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Dcalycinumines A-e,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-e(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HReSIMS,NMR spectroscopic analyses,ecD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

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Water Science and engineering 2024年第1期17卷 51-61页

作者： Xiao-jie Guo Wei-kang Fu Jing-yuan Ma bo-jun Xi Chen Wang Meng-yao Guan College of Materials and environmental engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and *** this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron *** Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room *** adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic *** adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface *** thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous *** X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on ***,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by *** to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium eXAFS Adsorption mechanism

A unique role of the pyrimidine de novo synthesis enzyme ODCase in Lysobacter enzymogenes

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Journal of Integrative Agriculture 2024年第9期 3066-3077页

作者： Mingming Yang Yunxiao Tan Jiabing Ma Yingjia Zhao Xia Yan Nana Wang Pingping Wang Jiaqi Tan Suilong Ai Xiaofei Liang Bangshuai Chang Obadah e.A.Yousif Chao Zhao bo Wang Guoliang Qian Lili Huang State Key Laboratory for Crop Stress Resistance and High-efficiency Production Northwest A&F University CChoillneage of Plant Protection Northwest A&F University College of Life Sciences Northwest A&F University College of Natural Resources and environment Northwest A&F University Shaanxi Provincial Tobacco Corporation of China National Tobacco Corporation Institute of Plant Protection Jiangsu Academy of Agricultural Sciences College of Plant Protection Laboratory of Plant ImmunityNanjing Agricultural University

Bacterial species of the genus Lysobacter are environmentally ubiquitous with strong antifungal biocontrol ***-stable antifungal factor （HSAF） secreted by the biocontrol bacterium Lysobacter enzymogenes OH11 has broad-spectrum and highly efficient antifungal *** the biosynthetic regulations of HSAF would lay an important foundation for strain engineering toward improved HSAF *** this work,we demonstrate that Le0752,an orotidine-5′-phosphate decarboxylase enzyme （ODCase） catalyzing a pivotal step of the UMP de novo biosynthesis pathway,is vital for HSAF-mediated antimicrobial activities and growth of *** OH11,but not for twitching *** gene regulates the production of HSAF by affecting the expression of lafB,a key gene in the HSAF biosynthesis operon,through the transcription factor ***,bioinformatics analysis revealed that Le0752 belongs to the Group III ODCases,whereas its homologs in the closely related genera Xanthomonas and Stenotrophomonas belong to Group I,which contains most ODCases from Gram-positive bacteria,Gramnegative bacteria and ***,the Group I ODCase PXO＿3614 from the Xanthomonas oryzae *** PXO99Astrain complemented the Le0752 mutant in regulating HSAF-mediated antagonistic ***,these results highlight the important requirement of de novo pyrimidine biosynthetic enzymes for antibiotic HSAF production in ***,which lays an important foundation for improving HSAF production via metabolic flow design and for dissecting the regulatory functions of bacterial ODCases

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Advanced System-Level Model Reduction Method for Multi-Converter DC Power Systems

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CSee Journal of Power and energy Systems 2024年第4期10卷 1550-1562页

作者： Lin Zhu Xueshen Zhao Xialin Li Li Guo bo Zhao Zhanfeng Deng Hao Lu Chengshan Wang the Key Laboratory of Smart Grid of Ministry of education Tianjin UniversityTianjin 300072China the Research Institute of State Grid Zhejiang electric Power Co. Ltd.Hangzhou 310014China the State Grid Global energy Interconnection Research Institute Beijing 102209China

For dynamic stability analysis and instability mechanism understanding of multi-converter medium voltage DC power systems with droop-based double-loop control,an advanced system-level model reduction method is *** this method,mathematical relationships of control parameters(e.g.,current and voltage control parameters)between the system and its equivalent reduced-order model are ***,open-loop and closed-loop equivalent reduced-order models of current control loop considering dynamic interaction among converters are *** instability mechanism(e.g.,unreasonable current control parameters)of the system can be revealed *** guidance for adjustment of current control parameters can also be ***,considering dynamic interaction of current control among converters,open-loop and closed-loop equivalent reduced-order models of voltage control loop are *** frequency and damping factor of DC bus voltage in a wide oscillation frequency range(e.g.,10–50 Hz)can be evaluated *** importantly,accuracy of advanced system-level model reduction method is not compromised,even for MVDC power systems with inconsistent control parameters and different number of ***,experiments in RT-boX hardware-in-the-loop experimental platform are conducted to validate the advanced system-level model reduction method.

