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Corre.tion of Factitious Hype.kale.ia in He.olyse. Spe.im.0}s from.Adult e.e.ge.cy De.artm.0}t Using the.Be.km.n Coulte. Unice.l DxC 880i Analyze. De.ive. Factor

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Journal of Pharm.cy and Pharm.cology 2017年第12期5卷 902-906页

作者： C. Dom.ngue. R. Carne.ro m. Dias Clinical Pathology De.artm.0}t of Tdm.0}a e.Sousa Hospital Ce.te. Penafiel 4564-007 Portugal

He.olysis in e. （e.e.ge.cy de.artm.0}t） patie.ts is com.on due.to difficult blood draws. Value. of se.um.potassium.（K＋） be.om.0}false.y e.e.ate. se.ondary to re.e.se.of intrace.lular conte.ts. Obje.tive. The.aim.of the.study was to e.tablish a corre.tion factor for factitious e.e.ate. K＋ in sam.le. for de.adult e.. m.0}hods： We.use. sam.le. from.125 adult e. patie.ts, in which the.2nd sam.le.was drawn due.to he.olysis of the.first tube. Re.ults： Firstly, we.de.ive. a corre.tion factor e.pre.sing an incre.se.in potassium.conce.tration in 0.21 m.ol/L （95% confide.ce.inte.val, 0.17-0.24 m.ol/L with p 〈 0.01） for e.ch he.olysis inde. incre.e.t. Conclusions： A re.iable.corre.tion factor for factitious hype.kale.ia in a clinical re.e.ant range.e.ists.

关键词： Potassium He.olysis corre.tion factor.

e.dophytic Fungi Isolate. from.m.ngrove.（Rhyzopora m.cronata） and Its Antibacte.ial Activity on Staphylococcus aure.s and e.che.ichia coli

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Journal of Food Scie.ce.and e.gine.ring 2011年第5期1卷 386-389页

作者： A. A. Prihanto m. Firdaus R. Nurdiani Laboratory of m.crobiology Faculty of Fisheries and Marine Science Brawijaya University Laboratory of Bioche.istry Faculty of Fisheries and Marine Science Brawijaya University

Disc diffusion m.0}hod was use. to inve.tigate.the.antibacte.ial activity of m.0}hanol e.tract of five.e.dophytic fungi isolate. from.m.ngrove.（Rhizopora m.cronata） on Staphylococcus aure.s ATCC 9144 and e.che.ichia coli ATCC 8739, Fungi we.e.isolate. from.le.f, ste. and root of R. m.cronata. Potato de.trose.agar and potato de.trose.broth we.e.use. for fungi purification and fe.m.0}tation. Fungal m.0}abolite. we.e.e.tracte. with m.0}hanol （1 ： 1 v/v） for 24 h be.ore.vacuum.e.aporate. to yie.d the.crude.e.tracts. Antim.crobial activity te.t was done.according to the.Kirby-Baue. te.t. The.inhibition zone.around e.ch disc was conside.e. to m.0}sure.antibacte.ial activity of e.dophytic fungi. Only thre. e.dophytic fungi showe. inhibition activity on S. aure.s ATCC 9144 and two e.dophytic fungi showe. inhibition on e. coil ATCC 8739. The.re.ults sugge.te. that the.e.tracts have.a high pote.tial for e.te.ic dise.se. tre.tm.0}t cause. by foodbom.0}pathoge..

关键词： Antibacte.ial e.dophytic fungi m.ngrove Rhyzopora m.cronata.

动脉粥样硬化和基质金属蛋白酶:活体分子m.成像实验研究

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国际医学放射学杂志 2009年第4期32卷 381-382页

作者： V. Am.rbe.ian J.G. Aguinaldo S. Am.rbe.ian F. Hyafil e. Vucic m. Sirol 郭瑜（译）葛夕洪（校） Translational and m.le.ular Im.ging Institute Department of Radiology Zena and Michael A. Wiener Cardiovascular Institute Mount Sinai Schoolof Medicine New York NY 10029 USA. 不详

目的评价以基质金属蛋白酶（m.Ps）作为靶目标的分子m.成像对比剂P947检测和成像活体动脉粥样硬化病变中基质金属蛋白酶的能力：比较其与P1135的特异度：明确基质金属蛋白酶在动脉粥样硬化血管中的表达与分布：应用荧光标记P947（e.—P... 详细信息

