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Atte.uate. re.inoic acid signaling is among the.e.rly re.ponse. in mouse.ute.us approaching e.bryo attachme.t

生殖与发育医学(英文) 2024年第1期08卷 61-65页

作者： Diao Honglu Xiao Shuo Zhou Tong Martin taylor e. Watford We.dy T. Ye.Xiaoqin De.artme.t of Infe.tious Dise.se. De.artme.t of Physiology and Pharmacology Colle.e.of Ve.e.inary Me.icine. 3. Unive.sity of Ge.rgia 4. Athe.s 5. GA 30602 6. USA De.artme.t of Physiology and Ce.l Biology Unive.sity of Ne.ada 9. Re.o School of Me.icine. 10. Re.o 11. NV 89557

The.ute.us is transie.tly re.e.tive.for e.bryo implantation. It re.ains to be.unde.stood why the.ute.us doe. not re.e.t a se.i-alloge.e.c e.bryo (to the.biological mothe.) or an alloge.e.c e.bryo (to a surrogate. for implantation. To gain insights, we.e.amine. ute.ine.e.rly re.ponse.ge.e. approaching e.bryo attachme.t on day 3 post coitum (D3) at 22 hours whe. blue.dye.re.ction, an indication of e.bryo attachme.t, had not manife.te. in mice. C57BL/6 pse.do-pre.nant (control) and pre.nant mouse.ute.i we.e.colle.te. on D3 at 22 hours for microarray analysis. The.se.f-asse.bling-manifold (SAM) algorithm ide.tifie. 21,858 unique.probe.e.s. Principal compone.t analysis indicate. a cle.r se.aration be.we.n the.pse.do-pre.nant and pre.nant groups. The.e.we.e.106 upre.ulate. and five.downre.ulate. prote.n-coding ge.e. in the.pre.nant ute.us with fold change.(fc) >1.5 andq value.e.e.ontology (GO) analysis of the.106 upre.ulate. ge.e. re.e.le. 38 significant GO biological proce.s (GOBP) te.ms (P e. we.e.associate. with immune.re.ponse., with a dominant natural kille. (NK) ce.l activation signature. Among the.top e.ght upre.ulate. prote.n-coding ge.e.,Cyp26a1 inactivate. re.inoic acid (RA) while.rat promote. vitamin A storage. both of which are.e.pe.te. to atte.uate.RA bioavailability;Atp6v0d2 andGjb2 play role. in ion transport and transme.brane.transport;Gzmb,Gzmc, andIl2rb are.involve. in immune.re.ponse.; andTdo2 is important for kynure.ine.pathway. Most of the.e.ge.e. or the.r re.ate. pathways have.functions in immune.re.ulations. RA signaling has be.n implicate. in immune.tole.ance.and immune.home.stasis, and ute.ine.NK ce.ls have.be.n implicate. in immunotole.ance.at the.mate.nal-fe.al inte.face.in the.place.ta. The.me.hanisms of immune.re.ponse. approaching e.bryo attachme.t re.ain to be.e.ucidate.. The.coordinate. e.fe.ts of the.e.rly re.ponse.ge.e. may hold the.ke.s to the.que.tion of why the.ute.us doe. not re.e.t an implanting e.bryo

关键词： e.bryo attachme.t Pse.do-pre.nant ute.us Pre.nant ute.us Natural kille. ce.l activation signature Re.inoic acid bioavailability Transme.brane.transport and ion transport

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沿厚度方向插入纤维的三维玻璃钢夹芯板的双向弯曲性能

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钢结构(中英文) 2010年第5期 78-79页

作者： M. Dawood e. taylor S. Rizkalla

详细介绍了评估三维玻璃纤维增强聚合物(玻璃钢)夹芯板的双向弯曲的性能试验。该板由带有泡沫核心的玻璃钢外观和沿厚度方向插入的纤维构成。这些板的单向弯曲性能相对容易理解,然而,对其双向弯曲性能研究较少。本文试验目的是评估集中... 详细信息

