximately 15°C during the cold Arctic *** polycarbonate sheets results in a 16.6%reduction in energy consumption compared to using double-glazing material in intermediate space,and a 26%reduction from the *** outcomes contribute to efficient indoor–outdoor connections and energy efficiency in Arctic housing.

关键词： Arctic housing intermediate spaces biophilic design positive thermal transitions daylight availability energy efficiency

Deep eutectic solvent-driven self-assembly of metal mercaptide complexes with enzyme-mimicking activities for detection of uric acid through one-step cascade catalytic reaction

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Green Chemical engineering 2024年第1期5卷 75-84页

作者： Jean claude Munyemana Jia Chen Xin Li Yangxia Han Hao Tang Hongdeng Qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing100039China Department of Pharmacy Gansu Provincial HospitalLanzhou730000China

This work presents a generic strategy to create a series of metal mercaptides complexes via coordination selfassembly between transition metals(Mn,Cu,Co,Fe,and Ni)and cysteine(Cys)by forming the sulfur-metal *** strategy involves dissolving metal chlorides and Cys into deep eutectic solvents(DeS),followed by the precipitation of metal mercaptides complexes(such as Cys-Mn)by adding water as an antisolvent,where DeS serves as the solvent,shape directing,and capping agent,thereby preventing the formation of other metal ***,the prepared complexes possess both laccase and peroxidase-like properties,allowing the design of a technique for the detection of L-3,4-dihydroxyphenylalanine(L-DOPA)and uric acid,*** prepared Cys-Mn can linearly oxidize L-DOPA with its concentrations from 0.1 to 130μM and the detection limit was calculated to be 75.5 n ***,the Cys-Mn can mimic the activity of peroxidase towards oxidization of o-phenylenediamine at neutral p H,allowing single-step and one-pot cascade reactions for visual and fluorometric measurements of uric acid(UA)that could work in the range of 0.2-500μM UA with a detection limit of 0.06μM and 0.054μМ,*** assay was successful in detecting UA in serum and urine samples with relative standard deviation(RSD)ranging from 7.3%to 10.2%and 3.0%-8.5%respectively,suggesting that it may prove useful in medical diagnostic testing.

关键词： Metal-mercaptides Deep eutectic solvents Self-assembly Peroxidase-mimic catalyst Uric acid detection

Manipulation of magnetocaloric and elastocaloric effects in Ni-Mn-In alloys by lattice volume and magnetic variation:effect of Co and Fe co-doping

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Journal of Materials Science & Technology 2024年第5期172卷 156-165页

作者： Xinzeng Liang Chi Zhang Jing Bai Jianglong Gu Yudong Zhang claude esling Xiang Zhao Liang Zuo School of Materials Science and engineering Shenyang University of TechnologyShenyang 110870China Key Laboratory for Anisotropy and Texture of Materials Northeastern UniversityShenyang 110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux LEM3 CNRSUMR 7239University of Lorraine57045 MetzFrance

The effects of Co and Fe co-doping Ni-Mn-In alloy on the phase stability,lattice parameters,mag-netic properties,and electronic structures are systematically investigated by using the first-principles *** indicate that Fe atoms replace the excess Mn2 atoms by direct and indirect coex-istence(Fe→Mn 2 and Fe→In→Mn2);Co substitutes the Ni atoms by direct substitution(Co→Ni)for the Ni-Mn-In *** austenites all exhibit the ferromagnetic(FM)state for the studied *** NM martensites are in the ferrimagnetic(FIM-1)state for the Ni_(2)Mn_(1.5)In_(0.5),Ni_(2)Mn_(1.25)In_(0.5)Fe 0.25,Ni_(1.75)Mn_(1.5)In_(0.5)Co_(0.25),and Ni_(1.75)Mn_(1.25)In_(0.5)Co_(0.25)Fe 0.25 alloys,while the other compositions are in the FM *** phase stability of austenite and martensite decreases with increasing Co and Fe co-doping.A magnetic-structural coupling transition occurs at xe_(0.08)alloys exhibit an A→6M→NM transformation,accompanied by a magnetic *** Co and Fe are co-doped,the hybridization strength between Co and Fe is greater than that between Co/Fe and *** enhancement of magnetocaloric and elastocaloric effects is favored by larger magnetization difference(△M)and lattice volume change(△V/V_(0)).Based on the calculated phase stability,magneto-structure coupling,△V/V 0 and c/a ratio,one can predict that the Ni_(2)-x Mn_(1.5)-y In_(0.5)Co x Fe y alloy with Co content 0≤x≤0.25 and Fe content 0≤y≤0.05 is predicted to have good magneto-controlled functional behavior.