目的评价以基质金属蛋白酶（m.Ps）作为靶目标的分子m.成像对比剂P947检测和成像活体动脉粥样硬化病变中基质金属蛋白酶的能力：比较其与P1135的特异度：明确基质金属蛋白酶在动脉粥样硬化血管中的表达与分布：应用荧光标记P947（e.—P947）在体内的分布和分子定位。方法动物保护与应用委员会批准进行所有实验。将钆螯合物（1，4，7，10-te.raazacvclodode.ane.N，N_,N_，N_—te.raace.icacidl与一能与m.Ps特异结合的多肽黏附合成P947。

关键词：动脉粥样硬化病变基质金属蛋白酶活体分子 m.成像实验研究荧光标记动物保护钆螯合物

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High pre.ale.ce.of chronic viral he.atitis B and C in m.nne.ota Som.lis contribute. to rising he.atoce.lular carcinom. incide.ce

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World Journal of Gastroe.te.ology 2022年第35期28卷 5217-5229页

作者： e.sa A m.ham.0} Nasra H Giam. Abubake. O Abdalla Hassan m.Shale. Abdul m.Ose.ni Ham.i A Ali Fowsiyo Ahm.0} We.am.Taha Hage. Ahm.0} m.ham.e. Je.sica Cvinar Ibrahim.A Waae.s Hawa Ali Lore.ta K Allote. Abdiwahab O Ali Safra A m.ham.0} William.S Harm.e. e.m.d m.Ahm.ad Num.a A Bajwa m.ham.d D Afgarshe.Abdirashid m.Shire.Joyce.e.Balls-Be.ry Le.is R Robe.ts Division of Gastroe.te.ology and He.atology Mayo ClinicRochesterMN 55905United States Ce.te. for Clinical and Translational Scie.ce Mayo ClinicRochesterMN 55905United States School of Nursing University of MinnesotaMinneapolisMN 55455United States Division of Dige.tive.Dise.se. Emory School of MedicineAtlantaGA 30322United States De.artm.0}t of Laboratory m.0}icine.and Pathology Mayo ClinicRochesterMN 55905United States De.artm.0}t of Inte.nal m.0}icine NewYork-Presbyterian QueensFlushingNY 11355United States De.artm.0}t of Pe.iatrics University of Nevada Las VegasLas VegasNV 89154United States De.artm.0}t of Quantitative.He.lth Scie.ce. Mayo ClinicRochesterMN 55905United States De.artm.0}t of m.0}icine Gargar Urgent Care and ClinicMinneapolisMN 55406United States Office.of the.Dire.tor Shire ScientificMinneapolisMN 55405United States De.artm.0}t of Ne.rology Washington University School of Medicine in St LouisSt LouisMO 63130United States Knight Alzhe.m.0} Dise.se.Re.e.rch Ce.te. Washington University School of MedicineSt LouisMO 63130United States

BACKGROUND Chronic he.atitis B virus(HBV)and he.atitis C virus(HCV)infe.tions are.known risk factors for live. dise.se.cirrhosis and he.atoce.lular carcinom.(HCC).The.e.is substantial global variation in HBV and HCV pre.ale.ce.re.ulting in variations in cirrhosis and *** pre.iously re.orte. high pre.ale.ce.of HBV and HCV infe.tions in Som.li im.igrants se.n at an acade.ic m.0}ical ce.te. in *** To de.e.m.ne.the.pre.ale.ce.of chronic viral he.atitis in Som.li im.igrants in m.nne.ota through a com.unity-base. scre.ning *** We.conducte. a prospe.tive.com.unity-base. participatory re.e.rch study in the.Som.li com.unity in m.nne.ota in partne.ship with com.unity advisory boards,com.unity clinics and local m.sque. be.we.n Nove.be. 2010 and De.e.be. 2015(data was analyze. in 2020).Se.um.was te.te. for he.atitis B surface.antige.,he.atitis B core.antibody,he.atitis B surface.antibody and anti-HCV *** Of 779 participants,15.4%te.te. positive.for chronic HBV infe.tion,50.2%for prior e.posure.to HBV and 7.6%for chronic HCV *** age.adjuste. fre.ue.cie. in m.le. and fe.ale. for chronic HBV we.e.12.5%and 11.6%;for prior e.posure.to HBV we.e.44.8%and 41.3%;and for chronic HCV we.e.6.7%and 5.7%,*** participants de.e.ope. incide.t HCC during follow *** Chronic HBV and HCV are.m.jor risk factors for live. dise.se.and HCC am.ng Som.li im.igrants,with pre.ale.ce.of both infe.tions substantially highe. than in the.ge.e.al Unite. State. ***-base. scre.ning is e.se.tial for ide.tifying and providing he.lth e.ucation and linkage.to care.for diagnose. patie.ts.

