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Probable.be.ign paroxysmal positional ve.tigo, spontane.usly re.olve.:Incide.ce.in me.ical practice. patie.ts’ characte.istics and the.natural course

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Journal of Otology 2019年第3期14卷 111-116页

作者： M.G.Alvare.-Morujo de.Sande.R. Gonzale.-Aguado G. Gue.ra-Jime.e. e. dome.e.h-Vadillo H. Gale.a-Ruiz e. Figue.ola-Massana A. Ramos-Macías C. Morale.-Angulo A.J. Martín-Mate.s e. domínguez-duran Hospital Unive.sitario Pue.ta de. Mar Cadiz Spain Hospital Unive.sitario Marque. de.Valde.illa Santander Spain Comple.o Hospitalario Unive.sitario Insular Mate.no-Infantil Las Palmas de Gran Canaria Spain Hospital Unive.sitari Joan XXIII Tarragona Spain Hospital Infanta Luisa Sevilla Spain

Background: Probable.be.ign paroxysmal positional ve.tigo, spontane.usly re.olve. (pBPPVsr), is a variant of be.ign paroxysmal positional ve.tigo (BPPV) in which the.e.is no obse.vable.nystagmus and no ve.tigo with any positional mane.ve.. Obje.tive.: To calculate.the.incide.ce.pBPPVsr, compare.the.characte.istics of the.patie.ts with pBPPVsr and BPPV not spontane.usly re.olve. and de.cribe.the.spontane.us re.olution in the.natural course.of BPPV. Me.hods: Multice.te. prospe.tive.de.criptive.study. During a one.ye.r pe.iod, all patie.ts with suspe.te. BPPV that pre.e.te. to the.Ne.rotology Units of five.participating ce.te.s we.e.re.ruite.. The.incide.ce.of pBPPVsr was calculate. as a pe.ce.tage.of the.total numbe. of patie.ts with BPPV. The.pre.ale.ce.of se.e.al variable. was compare. be.we.n pBPPVsr and BPPV not spontane.usly re.olve.. The.timing of spontane.us re.olution was e.timate. using Kaplan-Me.e. curve.. Re.ults: 457 patie.ts me. the.inclusion crite.ia. The.incide.ce.of pBPPVsr was 33.5%. It was significantly highe. in male., in patie.ts with normal bone.mass and in patie.ts who we.e.not taking sulpiride. A rate.of 18% of spontane.us re.olution afte. the.first month and 51% afte. the.first ye.r was found. This pe.ce.tage.did not change.in a significant way afte. this mome.t. The.curve. for male., patie.ts unde. 50 and patie.ts with normal blood pre.sure.de.re.se. significantly faste.. Conclusions: In our se.ie. BPPV spontane.usly re.olve. in half of the.patie.ts with BPPV during the.first ye.r. This se.me. to occur more.commonly in male. and could have.be.n hinde.e. by sulpiride.intake. oste.porosis, advance. age.and high blood pre.sure.

关键词： Be.ign paroxysmal positional ve.tigo Probable be.ign paroxysmal positional ve.tigo, spontane.usly re.olve. Oste.porosis Sulpiride Hype.te.sion

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e.fe.ts of soil me.al(loid)s pollution on microbial activitie. and e.vironme.tal risks in an abandone. che.ical sme.ting site

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Journal of e.vironme.tal Scie.ce. 2024年第9期143卷 60-70页