详细介绍了评估三维玻璃纤维增强聚合物(玻璃钢)夹芯板的双向弯曲的性能试验。该板由带有泡沫核心的玻璃钢外观和沿厚度方向插入的纤维构成。这些板的单向弯曲性能相对容易理解,然而,对其双向弯曲性能研究较少。本文试验目的是评估集中荷载下纤维的插入形式和板厚对双向弯曲性能的影响。用试验结果来验证非线性、静力有限元模型,这个模型引进一种简单方法预测反应。这种实测和预测的反应结果表明,在小挠度情况下,板以弯曲反应为主而大挠度以膜反应为主。用有限元分析进一步研究不同参数的影响,这些参数在试验中都没有进行测定。参数化研究表明,增加板的相对弯曲或剪切刚度能改变板的弯曲机理从而减少膜反应承载的百分比。

关键词：夹层结构膜反应弯曲板非线性分析推理法参数化研究

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e.fe.t of Androste.e.ione.on Adipoge.e.is in Murine.C3H10T1/2 Me.e.chymal Ce.ls

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Ope. Journal of e.docrine.and Me.abolic Dise.se. 2015年第2期5卷 9-18页

作者： Pandurangan Ramaraj Jorge.N. Artaza Indrani Sinha-Hikim Wayne.e. taylor De.artme.t of Bioche.istry Kirksville College of Osteopathic Medicine A.T. Still University of Health Sciences Kirksville MO USA Division of e.docrinology Charles R. Drew University of Medicine and Science Los Angeles CA USA De.artme.t of He.lth and Life.Scie.ce. Charles R. Drew University of Medicine and Science Los Angeles CA USA

Clinical trials of we.k androge. androste.e.ione.(AD) administe.e. at a high conce.tration, showe. an incre.se.in muscle.mass in me. like.strong androge.s te.toste.one.(T) and dihydrote.toste.one.(DHT), but did not show any inhibitory e.fe.t on fat mass unlike.strong androge.s. This obse.vation prompte. us to che.k the.in-vitro e.fe.t of AD on adipoge.e.is using mouse.me.e.chymal multipote.t ce.ls (C3H10T1/2), which can diffe.e.tiate.into both myoblasts and adipocyte.. Re.ults indicate. that AD inhibite. adipoge.e.is at 10 nM, 100 nM and 1 μM conce.trations, but not at 10 μM conce.tration. AD did not inhibit adipoge.e.is at 10 μM conce.tration and also did not inhibitmyoge.e.is at 10 μM conce.tration. Addition of bicalutamide. an androge. re.e.tor (AR) antagonist de.re.se. myoge.e.is and incre.se. adipoge.e.is, indicating that the.e.fe.t of AD was me.iate. through AR. Anothe. we.k androge. de.ydroe.iandroste.one.(DHe.) also showe. the.same.patte.n of adipoge.e.is in 10T1/2 ce.ls. AD also showe. a similar patte.n of adipoge.e.is in 3T3-L1 pre.dipocyte.ce.ls. Thus, the.in-vitro re.ults of AD on adipoge.e.is corre.ate. with the.in-vivo re.ults of AD on fat-mass from clinical trials and sugge.te. a possible.diffe.e.ce.in biological action be.we.n we.k androge.s (AD, DHe.) and strong androge.s (T, DHT) on adipoge.e.is. Since.the.biological action of AD was me.iate. through AR, this physiological diffe.e.ce.onadipoge.e.is could be.due.to the.nature.(partial agonist/antagonist) of AD binding to AR.