关键词： Closed-loop reduced-order model instability mechanism open-loop reduced-order model stability analysis system-level model reduction method

Resilience Augmentation in Unmanned Weapon Systems via Multi-Layer Attention Graph Convolutional Neural Networks

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Computers, Materials & Continua 2024年第8期80卷 2941-2962页

作者： Kexin Wang Yingdong Gou Dingrui Xue Jiancheng Liu Wanlong Qi Gang Hou bo Li Northwest Institute of Mechanical and electrical engineering Xianyang712099China

The collective Unmanned Weapon System-of-Systems(UWSOS)network represents a fundamental element in modern warfare,characterized by a diverse array of unmanned combat platforms interconnected through hetero-geneous network *** its strategic importance,the UWSOS network is highly susceptible to hostile infiltrations,which significantly impede its battlefield recovery *** methods to enhance network resilience predominantly focus on basic graph relationships,neglecting the crucial higher-order dependencies among nodes necessary for capturing multi-hop meta-paths within the *** address these limitations,we propose the enhanced-Resilience Multi-Layer Attention Graph Convolutional Network(e-MAGCN),designed to augment the adaptability of *** approach employs BeRT for extracting semantic insights from nodes and edges,thereby refining feature representations by leveraging various node and edge ***,e-MAGCN integrates a regularization-based multi-layer attention mechanism and a semantic node fusion algo-rithm within the Graph Convolutional Network(GCN)*** extensive simulation experiments,our model demonstrates an enhancement in resilience performance ranging from 1.2% to 7% over existing algorithms.

关键词： Resilience enhancement heterogeneous network graph convolutional network

Self-consistent and precise measurement of time-dependent radiative albedo of gold based on specially symmetrical triple-cavity Hohlraum

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Matter and Radiation at extremes 2024年第3期9卷 57-64页

作者： Zhiyu Zhang Yang Zhao Xiaoying Han Liling Li bo Qing Lifei Hou Yulong Li YuXue Zhang Huan Zhang Xiangming Liu bo Deng Gang Xiong Min Lv Tuo Zhu Chengwu Huang Tianming Song Yan Zhao Yingjie Li Lu Zhang Xufei Xie Jiyan Zhang Jiamin Yang Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China National Key Laboratory of Plasma Physcis Mianyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100088China

A self-consistent and precise method to determine the time-dependent radiative albedo,i.e.,the ratio of the reemission flux to the incident flux,for an indirect-drive inertial confinement fusion Hohlraum wall material is proposed.A specially designed symmetrical triple-cavity gold Hohlraum is used to create approximately constant and near-equilibrium uniform radiation with a peak temperature of 160 *** incident flux at the secondary cavity waist is obtained from flux balance analysis and from the shock velocity of a standard *** results agree well owing to the symmetrical radiation in the secondary cavity.A self-consistent and precise time-dependent radiative albedo is deduced from the reliable reemission flux and the incident flux,and the result from the shock velocity is found to have a smaller uncertainty than that from the multi-angle flux balance analysis,and also to agree well with the result of a simulation using the HYADeS opacity.

关键词： precise cavity radiative

Coordination-environment regulation of atomic Co-Mn dual-sites for efficient oxygen reduction reaction

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Nano Research 2024年第8期17卷 6841-6848页

作者： Caiting Sun Yarong Liu Zunhang Lv Rui Liu Changli Wang Liuhua Li Jinming Wang Yu Zhang Wenxiu Yang bo Wang Key Laboratory of Cluster Science(Ministry of education) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsAdvanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Library Beijing Institute of TechnologyBeijing 100081China