作者： Hao Li Jun Yao Jianli Liu Ning Min Ge.ffre. Sunahara Dongyang Me. Robe.t duran School of Wate. Re.ource. and e.vironme.t Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China De.artme.t of Natural Re.ource.Scie.ce. McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada e.uipe.e.vironne.e.t e. Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandone. che.ical sme.ting site. containing toxic substance. can se.iously thre.te. and pose.a risk to the.surrounding e.ological e.vironme.t.Soil sample. we.e.colle.te. from diffe.e.t de.ths(0 to 13 m)and analyze. for me.al(loid)s conte.t and fractionation,as we.l as microbial activitie..The.pote.tial e.ological risk indice. for the.diffe.e.t soil de.ths(orde.e. from high to low)we.e.1 m(D-1)>surface.S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging be.we.n 1840.65-13,089.62,and re.re.e.ting e.tre.e.y high e.vironme.tal risks,of which Cd(and probably not arse.ic)contribute. to the.highe.t e.vironme.tal risk.A modifie. combine. pollution risk inde.(MCR)combining total conte.t and mobile.proportion of me.al(loid)s,and re.ative.toxicitie.,was use. to e.aluate.the.de.re. of contamination and pote.tial e.vironme.tal risks.For the.ne.r-surface.sample.(S-0 and D-1 laye.s),the.MCR conside.e. that As,Cd,Pb,Sb,and Zn achie.e. high and alarming de.re.s of contamination,whe.e.s Fe.Mn,and Ti we.e.ne.ligible.or low to mode.ate.pollution de.re.s.Combine. microcalorime.ry and e.zymatic activity me.sure.e.ts of contaminate. soil sample. we.e.use. to asse.s the.microbial me.abolic activity characte.istics.Corre.ation analysis e.ucidate. the.re.ationship be.we.n me.al(loid)s e.change.ble.fraction or conte.t and microbial activity characte.istics(pe.microbial me.abolic activity in the.D-1 laye. was low pre.umably due.to he.vy me.al stre.s.e.zyme.activity indicators and microcalorime.ric growth rate.k)me.sure.e.ts we.e.conside.e. se.sitive.indicators to re.le.t the.soil microbial activitie. in abandone. che.ical sme.ting site..

关键词： Abandone. che.ical sme.ting site. Microbial activitie. Modifie. combine. pollution risk Microcalorime.ry e.zymatic activitie.

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Fully inte.rate. and broadband Si-rich silicon nitride.wave.e.gth conve.te. base. on Bragg scatte.ing inte.modal four-wave.mixing

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Photonics Re.e.rch 2024年第3期12卷 I0001-I0010页

作者： VALe.IO VITALI THALÍA domÍnguez BUCIO HAO LIU JOSÉMANUe. LUQUe.GONZÁLe. FRANCISCO JURADO-ROMe.O ALe.ANDRO ORTe.A-MOÑUX GLe.N CHURCHILL JAMe. C.GATe. JAMe. HILLIe. NIKOLAOS KALFAGIANNIS DANIe.e.Me.ATI Je.S H.SCHMID ILARIA CRISTIANI PAVe. CHe.e. J.GONZALO WANGÜe.e.T-PÉRe. ÑIGO MOLINA-Fe.NÁNDe. FRe.e.IC GARDe. COSIMO LACAVA Pe.IKLIS Pe.ROPOULOS Optoe.e.tronics Re.e.rch Ce.tre University of SouthamptonSouthampton SO171BJUK 2ElectricalComputer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy 3Telecommunication Research Institute(TELMA)Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain 4School of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK 5Department of Electrical EngineeringEindhoven University of TechnologyEindhoven 5600 MBThe Netherlands 6Department of Materials Science and EngineeringUniversity of IoanninaIoannina 45110Greece 7Centre de Nanosciences et de NanotechnologiesUniversitéParis-SaclayCNRS91120 PalaiseauFrance 8Advanced Electronics and Photonics Research CenterNational Research Council CanadaOttawaOntario K1A 0R6Canada

Inte.modal four-wave.mixing(FWM)proce.se. have.re.e.tly attracte. significant inte.e.t for all-optical signal proce.sing applications thanks to the.possibility to control the.propagation prope.tie. of wave. e.citing distinct spatial mode. of the.same.wave.uide.This allows,in principle.to place.signals in diffe.e.t spe.tral re.ions and satisfy the.phase.matching condition ove. conside.ably large. bandwidths compare. to intramodal proce.se..Howe.e.,the.de.onstrations re.orte. so far have.shown a limite. bandwidth and suffe.e. from the.lack of on-chip compone.ts de.igne. for broadband manipulation of diffe.e.t mode..We.de.onstrate.he.e.a silicon-rich silicon nitride.wave.e.gth conve.te. base. on Bragg scatte.ing inte.modal FWM,which inte.rate. mode.conve.sion,multiple.ing and de.multiple.ing functionalitie. on-chip.The.syste. e.able. wave.e.gth conve.sion be.we.n pump wave. and a signal locate. in diffe.e.t te.e.ommunication bands(se.arate. by 60 nm)with a 3 dB bandwidth e.ce.ding 70 nm,which re.re.e.ts,to our knowle.ge.the.wide.t bandwidth e.e. achie.e. in an inte.modal FWM-base. syste..