关键词： Androste.e.ione Adipoge.e.is Myoge.e.is Androge. Re.e.tor Bicalutamide

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On the.Solutions of xn＋1=f（xn）/xn-1Whe.e.fis Pie.e.ise.Line.r

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数学和系统科学：英文版 2016年第9期6卷 348-351页

作者： M. B. Fore.an R. B. Holme. W. e. taylor De.artme.t of Mathe.atics Texas Southern University Houston Texas

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结合压缩薄膜效应对BFRP筋自密实混凝土桥面板工作性能有限元分析

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玻璃钢／复合材料 2018年第5期 12-18页

作者：周玲珠郑愚 Susan.e.taylor 罗远彬东莞理工学院东莞523808 华南理工大学广州510640 英国贝尔法斯特女王大学哈尔滨工业大学(深圳) 深圳518055

采用非线性有限元方法对英国北爱尔兰Thompson桥中的BFRP筋增强自密实混凝土桥面板进行数值分析,通过对比数值模拟结果和试验结果表明所建立的有限元模型能够较准确地反映BFRP筋增强自密实混凝土桥面板在轮压负载下的工作性能。基于有... 详细信息

采用非线性有限元方法对英国北爱尔兰Thompson桥中的BFRP筋增强自密实混凝土桥面板进行数值分析,通过对比数值模拟结果和试验结果表明所建立的有限元模型能够较准确地反映BFRP筋增强自密实混凝土桥面板在轮压负载下的工作性能。基于有限元模型的有效性,采用非线性数值模拟对该新型桥面板进行极限承载力和破坏模式进行预测及参数化分析。结果表明,BFRP筋自密实桥面板极限承载力大约为欧洲轮压负载150 k N的6倍(100 t),由于现行桥面板设计规范忽略了压缩薄膜效应的存在而导致桥面板极限承载力设计过于保守,参数化分析发现配筋率和筋材类型对桥面板极限承载力影响不大,而混凝土强度和跨高比是影响桥面板极限承载力的主要因素。

关键词：非线性有限元法 BFRP筋增强自密实桥面板压缩薄膜效应承载性能

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严重疟疾患儿视网膜病变预后的重要性和病程

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美国医学会眼科杂志（中文版） 2005年第2期17卷 121-122页

作者： Nicholas A. Be.re.Caroline.Southe.n Chipo Chalira Te.rie.e. taylor Malcolm e. Molyne.x Simon P. Harding 陆遥（译）

目的：研究严重疟疾患儿视网膜变化和疾病结果的关系，并观察眼底改变的进程。方法：对2个疟疾流行季节里参加Malawi，Blantyre.疾研究项目脑型疟疾（CM）和疟疾贫血的患儿进行前瞻性研究。如果患者能够合作，在就诊时和此后每天进行... 详细信息

目的：研究严重疟疾患儿视网膜变化和疾病结果的关系，并观察眼底改变的进程。方法：对2个疟疾流行季节里参加Malawi，Blantyre.疾研究项目脑型疟疾（CM）和疟疾贫血的患儿进行前瞻性研究。如果患者能够合作，在就诊时和此后每天进行直接和间接眼底镜检查。

关键词：脑型疟疾视网膜病变患儿间接眼底镜检查病程预后前瞻性研究视网膜变眼底改变流行季节

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In vivo mouse.mode.s to study bile.acid synthe.is and signaling

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 466-473页

作者： Anisha Bhattacharya Rulaiha e.taylor Grace.L Guo De.artme.t of Pharmacology and Toxicology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew JerseyUSA Rutge.s Ce.te. for Lipid Re.e.rch RutgersThe State University of New JerseyNew BrunswickNew JerseyUSA e.vironme.tal and Occupational He.lth Scie.ce. Institute RutgersThe State University of New JerseyPiscatawayNew JerseyUSA VA Ne. Je.se. He.lth Care.Syste. Veterans Administration Medical CenterEast OrangeNew JerseyUSA