Precisely designing atomic metal-nitrogen-carbon(M-N-C)catalysts with asymmetric diatomic configurations and studying their structure–activity relationships for oxygen reduction reaction(ORR)are important for zinc-air batteries(ZABs).Herein,a dualatomic-site catalyst(DASC)with CoN_(3)S-MnN_(2)S_(2)configuration was prepared for the cathodes of *** with Co-N-C(Mn-free)and CoMn-N-C(S-free doping),CoMn-N/S-C exhibits excellent half-wave potential(0.883 V)and turnover frequency(1.54 e·s^(−1)·site^(−1)),surpassing most of the reported state-of-the-art Pt-free ORR *** CoMn-N/S-C-based ZABs achieve extremely high specific capacity(959 mAh·g^(−1))and good stability(350 h@5 mA·cm^(−2)).Density functional theory(DFT)calculation shows that the introduction of Mn and S can break the electron configuration symmetry of the original Co 3d orbital,lower the dband center of the Co site,and optimize the desorption behavior of*OH intermediate,thereby increasing the ORR activity.

关键词： metal organic frameworks oxygen reduction reaction dual-atom catalyst coordination-environment regulation zinc-air batteries

Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers:A Life Course Perspective

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China CDC weekly 2024年第11期6卷 219-224,I0014-I0017页

作者： Cedric Zhang bo Lua Yajie Gao Jinming Li Xingqi Cao Xinwei Lyu Yinuo Tu Shuyi Jin Zuyun Liu Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and Department of Big Data in Health Science School of Public Healththe Key Laboratory of Intelligent Preventive Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina Institute of epidemiology and Health Care University College LondonLondonUK College of Chemical and Biological engineering Zhejiang UniversityHangzhou CityZhejiang ProvinceChina

Assessing individual risks of healthy aging using biomarkers and identifying associated factors have become important areas of *** this study,we conducted a literature review of relevant publications between 2018 and 2023 in both Chinese and english *** studies have predominantly used single biomarkers,such as C-reactive protein,or focused on specific life course stages and factors such as socioeconomic status,mental health,educational levels,and unhealthy *** summarizing the progress in this field,our study provides valuable insights and future directions for promoting healthy aging from a life course perspective.

关键词： such insight directions

Albizzia chinensis(Osbeck)Merr extract YS ameliorates ethanol-induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway

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Animal Models and experimental Medicine 2024年第3期7卷 275-282页

作者： bo Tang Liangning Li Yuanzhi Yu Guibin Wang Shuanggang Ma Shishan Yu Jianjun Zhang Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Digestive Health BeijingChina State Key Laboratory of Bioactive Substance and Function of Natural Medicines BeijingChina

Background:Around the world,there is a high incidence of gastric ***,an extract from the Chinese herb Albizzia chinensis(Osbeck)Merr,has potential therapeutic applications for gastrointestinal *** we elucidated the protective effect and underlying mechanism of action of YS on gastric ulcer in rats injured by ***:The ethanol-i nduced gastric ulcer rat model was used to assess the protective effect of YS.A pathological examination of gastric tissue was performed by H&e ***-1 cells damaged by hydrogen peroxide were used to simulate oxidative damage in gastric mucosal epithelial *** NRF2 was knocked down using small interfering *** was used to detect ubiquitination of ***-i mmunoprecipitation was used to detect the NRF2-Keap1 ***:YS(10 and 30 mg/kg,i.g.)significantly reduced the ulcer index,decreased MDA level,and increased SOD and GSH levels in gastric tissues damaged by *** promoted NRF2 translocation from cytoplasm to nucleus and enhanced the NQO1 and HO-1 expression levels in injured rat gastric *** addition,YS regulated NQO1 and HO-1 via NRF2 in H_(2)O_(2)-i nduced oxidative injured GeS-1 *** studies on the underlying mechanism indicated that YS reduced the interaction between NRF2 and Keap1 and decreased ubiquitylation of NRF2,thereby increasing its stability and expression of downstream ***2 knockdown abolished the effect of YS on MDA and SOD in GeS-1 cells treated with H_(2)O_(2).Conclusion:YS reduced the NRF2-Keap1 interaction,promoting NRF2 translocation into the nucleus,which increasing the transcription and translation of NQO1 and HO-1 and improved the antioxidant capacity of rat stomach.

关键词： antioxidative ethanol gastric ulcer NRF2 YS