关键词： scatte.ing pump modal

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Spatiote.poral variation in the.adult se. ratio,male.aggre.ation,and move.e.t of two tropical cloud fore.t dung be.tle.

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Curre.t Zoology 2022年第6期68卷 635-644页

作者： Julliana BARRe.TO Martha L.BAe.A Israe. Hue.ca domınguez Fe.e.ico e.COBAR Re. de.e.oe.ologıa Instituto de EcologıaXalapaC.P.91073Mexico Instituto de.Inve.tigacione. Biologicas Universidad Veracruzana.Av.Luis Castelazo Ayala s/n Col.IndustrialAnimasXalapaC.P.91190Mexico

While.the.ry sugge.ts that at conce.tion the.se. ratio should be.balance.(1:1),this can be.variable.across space.and time.in wild populations.Curre.tly,studie. of the.e.vironme.tal factors that re.ulate.adult se. ratio(ASR)in spe.ie. with diffe.e.t life.history traits are.scarce.Using capture.re.apture.ove. a ye.r,we.analyze. the.influe.ce.of habitat type.fore.t and nonfore.t)and se.son(rainy and dry)on variation in ASR,male.aggre.ation and the.traje.tory move.e.t of 2 dung be.tle.spe.ie. with diffe.e.t life.history traits:De.tochilum me.icanum(a hornle.s rolle. spe.ie.)and Dichotomius satanas(a tunne.e. spe.ie. with horns on its he.d and thorax).We.found opposite.te.de.cie..The.D.me.icanum population te.ds to be.fe.ale.biase.,but the.population of D.satanas te.ds to be.pre.0}inantly male.and obse.ve. value. we.e.not re.ate. to habitat type.or se.son.Howe.e.,the.95%confide.ce.inte.vals e.timate. we.e.highly variable.be.we.n se.sons de.e.ding on habitat.On e.amining the.monthly variation in ASR for both habitats,we.found that it de.e.ds on the.spe.ie..In addition,male.aggre.ation diffe.e. be.we.n spe.ie. de.e.ding on habitat type.and se.son,and spe.ie. move.e.t patte.ns we.e.close.y re.ate. to the.r habitat pre.e.e.ce..Base. on our re.ults,we.argue.that comparative.population studie. of spe.ie. with diffe.e.t life.history traits are.ne.e.sary to unde.stand the.variation in de.ographic parame.e.s as we.l as its e.ological and e.olutionary implications in the.face.of spatial and climatic e.vironme.tal variation.

关键词： habitat pre.e.e.ce mark-re.apture me.n crowding se.sonality Scarabae.nae se. proportion

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A fuzzy cognitive.map-base. algorithm for pre.icting wate. consumption in Spanish he.lthcare.ce.tre.

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Building Simulation 2023年第11期16卷 2193-2205页

作者： Gonzalo Sánche.-Barroso Jaime.Gonzále.-domínguez Joao Paulo Alme.da-Fe.nande. Justo García-Sanz-Calce.o e.gine.ring Proje.ts Are. University of ExtremaduraAv.Elvas06006BadajozSpain De.artme.t of Paisage. Ambiente e OrdenamentoUniversity of EvoraR.Romão Ramalho7000-650ÉvoraPortugal

The.manage.e.t of wate. consumption in he.lthcare.ce.tre. can have.positive.impacts on both the.e.vironme.tal pe.formance.and profitability of he.lth syste.s.Computational tools assist in the.de.ision-making proce.s of managing the.ope.ation and mainte.ance.of he.lthcare.ce.tre..This re.e.rch aime. to inte.rate.the.e.pirical knowle.ge.of e.pe.ts in He.lthcare.e.gine.ring and the.historical data from 66 he.lthcare.ce.tre. in a Fuzzy Cognitive.Map.The.outputs of the.pre.ictive.mode. include. wate. consumption,wate. cost,and CO_(2) e.issions in he.lthcare.facilitie.,along with e.e.e. variable. to discove. the.cause. and conse.ue.ce. of wate. consumption in he.lthcare.ce.tre..A he.lthcare.ce.tre.with about 12350 use.s,locate. in a city that e.pe.ie.ce. an ave.age.of 1100 he.ting de.re. days,whose.facilitie. be.mode.ate.y e.e.gy-e.ficie.t contributing ove. 50%with re.e.able.e.e.gie. is e.pe.te. to consume.8.4 dam^(3) of wate. with 32.1 k€of cost,and contribute.re.lising 30.8 ton CO_(2)e. e.issions.The.use.of Fuzzy Cognitive.Maps for pre.iction can provide.a high le.e. of e.fe.tive.e.s in ide.tifying the.factors that contribute.to wate. consumption and in de.igning ke. pe.formance.indicators to manage.the.e.vironme.tal pe.formance.of he.lthcare.buildings.This tool is e.tre.e.y e.fe.tive.in e.hancing the.pe.formance.of the.manage.e.t division of he.lth syste.s.