The.synthe.is of bile.acids(BAs)is carrie. out by comple. pathways characte.ize. by se.ue.tial che.ical re.ctions in the.live. through various cytochrome. P450(CYP)and othe. *** the.inte.rity of the.e.pathways is crucial for normal physiological function in mammals,e.compassing he.atic and ne.rological *** on the.de.icie.cie. in BA synthe.is ge.e. offe.s valuable.insights into the.significance.of BAs in modulating farne.oid X re.e.tor(FXR)signaling and me.abolic *** cre.ting mouse.knockout(KO)mode.s,re.e.rche.s can manipulate.de.icie.cie. in ge.e. involve. in BA synthe.is,which can be.use. to study human dise.se. with BA *** KO mouse.mode.s allow for a more.profound unde.standing of the.functions and re.ulations of ge.e. re.ponsible.for BA ***,KO mouse.mode.s she. light on the.distinct characte.istics of individual BA and the.r role. in nucle.r re.e.tor ***,alte.ations of BA synthe.is ge.e. in mouse.mode.s have.distinct diffe.e.ce. whe. compare. to human dise.se. cause. by the.same.BA synthe.is ge.e.*** re.ie. summarize. se.e.al mouse.KO mode.s use. to study BA synthe.is and re.ate. human dise.se.,including mice.de.icie.t in Cyp7a1,Cyp27a1,Cyp7a1/Cyp27a1,Cyp8b1,Cyp7b1,Cyp2c70,Cyp2a12,and Cyp2c70/Cyp2a12,as we.l as ge.m-fre. mice.

关键词： Bile.acid Spe.ie. diffe.e.ce Farne.oid X re.e.tor Live. dise.se.

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Ground-base. and additional scie.ce.support for SMILe

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e.rth and Plane.ary Physics 2024年第1期8卷 275-298页

作者： J.A.Carte. M.Dunlop C.Forsyth K.Oksavik e.Donovon A.Kavanagh S.e.Milan T.Se.gie.ko R.C.Fe.r D.G.Sibe.k M.Connors T.Ye.man X.Tan M.G.G.T.taylor K.McWilliams J.Gje.loe. R.Barne. D.D.Bille. G.Chisham A.Dimmock M.P.Fre.man D.-S.Han M.D.Hartinge. S.-Y.W.Hsie. Z.-J.Hu M.K.Jame. L.Juusola K.Kauristie.e.A.Kronbe.g M.Le.te. J.Manue. J.Matzka I.McCre. Y.Miyoshi J.Rae.L.Re. F.Sige.ne. e.Spanswick K.Ste.ne.A.Ste.we. T.Sun M.-T.Walach B.Walsh C.Wang J.We.gand J.Wild J.Yan J.Zhang Q.-H.Zhang Plane.ary Scie.ce. Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Ruthe.ford Apple.on Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space.and e.vironme.t Beihang UniversityBeijing 100191China Ke. Laboratory of Space.e.vironme.t Monitoring and Information Proce.sing Ministry of Industry and Information TechnologyBeijing 100017China De.artme.t of Space.and Climate.Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birke.and Ce.tre.for Space.Scie.ce Department of Physics and Technology.University of BergenBergenNorway De.artme.t of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Surve. CambridgeUK Swe.ish Institute.of Space.Physics KirunaSweden We.t Highfie.d Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space.Flight Ce.te. NASAGreenbeltMarylandUSA Athabasca Unive.sity AthabascaCanada e.Te. European Space AgencyNetherlands Unive.sity of Saskatche.an SaskatoonCanada The.Johns Hopkins Unive.sity Applie. Physics Laboratory LaurelMarylandUSA Swe.ish Institude.of Space.Physics UppsalaSE 75121Sweden Tongji Unive.sity Shanghai 200092China Ce.te. for Space.Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Re.e.rch Institute.of China Shanghai 200136China Finnish Me.e.rological Institute.FMI) Finland De.artme.t of e.rth and e.vironme.tal Scie.ce.(Ge.physics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space.Age.cy MontrealCanada GFZ Ge.man Re.e.rch Ce.tre.for Ge.scie.ce. PotsdamGermany Nagoya Unive.sity Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria Unive.sity Newcastle upon TyneTyne and WearUK NE18ST National Space.Scie.ce.Ce.te. Chinese Academy SciencesBeijing 100190China Arctic Ge.physics University Centre in Svalbard

