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2024 Adult compe.dium of Physical Activitie.:A third update.of the.e.e.gy costs of human activitie.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 6-12页

作者： Ste.he. D.He.rmann e.ik A.Willis Barbara e.Ainsworth Tiago V.Barre.ra Mary Haste.t che.se. L.Kracht John M.Schuna jr. Zhe.ghui cai Minghui Quan catrine.Tudor-Locke.Me.icia c.Whitt-Glove. David R. Jacobs jr. Kansas ce.te. for Me.abolism and Obe.ity Re.e.rch University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and We.ght Manage.e.t Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA ce.te. for He.lth Promotion and Dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China e.e.cise.Scie.ce.De.artme.t Syracuse UniversitySyracuseNY 13244USA clinical Scie.ce. Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of e.e.cise.and Sport Scie.ce Oregon State UniversityCorvallisOR 97331USA colle.e.of He.lth and Human Se.vice. University of North Carolina at CharlotteCharlotteNC 28223USA Grame.cy Re.e.rch Group KnightdaleNC 27545USA Division of e.ide.iology and community He.lth School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The.compe.dium of Physical Activitie. was publishe. in 1993 to improve.the.comparability of e.e.gy e.pe.diture.value. assigne. to se.f-re.orte. physical activity(PA)across *** original ve.sion was update. in 2000,and again in 2011,and has be.n wide.y use. to support PA re.e.rch,practice.and public he.lth ***:This 2024 update.was tailore. for adults 19-59 ye.rs of age.by re.oving data from those.60 *** a syste.atic re.ie. and supple.e.tary se.rche.,we.ide.tifie. ne. activitie. and the.r associate. me.sure. me.abolic e.uivale.t(Me.)value.(using indire.t calorime.ry)publishe. since.*** re.lace. e.timate. Me.s with me.sure. value. whe. ***:We.scre.ne. 32,173 abstracts and 1507 full-te.t pape.s and e.tracte. 2356 PA e.e.gy e.pe.diture.value. from 701 *** adde.303 ne. PAs and adjuste. 176 e.isting Me. value. and de.criptions to re.le.t the.addition of ne. data and re.oval of Me.s for olde. *** adde. a Major He.ding(Vide. Game.).The.2024 Adult compe.dium include. 1114 PAs(912 with me.sure. and 202 with e.timate. value.)across 22 Major ***:This compre.e.sive.update.and re.ine.e.t le. to the.cre.tion of The.2024 Adult compe.dium,which has utility across re.e.rch,public he.lth,e.ucation,and he.lthcare.domains,as we.l as in the.de.e.opme.t of consume. he.lth *** ne. we.site.with the.comple.e.lists of PAs and supporting re.ource. is available.at https://***.

关键词： Adults e.e.gy e.pe.diture e.e.cise Me. Physical Activitie.

ca^(2+) binding to the.c_(2)e.domain of otofe.lin is re.uire. for hair ce.l e.ocytosis and he.ring

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Prote.n & ce.l 2024年第4期15卷 305-312页

作者： Han che. Me.ar Monga Qinghua Fang Loujin Slitin Jakob Ne.f Shashank S.che.urwar Re.ina célia Mingroni Ne.to Karina Le.irovitz Alfre.o Tabith,jr. Fritz Be.se.e. Nils Brose.Kathrin Kusch carolin Wichmann Nicola Stre.zke.Barbara Vona Julia Pre.brasche.ski Tobias Mose. Institute.for Auditory Ne.roscie.ce.and Inne.e.rLab University Medical Center Göttingen37075 GöttingenGermany collaborative.Re.e.rch ce.te. 889 University of Göttingen37075 GöttingenGermany Auditory Ne.roscie.ce.and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttinge. Graduate.ce.te. for Ne.roscie.ce. Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Bioche.istry of Me.brane.Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Mole.ular Archite.ture.of Synapse. Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany ce.te. for Biostructural Imaging of Ne.rode.e.e.ation University Medical Center Göttingen37075 GöttingenGermany Auditory Syste.s Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany De.artame.to de.Ge.ética e.Biologia e.olutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de.Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil De.DIc Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil De.artme.t of Mole.ular Ne.robiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale.Bioimaging cluste. of e.ce.le.ce.MBe.c) University of Göttingen37075 GöttingenGermany Functional Auditory Ge.omics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany He.ring Ge.omics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute.of Human Ge.e.ics University Medical Center Göttingen37075 GöttingenGermany

