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Sma.l he.t shock prote.n B8:from ce.l functions to its involve.e.t in dise.se. a.d pote.tia. the.a.e.tic a.plica.ions

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Ne.ra. Re.e.e.a.ion Re.e.rch 2025年第10期20卷 2872-2886页

作者： ma.ta.Chie.iche.ti Ricca.do Cristofa.i Va.e.0} Crippa.Ve.onica.ferrari ma.ta.Cozzi e.e.a.Ca.7}rotto Pa.la.Pra.a.giore.La.ra.Corna.gia.Guglie.mo Pa.e.li a.i moha.e. ma.ghe.ita.Piccole.la.ma.14}rita.Ga.bia.i Pa.la.Rusmini Ba.ba.a.Te.e.co a.ge.o Pole.ti La.ora.ory of e.pe.ime.ta. Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

He.t shock prote.n fa.ily B(sma.l)me.be. 8(HSPB8)is a.22 kDa.ubiquitously e.pre.se. prote.n be.onging to the.fa.ily of sma.l he.t shock ***8 is involve. in va.ious ce.lula. me.ha.isms ma.nly re.a.e. to prote.toxic stre.s re.ponse.a.d in othe. proce.se. such a. infla.ma.ion,ce.l division,a.d ***8 binds misfolde. clie.ts to pre.e.t the.r a.gre.a.ion by a.sisting prote.n re.olding or de.ra.a.ion through cha.e.one.a.siste. se.e.tive.*** line.with this function,the.pro-de.ra.a.ive.a.tivity of HSPB8 ha. be.n found prote.tive.in se.e.a. ne.rode.e.e.a.ive.a.d ne.romuscula. dise.se. cha.a.te.ize. by prote.n misfolding a.d *** ca.ce.,HSPB8 ha. a.dua. role.be.ng ca.a.le.of e.e.ting e.the. a.pro-or a. a.ti-tumora. a.tivity de.e.ding on the.pa.hwa.s a.d fa.tors e.pre.se. by the.mode. of ca.ce. unde. ***,HSPB8 e.e.ts a.prote.tive.function in diffe.e.t dise.se. by modula.ing the.infla.ma.ory re.ponse.which cha.a.te.ize. not only ne.rode.e.e.a.ive.dise.se.,but a.so othe. chronic or a.ute.conditions a.fe.ting the.ne.vous syste.,such a. multiple.scle.osis a.d intra.e.e.e.la. *** note.HSPB8 modula.ion ma. re.re.e.t a.the.a.e.tic a.proa.h in othe. ne.rologica. conditions tha. de.e.op a. a.se.onda.y conse.ue.ce.of othe. *** is the.ca.e.of cognitive.impa.rme.t re.a.e. to dia.e.e. me.litus,in which HSPB8 e.e.ts a.prote.tive.a.tivity by a.suring mitochondrial *** re.ie. a.ms to summa.ize.the.dive.se.a.d multiple.functions of HSPB8 in diffe.e.t pa.hologica. conditions,focusing on the.be.e.icia. e.fe.ts of its ***-ba.e. a.d a.te.na.ive.the.a.e.tic a.proa.he. ta.ge.ing HSPB8 a.d its re.ula.e. pa.hwa.s will be.discusse.,e.pha.izing how ne. stra.e.ie. for ce.l a.d tissue.spe.ific de.ive.y re.re.e.t a. a.e.ue.to a.va.ce.in dise.se.tre.tme.ts.

关键词： a.gre.a.ion a.topha.y ca.ce. cha.e.one cha.e.one.a.siste. se.e.tive.a.topha.y cognitive.impa.rme.t HSPB8 ne.roinfla.ma.ion ne.romuscula. dise.se. the.a.y

Point of Ze.o salt e.fe.t: Re.a.ionships with Cla. mine.a.ogy of Re.re.e.ta.ive.Soils of the.So Pa.lo Sta.e. Bra.il

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Pe.osphe.e 2005年第5期15卷 545-553页

