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Refined families of Dothideomycetes:orders and families incertae sedis in Dothideomycetes

Fungal Diversity 2020年第6期105卷 17-318页

作者： Sinang Hongsanan kevin D.Hyde rungtiwa phookams.k Dhanushka N.Wanasinghe eric H.C.Mckenzie V.Venkateswara Sarma Robert Lücking Saranyaphat boonmee Jayarama D.bhat Ning-Guo Liu Danushka S.Tennakoon Dhandevi Pem Anuruddha karunarathna Shu-Hua Jiang gareth e.b.jones Alan J.L.Phillips Ishara S.Manawasinghe Saowaluck Tibpromma Subashini C.Jayasiri Diana Sandamali Ruvishika S.Jayawardena Nalin N.Wijayawardene Anusha H.ekanayaka Rajesh Jeewon Yong-Zhong Lu Chayanard Phukhamsakda Asha J.Dissanayake Xiang-Yu Zeng Zong-Long Luo Qing Tian kasun M.Thambugala Dongqin Dai Milan C.Samarakoon k.W.Thilini Chethana Damien ertz Mingkwan Doilom Jian-kui(Jack)Liu Sergio Pérez-Ortega Ave Suija Chanokned Senwanna Subodini N.Wijesinghe Mekala Niranjan Sheng-Nan Zhang Hiran A.Ariyawansa Hong-bo Jiang Jin-Feng Zhang Chada Norphanphoun Nimali Ide Silva Vinodhini Thiyagaraja Huang Zhang Jadson D.P.bezerra Ricardo Miranda-González AndréAptroot Hiroyuki kashiwadani Dulanjalee Harishchandra emmanuël Sérusiaux Pranami DAbeywickrama Dan-Feng bao bandarupalli Devadatha Hai-Xia Wu kwang Hee Moon Cecile Gueidan Felix Schumm Digvijayini bundhun Ausana Mapook Jutamart Monkai Chitrabhanu S.bhunjun Putarak Chomnunti Satinee Suetrong Napalai Chaiwan Monika C.Dayarathne Jing Yang Achala R.Rathnayaka Jian-Chu Xu Jiesheng Zheng Gang Liu Yao Feng Ning Xie Guangdong Provincial key Laboratory for Plant epigenetics Shenzhen Key Laboratory of Microbial Genetic EngineeringCollege of Life Science and OceanographyShenzhen UniversityShenzhen 518060People’s Republic of China Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand CAS key Laboratory for Plant Diversity and biogeography of east Asia(kLPb) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China east and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50002Thailand Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China World Agroforestry Centre East and Central Asia132 Lanhei RoadKunming 650201YunnanPeople’s Republic of China Manaaki Whenua-Landcare Research Private Mail Bag 92170AucklandNew Zealand Fungal biotechnology Lab Department of BiotechnologySchool of Life SciencesPondicherry UniversityKalapetPondicherry 605014India School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand botanischer Garten und botanisches Museum Freie Universität BerlinKönigin-Luise-Straße 6-814195 BerlinGermany 13128/1-J Azad Co-Op Housing SocietyCurcaP.O.Goa Velha 403108India Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Guizhou key Laboratory of Agricultural biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China State key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of C

Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et *** 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern *** this paper,we provide a refined updated document on orders and families incertae sedis of *** family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological *** also provide phylogenetic trees for each *** this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological *** new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are *** genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are *** new species(Acrospermum urticae,bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different *** new combinations are also provided in this paper.

关键词： Abrothallales Ascrospermales Asterinales botryosphaeriales Catinellales Cladoriellales Collemopsidiales Dyfrolomycetales eremithallales eremomycetales Jahnulales kirschsteiniotheliales Lembosinales Lichenotheliales Microthyriales Minutisphaerales Monoblastiales Murramarangomycetales new family new genera new order new species Parmulariales Patellariales Phaeotrichales Phylogeny Stigmatodiscales Strigulales Superstratomycetales Taxonomy Trypetheliales Tubeufiales Valsariales Venturiales Zeloasperisporiales

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***电子商务宝典

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丛书名：美国计算机“宝典”丛书

2002年

作者：（美）Don jones 邱仲潘等译

本书全面系统介绍了电子商务站点的设计、开发、维护、测试方法，特别是Microsoft产品和其他相关产品的运用方法，包括计划阶段如何设计外观、设计客户体验、支持业务过程等。