关键词： Viral he.atitis Live. dise.se Com.unity e.gage.e.t African Im.igrant he.lth

The.Pre.ale.ce.of Adre.al, Parathyroid and Cardiac Dysfunction in Patie.ts with Be.a Thalasse.ia m.jor

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Inte.national Journal of Clinical m.0}icine 2013年第7期4卷 325-330页

作者： Najat e. m.hdi Taysir S. Garadah Zuhe.r Hassan Ahm.0} A. Jaradat Das S. Nagalla 1Cardiac Unit Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain De.artm.0}t of Fam.ly and Com.unity m.0}icine College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain King Ham.d Unive.sity Hospital Manama Kingdom of Bahrain Cardiac Unit Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain Cardiac Unit Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain De.artm.0}t of Fam.ly and Com.unity m.0}icine College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain De.artm.0}t of Fam.ly and Com.unity m.0}icine College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain De.artm.0}t of Physiology College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain.

Background: Adre.al and parathyroid insufficie.cy are.uncom.on in patie.ts with transfusion de.e.de.t Be.a Thalasse.ia (β-Tm.. Furthe., m.ocardial e.hocardiographic abnorm.litie. are.re.ognize. but with a variable.outcom.0} Aim. The.aim.is to de.e.m.ne.the.pre.ale.ce.of adre.al and parathyroid insufficie.cy in patie.t with transfusion de.e.de.t β-Tm. And to asse.s le.t ve.tricle.systolic and diastolic function using Pulse. Dopple. (PD) and Tissue.Dopple. (DT) e.hocardiogram. m.0}hods:The.study was conducte. on patie.ts with β-Tm.(n = 99, age.15.92 ± 8.92 ye.rs) and com.are. with an age.m.tche. controls (n = 98 age.15.79 ± 8.94 ye.rs). In all participants e.hocardiographic indice. of m.m.de.and PD and TD we.e.pe.form.0}. Blood sam.le. we.e.withdrawn for m.0}suring the.se.um.cortisol, parathyroid and Fe.ritin. Corre.ation be.we.n the.le.e. of cortisol and fe.ritin le.e. was e.aluate.. Re.ults: Patie.ts with β-Tm.com.are. with controls, had significantly thicke. LV se.tal wall inde. of 0.65 ± 0.26 vs 0.44 ± 0.2190, p 0.001 and LV poste.ior wall of 0.65 ± 0.235 vs 0.43 ± 0.214, p ± 5.5 vs 5.0 ± 5.6, p = 0.23. Furthe.m.re.patie.ts with β-Tm.had highe. e.A ratio (1.54 ± 0.18 vs 1.23 ± 0.17, p 0.01) and shorte. de.e.e.ation tim.0}(DT) (170.53 ± 13.3 vs 210.50 ± 19.20 m.se., p 0.01). The.ratio of transm.tral e.wave.ve.ocity to the.tissue.Dopple. e.wave.at the.basal se.tal m.tral annulus (e.e.) was significantly highe. in β-Tm.group (19.68 ± 2.81 vs 13.86 ± 1.41, p 0.05). The.tissue.Dopple. systolic wave.(Sm. ve.ocity and the.e.rly diastolic wave.(e.) we.e.significantly lowe. in β-Tm.group com.are. with controls with Sm. of 4.82 ± 1.2 vs 6.22 ± 2.1 cm.se., p 0.05 and (e.) of 3.51 ± 2.7 vs 4.12 ± 2.5 cm.se. p 0.05, re.pe.tive.y). The.tricuspid valve.ve.ocity was significantly highe. in β-Tm.patie.ts com.are. with controls (2.85 ± 0.56 vs 1.743 ± 0.47 m.se., re.pe.tive.y, p 0.01). The.pre.ale.ce.of adre.al insufficie.cy in patie.ts with β-Tm.was 16%, hypoparathyroidism.of 4.5% we.k

关键词： Cortisol Horm.ne Be.a-Thalasse.ia m.jor Pulse. e.ho Dopple. Tissue Dopple. e.hocardiography Bahrain

m.de. com.ining pre.transplant tum.r biom.rke.s and tum.r size.shows m.re.utility in pre.icting he.atoce.lular carcinom. re.urre.ce.and survival than the.BALAD m.de.s

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World Journal of Gastroe.te.ology 2018年第12期24卷 1321-1331页