关键词： Ni-Mn-In-Co-Fe Phase stability Magnetocaloric effect elastocaloric effect

On electron Clouds and Light

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Journal of Modern Physics 2024年第4期15卷 491-510页

作者： claude Daviau Fondation Louis de Broglie Paris France

The wave equation of the electron, recently improved, allows physics to obtain all the quantum numbers and other results explaining the hydrogen spectrum. The Pauli exclusion principle then gives the description of electron clouds used in chemistry. The relativistic wave equation is associated with a Lagrangian density, thus also with an energy-momentum tensorial density. The wave of an electron cloud adds these energy-momentum densities, while photons in light are precisely those differences between such energy-momentum densities.

关键词： Quantum Mechanics Nonlinear Wave equation Relativity electron Clouds Photon Light

A Generic and Reliable Land Acquisition Protocol Implementation for Sub-Saharan Africa Countries

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Journal of Computer and Communications 2024年第1期12卷 208-245页

作者： Bayomock Linwa André claude Traore Hamidou Department of Computer Science International University of Grand-Bassam Grand-Bassam Ivory Coast

Land acquisition is subject of many frauds worldwide. In Africa countries, land acquisition frauds are a real curse. Main reasons of the high land acquisition frauds in Africa are a lack of a reliable land acquisition protocol implementation, no centralized information system that records land transactions and integrates all actors, lack of education about the acquisition protocol and lack of applied sanctions in case of frauds. As of sanctions, the issue is bound to the corruption plague in Africa. Authorities that are supposed to rule the laws are not well paid and are part of the corruption scheme. Most frequent frauds are multiple sales of the same land, falsified land title, false owner identification. In Africa, a land belongs generally to the first residents of the area. To claim ownership of a land, an owner should be recognized by the rural or city authorities. To achieve this recognition, he must obtain from those authorities an attribution letter. The author proposed a complete and reliable land acquisition protocol named ACLAP (Africa Countries Land Acquisition Protocol). The purpose of this paper is to explain the main components of the protocol implementation and show its efficiency when confronting fraud threats. In this paper, a Generic and Reliable Land Acquisition Protocol Implementation in Sub-Saharan Africa countries context is proposed. The platform keeps relevant land transaction information for administrators, managers, buyers, sellers, or for people consultation purpose. The application may be used in village, city, department, region, or country for land management decision making.

关键词： Land Acquisition Protocol Reliable Africa

Unraveling magnetic properties and martensitic transformation in Mn-rich Ni-Mn-Sn alloys:first-principles calculations and experiments

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Rare Metals 2024年第4期43卷 1769-1785页

作者： Yu Zhang Jing Bai Ke-Liang Guo Jia-Xin Xu Jiang-Long Gu Nicola Morley Qui-Zhi Gao Yu-Dong Zhang claude esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Dielectric and electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao066004China Department of Material Science and engineering University of SheffieldSheffieldS13JDUK State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux University of Lorraine57045MetzFrance

