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Improved sexual behavior in male rats treated with a Chinese herbal extract： hormonal and neuronal implications

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Asian Journal of Andrology 2008年第6期10卷 937-945页

作者： Paola Zanoli Augusta Benelli Manuela Zavatti Marianna Rivasi Claudia baraldi Mario baraldi Department of Biomedical Sciences Section of Pharmacology and National InterUniversity Consortium for the Study of Natural Active Principles University of Modena and Reggio Emilia Modena 41100 Italy

Aim： To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods： The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely （one time, 45 min before mating test） or subchronically （daily for 10 days） in sexually potent and sexually sluggish/impotent rats. Sexual behavior, serum levels of luteinizing hormone （LH） and testosterone （T） were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmission was assessed in the nucleus accumbens using a microdialysis technique. Results： In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 min after the acute administration. Conclusion： The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be ascribed to increased serum T level in parallel with the activation of the central dopaminergic system.

关键词： sexual behavior rats testosterone luteinizing hormone microdialysis dopamine 3,4-dihydroxyphenylacetic acid

Semantic and syntactic interoperability in online processing of big earth observation data

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International Journal of Digital earth 2018年第1期11卷 95-112页

作者： Martin Sudmanns Dirk Tiede Stefan Lang Andrea baraldi Department of Geoinformatics–Z_GIS University of SalzburgSalzburgAustria Department of Agricultural and Food Sciences University of Naples FedericoⅡNapoliItaly

The challenge of enabling syntactic and semantic interoperability for comprehensive and reproducible online processing of big earth observation(eO)data is still *** both types of interoperability is one of the requirements to efficiently extract valuable information from the large amount of available multi-temporal gridded data *** proposed system wraps world models,(semantic interoperability)into OGC Web Processing Services(syntactic interoperability)for semantic online *** models describe spatio-temporal entities and their relationships in a formal *** proposed system serves as enabler for(1)technical interoperability using a standardised interface to be used by all types of clients and(2)allowing experts from different domains to develop complex analyses together as collaborative *** are connecting the world models online to the data,which are maintained in a centralised storage as 3D spatio-temporal data *** allows also non-experts to extract valuable information from eO data because data management,low-level interactions or specific software issues can be *** discuss the concept of the proposed system,provide a technical implementation example and describe three use cases for extracting changes from eO images and demonstrate the usability also for non-eO,gridded,multitemporal data sets(CORINe land cover).

关键词： OGC WPS big earth data time series large-scale processing model-driven semantic analyses

Big earth data:disruptive changes in earth observation data management and analysis?

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International Journal of Digital earth 2020年第7期13卷 832-850页

作者： Martin Sudmanns Dirk Tiede Stefan Lang Helena Bergstedt Georg Trosta Hannah Augustin Andrea baraldi Thomas Blaschke Department of Geoinformatics-Z_GIS University of SalzburgSalzburgAustria Italian Space Agency(ASI) RomeItaly

Turning earth observation(eO)data consistently and systematically into valuable global information layers is an ongoing challenge for the eO ***,the term‘big earth data’emerged to describe massive eO datasets that confronts analysts and their traditional workflows with a range of *** argue that the altered circumstances must be actively intercepted by an evolution of eO to revolutionise their application in various *** disruptive element is that analysts and end-users increasingly rely on Web-based *** this contribution we study selected systems and portals,put them in the context of challenges and opportunities and highlight selected shortcomings and possible future developments that we consider relevant for the imminent uptake of big earth data.

关键词： Digital earth data access satellite data portals objectbased image analysis(OBIA) remote sensing workflow

enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

Innovative Analysis Ready Data(ARD)product and process requirements,software system design,algorithms and implementation at the midstream as necessary-but-notsuffcient precondition of the downstream in a new notion of Space economy 4.0-Part 1:Problem background in Artificial General Intelligence(AGI)

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Big earth Data 2023年第3期7卷 455-693页

作者： Andrea baraldi Luca D.Sapia Dirk Tiede Martin Sudmanns Hannah L.Augustin Stefan Lang Spatial Services GmbH SalzburgAustria CGI Italy FrascatiItaly Department of Geoinformatics-Z_GIS University of SalzburgSalzburgAustria

Aiming at the convergence between earth observation(eO)Big Data and Artificial General Intelligence(AGI),this two-part paper identifies an innovative,but realistic eO optical sensory imagederived semantics-enriched Analysis Ready Data(ARD)productpair and process gold standard as linchpin for success of a new notion of Space economy *** be implemented in operational mode at the space segment and/or midstream segment by both public and private eO big data providers,it is regarded as necessarybut-not-sufficient“horizontal”(enabling)precondition for:(I)Transforming existing eO big raster-based data cubes at the midstream segment,typically affected by the so-called data-rich information-poor syndrome,into a new generation of semanticsenabled eO big raster-based numerical data and vector-based categorical(symbolic,semi-symbolic or subsymbolic)information cube management systems,eligible for semantic content-based image retrieval and semantics-enabled information/knowledge discovery.(II)Boosting the downstream segment in the development of an ever-increasing ensemble of“vertical”(deep and narrow,user-specific and domain-dependent)value–adding information products and services,suitable for a potentially huge worldwide market of institutional and private end-users of space *** the sake of readability,this paper consists of two *** the present Part 1,first,background notions in the remote sensing metascience domain are critically revised for harmonization across the multidisciplinary domain of cognitive *** short,keyword“information”is disambiguated into the two complementary notions of quantitative/unequivocal information-as-thing and qualitative/equivocal/inherently ill-posed ***,buzzword“artificial intelligence”is disambiguated into the two better-constrained notions of Artificial Narrow Intelligence as part-without-inheritance-of ***,based on a betterdefined and better-understood vocabulary of multid

关键词： Artificial Narrow Intelligence big data cognitive science computer vision earth observation essential climate variables Global earth Observation System of(component)Systems inductive/deductive/hybrid inference Scene Classification Map Space economy 4.0 radiometric corrections of optical imagery from atmospheric,topographic,adjacency and bidirectional reflectance distribution function effects semantic content-based image retrieval 2D spatial topology-preserving/retinotopic image mapping world ontology(synonym for conceptual/mental/perceptual model of the world)

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV S.KHATIR T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Non-linear Analysis of Bridge“Guglie”in Venice:Sensitivity to Designed and Realized Shape

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Journal of Civil engineering and Architecture 2019年第2期13卷 77-87页

作者： Daniele.baraldi Anna Manzato Antonella Cecchi Department of Architecture Construction Conservation Università IUAV di VeneziaDorsoduro 220630123VeniceItaly

In this paper,numerical non-linear analyses of the “Guglie” bridge,located in the historical city of Venice(Italy),are *** focus is twofold:on the sensitivity of the realized shape of the bridge by reference to originally designed shape;and on sensitivity to mechanical parameters of constituent *** history of this bridge is very interesting,and the bridge actually built is different from the Marchesini’s project(1580).In fact,in the original design drawing,the shape of the arch is a perfect circle arch,while the shape of the actually built arch is not perfectly ***,in the aim to evaluate sensitivity of bridge behaviour to designed and realized shape,non-linear analyses are carried on by means of FeMs(Finite element Models)under in-plane state ***,parametric tests are also performed for evaluating the influence of masonry mechanical parameters on non-linear bridge behaviour.

关键词： FeM masonry bridge pushover analysis parametric tests Mohr-Coulomb yield criterion