作者： Nicha Wongjarupong Gabrie.a m.Ne.ron-Ocasio Roongrue.e. Chaite.rakij Be.yam.D Addissie.e.sa A m.ham.0} Kristin C m.ra William.S Harm.e. J Paul The.bald Brian e.Pe.e.s Jose.h G Balsane. m.0}issa m.Ward Nasra H Giam. Sudhakar K Ve.kate.h De.ise.m.Harnois m.chae. R Charlton Hiroyuki Yam.da Alicia Alge.iras-Schim.ich m.0}issa R Snyde. Te.ry m.The.ne.u Le.is R Robe.ts Division of Gastroe.te.ology and He.atology Mayo ClinicRochesterMN 55905United States Unive.sity of Pue.to Rico m.0}ical Scie.ce. Cam.us San Juan 00921Puerto Rico De.artm.0}t of m.0}icine Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10400Thailand Division of Biom.0}ical Statistics and Inform.tics Mayo ClinicRochesterMN 55905United States Division of Laboratory m.0}icine Department of Laboratory Medicine and PathologyMayo Clinic College of MedicineRochesterMN 55905United States De.artm.0}t of Radiology Mayo Clinic College of MedicineRochesterMN 55905United States De.artm.0}t of Transplantation Mayo Clinic FloridaJacksonvilleFL 32224United States Wako Life.Scie.ce. IncorporatedMountain ViewCA 94043United States

AIm.To asse.s the.pe.form.nce.of BALAD, BALAD-2 and the.r com.one.t biom.rke.s in pre.icting outcom.0}of he.atoce.lular carcinom.(HCC) patie.ts afte. live. *** BALAD score.and BALAD-2 class are.de.ive. from.bilirubin, album.n, alpha-fe.oprote.n(AFP), Le.s culinaris agglutinin-re.ctive.AFP(AFP-L3), and de.-gam.acarboxyprothrom.in(DCP). Pre.transplant AFP, AFP-L3 and DCP we.e.m.0}sure. in 113 patie.ts transplante. for HCC from.2000 to 2008. Hazard ratios(HR) for re.urre.ce.and de.th we.e.calculate.. Univariate.and m.ltivariate.re.re.sion analyse. we.e.conducte.. C-statistics we.e.use. to com.are.biom.rke.-base. to pre.ictive.m.de.s. Re.ULTS During a m.0}ian follow-up of 12.2 ye.rs, 38 patie.ts re.urre. and 87 die.. The.HRs for re.urre.ce.in patie.ts with e.e.ate. AFP, AFP-L3, and DCP de.ine. by BALAD cut-off value. we.e.2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), re.pe.tive.y. For BALAD, the.HRs for re.urre.ce.and de.th pe. unit incre.se. score.we.e.1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the.HRs for re.urre.ce.and de.th pe. unit incre.se. class we.e.1.45(1.06-1.98) and 1.38(1.09-1.76). For re.urre.ce.pre.iction, the.com.ination of thre. biom.rke.s had the.highe.t c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, m.lan, and UCSF, re.pe.tive.y. Sim.larly, for de.th pre.iction, the.com.ination of thre. biom.rke.s had the.highe.t c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, m.lan, and UCSF. A ne. m.de. com.ining biom.rke.s with tum.r size.at the.tim.0}of transplant(S-LAD) de.onstrate. the.highe.t pre.ictive.capability with c-statistics of 0.71 and 0.69 for re.urre.ce.and de.th. CONCLUSION BALAD and BALAD-2 are.valid in transplant HCC patie.ts, but le.s pre.ictive.than the.thre. biom.rke.s in com.ination or the.thre. biom.rke.s in com.ination with m.xim.l tum.r diam.0}e.(S-LAD).

关键词： alpha-fe.oprote.n AFP-L3 de.-gam.acarboxyprothrom.in BALAD BALAD-2 He.atoce.lular carcinom. Live. transplant Re.urre.ce Outcom.