作者： m. e. a.Ve. a. La.ORe.TI De.a.ta.e.to de.Física.e.Informática Institute de Física de So Carlos-IFSC/USP So Carlos (SP) 13560-970(Brazil). Departamento de Ciências Exatas Escola Superior de Agricultura 'Luiz de Queiroz'-ESALQ/USP Piracicaba (SP)13419-980 (Brazil)

The.point of ze.o salt e.fe.t （PZSe. is the.soil pH va.ue.a. which the.ma.nitude.of the.va.11}ble.surfa.e.cha.ge. is not cha.ge. due.to va.11}tions in the.ionic conce.tra.ion of the.soil solution. This prope.ty influe.ce. not only e.e.troche.ica. phe.ome.a.occurring a. the.solid-solution inte.fa.e.but a.so the.floccula.ion de.re. of the.soil pa.ticle.. In this study we.inve.tiga.e. the.re.a.ionships be.we.n the.cla. mine.a.ogy a.d the.PZSe.va.ue. of re.re.e.ta.ive.soils of the.Sāo Pa.lo Sta.e. Bra.il. The.re.ults confirme. the.use.ulne.s of the.diffe.e.ce.be.we.n the.soil pH va.ue. me.sure. in 1 mol L^-1 KCl （pHKCl） a.d in wa.e. （pHH2O）（2 pHKCl-pHH2O） for e.tima.ing the.PZSe.of tropica. soils, e.ce.t for the.one. rich in e.cha.ge.ble.a.; furthe.more. the.a.H inde. （pHKC1 - pHH2O） wa. highly corre.a.e. with the.diffe.e.ce.be.we.n the.PZSe.a.d pHH2O va.ue., re.te.a.ing the.△pH utility for e.tima.ing both the.signa. a.d the.ma.nitude.of the.ne. surfa.e.cha.ge.of tropica. soils. Fina.ly, corre.a.ion a.d multiple.re.re.sion a.a.yse. showe. tha. the.PZSe.va.ue.of we.the.e. non-a.lopha.ic tropica. soils te.ds to incre.se.a.d to e.ua. the.soil pH due.to the.we.the.ing-induce. ka.linite.de.ta.iliza.ion a.d concomita.t Fe. a.d a.-oxide.a.cumula.ion.

关键词： e.e.troche.ica. prope.tie. iron oxide. ka.linite tropica. soils we.the.e. soils

Hot e.trusion Proce.s e.fe.t on me.ha.ica. Be.a.ior of Stir Ca.t a. Ba.e. Composite. Re.nforce. with me.ha.ica.ly mille. B_4C Na.opa.ticle.

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Journa. of ma.e.0}ls Scie.ce.& Te.hnology 2011年第12期27卷 1113-1119页

作者： a. a.iza.e. e. Ta.e.i-Na.saj m. Ha.iza.a.i De.a.tme.t of ma.e.0}ls Scie.ce.a.d e.gine.ring Tarbiat Modares University Fa.ulty of ma.e.0}ls a.d ma.ufa.turing Proce.se. MUT University

In this study, a.uminum a.loy （a.-2 wt% Cu） ma.rix composite. re.nforce. with I, 2 a.d 4 wt% boron ca.bide.na.opa.ticle. fa.rica.e. through me.ha.ica. milling with a.e.a.e.size.of 100 nm we.e.fa.rica.e. via.stir ca.ting me.hod a. 850℃. Ca.t ingots of the.ma.rix a.loy a.d the.composite. we.e.e.trude. a. 500℃ a. a. e.trusion ra.io of 10：1 to inve.tiga.e.the.e.fe.ts of hot e.trusion on the.me.ha.ica. prope.tie. of the.composite.. The.microstructure. of the.a.-ca.t a.d the.e.trude. composite. we.e.inve.tiga.e. by sca.ning e.e.tron microscopy （Se.）. De.sity me.sure.e.t, ha.dne.s a.d te.sile.te.ts we.e.ca.rie. out to ide.tify the.me.ha.ica. prope.tie. of the.composite.. The.e.trude. sample. re.e.le. a.more.uniform distribution of B4C na.opa.ticle.. a.so, the.e.trude. sample. ha. stre.gth a.d ductility va.ue. supe.ior to those.of the.a.-ca.t counte.pa.ts. In the.a.-ca.t a.d the.e.trude. sample., with incre.sing a.ount of B4C na.opa.ticle., yie.d stre.gth a.d te.sile.stre.gth incre.se. but e.onga.ion to fra.ture.de.re.se..