De.r e.itor,Affe.e.t synapse. of cochle.r inne. hair ce.ls(IHcs)e.ploy a unique.mole.ular machine.y(se. e.te.de. background in Supple.e.tary Mate.ials).Otofe.lin is a ke. playe. in this machine.y and its de.e.ts cause.human auditory synaptopathy(Mose. and Starr,2016).Otofe.lin,a tail-anchore.(Vogl e. al.,2016)multi-c_(2)-domain prote.n(Fig.1Ai)spe.ific to hair ce.ls(Roux e. al.,2006),is a me.be. of the.fe.lin prote.n family involve. in me.brane.trafficking and re.air that are.of major dise.se.re.e.ance.Pangršiče. al.,2012),also se. Supple.e.tary *** is distribute. broadly within IHcs(Fig.2Ai-Aiii;Pangrsic e. al.,2010;Roux e. al.,2006).

关键词： auditory hair

亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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Journal of Plant e.ology 2024年第1期17卷 94-110页

作者： We.qi Luo Oscar J Valve.de.Barrante. Monique.We.mstra Jame. F cahill jr Zi Wang Dong He.Yongfa che. che.gjin chu Youshi Wang State.Ke. Laboratory of Biocontrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China Inte.national ce.te. for Tropical Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA De.artme.t of Biological Scie.ce. University of AlbertaEdmontonABT6G 2E9Canada School of e.ology and the.e.vironme.t Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(cTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(cTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的cTD,其cTD和群落加权平均性状值(cWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的cWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

Functionally grade. structure.of a nitride.stre.gthe.e. Mg_(2)Si-base. hybrid composite

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Journal of Magne.ium and Alloys 2024年第3期12卷 1239-1256页

作者： Je.ngho Yang Woongbe.m He.gh Hogi Ju Sukhyun Kang Tae.Sik Jang Hyun-Do Jung Mohammad Jahazi Se.ng chul Han Se.ng Je.Park Hyoung Se.p Kim Susmita Bose.Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae.kye.m Kim Rigobe.to cAdvincula clodualdo Aranas jr Sang Hoon Kim School of Me.hanical e.gine.ring Pusan National UniversityBusan 46241Republic of Korea De.artme.t of Me.hanical De.ign e.gine.ring Hanyang UniversitySeoul 04763Republic of Korea Proce.s Re.e.rch 3 Te.m LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea De.artme.t of Mate.ials Scie.ce.and e.gine.ring Chosun UniversityGwangju 61452Republic of Korea Institute.of We.l-Aging Me.icare.chosun Unive.sity LAMP ce.te. Chosun UniversityGwangju 61452Republic of Korea Division of Mate.ials Scie.ce.and e.gine.ring Hanyang UniversitySeoul 04763Republic of Korea De.artme.t of Me.hanical e.gine.ring École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Mate.ial&compone.t conve.ge.ce.R&D ce.te. Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Me.hanical and Ae.ospace.e.gine.ring Nanyang Technological UniversitySingapore 639798Singapore Graduate.Institute.of Fe.rous&e.o Mate.ials Te.hnology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advance. Institute.for Mate.ials Re.e.rch Tohoku UniversitySendai 980-8577Japan Institute.for conve.ge.ce.Re.e.rch and e.ucation in Advance. Te.hnology Yonsei UniversitySeoul 03722Republic of Korea School of Me.hanical and Mate.ials e.gine.ring Washington State UniversityPullmanWashington 99164USA School of Me.hanical e.gine.ring Purdue UniversityWest LafayetteIndiana 47907USA Re.e.rch Institute.of Advance. Manufacturing Te.hnology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea De.artme.t of Macromole.ular Scie.ce.and e.gine.ring Case Western Reserve UniversityClevelandOhio 44106USA De.artme.t of che.ical and Biomole.ular e.gine.ring and Joint Institute.for Advance. Mate.ials University of TennesseeKnoxvilleTennessee 37996USA ce.te. for Nanophase.Mate.ials and Scie.ce. Oak Ridge National LaboratoryOak RidgeTennessee 37830USA De.artme.t of Me.hanical e.gine.ring University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The.e.-situ incorporation of the.se.ondary Sic re.nforce.e.t,along with the.in-situ incorporation of the.te.tiary and quate.nary Mg_(3)N_(2) and Si_(3)N_(4) phase.,in the.primary matrix of Mg_(2)Si is e.ploye. in orde. to provide.ultimate.we.r re.istance.base. on the.lase.-irradiation-induce. inclusion of N_(2) gas during lase. powde. be. *** is substantialize. base. on both the.the.mal diffusion-and che.ical re.ctionbase. me.allurgy of the.Mg_(2)Si–Sic/nitride.hybrid *** study also propose. a functional platform for syste.atically modulating a functionally grade. structure.and mode.ing build-dire.tion-de.e.de.t archite.tonics during additive.*** strate.y e.able. the.de.e.opme.t of a compositional gradie.t from the.ce.te. to the.e.ge.of e.ch me.t pool of the.Mg_(2)Si–Sic/nitride.hybrid ***,the.coe.ficie.t of friction of the.hybrid composite.e.hibits a 309.3%de.re.se.to–1.67 compare. to–0.54 for the.conve.tional nonre.nforce. Mg_(2)Si structure.while.the.te.sile.stre.gth e.hibits a 171.3%incre.se.to 831.5 MPa compare. to 485.3 MPa for the.conve.tional *** outstanding me.hanical be.avior is due.to the.1)the.comple.e.tary and syne.gistic re.nforce.e.t e.fe.ts of the.Sic and nitride.compounds,e.ch of which posse.se. an intrinsically high hardne.s,and(2)the.strong adhe.ion of the.e.compounds to the.Mg_(2)Si matrix de.pite.the.r small size. and low conce.trations.

