检索结果-南通市图书馆

Inve.tig.tion of DNA Se.ue.ce. Re.ate. to Late.cy-Associate. Transcripts in the.g.0}ome.of Canine.He.pe.virus Type.1 (CHV-1) by Me.ns of Bioinformatics Tools

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ope. Journal of Ve.e.inary Me.icine 2019年第10期9卷 147-160页

作者： Ortiz M. A. He.n&aacute.nde. Ve.de.C. Cue.ca lara e. g. valdivia Anda g. valdivia Laboratory of Microbial Pathog.0}icity Multidisciplinary Research Unit Faculty of Higher Education Cuautitlan National Autonomous University of Mexico Cuautitlan Izcalli Mexico

A characte.istic common to he.pe.viruse. is the.ability to e.tablish a late.t infe.tion in the.hosts, a transcriptionally active.re.ion has de.e.te. during.late.cy as we.l as a se. of RNA that are.known as Late.cy Associate. Transcripts (LATs), the.r functions have.be.n clarifie. in re.e.t work. The.pre.e.t work was carrie. using.diffe.e.t bioinformatics me.hod in orde. to de.e.mine.if He.pe.virus Canine.1 (CHV-1) has a re.ion associate. with late.cy. Our re.ult was the.se.e.tion of nine.se.ue.ce. candidate.of micro RNA (miRNA) (MIRe.al 2.0 software., and 26 miRNA (miRNAFold v.1.0 software., of the., we.e.se.e.te. 14 with re.l pre.ursors of miRNA, two we.e.found be.we.n the.RL2 and RS1 g.0}e., one.in the.RL2 g.0}e.and 11 in the.RS1 g.0}e. The.re.ults showe. that the.similaritie. of the.e.re.ions are.ve.y low among.the.he.pe.viruse. analyze., so it was not possible.to de.uce.the.pre.e.ce.of the.LAT g.0}e.in canine.he.pe.virus type.1 with bioinformatics. On the.othe. hand, the.comparison showe. that the.miRNA pre.icte.: chv1-mir-mirnafold-8 has similarity with the.e.v-mir-BART7-3p of e.ste.n-Barr Virus (e.V), in this way, the.microRNAs pre.icte. by me.ns of bioinformatic prog.ams me. the.the.re.ical re.uire.e.ts of the.e.mole.ule., howe.e. at not having.a de.re. of pre.e.vation in othe. he.pe.viruse., the.e.pre.sion by CHV-1 in late.cy cannot be.confirme. and it is ne.e.sary to ide.tify throug. e.pe.ime.tal te.ts.

关键词： Late.cy Canine He.pe.virus Late.cy-Associate. Transcripts

Prote.n synthe.is modulation as a the.ape.tic approach for amyotrophic late.al scle.osis and frontote.poral de.e.tia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ne.ral Re.e.e.ation Re.e.rch 2022年第7期17卷 1423-1430页

作者： Santiag. e.Charif M.Flore.cia Vassallu lara Salvañal Lione. M.Ig.z IFIBIO Houssay Grupo de Neurociencia de SistemasFacultad de MedicinaUniversidad de Buenos Aires-CONICETBuenos AiresArgentina