ISBN: (数字)7505375660

ISBN: (纸本)7505375660

关键词：基本知识电子商务

来源：畅想之星图书光盘版（南... 评论

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前列腺特异性膜抗原（PSMA）靶向18F-DCFPyL在外周神经节的摄取模式

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中华核医学与分子影像杂志 2018年第5期38卷 379-380页

作者：李慧玲兰晓莉 Rudolf A.Werner Sara Sheikhbahaei krystyna M.jones Mehrbod S.Javadi Lilja b.Solnes Ashley e.Ross Mohamad e.Allaf kenneth J.Pienta Constantin Lapa ANDreas k.buck Takahiro Higuchi Martin G.Pomper Michael A.Gorin Steven P.Rowe 华中科技大学同济医学院附属协和医院核医学科 Division of Nuclear Medicine and Molecular Imaging The Russell H.Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of Medicine Department of Nuclear Medicine University Hospital Würzburg

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PeT显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PeT/CT显像的患... 详细信息

目的靶向前列腺特异性膜抗原（PSMA）的放射性显像剂在许多正常结构、解剖变异和非前列腺癌组织中有摄取。该研究探讨PSMA靶向显像剂18F-DCFPyL在外周神经节PeT显像的摄取频次和程度。方法回顾性分析98例接受18F-DCFPyL PeT/CT显像的患者,包括76例前列腺癌（PCa）男性患者和22名肾细胞癌（RCC）患者（男13例、女9例）。评估颈、星状、腹腔、腰、骶神经节的摄取。记录所有放射性摄取高于背景的神经节的摄取值,包括最大标准摄取值(SUVmax)和用瘦体质量校准的SULmax。计算SUVmax和SULmax除以升主动脉平均摄取(Aortamean)和右臀肌肉平均摄取(Gluteusmean),得到神经节/背景比值。结果 98例患者中有95例（96.9%）在至少1个外周神经节中有摄取。在PCa病例中,最常见的放射性聚集部位是腰交感神经节（55/76,72.4%）,其次是颈神经节（51/76,67.1%）。大多数患者是双侧摄取[腰椎44/55（80%）和颈椎30/51（58.8%）]。此外,星状神经节、腹腔神经节、骶神经节有明显放射性摄取者比例分别为65.8%（50/76）、59.2%（45/76）、6.6%（5/76）。RCC患者也有类似的发现,最常见的放射摄取部位是腰神经节（90.9%,20/22）和颈神经节（86.4%,19/22）。这2个部位的PSMA配体平均摄取量在PCa和RCC中均无差异。结论随着靶向PSMA显像剂的广泛应用,必须了解其在肿瘤不直接相关的组织结构中的摄取方式。该研究首次系统评价18F-DCFPyL在神经节中的摄取,结果显示其在腰椎、颈椎、星状神经节、腹腔神经节和骶神经节中的摄取频率呈下降趋势。然而,导致PSMA靶向放射性显像剂在外周神经节中摄取出现差异的生物学原因目前尚不清楚,需进一步研究。

关键词： 18F-DCFPyL 显像误区前列腺癌 PSMA 神经节

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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

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bone Research 2020年第2期8卷 157-168页

作者： Tobias Schwerd Freia krause Stephen R.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe borgmeyer Miryam Müller Santiago Manrique Neele Schumacher Steven A.Wall Jonathan Jung Timo Damm Claus-Christian Glüer Jürgen Scheller Stefan Rose-John e.Yvonne jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Holm H.Uhlig Translational Gastroenterology Unit John Radcliffe HospitalUniversity of OxfordOxfordUK Department of Pediatrics Dr von Hauner Children’s HospitalLMU MunichMunichGermany Christian-Albrechts-University kiel Institute of BiochemistryKielGermany Clinical Genetics Group MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordUK Center for Molecular Neurobiology Hamburg(ZMNH) University Medical Center Hamburg-EppendorfHamburgGermany Division of Structural biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK Craniofacial Unit Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK Section biomedical Imaging Department of Radiology and NeuroradiologyUniversity Medical Center Schleswig-HolsteinKielGermany Institute of biochemistry and Molecular biology Ⅱ Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Department of Paediatrics University of OxfordOxfordUK NIHR Oxford biomedical Research Centre OxfordUK The beatson Institute for Cancer Research GlasgowUK School of Medicine University of GlasgowGlasgowUK

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.R279 Q. We show that human GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSM, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 RA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects.