关键词： wate. consumption Fuzzy Cognitive.Maps he.lthcare.ce.tre. He.lthcare.e.gine.ring wate. manage.e.t

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Impact of chitosan-base. nanocarrie.s on cytoske.e.on dynamics:Curre.t status and challe.ge.

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BIOCe.L 2022年第4期46卷 885-891页

作者： M.CAROLINA DI SANTO AGUSTINA ALAIMO ANA PAULA domÍnguez RUBIO OSCAR e.PÉRe. De.artame.to de.Química Biológica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Instituto de.Química Biológica de.la Facultad de.Cie.cias e.actas y Naturale. Consejo Nacional de Investigaciones Científicas y Técnicas(IQUIBICENCONICET)Buenos AiresArgentina

Chitosan-base. nanocarrie.s(CS-NCs)show a promising role.in improving drugs and bioactive.compounds de.ive.y for the.apy.Howe.e.,the.e.fe.ts e.e.te. by CS-NCs at the.ce.lular le.e.,including the.r re.ognition and uptake.have.not be.n fully inve.tigate. ye..Many factors,including size.shape.conce.tration,and surface.che.istry of CS-NCs,play an important role.in de.e.mining the.type. of intrace.lular signals trigge.e..The.me.hanism of uptake.and the.involve.e.t of the.cytoske.e.on during the.CS-NCs e.docytosis variate. among the.diffe.e.t ce.l type. as we.l as furthe. e.fe.ts obse.ve. inside.ce.ls.In the.pre.e.t work,we.discuss the.e.fe.ts induce. by CS-NCs pe. se.on the.cytoske.e.on,a ke. compone.t in ce.l archite.ture.and physiology.The.focus of this re.ort is made.on tumoral and normal biological mode.s in which CS-NCs could diffe.e.tially affe.t the.ce.l cytoske.e.on.The.re.e.t ye.rs re.orts re.arding the.impact of CS-NCs on cytoske.e.on dynamics and the.curre.t te.hnique. for its e.aluation are.summarize. and discusse..Unde.standing me.hanisms unde.lying cytoske.e.al impact afte. ce.l e.posure.to CS-NCs is critical for the.de.ign of safe.t value.adde. formulations in the.biome.ical fie.d.Furthe.more.this re.ision points out some.inte.e.ting aspe.ts of cytoske.e.al change. and ce.l de.th e.compassing anti-tumoral e.fe.ts.

关键词： Cytoske.e.al dynamics Ce.lular uptake e.docytosis Nanocarrie.s Chitosan Bioactive.compounds

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Implications of re.e.tor for advance. glycation e.d products for progre.sion from obe.ity to diabe.e. and from diabe.e. to cance.

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World Journal of Diabe.e. 2023年第7期14卷 977-994页

作者： Andre. Garza-Campos José Robe.to Prie.o-Corre. José Alfre.o domínguez-Rosale. Zamira He.e.a He.nánde.-Nazará Programa de.Doctorado e. Cie.cias e. Biología Mole.ular e. Me.icina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico De.artame.to de.Biología Mole.ular y Ge.ómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obe.ity and type.2 diabe.e. me.litus(T2DM)are.chronic pathologie. with a high incide.ce.worldwide.The. share.some.pathological me.hanisms,including hype.insuline.ia,the.production and re.e.se.of hormone.,and hype.glyce.ia.The.above.ove. time.affe.ts othe. syste.s of the.human body by causing tissue.hypoxia,low-grade.inflammation,and oxidative.stre.s,which lay the.pathophysiological groundwork for cance..The.le.ding cause. of de.th globally are.T2DM and cance..Othe. main alte.ations of this pathological triad include.the.accumulation of advance. glycation e.d products and the.re.e.se.of e.doge.ous alarmins due.to ce.l de.th(i.e.,damage.associate. mole.ular patte.ns)such as the.intrace.lular prote.ns high-mobility group box prote.n 1 and prote.n S100 that bind to the.re.e.tor for advance. glycation products(RAGe.-a multiligand re.e.tor involve. in inflammatory and me.abolic and ne.plastic proce.se..This re.ie. analyze. the.late.t advance. re.orts on the.role.of RAGe.in the.de.e.opme.t of obe.ity,T2DM,and cance.,with an aim to unde.stand the.intrace.lular signaling me.hanisms linke. with cance. initiation.This re.ie. also e.plore. inflammation,oxidative.stre.s,hypoxia,ce.lular se.e.ce.ce.RAGe.ligands,tumor microe.vironme.t change.,and the.cance. hallmarks”of the.le.ding tumors associate. with T2DM.The.assimilation of this information could aid in the.de.e.opme.t of diagnostic and the.ape.tic approache. to lowe. the.morbidity and mortality associate. with the.e.dise.se..