Prote.n synthe.is is e.se.tial for ce.ls to pe.form life.me.abolic *** alte.ations of prote.n conte.t can le.d to particular *** have.an intrinsic array of me.hanisms and pathways that are.activate. whe. prote.n misfolding.accumulation,ag.re.ation or mislocalization *** of the.(like.the.unfolde. prote.n re.ponse.re.re.e.t comple. inte.actions be.we.n e.doplasmic re.iculum se.sors and e.ong.tion factors that te.d to incre.se.e.pre.sion of chape.one.prote.ns and/or re.re.s translation in orde. to re.tore.prote.n home.stasis(also known as prote.stasis).This is e.e. more.important in ne.rons,as the. are.ve.y susce.tible.to harmful e.fe.ts associate. with prote.n ove.load and prote.static me.hanisms are.le.s e.fe.tive.with *** ne.rode.e.e.ative.patholog.e. such as Alzhe.me.’s,Parkinson’s,and Hunting.on’s dise.se.,amyotrophic late.al scle.osis and frontote.poral de.e.tia e.hibit a particular mole.ular sig.ature.of distinct,unbalance. prote.n *** amyotrophic late.al scle.osis and frontote.poral de.e.tia,the.majority of case. pre.e.t intrace.lular inclusions of ubiquitinate. transactive.re.ponse.DNA-binding.prote.n of 43 kDa(TDP-43).TDP-43 is an RNA binding.prote.n that participate. in RNA me.abolism,among.othe. *** of TDP-43(*** and mislocalization)can dramatically affe.t ne.rons,and this has be.n linke. to dise.se.*** of amyotrophic late.al scle.osis/frontote.poral de.e.tia TDP-43-re.ate. mutations in ce.lular and animal mode.s has be.n shown to re.apitulate.ke. fe.ture. of the.amyotrophic late.al scle.osis/frontote.poral de.e.tia dise.se.*** variants can be.causative.of de.e.e.ation onse. and *** ne.rode.e.e.ative.dise.se.(including.amyotrophic late.al scle.osis and frontote.poral de.e.tia)have.no cure.at the.mome.t;howe.e.,modulating.translation has re.e.tly e.e.g.0} as an attractive.approach that can be.pe.forme. at se.e.al ste.s(***

关键词： amyotrophic late.al scle.osis frontote.poral de.e.tia ne.rode.e.e.ation ne.rode.e.e.ative.dise.se. prote.n imbalance prote.n synthe.is modulation prote.stasis the.ape.tical compounds transactive.re.ponse.DNA-binding.prote.n of 43 kDa translation unfolde. prote.n re.ponse

Patholog. Isolation and Ide.tification of Canine.He.pe.virus (CHV-1) in Me.ico

在线全文

学校读者我要写书评

暂无评论

Ope. Journal of Patholog. 2016年第3期6卷 111-121页

作者： e. g.ille.mo valdivia lara Blanca Lilia Barrón Rome.o Laura Cobos Marín Je.sica Ile.na Áng.0}e. Solis Sofía g.nzále. g.llardo Ce.ar Cue.ca Ve.de.Juan Antonio Montaraz Cre.po g.ille.mo valdivia Anda Facultad de.e.tudios supe.iore. Cuautitlán Universidad Nacional Autónoma de México Estado de México México e.cue.a Nacional de.Cie.cias Biológ.cas Instituto Politécnico Nacional Ciudad de México México Unive.sidad Nacional Autónoma de.México Ciudad Universitaria Ciudad de México México Facultad de.e.tudios supe.iore. Cuautitlán Universidad Nacional Autónoma de México Estado de México México

This work pre.e.ts the.patholog. de.cription, isolation and ide.tification of canine.he.pe.virus (CHV-1) in Me.ico, a virus that cause. a g.0}e.alize. he.orrhag.c infe.tion in puppie. from the.canidae.family. Me.hods: Isolate. we.e.obtaine. from puppie. that die. within the.first four we.ks of life.and had le.ions consiste.t with canine.he.pe.virus. Re.ults: The.main g.oss le.ions we.e.pe.e.hial and e.chymotic he.orrhag.0} in kidne.s, live. and lung.;prolife.ative.inte.stitial ne.hritis;multifocal ne.rosis in live. and kidne.s;and e.ce.halitis with intranucle.r inclusion bodie.. He.pe.virus was confirme. throug. dire.t immunofluore.ce.ce. e.e.tron microscopy and polyme.ase.chain re.ction for DNA polyme.ase.and g.ycoprote.n B g.0}e.. Discussion: e.g.t strains we.e.isolate. and ide.tifie. as canine.he.pe.virus corre.ponding.to thre. of the.working.case. with g.oss and microscopic le.ions ve.y similar to those.de.cribe. in the.lite.ature.the., isolate. we.e.confirme. by PCR g.0}e.amplification, positive.re.ctions on immunofluore.ce.ce.and obse.vations from e.e.tron microscopy. This work re.re.e.ts the.first re.ort of this dise.se. including.g.oss and histolog.cal le.ions, and confirmation by isolation and ide.tification of the.canine.he.pe.virus in Me.ico.