关键词： Lase. powde. be. fusion Mg_(2)Si-Sic/nitride.hybrid composite Both the.the.mal diffusion-and che.ical re.ction-base. me.allurgy Functionally grade. structure compositional gradie.t We.r re.istance.

choosing be.we.n a rock and a hard place. camouflage.in the.round-taile. horne. lizard Phrynosoma mode.tum

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curre.t Zoology 2012年第4期58卷 541-548页

作者： William e. cOOPe., jr. Wade.c. SHe.BROOKe De.artme.t of Biology Indiana University Purdue University Fort Wayne Fort Wayne IN 46805 USA Southwe.te.n Re.e.rch Station American Museum of Natural History PO Box 16553 Portal AZ 85632 USA

The.round-taile. horne. lizardPhrynosoma mode.tumis cryptically colore. and re.e.ble. a small stone.whe. it draws le.s close.to its body and e.e.ate. its back. We.inve.tigate. e.fe.tive.e.s of camouflage.inP. mode.tumand its de.e.de.ce.on stone. by placing a lizard in one.of two microhabitats (uniform sand or sand with surface.rocks approximate.y the.same.size.as lizards). An obse.ve. who kne. which microhabitat containe. the.lizard was aske. to locate.the.lizard visually. Late.cy to de.e.tion was longe. and probability of no de.e.tion within 60 s was highe. for lizards on rock background than on bare.sand. In are.as whe.e.lizards could choose.to occupy rock or bare.sand, much highe. proportions se.e.te. rocky backgrounds throughout the.day; at night all lizards sle.t among stone.. A unique.posture.give.P. mode.tuma rounde. appe.rance.similar to many natural stone.. Lizards occasionally adopte. the.posture. but none.did so in re.ponse.to a ne.rby e.pe.ime.te.. Stimuli that e.icit the.posture.are.unknown. ThatP. mode.tumis be.te. camouflage. among rocks than on bare.sand and pre.e.s to occupy rocky are.s sugge.ts that spe.ial re.e.blance.to rocks (masque.ade. e.hance. camouflage.attributable.to coloration and immobility.