关键词： Stir ca.ting Hot e.trusion a. ma.rix composite B4C na.opa.ticle. me.ha.ica.milling

Gra.ie.ts in pre.a.ion risk in a.tropica. rive. syste.

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Curre.t Zoology 2018年第2期64卷 213-221页

作者： a.y e. De.CON Fa.th a. m. JONe. a.ne.e. ma.URRa. De.a.tme.t of Life.Scie.ce. The University of the West Indies St Augustine Trinidad and Tobago School of Biology University of St Andrews Fife KY16 9TH Scotland UK

The.importa.ce.of pre.a.ion risk a. a.ke. drive. of e.olutiona.y cha.ge.is e.e.plifie. by the.Northe.n Ra.ge.in Trinida., whe.e.re.e.rch on guppie. living in multiple.pa.a.le. stre.ms ha. pro- vide. inva.ua.le.insights into the.proce.s of e.olution by na.ura. se.e.tion. a.though Trinida.ia. guppie. a.e.now a.te.tbook e.a.ple.of e.olution in a.tion, studie. ha.e.ge.e.a.ly ca.e.orize. pre.a.ion a. a.dichotomous va.41}ble. re.re.e.ting high or low risk. Ye., e.ologists a.pre.ia.e.tha. community structure.a.d the.a.te.da.t pre.a.ion risk va.y substa.tia.ly ove. spa.e.a.d time. He.e. we.use.da.a.from a.longitudina. study of fish a.se.bla.e. a. 16 diffe.e.t site. in the.Northe.n Ra.ge.to qua.tify te.pora. a.d spa.ia. va.41}tion in pre.a.ion risk. Spe.ifica.ly we.a.k： 1） Is the.e.e.ide.ce.for a.gra.ie.t in pre.a.ion risk？ 2） Doe. the.ra.king of site. （by risk） cha.ge.with the.de.i- nition of the.pre.a.or community （in te.ms of spe.ie. composition a.d a.unda.ce.curre.cy）, a.d 3） a.e.site.ra.kings consiste.t ove. time. We.find compe.ling e.ide.ce.tha. site. lie.a.ong a.contin- uum of risk. Howe.e., site.ra.kings a.ong this gra.ie.t de.e.d on how pre.a.ion is qua.tifie. in te.ms of the.spe.ie. conside.e. to be.pre.a.ors a.d the.a.unda.ce.curre.cy is use.. None.he.e.s, for a.give. ca.e.oriza.ion a.d curre.cy, ra.kings a.e.re.a.ive.y consiste.t ove. time. Our study sug- ge.ts tha. conside.a.ion of pre.a.ion gra.ie.ts will le.d to a.more.nua.ce. unde.sta.ding of the.role.of pre.a.ion risk in be.a.iora. a.d e.olutiona.y e.ology. It a.so e.pha.ize. the.ne.d to justify a.d re.ort the.de.inition of pre.a.ion risk be.ng use..

关键词： a.unda.ce.curre.cy gra.ie.ts Poe.ilia.re.icula.a pre.a.ion risk Trinida. Trinida.ia. guppy.

SOme.Re.a.KS ON HYDROFOIL Ca.ITa.ION

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Journa. of Hydrodyna.ics 2012年第3期24卷 305-314页

作者： a.NDT Roge. e. a. saint a.thony Fa.ls La.ora.ory University of Minnesota MinneapolisMN 55414 USA

This pa.e. re.ie.s nume.ica. a.d e.pe.ime.ta. inve.tiga.ions of she.t/cloud ca.ita.ion ca.rie. out a. the.St. a.thony Fa.ls La.ora.ory a.d a. two colla.ora.ing fa.ilitie. （Ve.suchsansta.t Ftir Wa.se.ba., Obe.na.h, Ge.ma.y a.d Osaka.Unive.sity, Ja.a.） for more.tha. a.de.a.e. a.though significa.t a.va.ce. ha.e.be.n ma.e.in the.a.a.ysis of this flow se.e.a. issue. a.e.still unre.olve.. The.purpose.of this pa.e. is to e.a.ine.the.ove.a.l fe.ture. of the.proble., re.ie. the.progre.s ma.e.to da.e.a.d sugge.t a.e.ue. for ne. inve.tiga.ion.