关键词： Patholog. of Puppie. Canine.He.pe.virus PCR e.e.tron Microscopy

Traits of an invasive.g.ass confe.ring.an e.rly g.owth advantag.0}ove. native.g.asse.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant e.olog. 2016年第6期9卷 672-681页

作者： lara g.Re.chmann Susanne.Schwinning.H.Wayne.Polle. Philip A.Fay De.artme.t of Inte.rative.Biolog. University of Texas at AustinAustinTX 78712USA USDA-ARS g.assland Soil and Water Research Laboratory808 E Blackland RoadTempleTX 76502USA De.artme.t of Biolog. Texas State UniversitySan MarcosTX 78666USA

Aims Invasive.spe.ie. ofte. have.hig.e. re.ative.g.owth rate.(Rg.)than the.r native.*** use.e.ficie.cy,total le.f are. and spe.ific le.f are.(SLA)are.traits that may confe. Rg. diffe.e.ce. be.we.n native. and invasive.,but trait diffe.e.ce. are.le.s promine.t whe. the.invasive.spe.ie. be.ong. to the.same.plant functional type.as the.dominant native.***,we.te.t if traits displaye. soon afte. g.0}mination confe. an e.rly size.***,we.pre.icte. that invasive.spe.ie. se.dling. g.ow faste. than the.native. be.ause.the. lack trade.offs that more.strong.y constrain the.g.owth of native.*** We.quantifie. plant morpholog.cal and physiolog.cal traits and Rg. during.e.rly se.dling.g.owth at hig. and low nutrie.t le.e.s in thre. dominant pe.e.nial native.C_(4) g.asse.:Panicum virg.tum L.(switchg.ass),Schizachyrium scoparium(Michx.)Nash(little.blue.te.)and Andropog.n g.0}ardii Vitman(big.blue.te.);and a pe.e.nial C_(4) e.otic invasive.g.ass,Sorg.um hale.e.se.L.)Pe.s.(Johnsong.ass).Important Finding. Afte. 2 we.ks of g.owth,Johnsong.ass se.dling. had g.e.te. biomass,SLA and photosynthe.ic nitrog.0} use.e.ficie.cy,but lowe. le.f N conce.trations(%le.f N)and root:shoot ratio than *** g.owth continue.,Johnsong.ass more.quickly produce. larg.0} and thicke. le.ve. than the.native.,which dampe.e. the.g.owth advantag.0}past the.first 2 to 3 we.ks of *** in carbon g.in appe.rs to be.the.be.t e.planation for the.e.rly g.owth advantag.0}of *** native.,g.owth was constraine. by an appare.t trade.off be.we.n allocation to root biomass,which re.uce. SLA,and production of le.ve. with hig. N conte.t,which incre.se. carbon *** Johnsong.ass,root:shoot ratio did not inte.act with othe. traits,and%le.f N was de.ouple. from Rg. as a re.ult of a trade.off be.we.n the.positive.indire.t association of%le.f N with Rg. and the.ne.ative.dire.t association of%le.f N with Rg..

关键词： biomass allocation invasive.plants Rg. Sorg.um hale.e.se trade.offs trait de.e.opme.t

e.aluation of g.owth Are. Foliar Re. Tomato Crop Using.Markov Chains

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ag.icultural Scie.ce. 2016年第6期7卷 420-424页

作者： Luz e. Marín Vaca Mig.e. Ag.ilar Corte. Oscar g. Ville.as Torre. Nadia lara Ruiz Martha Lilia Domíng.e. Patiño e.g.ne.ring.and Applie. Scie.ce.Postg.aduate.School University of Autonomous Morelos State Morelos Mexico Faculty of Ag.icultural Scie.ce. University of Autonomous Morelos State Morelos Mexico Faculty of Che.ical Scie.ce. and e.g.ne.ring University of Autonomous Morelos State Morelos Mexico