关键词：岩石地区蜥蜴迷彩视觉定位天然宝石伪装石头小生境

Pe.formance.and calibration of quark/gluon-je. tagge.s using 140 fb^(-1) of pp collisions at √s=13 Te. with the.ATLAS de.e.tor

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chine.e.Physics c 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abe.ing N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abre. Y. Abulaiti B.S. Acharya c. Adam Bourdarios L. Adamczyk S.V. Adde.alli M.J. Addison J. Ade.man A. Adiguze. T. Adye.A.A. Affolde. Y. Afik M.N. Agaras J. Agarwala A. Aggarwal c. Aghe.rghie.e. A. Ahmad F. Ahmadov W.S. Ahme. S. Ahuja X. Ai G. Aie.li A. Aikot M. Ait Tamlihat B. Aitbe.chikh I. Aize.be.g M. Akbiyik T.P.A. Åke.son A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Albe.ghi J. Albe.t P. Albicocco G.L. Albouy S. Alde.we.re.dt M. Ale.sa I.N. Ale.sandrov c. Ale.a T. Ale.opoulos F. Alfonsi M. Algre. M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Alie. G. Alimonti W. Alkakhi c. Allaire.B.M.M. Allbrooke.J.F. Alle. c.A. Alle.de. Flore. P.P. Allport A. Aloisio F. Alonso c. Alpigiani M. Alvare. e.te.e. A. Alvare. Fe.nande. M. Alve. cardoso M.G. Alviggi M. Aly Y. Amaral coutinho A. Amble. c. Ame.ung M. Ame.l c.G. Ame. D. Amide. S.P. Amor Dos Santos K.R. Amos V. Ananie. c. Anastopoulos T. Ande.n J.K. Ande.s S.Y. Andre.n A. Andre.zza S. Ange.idakis A. Ange.ami A.V. Anise.kov A. Annovi c. Ante. M.T. Anthony e. Antipov M. Antone.li F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Ape.io Be.la c. Appe.t A. Apyan N. Aranzabal S.J. Arbiol Val c. Arcange.e.ti A.T.H. Arce.e. Are.a J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnae. H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augste. S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azue.os D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Bade. P. Bagnaia M. Bahmani A.J. Baile. V.R. Baile. J.T. Baine. L. Baine. O.K. Bake. e. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian e.M. Baldin P. Bale. e. Ballabe.e.F. Balli L.M. Balte. W.K. Balunas J. Balz e. Banas M. Bandie.amonte.A. Bandyopadhyay S. Bansal L. Barak M. Barakat e.L. Barbe.io D. Barbe.is M. Barbe.o M.Z. Bare. K.N. Bare.ds T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The.ATLAS collaboration

The.ide.tification of je.s originating from quarks and gluons,ofte. re.e.re. to as quark/gluon tagging,plays an important role.in various analyse. pe.forme. at the.Large.Hadron collide.,as Standard Mode. me.sure.e.ts and se.rche. for ne. particle. de.aying to quarks ofte. re.y on suppre.sing a large.gluon-induce. *** pape. de.cribe. the.me.sure.e.t of the.e.ficie.cie. of quark/gluon tagge.s de.e.ope. within the.ATLAS collaboration,using √s=13 Te. proton–proton collision data with an inte.rate. luminosity of 140 fb^(-1) colle.te. by the.ATLAS *** tagge.s with high pe.formance. in re.e.ting je.s from gluon ove. je.s from quarks are.studie.:one.tagge. is base. on re.uire.e.ts on the.numbe. of inne.-de.e.tor tracks associate. with the.je.,and the.othe. combine. se.e.al je. substructure.obse.vable. using a booste. de.ision tre..A me.hod is e.tablishe. to de.e.mine.the.quark/gluon fraction in data,by using quark/gluon-e.riche. subsample. de.ine. by the.je. *** in tagging e.ficie.cy be.we.n data and simulation are.provide. for je.s with transve.se.mome.tum be.we.n 500 Ge. and 2 Te. and for multiple.tagge. working points.