We have investigated the phase stability,magnetic properties,and martensitic transformation thermodynamics/kinetics of the Ni_(24-x)Mn_(18+x+y)Sn_(6-y)(x,y=0,1,2)system by combining the first-principles calculations and *** calculation results show that the optimized lattice parameters are consistent with the experimental ***,we obtain the relation equation for the austenite formation energy(e_(form-A))and Mn content(X_(Mn)):e_(form-A)=507.358X_(Mn)-274.126,as well as for the six-layer modulated(6M)martensite formation energy(e_(form-6M))and Ni content(X_(Ni)):e_(form-6M)=-728.484X_(Ni)+*** ternary phase diagram of the total magnetic moment was *** excess Mn will reduce the total magnetic moment of 6M(Mag6M)and non-modulated(NM)(MagNM)martensites,with the following equations relating the total magnetic moment and Mn content:Mag_(6M)=-15.905X_(Mn)+7.902and Mag_(NM)=-14.781X_(Mn)+7.411,while the effect on austenite is *** variation of total magnetic moment is mainly dominated by the Mn atomic magnetic *** 3d electrons of Mn_(Sn)(Mn at Sn sublattice)play an important role in magnetic properties from the perspective of the electronic density of *** on the thermodynamics of martensitic transformation,the alloys will likely undergo austenite?6M?NM transformation *** the thermodynamic and kinetic results,the martensitic transformation temperature decreases with x increasing and increases with y *** results are expected to provide reference for predicting the phase stability and magnetic properties of NiMn-Sn alloys.

关键词： Ni-Mn-Sn First-principles calculations Martensitic transformation Magnetic property Kinetics

The Relation between Mental Workload and Face Temperature in Flight Simulation

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Journal of Behavioral and Brain Science 2024年第2期14卷 64-92页

作者： Amin Bonyad Hamdi Ben Abdessalem claude Frasson D&eacute partement d’Informatique et de Recherche Op&eacuterationnelle Universit&eacute de Montr&eacuteal Montr&eacuteal Canada D&eacute partement d’Informatique et de Math&eacutematique Universit&eacute du Qu&eacutebec &agrave Chicoutimi Chicoutimi Canada

In this research, we study the relationship between mental workload and facial temperature of aircraft participants during a simulated takeoff flight. We conducted experiments to comprehend the correlation between work and facial temperature within the flight simulator. The experiment involved a group of 10 participants who played the role of pilots in a simulated A-320 flight. Six different flying scenarios were designed to simulate normal and emergency situations on airplane takeoff that would occur in different levels of mental workload for the participants. The measurements were workload assessment, face temperatures, and heart rate monitoring. Throughout the experiments, we collected a total of 120 instances of takeoffs, together with over 10 hours of time-series data including heart rate, workload, and face thermal images and temperatures. Comparative analysis of eeG data and thermal image types, revealed intriguing findings. The results indicate a notable inverse relationship between workload and facial muscle temperatures, as well as facial landmark points. The results of this study contribute to a deeper understanding of the physiological effects of workload, as well as practical implications for aviation safety and performance.

关键词： Mental Workload eeG Thermal Images Flight Simulation Aviation Face Temperature

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外推法导引及应用

数学进展 2024年第1期53卷 13-40页

作者： claude BReZINSKI Michela ReDIVO-ZAGLIA 保罗·潘勒韦实验室法国国家科学研究中心混合研究单位8524里尔大学法国里尔59655 帕多瓦大学意大利帕多瓦35122

在数值科学和应用科学中,人们经常需要考虑多种类型的序列:标量、向量、四元数、矩阵以及后来出现的张量.这些序列可能收敛,也可能发散.当它们收敛时,其收敛速度可能会非常缓慢,以至于其实际用途十分有限.在某些情况下,可以修改建立这... 详细信息

在数值科学和应用科学中,人们经常需要考虑多种类型的序列:标量、向量、四元数、矩阵以及后来出现的张量.这些序列可能收敛,也可能发散.当它们收敛时,其收敛速度可能会非常缓慢,以至于其实际用途十分有限.在某些情况下,可以修改建立这些序列的过程,但在其他情况下,这个过程是一个无法进入的黑箱.那么,规避这一困难的一个可行方法就是将序列变换成另一个序列,希望它能收敛到相同的极限,并且收敛得更快.这种序列变换背后的思想就是外推法.本文是关于这些方法中最重要的方法以及其理论基础和算法方面的导引.本文还介绍了一些应用.

关键词：外推法收敛加速序列变换安德森加速张量非线性方程吉布斯现象