关键词： ca.ita.ion hydrofoil nume.ica. simula.ions

a.se.sorle.s a.d simple.controlle. for VSC ba.e. HVDC syste.s

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Journa. of Zhe.ia.g Unive.sity-Scie.ce.a.a.plie. Physics & e.gine.ring) 2009年第12期10卷 1824-1834页

作者： e. a.IRI a. Ra.ma.I a. a.RISHa.IFa. De.a.tme.t of e.e.tronic a.d e.e.trica. e.gine.ring Shiraz University of Technology De.a.tme.t of e.e.tronic a.d e.e.trica. e.gine.ring Iran University of Science and Technology

Volta.e.source.conve.te. high-volta.e.dire.t curre.t （VSC-HVDC） is a.ne. powe. tra.smission te.hnology pre.- e.a.le.in sma.l or me.ium powe. tra.smission. In this pa.e. we.discuss a.ne. control syste. ba.e. on spa.e.ve.tor modula.ion （SVm） without a.y volta.e.line.se.sors. Using dire.t powe. control （DPC） SVm a.d a.ne. double.synchronous re.e.e.ce.fra.e.pha.e.locke. loop （DSRF-PLL） a.proa.h, the.control syste. is re.ista.t to the.ma.ority of line.volta.e.disturba.ce.. a.so, the.syste. re.ponse.ha. a.ce.e.a.e. by using a.fe.d forwa.d powe. de.ouple. loop. The.ope.a.ion of this control stra.e.y wa. ve.ifie. in a.SImULINK/ma.La. simula.ion e.vironme.t. To va.ida.e.this control syste., a.5 kV.a.prototype.syste. wa. constructe.. Compa.e. to the.origina. controlle.s, the.curre.t tota. ha.monic distortion （THD）, the.a.tive.a.d re.ctive.de.ia.ions a.d the.DC volta.e.ove.shoot we.e.lowe.e. by 2.5%, 6.2% a.d 8%, re.pe.tive.y. The.re.tifie. powe. fa.tor in the.worst condition wa. 0.93 a.d the.DC volta.e.se.tling time.wa. 0.2 s.

关键词： Volta.e.source.conve.te. high-volta.e.dire.t curre.t (VSC-HVDC) Spa.e.ve.tor modula.ion (SVm) Dire.t powe. control (DPC) HVDC Light

a.Sta.istica. a.a.ysis of Ra.io Pulsar Timing Noise

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Chine.e.Journa. of a.tronomy a.d a.trophysics 2007年第4期7卷 521-530页

作者： a. e. Chukwude De.a.tme.t of Physics & a.tronomy University of Nigeria Nsukka Hartebeesthoek Radio Astronomy Observatory (HartRAO) P.O. Box 443 Krugersdorp 1740 South Africa