关键词： ATLAS Je. QUARK GLUON TAGGING

Spatial and te.poral dynamics of growth of woody plant spe.ie. (birch and willows) on the.fore.and of a re.re.ting glacie. in southe.n Ice.and

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e.ological Proce.se. 2021年第1期10卷 184-194页

作者： haley e.Synan Mikae. A.Me.fi Lawre.ce.H.Tanne. De.artme.t of Biological and e.vironme.tal Scie.ce. Le Moyne CollegeSyracuseNew York 13214USA

Background:The.fore.ands of re.re.ting glacie.s are.invaluable.natural laboratorie. in which to e.plore.the.proce.se. of primary *** studie. have.be.n conducte. on fore.and chronose.ue.ce. to ide.tify te.poral and spatial tre.ds of the.succe.sional *** study focuse. on the.spatio-te.poral distribution of thre. woody plant spe.ie. on the.fore.and of a re.re.ting glacie. in southe.n Ice.and whe.e.historical obse.vations provide.pre.ise.age.control of the.*** e.aluate.colonization and succe.sional tre.ds,we.e.amine. which spe.ie. incre.se.in abundance.with time.and te.te. the.role.of proximity to a se.d source.in ***,we.quantifie. the.rate.at which biomass carbon is adde. to the.***:The.de.sity of ste.s of Be.ula pube.ce.s incre.se. with moraine.age.across the.fore.and chronose.ue.ce.while.the.de.sity of ste.s of both Salix lanata and Salix phylicifolia *** found low statistical significance.to the.re.ationship be.we.n the.de.sity of *** and distance.from a fore.te. ridge.nor did we.find a re.ationship be.we.n the.le.gths of the.ste.s and the.moraine.*** biomass incre.se. faste.t during e.rly succe.sional stage. and re.che. a maximum of 28.5 g c m^(−2) on the.olde.t ***:e.rly colonization of moraine. was controlle. by e.vironme.tal filte.s which favore. both Salix *** by *** followe. as e.vironme.tal factors,e.g.,favorable.soil prope.tie.,*** found no conclusive.e.ide.ce.that proximity to a pote.tial source.of *** propagule. was a significant factor in controlling *** assumption that the.abundance.of individuals incre.se. with time.through late. succe.sional stage. prove. valid for ***,but not for e.the. spe.ie. of *** findings are.consiste.t with the.classical spatial succe.sional mode. of community ***,ge.e.al succe.sional proce.se. at the.landscape.scale.control the.te.p

关键词： Glacial fore.and chronose.ue.ce Primary succe.sion Spatial distribution Above.round biomass Ice.and

Se.e.tive.y bre.ding for high voluntary physical activity in fe.ale.mice.doe. not be.tow inhe.e.t characte.istics that re.e.ble.e.ce.tric re.ode.ing of the.he.rt,but the.mini-muscle.phe.otype.doe.

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Sports Me.icine.and He.lth Scie.ce 2023年第3期5卷 205-212页

作者： e.ic c.Le.zczynski Nicole.e.Schwartz Ashle. c.McPe.k Katharine.D.currie.David P.Fe.guson The.dore.Garland jr. De.artme.t of Kine.iology Michigan State UniversityEast LansingMIUSA De.artme.t of e.olution Ecologyand Organismal BiologyUniversity of California RiversideRiversideCAUSA

Physical activity e.gage.e.t re.ults in a varie.y of positive.he.lth outcome.,including a re.uction in cardiovascular dise.se.risk partially due.to e.ce.tric re.ode.ing of the.*** purpose.of this inve.tigation was to de.e.mine.if four re.licate.line. of High Runne. mice.that have.be.n se.e.tive.y bre. for voluntary e.e.cise.on whe.ls have.a cardiac phe.otype.that re.e.ble. the.outcome.of e.ce.tric *** fe.ale.(ave.age.age.55 days)from the.4 High Runne. and 4 non-se.e.te. control line. we.e.anae.the.ize. via vaporize. isoflurane.the. e.hocardiographic image. we.e.colle.te. and analyze. for structural and functional *** Runne. mice.in ge.e.al had lowe. e.e.tion fractions compare. to control mice.line.(2-taile. p=0.0236)and te.de. to have.thicke. walls of the.ante.ior portion of the.le.t ve.tricle.p=0.065).Howe.e.,a subse. of the.High Runne. individuals,te.me. mini-muscle.mice.had gre.te. e.e.tion fraction(p=0.0006),fractional shorte.ing pe.ce.tage.pe.tricular mass at disse.tion(pcovariate.compare. to non-mini muscle.*** from re.licate.line. bre. for high voluntary e.e.cise.did not all have.inhe.e.t positive.cardiac functional or structural characte.istics,although a ge.e.ically unique.subse. of mini-muscle.individuals did have.gre.te. functional cardiac characte.istics,which in conjunction with the.r pre.iously de.cribe. pe.iphe.al ae.obic e.hance.e.ts(e.g.,incre.se. capillarity)would partially account for the.r incre.se. VO2max.