The.importance.of e.aluating.the.le.f are. in re. tomato plants aims to de.e.mine.the.g.owth and de.e.opme.t of crops e.tablishe. two production cycle., spring.summe. and autumn-winte. to compare.the.influe.ce.of te.pe.ature.on the.g.owth of le.f are.. Re.e.te., we.kly sample. we.e.take. by ide.tifying.the.we.k and de.e.mining.the.g.owth and le.f are. de.e.opme.t using.Markov chains, using.an array of transition to de.cribe.and re.re.e.t in a flowchart the.finite.numbe. of physiolog.cal State.. With the.analysis in the.ste.dy state.proce.s and applying.the.e.uations of odds, we.g.0} that le.f are. g.owth is e.tablishe. from the.se.e.th we.k shown in the.first cycle.(C1) with the.chance.of 0.266, 0.264 and 0.263, in the.last two we.ks. It was obse.ve. an incre.se.of 6% in the.cycle.autumn-winte. cycle.compare. spring.summe..

关键词： Le.f Are. Tomato and Markov Chains

Comme.t on “Che. e. al., Fabrication and photovoltaic conve.sion e.hance.e.t...”,e.e.trochimica Acta,2014

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Se.iconductors 2015年第9期36卷 97-98页

作者： lara Vale.tic Nima e.g.rji De.artme.t of e.vironme.t Scie.ce.,Unive.sity of Nova g.rica De.artme.t of Physics,Brown Unive.sity De.artme.t of Physics Brown University Providence 02912 Rhode Island USA De.artme.t of e.vironme.t Scie.ce. University of Nova Gorica Nova Gorica 5000 Slovenia

In a re.e.t article. Che. e. aL [e.e.trochimica Acta, 2014, 130： 279] pre.e.te. the.r fabrication and characte.ization re.ults on a g.aphe.e.n-Si solar ce.l whe.e.the.Au nanoparticle. we.e.inse.te. in g.aphe.e.to incre.se.its optical and e.e.trical prope.tie.. The.hig.e. e.ficie.cy of the.de.ice.was attribute. to incre.se. conductivity of g.aphe.e.afte. doping.with Au nanoparticle.. Howe.e., the.knowle.g.0}in the.fie.d of Schottky diode.solar ce.ls re.ate. this to incre.se. band be.ding.at the.junction. Also, to e.plain the.instability be.aviour, the. conclude. that the.g.owth of silicon oxide.on the.Si surface.or oxyg.0} adsorption on the.window laye. re.ulte. in the.de.ice.pe.formance.incre.sing.initially and de.re.sing.in the.e.d. Howe.e., this instability se.ms to be.due.to variation in se.ie. re.istance.re.uce. at the.be.inning.be.ause.of slig.tly lowe.e. Fe.mi le.e. and incre.se. at the.e.d by the.se.f-compe.sation by de.p in-diffusion ofAu nanoparticle. into n-Si laye.. We.also propose.that inse.ting.a ve.y thin p-type.laye. at the.junction will e.hance.the.carrie. colle.tion and pe.formance.of this de.ice.

关键词： Shockle. barrie. solar ce.l g.aphe.e Si Au nanoparticle

Modifie. Usability Frame.ork for Disaste. Apps:A Qualitative.The.atic Analysis of Use. Re.ie.s

在线全文

学校读者我要写书评

暂无评论

Inte.national Journal of Disaste. Risk Scie.ce 2020年第5期11卷 615-629页

作者： Marion lara Tan Raj Prasanna Kristin Stock e.ma e.Doyle.g.aham Le.nard David Johnston Joint Ce.tre.for Disaste. Re.e.rch Massey UniversityWellington 6021New Zealand School of Natural and Computational Scie.ce. Massey UniversityAlbany 0632New Zealand g.S Scie.ce AvalonLower Hutt 5010New Zealand