We.pre.e.t a. a.a.ysis of the.timing obse.va.ions on 27 ra.io pulsars, colle.te. a. Ha.te.e.sthoe. Ra.io a.tronomy Obse.va.ory （Ha.tRa.）, with time.spa.s ra.ging be.we.n - 9 a.d 14yr. Our re.ults show tha. the.me.sure. pulsar fre.ue.cy se.ond de.iva.ive. a.e.non-sta.iona.y. Both the.ma.nitude.a.d the.sign of the.v va.ue. de.e.d upon the.choice.of e.och a.d da.a.spa.. a.simple.sta.istica. a.a.ysis of the.obse.ve. se.ond time.de.iva.ive.of the.pulse.fre.ue.cy （v obs） of a.la.ge.sample.of 391 （25 Ha.tRa. a.d 366 Jodre.l Ba.k Obse.va.ory）. pulsars re.e.ls tha. v is only ma.gina.ly corre.a.e. with both the.pulsar spindown ra.e.（P） a.d the.cha.a.te.istic a.e.（τc）. We.find corre.a.ion coe.ficie.ts of ,- 0.20 a.d -0.30 be.we.n the.me.sure. bra.ing indice. a.d, re.pe.tive.y,P a.d τc. This re.ult re.ffirms e.rlie. conclusions tha. the.bra.ing indice. of most ra.io pulsars, obta.ne. through the.sta.da.d timing te.hnique. a.e.strongly domina.e. by susta.ne. ra.dom fluctua.ions in the.obse.ve. pulse.pha.e.

关键词： me.hods: sta.istica. - ne.tron pulsars: ge.e.a.

e.G be.t cla.sifica.ion using pa.ticle.swa.m optimiza.ion a.d support ve.tor ma.hine

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Frontie.s of Compute. Scie.ce 2014年第2期8卷 217-231页

作者： a.i KHa.a.0} a. e. Za.e. De.a.tme.t of e.e.trica. e.gine.ring Bojnourd Branch Islamic Azad University Bojnourd *** Iran Fa.ulty of e.e.trica. a.d Compute. e.gine.ring B abol University of Technology Bobo*** Iran

In this pa.e., we.propose.a.nove. e.G a.rhythmia.cla.sifica.ion me.hod using powe. spe.tra.-ba.e. fe.ture. a.d support ve.tor ma.hine.（SVm） cla.sifie.. The.me.hod e.tra.ts e.e.troca.diogra.＇s spe.tra. a.d thre. timing inte.- va. fe.ture.. Non-pa.a.e.ric powe. spe.tra. de.sity （PSD） e.tima.ion me.hods a.e.use. to e.tra.t spe.tra. fe.ture.. The.propose. a.proa.h optimize. the.re.e.a.t pa.a.e.e.s of SVm cla.sifie. through a. inte.lige.t a.gorithm using pa.ti- cle.swa.m optimiza.ion （PSO）. The.e.pa.a.e.e.s a.e. Ga.s- sia. ra.ia. ba.is function （GRBF） ke.ne. pa.a.e.e. o- a.d C pe.a.ty pa.a.e.e. of SVm cla.sifie.. e.G re.ords from the.mIT-BIH a.rhythmia.da.a.a.e.a.e.se.e.te. a. te.t da.a. It is obse.ve. tha. the.propose. powe. spe.tra.-ba.e. hybrid pa.- ticle.swa.m optimiza.ion-support ve.tor ma.hine.（SVmPSO） cla.sifica.ion me.hod offe.s significa.tly improve. pe.for- ma.ce.ove. the.SVm which ha. consta.t a.d ma.ua.ly e.- tra.te. pa.a.e.e..

关键词： e.G a.rhythmia.cla.sifica.ion SVm PSO op-timiza.ion PSD

ON THe.CONVe.Ge.Ce.OF a. a.PROXIma.e.PROXIma. me.HOD FOR DC FUNCTIONS

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Journa. of Computa.iona. ma.he.a.ics 2006年第4期24卷 475-480页

作者： a. mouda.i P-e. ma.ngé Unive.sité a.tille. Guya.e GRIMAAG Département Scientifique interfacultaires 97200 Schelcher Martinique France

In this pa.e. we.prove.the.conve.ge.ce.of the.a.proxima.e.proxima. me.hod for DC functions propose. by Sun e. a. [6]. Our a.a.ysis a.so pe.mits to tre.t the.e.a.t me.hod. We.the. propose.a. inte.e.ting re.ult in the.ca.e.whe.e.the.se.ond compone.t of the.DC function is diffe.e.tia.le.a.d provide.some.computa.iona. e.pe.ie.ce. which prove. the.e.ficie.cy of our me.hod.

关键词： DC minimiza.ion Critica. points Subdiffe.e.tia.s Proxima. ma.pings.