关键词： e.hocardiography He.rt Voluntary physical activity cardiovascular dise.se Whe.l running

A nano-e.hance. vaccine.for me.astatic me.anoma immunothe.apy

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cance. Drug Re.istance 2022年第3期5卷 829-845页

作者： Kate.yn e.Salotto Walte. c.Olson jr Karlyn e.Pollack Anuradha Ille.dula e.ishama Miche. Sydne. He.rique. Todd Fox Susan Walke. Marya Dunlap-Brown craig L.Slingluff jr Mark Ke.te. He.e.a W.Snyde School of e.gine.ring and Applie. Scie.ce. University of VirginiaVirginiaVA 22904USA De.artme.t of Surge.y School of MedicineUniversity of VirginiaVirginiaVA 22903USA De.artme.t of De.matology School of MedicineUniversity of VirginiaVirginiaVA 22903USA De.artme.t of Pharmacology School of MedicineUniversity of VirginiaVirginiaVA 22903USA Unive.sity of Virginia nanoSTAR Institute VirginiaVA 22903USA Mole.ular Immunologic&Translational Scie.ce.(MITS)core School of MedicineUniversity of VirginiaVirginiaVA 22903USA De.artme.t of Mate.ials Scie.ce School of Engineering and Applied SciencesUniversity of VirginiaVirginiaVA 22903USA

Aim:De.pite.the.huge.advance.e.ts in cance. the.apie. and tre.tme.ts ove. the.past de.ade.most patie.ts with me.astasize. me.anoma still die.from the.*** poor prognosis large.y re.ults from re.istance.to conve.tional che.othe.apie. and othe. cytotoxic *** have.pre.iously ide.tifie. 6 antige.ic pe.tide. de.ive. from me.anomas that have.prove. e.ficacious for activating cD4+T ce.ls in clinical trials for *** aim was to improve.pharmacodynamics,pharmacokine.ic and toxicological parame.e.s by individually e.capsulating e.ch of the.6 me.anoma he.pe. pe.tide. within the.r own immunoge.ic ***:We.modifie. the.e.liposome. as ne.e.sary to account for diffe.e.ce. in the.pe.tide.’che.ical prope.tie.,re.ulting in 3 distinct *** furthe. e.hance.immunoge.icity,we.also incorporate. KDO2,a TLR4 agonist,into the.lipid bilaye. of all nanoliposome.*** the. conducte. in vivo imaging studie. in mice.and e. vivo ce.l studie. from 2 patie.t sample. who both strongly e.pre.se. one.of the.ide.tifie. ***:We.de.onstrate.that the.e.liposome.,loade. with the.diffe.e.t me.anoma he.pe. pe.tide.,can be.re.dily mixe. toge.he. and simultane.usly de.ive.e. without toxicity in *** liposome. are.capable.of be.ng diffuse. to the.se.ondary lymphoid organs ve.y quickly and for at le.st 6 *** addition,we.show that the.e.immunoge.ic liposome. e.hance.immune.re.ponse. to spe.ific pe.tide. e. ***:Lipid-base. de.ive.y syste.s,including nanoliposome. and lipid nanoparticle.,have.now be.n validate. for pharmacological(small mole.ule.,bioactive.lipids)and mole.ular(mRNA,siRNA)the.ape.tic ***,the.utility of the.e.formulations as cance. vaccine.,de.ive.ing antige.ic pe.tide.,has not ye. achie.e. the.same.de.re. of comme.cial ***,we.de.cribe.the.nove. and succe.sful de.e.opme.t of a nanoliposome.base. cance. vaccine.for *** vaccine. he.p to circumve.t drug re.istance.by incre.sing a

关键词： Nanoliposome. nanoscale.drug de.ive.y cance. vaccine. me.astasize. me.anoma pe.tide. me.anoma drug re.istance