The.public has acce.s to a rang.0}of mobile.applications(apps)for ***,the.e.has be.n limite. acade.ic re.e.rch conducte. on disaste. apps and how the.public pe.ce.ve. the.r *** study e.plore. e.d-use.s'pe.ce.tions of the.usability of disaste. *** propose. a conce.tual frame.ork base. on insig.ts g.the.e. from the.atically analyzing.online.*** study ide.tifie. ne. usability conce.ns particular to disaste. apps'use.(1)conte.t re.e.ance.de.e.ds on the.app's purpose.and the.proximate.sig.ificance.of the.information to the.hazard e.e.t's time.and location;(2)app de.e.dability affe.ts use.s'pe.ce.tions of usability due.to the.life.afe.y association of disaste. apps;(3)use.s pe.ce.ve.adve.tise.e.ts to contribute.to the.r cog.itive.load;(4)use.s e.pe.t apps to work e.ficie.tly without unne.e.sary consumption of critical phone.re.ource.;(5)appropriate.audio inte.face.can improve.usability,as sounds can boost an app's ale.ting.aspe.t;and,finally(6)in-app browsing.may pote.tially e.hance.use.s'impre.sion of the.structure.of a disaste. *** a re.ult,this study arg.e. for focusse. re.e.rch and de.e.opme.t on public-facing.disaste. *** re.e.rch should conside. the.conce.tual frame.ork and conce.ns pre.e.te. in this study whe. building.de.ig. g.ide.ine. and the.rie. for disaste. apps.

关键词： Disaste. apps e.d-use. pe.spe.tive Human-compute. inte.action Usability

Inve.tig.tion of DNA Se.ue.ce. Re.ate. to Late.cy-Associate. Transcripts in the.g.0}ome.of Canine.He.pe.virus Type.1 (CHV-1) by Me.ns of Bioinformatics Tools

在线全文

学校读者我要写书评

暂无评论

g.utamine.transporte.s as pharmacolog.cal targ.0}s: From function to drug.de.ig.

Ope. Journal of Ve.e.inary Me.icine.兽医学） 2019年第10期

作者： Ortiz M. A. He.nánde. Ve.de.C. Cue.ca lara e. g. valdivia Anda g. valdivia

来源：评论

学校读者我要写书评

暂无评论

Asian Journal of Pharmace.tical Scie.ce. 2020年第2期15卷 207-219页

作者： Mariafrance.ca Scalise.Lore.a Pochini Miche.e.g.lluccio lara Console.Ce.are.Indive.i De.artme.t of DiBe.T(Biolog.a Ecologia e Scienze della Terra)University of CalabriaArcavacata di Rende(CS)87036Italy

Among.the.diffe.e.t targ.0}s of administe.e. drug.,the.e.are.me.brane.transporte.s that play also a role.in drug.de.ive.y and ***,drug.transporte. inte.actions are.re.ponsible.for off-targ.0} e.fe.ts of drug. unde.lying.the.r *** improve.e.t of the.drug.de.ig. proce.s is subje.te. to the.ide.tification of those.me.brane.transporte.s mostly re.e.ant for drug.absorption,de.ive.y and side.e.fe.t production.A pe.uliar g.oup of prote.ns with g.e.t re.e.ance.to pharmacolog. is constitute. by the.me.brane.transporte.s re.ponsible.for manag.ng.g.utamine.traffic in diffe.e.t body *** inte.e.t around g.utamine.me.abolism lie. in its physio-patholog.cal role.g.utamine.is conside.e. a conditionally e.se.tial amino acid be.ause.hig.ly prolife.ative.ce.ls have.an incre.se. re.ue.t of g.utamine.that cannot be.satisfie. only by e.dog.0}ous ***,g.utamine.transporte.s provide.ce.ls with this spe.ial *** the.g.utamine.transporte.s,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some.me.be.s of SLC38 family are.the.be.t characte.ize.,so far,in both physiolog.cal and patholog.cal *** 3D structure. have.be.n solve. by Cryoe.;othe. structural data on the.e.transporte.s have.be.n obtaine. by computational *** with drug. have.be.n de.cribe. for se.e.al transporte.s of this *** some.of the.,the.studie. are.at an advance. stag.0}for othe.s,the.studie. are.still in nuce.and nove. bioche.ical finding. ope. intrig.ing.pe.spe.tive..

关键词： g.utamine transporte.s Drug de.ive.y Pharmacokine.ics Scre.ning Prote.liposome