关键词： Type.2 diabe.e. Cance. Obe.ity Advance. glycation e.d product re.e.tor Re.e.tor for advance. glycation e.d products Glycation e.d products,advance.

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The.de.rime.tal e.fe.ts of lipopolysaccharide.nduce. ne.roinflammation on adult hippocampal ne.roge.e.is de.e.d on the.duration of the.pro-inflammatory re.ponse

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Ne.ral Re.e.e.ation Re.e.rch 2019年第5期14卷 817-825页

作者： Martha Pére.-domínguez e.ange.ina ávila-Mu?oz e.uardo domínguez-Rivas Angélica Ze.e.a De.artame.to de.Me.icina Ge.ómica y Toxicología Ambie.tal Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal ne.roge.e.is is a fine.y tune. proce.s re.ulate. by e.trinsic factors. Ne.roinflammation is a hallmark of se.e.al pathological conditions unde.lying dysre.ulation of ne.roge.e.is. In animal mode.s, lipopolysaccharide.LPS)-induce. ne.roinflammation le.ds to a ne.roge.ic de.re.se.mainly associate. to the.e.rly inflammatory re.ponse. Howe.e., it is not we.l unde.stood how the.ne.roinflammatory re.ponse.progre.se. ove. time.and if ne.roge.e.is continue. to be.diminishe. during the.late.ne.roinflammatory re.ponse. More.ve., it is unknown if re.e.te. inte.mitte.t administration of LPS along time.induce. a gre.te. re.uction in ne.roge.e.is. We.administe.e. one.single.intrape.itone.l inje.tion of LPS or saline.or four re.e.te. inje.tions(one.pe. we.k) of LPS or saline.to young-adult mice. A cohort of ne. ce.ls was labe.e. with thre. 5-bromo-2-de.xyuridine.inje.tions(one.pe. day) 4 days afte. the.last LPS inje.tion. We.e.aluate. syste.ic and ne.roinflammation-associate. parame.e.s and compare. the.e.fe.ts of the.late.ne.roinflammatory re.ponse.on ne.roge.e.is induce. by e.ch protocol. Our re.ults show that 1) a single.LPS inje.tion le.ds to a late.pro-inflammatory re.ponse.characte.ize. by microglial activation, mode.ate.astrocytic re.ction and incre.se. inte.le.kin-6 le.e.s. This re.ponse.corre.ate. in time.with de.re.se. ne.roge.e.is and 2) a re.e.te. inte.mitte.t inje.tion of LPS doe. not e.icit a late.pro-inflammatory re.ponse.although activate. microglia pe.sists. The.latte. profile.is not accompanie. by a continue. longte.m hippocampal ne.roge.ic de.re.se. He.e.y, we.provide.e.ide.ce.that the.ne.roinflammatory re.ponse.is a dynamic proce.s that progre.se. in a milie.-de.e.de.t manne. and doe. not ne.e.sarily le.d to a ne.roge.ic de.re.se. highlighting the.comple. inte.action be.we.n the.immune.syste. and ne.roge.e.is.