The.joint e.rope.n Space.Age.cy and Chine.e.Acade.y of Scie.ce. Solar wind Magne.osphe.e.Ionosphe.e.Link e.plore.(SMILe.mission will e.plore.global dynamics of the.magne.osphe.e.unde. varying solar wind and inte.plane.ary magne.ic fie.d conditions,and simultane.usly monitor the.auroral re.ponse.of the.Northe.n He.isphe.e.*** the.e.large.scale.re.ponse. with me.ium and fine.scale.me.sure.e.ts at a varie.y of cade.ce. by additional ground-base. and space.base. instrume.ts will e.able.a much gre.te. scie.tific impact be.ond the.original goals of the.SMILe.***,we.de.cribe.curre.t community e.forts to pre.are.for SMILe.and the.be.e.its and conte.t various e.pe.ime.ts that have.e.plicitly e.pre.se. support for SMILe.can offe..A de.icate. group of inte.national scie.tists re.re.e.ting many diffe.e.t e.pe.ime.t type. and ge.graphical locations,the.Ground-base. and Additional Scie.ce.Working Group,is facilitating the.e.*** include.constructing an online.SMILe.Data Fusion Facility,the.discussion of particular or spe.ial mode. for e.pe.ime.ts such as cohe.e.t and incohe.e.t scatte. radar,and the.conside.ation of particular obse.ving strate.ie. and space.raft *** anticipate.growing inte.e.t and community e.gage.e.t with the.SMILe.mission,and we.we.come.nove. ide.s and insights from the.solar-te.re.trial community.

关键词： magne.osphe.e ionosphe.e magne.osphe.e.ionosphe.e.coupling ground-base. e.pe.ime.tation SMILe conjunctions missions

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Ge.ome.and clonal he.atopoie.is stability contrasts with immune.cfDNA,mitochondrial,and te.ome.e.le.gth change. during short duration space.light

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Pre.ision Clinical Me.icine 2024年第1期7卷 1-13页

作者： J.Se.astian Garcia-Me.ina Karolina Sie.kie.icz S.Anand Narayanan e.iah G.Ove.be. Kirill Grigore. Krista A.Ryon Marissa Burke.Jacque.ine.Proszynski Brade. Tie.ne. Cale. M.Schmidt Nuria Me.cia-Trinchant Re.i Klotz Ve.onica Ortiz Jonathan Foox Christophe. Chin De.na Najjar Irina Mate. Ire.ae.s Chan Carlos Cruchaga Ashle. Kle.nman JangKe.n Kim Ale.ande. Lucaci Conor Loy Omary Mzava Iwijn De.Vlaminck Anvita Singaraju Lynn e.taylor Julian C.Schmidt Michae. A.Schmidt Ke.ly Ble.se.Juan More.o Andre. Boddicke. Junhua Zhao Bryan Lajoie.Andre. Altomare.Se.yon Kruglyak Shawn Le.y Min Yu Duane.C.Hassane.Susan M.Baile. Ke.ly Bolton Jaime.Mate.s Christophe. e.Mason De.artme.t of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The.HRH Prince.Alwale.d Bin Talal Bin Abdulaziz Alsaud Institute.for Computational Biome.icine Weill Cornell MedicineNew YorkNY 10021USA De.artme.t of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA De.artme.t of Ste. Ce.l Biology and Re.e.e.ative.Me.icine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space.e.ploration Te.hnologie. Corporation HawthomeCA 90250USA Sovaris Ae.ospace BoulderCO 80302USA Advance. Patte.n Analysis&Human Pe.formance.Group BoulderCO 80302USA Childre.'s Cance. and Blood Foundation Laboratorie. Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Me.e. Cance. Ce.te. Weill Cornell MedicineNew YorkNY 10065USA De.artme.t of Nutrition and Inte.rative.Physiology Florida State UniversityTallahasseeFL 32306USA De.artme.t of Syste.s e.gine.ring Colorado State UniversityFort CollinsCO 80523USA e.e.e.t Bioscie.ce. San DiegoCA 10055USA De.artme.t of e.vironme.tal and Radiological He.lth Scie.ce. Colorado State UniversityFort CollinsCO 80523USA Ce.l and Mole.ular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington Unive.sity St Louis Oncology Division St.LouisMO 63100USA Me.nig School of Biome.ical e.gine.ring Cornell UniversityIthacaNY 14853USA The.Fe.l Family Brain and Mind Re.e.rch Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative.for Quantitative.Pre.iction Weill Cornell MedicineNew YorkNY 10021USA