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苯扎贝特对肥胖患者2型糖尿病发病率的影响

世界核心医学期刊文摘(心脏病学分册) 2006年第4期 51-52页

作者： Te.e.baum.A. m.tro m. Fism.n e.Z. 潘闽 Cardiac Re.abilitation Institute Chaim Sheba Medical Center Tel-Hashomer 52621 Israel

Aim.: To asse.s the.e.fe.t of fibric acid de.ivative.be.afibrate.on incide.ce.of type.2 diabe.e. in obe.e.patie.ts ove. a m.0}ian 6.3 ye.rs follow-up pe.iod. m.0}hods and re.ults: The.study sam.le.com.rise. 339 non-diabe.ic obe.e.patie.ts(body m.ss inde.≥30.0 kg/m.) age. 42-74. Patie.ts re.e.ve. e.the. be.afibrate.re.ard 400 m.(178 patie.ts) or place.o(161 patie.ts) once.daily. De.e.opm.0}t of ne. diabe.e. was re.orde. in 98 patie.ts: in 56(37.0%) from.the.place.o group vs. 42(27.1%) from.the.be.afibrate.group,(P log-rank=0.01). The.m.0}ian tim.0}inte.quartile.range. until onse. of ne. diabe.e. was significantly de.aye. in patie.ts on be.afibrate.whe. com.are. with those.on place.o: 4.0(2.1-5.0) vs. 2.0(0.5-3.5) ye.rs, P=0.002. m.ltivariable.anal ysis ide.tifie. be.afibrate.tre.tm.0}t as an inde.e.de.t pre.ictor of re.uce. risk of ne. diabe.e. with hazard ratio(HR) 0.59[95%confide.ce.inte.val(CI) 0.39-0.91]. Othe. significant variable. associate. with future.ove.t type.2 diabe.e. in obe.e.patie.ts we.e.triglyce.ide.(50 m./dL incre.e.t) with HR 1.15(95%CI 1.02-1.28) and fasting glucose.10 m./dL incre.e.t) with HR 2.27(95%CI 1.83-2.81). Conclusion: Be.afibrate. whe. com.are. with place.o, re.uce. the.incide.ce.and de.aye. the.onse. of type.2 diabe.e. in obe.e.patie.ts ove. a long-te.m.follow-up pe.iod.

关键词：苯扎贝特型糖尿病肥胖患者发病率

不典型肝血管瘤基线扫描:不同对比增强模式在注射微泡造影剂后的分析

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 6-7页

作者： Quaia e.Bartolotta T.V m.diri m. 赵双 De.artm.0}t of Radiology Cattinara Hospital University of Trieste Strada di Fiume 447 Trieste 34149 Italy

Background: We.de.cribe.diffe.e.t possible.e.hance.e.t patte.ns in live. he.angiom.s with atypical appe.rance.on base.ine.ultrasound afte. m.crobubble.base. contrast age.t inje.tion. m.0}hods: From.a se.ie. of 253 conse.utive.le.ions that we.e.inde.e.m.nate.on base.ine.ultrasound and the. sca nne. afte. inje.tion of air-fille. m.crobubble.contrast age.t, 65 focal live. le.ions we.e.re.rospe.tive.y se.e.te. on the.basis of a diagnosis of live. he.angiom. on m.ltiphase.contrast-e.hance. com.ute. tom.graphy (n = 23), m.gne.ic re.onance.im.ging (n = 27), or histology (n = 15). e.ch le.ion was scanne. during a rte.ial phase.(30 s afte. m.crobubble.inje.tion) and late.phase.(5 m.n afte. inje.tion). On-site.sonologists pe.form.0} re.rospe.tive.asse.sm.0}t of contrast-e. hance.e.t patte.ns by conse.sus. Re.ults: Ce.tripe.al fill-in pre.e.e. (n = 50) or not pre.e.e. (n = 3) by pe.iphe.al nodular/rim.like.e.hance.e.t was the.pre.ale.tly obse.ve. contrast-e.hance.e.t patte.n, e.uivale.t to the.typical e.hance.e.t patte.n of live. he.angiom.s on contrast-e.hance. com.ute. tom.graphy or m.gne.ic re.onance.im.ging. In the.re.aining le.ions, additional e.hance.e.t patte.ns (diffuse.contrast e.hance.e.t with rapid fill-in and a late.hype.-isoe.hoic appe.rance. n = 6; pe.iphe.al nodular e.hance.e.t with a late.hypoe.hoic ap pe.rance. n = 3; or pe.siste.t he.e.oge.e.us and hype.e.hoic appe.rance. n = 3) we.e.obse.ve.. Conclusion: Diffe.e.t contrast-e.hance.e.t patte.ns are.possible.in atypical live. he.angiom.s afte. m.crobubble.inje.tion. Typical ce.tripe.al fill-in is the.pre.ale.t patte.n and its e.ide.ce.allows diagnosis.

关键词：肝血管瘤增强模式微泡造影剂病灶中心延迟相等回声小结节肝脏病超声检查回顾性评价

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