关键词： IL11 cytokine facial

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Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene kevin D.Hyde kunhiraman C.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.kirk Uwe braun Rajshree V.Singh Pedro W.Crous Martin kukwa Robert Lücking Cletus P.kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch einar Timdal Damien ertz Javier etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika C.Dayarathne Gothamie Weerakoon e.b.gareth jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.bahkali ka-Lai Pang kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura kasun M.Thambugala Dhanushka N.Wanasinghe bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri eleonora egidi Huzefa A.Raja Rampai kodsueb Marcela e.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana Monteiro Larissa N.Vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu konstanze bensch Nimali Indeewari de Silva AndréDe kesel Anuruddha karunarathna Saranyaphat boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa Samantha C.karunarathna key Laboratory for Plant Diversity and biogeography of east Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland botanic Garden and botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference Library and Herbarium of Cryptogamic botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and evolutionary biology Harvard University22 Divinity AvenueCambridgeMA 02138USA AbL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&education The Field Museum1400

knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

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大麦双列杂交种的性状表现及其产量和麦芽品质的配合力

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大麦科学 1995年第1期 48-53页

作者： e.A.Hockett A.F.Cook M.A.khan I.M.mastin b.L.jones 赵素珍韩海内蒙古农科院作物所

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Phylogenetic relationships and morphological reappraisal of Melanommataceae(Pleosporales)

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Fungal Diversity 2015年第5期74卷 267-324页

作者： Qing Tian Jian kui Liu kevin D.Hyde Dhanushka N.Wanasinghe Saranyaphat boonmee Subashini C.Jayasiri Zong Long Luo Joanne e.Taylor Alan J.L.Phillips Darbhe J.bhat Wen Jing Li Hiran Ariyawansa kasun M.Thambugala ebgareth jones Putarak Chomnunti Ali H.bahkali Jian Chu Xu erio Camporesi key Laboratory for Plant Diversity and biogeography of east Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Center for Mountain ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guizhou key Laboratory of Agricultural biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Royal botanic Garden edinburgh 20A Inverleith RowEdinburgh EH35LRUK UCIbIO Faculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal Formerly Department of BotanyGoa UniversityGoa-403206India Res:No.128/1–J Azad Housing SocietyCurcaP.O.Goa Velha-403108India Department of botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia A.M.b.Gruppo Micologico Forlivese bAntonio Cicognani Via Roma 18ForlìItaly A.M.b.Circolo Micologico bGiovanni Carini C.P.314 BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.144 BagnacavalloRAItaly

The family Melanommataceae is widespread in temperate and subtropical regions and species invariably occur on twigs or bark of various woody plants in terrestrial,marine or freshwater *** this paper,the type species of 26 genera of the family are re-described and illustrated.A multi-gene phylogeny based on maximum likelihood and bayesian analyses of LSU,SSU,RPb2 and eF-1αsequence data of species of Melanommataceae is *** new genera,Muriformistrickeria,Pseudostrickeria and Thysanolaenae are *** is synonymized under ***,Astrosphaeriella,beverwykella,Caryosporella,Sporidesmiella and Pseudotrichia are excluded from Melanommataceae based on molecular phylogenetic ***,20 genera are accepted in *** on the phylogenetic data,five new species,byssosphaeria siamensis,Herpotrichia vaginatispora,Pseudostrickeria muriformis,Pseudostrickeria ononidis and Muriformistrickeria rubi,are introduced.

关键词： byssosphaeria Herpotrichia Multi-gene Phylogeny Muriformistrickeria New species Pseudostrickeria Taxonomy Thysanolaenae Type

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Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4e-bP-independent manner

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Journal of Molecular Cell biology 2014年第3期8卷 255-266页