Background The.Inspiration4(I4)mission,the.first all-civilian orbital flight mission,inve.tigate. the.physiological e.fe.ts of short-duration space.light through a multi-omic *** advance.,the.e.re.ains much to le.rn about human adaptation to space.light's unique.challe.ge.,including microgravity,immune.syste. pe.turbations,and radiation *** To provide.a de.aile. ge.e.ics analysis of the.mission,we.colle.te. drie. blood spots pre.,during,and post-flight for DNA *** le.gth was me.sure. by quantitative.PCR,while.whole.ge.ome.and cfDNA se.ue.cing provide. insight into ge.omic stability and immune.adaptations.A robust bioinformatic pipe.ine.was use. for data analysis,including variant calling to asse.s mutational *** Te.ome.e.e.ongation occurre. during space.light and shorte.e. afte. re.urn to ***-fre. DNA analysis re.e.le. incre.se. immune.ce.l signature. *** significant clonal he.atopoie.is of inde.e.minate.pote.tial(CHIP)or whole.ge.ome.instability was *** long-te.m ge.e.e.pre.sion change. across immune.ce.ls sugge.te. ce.lular adaptations to the.space.e.vironme.t pe.sisting months *** Our findings provide.valuable.insights into the.physiological conse.ue.ce. of short-duration space.light,with te.ome.e.dynamics and immune.ce.l ge.e.e.pre.sion adapting to space.light and pe.sisting afte. re.urn to *** se.ue.cing data will se.ve.as a re.e.e.ce.point for studying the.e.rly de.e.opme.t of CHIP in astronauts,an unde.studie. phe.ome.on as pre.ious studie. have.focuse. on care.r *** study will se.ve.as a re.e.e.ce.point for future.comme.cial and non-comme.cial space.light,low e.rth orbit(Le.)missions,and de.p-space.e.ploration.

关键词： ge.ome. clonal he.atopoie.is stability immune mitochondria ribosome. space.light

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The.capsid re.olution

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Journal of Mole.ular Ce.l Biology 2023年第11期15卷 1-11页

作者： Ian A.taylor Aribe.to Fassati Macromole.ular Structure.Laboratory The Francis Crick InstituteLondon NW11ATUK Division of Infe.tion and Immunity University College LondonLondon WC1E 6JFUK Institute.of Immunity and Transplantation University College LondonLondon NW32PPUK

Le.acapavir,targe.ing the.human immunode.icie.cy virus type.1(HIV-1)capsid,is the.first-in-class antire.roviral drug re.e.tly approve. for clinical *** de.e.opme.t of Le.acapavir is attribute. to the.re.arkable.progre.s in our unde.standing of the.capsid prote.n made.during the.last fe. *** little.more.than a compone.t of the.virus she.l to be.she. e.rly during infe.tion,the.capsid has be.n found to be.a ke. playe. in the.HIV-1 life.cycle.by inte.acting with multiple.host factors,e.te.ing the.nucle.s,and dire.ting ***,we.de.cribe.the.ke. advance. that le. to this‘capsid re.olution’.

关键词： HIV-1 capsid CPSF6 Le.acapavir inte.ration IP6 nucle.s re.e.se.transcription

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