关键词： de.tate gyrus subgranular zone inflammation microglia astrocyte. IL-6 cytokine. ce.l prolife.ation ne.ral proge.itor ce.ls immature ne.rons long-te.m short-te.m adult hippocampal ne.roge.e.is

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Nanoscale.mapping of optically inacce.sible.bound-state.-in-the.continuum

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Light(Scie.ce.& Applications) 2022年第2期11卷 188-196页

作者： Zhaogang Dong Zackaria Mahfoud Ramón Paniagua-domínguez Hongtao Wang Antonio I.Fe.nánde.-domínguez Se.ge. Gore.ik Son Tung Ha Fe.iana Tjiptoharsono Arse.iy I.Kuzne.sov Miche. Bosman Joe. K.W.Yang Institute.of Mate.ials Re.e.rch and e.gine.ring A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-03 Innovis138634 SingaporeSingapore De.artme.t of Mate.ials Scie.ce.and e.gine.ring National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Singapore.Unive.sity of Te.hnology and De.ign 8 Somapah Road487372 SingaporeSingapore De.artame.to de.Física Te.rica de.la Mate.ia Conde.sada and Conde.se. Matte. Physics Ce.te. Universidad Autónoma de Madrid28049 MadridSpain Singapore.Institute.of Food and Biote.hnology Innovation A*STAR(Agency for ScienceTechnology and Research)31 Biopolis Way#01-02 Nanos138669 SingaporeSingapore

Bound-state.-in-the.continuum(BIC)is an e.e.ging conce.t in nanophotonics with pote.tial impact in applications,such as hype.spe.tral imaging,mirror-le.s lasing,and nonline.r harmonic ge.e.ation.As true.BIC mode. are.nonradiative.the. cannot be.e.cite. by using propagating light to inve.tigate.the.r optical characte.istics.In this pape.,for the.1st time.we.map out the.strong ne.r-fie.d localization of the.true.BIC re.onance.on arrays of silicon nanoante.nas,via e.e.tron e.e.gy loss spe.troscopy with a sub-1-nm e.e.tron be.m.By syste.atically bre.king the.de.igne. ante.na symme.ry,e.issive.quasi-BIC re.onance. be.ome.visible.This give. a unique.e.pe.ime.tal tool to de.e.mine.the.cohe.e.t inte.action le.gth,which we.show to re.uire.at le.st six ne.ghboring ante.na e.e.e.ts.More.importantly,we.de.onstrate.that quasi-BIC re.onance. are.able.to e.hance.localize. light e.ission via the.Purce.l e.fe.t by at le.st 60 time.,as compare. to unpatte.ne. silicon.This work is e.pe.te. to e.able.practical applications of de.igne.,ultra-compact BIC ante.nas such as for the.controlle.,localize. e.citation of quantum e.itte.s.

关键词： ante.na state. mapping

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Hybrid High‑Orde. Me.hods for the.Acoustic Wave.e.uation in the.Time.domain

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Communications on Applie. Mathe.atics and Computation 2022年第2期4卷 597-633页

作者： e.ik Burman Omar duran Ale.andre.e.n De.artme.t of Mathe.atics University College LondonLondon WC1E 6BTUK Ce.MICS Ecole des Ponts77455 Marne la Vallée Cedex 2France INRIA Paris 75589 ParisFrance

We.de.ise.hybrid high-orde.(HHO)me.hods for the.acoustic wave.e.uation in the.time.domain.We.frst conside. the.se.ond-orde. formulation in time.Using the.Ne.mark sche.e.for the.te.poral discre.ization,we.show that the.re.ulting HHO-Ne.mark sche.e.is e.e.gy-conse.vative.and this sche.e.is also ame.able.to static conde.sation at e.ch time.ste..We.the. conside. the.formulation of the.acoustic wave.e.uation as a frst-orde. syste. toge.he. with singly-diagonally implicit and e.plicit Runge.Kutta(SDIRK and e.K)sche.e..HHO-SDIRK sche.e. are.ame.able.to static conde.sation at e.ch time.ste..For HHO-e.K sche.e.,the.use.of the.mixe.-orde. formulation,whe.e.the.polynomial de.re. of the.ce.l unknowns is one.orde. highe. than that of the.face.unknowns,is ke. to be.e.t from the.e.plicit structure.of the.sche.e.Nume.ical re.ults on te.t case. with analytical solutions show that the.me.hods can de.ive. optimal conve.ge.ce.rate. for smooth solutions of orde. O(hk+1)in the.H1-norm and of orde. O(h^(k+2))in the.L^(2)-norm.More.ve.,te.t case. on wave.propagation in he.e.oge.e.us me.ia indicate.the.be.e.ts of using high-orde. me.hods.

关键词： Hybrid high-orde. me.hods Wave.e.uation Ne.mark sche.e Runge.Kutta sche.e

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