作者： Rachel Miloslavski elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith kasir Rajini Mudhasani Stephen N. jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas Department of biochemistry and Molecular biology The Institute for Medical Research - Israel-Canada The Hebrew University-Hadassah Medical School Jerusalem 91120 Israel Department of Cell biology University of Massachusetts Medical School North Worcester MA 01655 USA biozentrum University of Basel Klingelbergstrasse 70 CH-4056 Basel Switzerland Department of Oncolo'gy-Pathology Karolinska Instituie Stockholm SE-171 76 Sweden Lady Davis Institute for Medical Research Sir Mortimer B. Davis-Jewish General Hospital and Department of Oncology McGill University Montreal QC H3T 1E2 Canada Present address: Migal-Galilee Research Institute Kiryat Shmona 11016 Israel Present address: United States Army Medical Research Institute of Infectious Diseases Frederick MD 21702-5011 USA Present address: ADAM Montreal QC H3N 2C7 Canada

遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb，当 Rheb 的 TSC1 ... 详细信息

遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb，当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4e-bP 的 hypophosphorylated 状态相关，一个翻译抑压者。然而， seriesof 4e-bP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4e-bP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且，血缺氧的 repressiveeffect 类似于由 Torin 1，而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样，猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率，没能压制最高的 mRNAs 的调停氧的翻译激活。最后， TIA-1 和 TIAR co 击倒，二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有， failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此，近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。

关键词：翻译效率 mRNA TOP 信号通路氧气 RNA结合蛋白控制压力条件

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阿尔茨海默病静息eeG的同步活动出现异常波动

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 17-18页

作者： Stam C.J. Montez T. jones b.F. 江山 Alzheimer Centre Dept. of C linical Neurophysiology VU University Medical Centre P.O. Box 7057 1007 MB AmsterdamNetherlands

Objective: We examined the hypothesis that cognitive dy-sfunction in Alzheimer’s disease is associated with abnormal spontaneous fluc tuations of eeG synchronization levels during an eyes-closed resting state. Met hods: eeGs were recorded during an eyes-closed resting state in Alzheimer patie nts (N=24;9 males; mean age 76.3 years; SD 7.8; range 59-86) and nondemented su bjects with subjective memory complaints (N=19;9males;mean age 76.1 years; SD 6. 7; range: 67-89). The mean level of synchronization was determined in different frequency bands with the synchronization likelihood and fluctuations of the syn chronization level were analysed with detrended fluctuation analysis (DFA). Resu lts: The mean level of eeG synchronization was lower in Alzheimer patients in th e upper alpha (10-13 Hz) and beta (13-30 Hz) band. Spontaneous fluctuations of synchronization were diminished in Alzheimer patients in the lower alpha (8-10 Hz) and beta bands. In patients as well as controls the synchronization fluctuat ions showed a scale-free pattern. Conclusions: Alzheimer’s disease is characte rized both by a lower mean level of functional connectivity as well as by dimini shed fluctuations in the level of *** dynamics of these fluctuat ions in patients and controls was scale-free which might point to self-organiz ed criticality of neural networks in the brain. Significance: Impaired functiona l connectivity can manifest itself not only in decreased levels of synchronizati on but also in disturbed fluctuations of synchronization levels.

关键词：阿尔茨海默病 eeG β波 α波 analysed resting diminished connectivity 临界状态 bands

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中国南海红树内生真菌No.1403次级代谢物的研究

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中山大学学报（自然科学版） 2000年第6期39卷 68-72页

作者：姜广策林永成周世宁 L.L.P.VRIJMOeD e.b.G.jones 中山大学化学与化学工程学院广东广州510275 中山大学生命科学学院广东广州510275 香港城市大学生物和化学系

中国南海红树的内生真菌No 140 3是由香港城市大学Vrijmoed教授等分离出来的 .其发酵液粗提物有明显的抗菌活性 ,对酵母菌和霉菌均有抑制作用 .采用硅胶柱层析、核磁共振、质谱 ,红外光谱和X光结晶衍射等方法对该菌静置培养的发酵液化... 详细信息

中国南海红树的内生真菌No 140 3是由香港城市大学Vrijmoed教授等分离出来的 .其发酵液粗提物有明显的抗菌活性 ,对酵母菌和霉菌均有抑制作用 .采用硅胶柱层析、核磁共振、质谱 ,红外光谱和X光结晶衍射等方法对该菌静置培养的发酵液化学成分进行研究 ,发现真菌No 140 3能产生灰黄霉素A和多种醌类抗生素b ,C ,D及其它化合物 ,其中C未见文献报道 .A的产量很高 ,约为 2 0mg/L ,本研究表明No 140 3是有应用价值的灰黄霉素新的产生菌 .

关键词：内生真菌次级代谢物抗生素抗菌活动红树

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