检索结果-南通市图书馆

Prospe.ts for the.continue. de.e.opme.t of e.vironme.tally-re.listic toxicity te.t susing microorganisms

在线全文

学校读者我要写书评

暂无评论

Journal of e.vironme.tal Scie.ce. 1993年第3期5卷 253-268页

作者： John Cairns,jr. Paul V.McCormick Scott e.Be.ange. De.artme.t of Biology and Unive.sity Ce.te. for e.vironme.tal and Hazardous Mate.ials Studie. Virginia Polytechnic Institute and State UniversityBlacksburgVirginia 24061-0415U.S.A. De.artme.t of Biology Elizabethtown CollegeElizabethtownPennsylvania-17022-2298U.S.A.and Senior Research AssociateUniversity Center for Environmental and Hazardous Materials StudiesVirginia Polytechnic Institute and State UniversityBlacksburgVirginia-24061-0415U.S.A. Stre.m e.osyste. Re.e.rch Se.tion Environmental Safety DepartmentThe Procter and Gamble CompanyCincinnatiOhio-45217U.S.A.

The.focus of e.vironme.tal re.ulations has change. significantly since.the.introduction of the.bioassay as a standard me.ns of asse.sing e.vironme.tal *** in this change.is an incre.sing e.phasis on prote.ting the.inte.rity of natural e.osyste.s,which incorporate.community-and syste.-le.e. prope.tie. as we.l as organismal and population ***,support for the.use.of multispe.ie. te.ting has wide.e. to include.not only e.ologists in acade.ia but e.vironme.tal scie.tists in the.re.ulatory and industrial se.tor as *** re.son for this tre.d is cle.r:the.additional e.vironme.tal re.lism gaine. from te.ts utilizing communitie. of organisms allows for gre.te. insight into the.pote.tial hazard of che.icals and othe. forms of human activity to natural e.osyste.s that cannot be.obtaine. from single.spe.ie. te.ts *** of the.proble.s cite. for multispe.ie. te.ting e.rly in the.r e.olution as a hazard asse.sme.t tool have.be.n re.ute. or *** particular,the.use.of natural microbial communitie. minimize. se.e.al shortcomings typically associate. with multispe.ie. toxicity *** discussion include. the.utility of microcosm and me.ocosm te.ts using aquatic microbial communitie. as hazard asse.sme.t tools in conjunction with accumulating information on the.r pe.formance.in toxicity te.ting *** incre.sing body of e.pe.ime.tal e.ide.ce.supports an e.pansion in the.use.of the.e.te.ts for a varie.y of re.ulatory and re.e.rch purpose..A shift in re.e.rch focus is ne.de.,howe.e.,to answe. re.aining que.tions and furthe. re.ine.standard protocols for the.e.valuable.e.otoxicological tools.

关键词： e.vironme.tally-re.listic toxicity te.ts microorganisms.

SARS-COV-2 infe.tion(coronavirus dise.se.2019)for the.gastrointe.tinal consultant

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroe.te.ology 2020年第14期26卷 1546-1553页

作者： Kave. Hajifathalian Srihari Mahade. Robe.t e.Schwartz Shawn Shah Kartik Sampath Fe.ice.Schnoll-Sussman Robe.t S Brown jr David Carr-Locke.David e.Cohe. Re.m Z Sharaiha Division of Gastroe.te.ology and He.atology Weill Cornell MedicineNew York-Presbyterian HospitalNew YorkNY 10021United States

The.curre.t pande.ic due.to the.se.e.e.acute.re.piratory syndrome.coronavirus 2 has cause. an e.tre.e.burde. for he.lth care.syste.s globally,and the.numbe. of case. is e.pe.te. to continue.to incre.se.at le.st in the.imme.iate.*** virus is e.timate. to have.infe.te. more.than 1.5 million *** available.re.orts sugge.t that gastrointe.tinal(GI)involve.e.t in coronavirus dise.se.2019(COVID-19)is common and in some.case. the.GI symptoms may pre.e.e.the.re.piratory *** addition to dire.t e.fe.ts of se.e.e.acute.re.piratory syndrome.coronavirus 2,the.infe.te. patie.ts re.ain at risk for the.complications commonly manage. by gastroe.te.ology and he.atology *** most commonly re.orte. GI manife.tation of COVID-19 is diarrhe.,which is re.orte. in a third to up to more.than half of the.*** to mode.ate.e.e.ation of the.live. e.zyme. are.also common,although no case.of acute.live. failure.has be.n re.orte. so *** of the.me.ications use. for tre.tme.t of COVID-19 can also be.associate. with GI symptoms or live. injury and can be.include. in the.diffe.e.tial diagnosis in the.e.*** the.diagnosis of the.infe.tion is curre.tly base. on RNA analysis in re.piratory sample.,the.available.lite.ature.on fe.al she.ding of this virus sugge.ts that fe.al RNA te.ting might prove.to be.a use.ul diagnostic *** is re.sonable.to de.ay all non-urge.t e.doscopic proce.ure. during the.pe.k of the.pande.ic and use.additional prote.tive.e.uipme.t such as N95 re.pirators during e.doscopy while.most patie.ts can be.conside.e. high risk for having be.n e.pose. to the.virus.

关键词： SARS-CoV-2 COVID-19 Gastroe.te.ology He.atology Live.

Ce.l de.th and survival following manual and fe.tose.ond lase.-assiste. capsulotomy in age.re.ate. cataract

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inte.national Journal of Ophthalmology(e.glish e.ition) 2018年第9期11卷 1440-1446页

作者： Andre. Krisztina Siikosd Judit Rapp Diatna Fe.le. Gyorgy Se.alo jr Be.ta Gaspar Judit e.Pongracz Hajnalka Abraham Zsolt Biro De.artme.t of Ophthalmology the University of Pecs Medical School and Clinical CentrePecs 7623Hungary De.artme.t of Pharmace.tical Biote.hnology Faculty of Pharmacythe University of PecsPecs 7624Hungary Janos Sze.tagothai Re.e.rch Ce.tre.of the.Unive.sity of Pe.s Pecs 7624Hungary De.artme.t of Me.ical Biology and Ce.tral e.e.tron Microscopic Laboratory the University of Pecs Medical SchoolPecs 7624Hungary Optimum Lase. Ce.tre Budapest 1124Hungary

AIM： To study mole.ular and morphological change. in le.s e.ithe.ial ce.ls following fe.tose.ond lase.-assiste. and manually pe.forme. continuous curviline.r capsulotomy（CCC） in orde. to ge. information about the.e.me.hods re.arding the.r pote.tial role.in the.induction of de.e.opme.t of se.ondary cataract. Me.HODS： Ante.ior le.s capsule.（ALC） we.e.re.ove. from 40 patie.ts with age.re.ate. cataract by manual CCC and by fe.tose.ond lase.-assiste. capsulotomy（FLAC）. Sample. re.ove. by manual CCC we.e.assorte. in group 1, FLAC sample. we.e.classifie. in group 2. Morphology of le.s e.ithe.ial ce.ls was e.amine. with light and e.e.tron microscope.. Following capsulotomy, e.pre.sions of p53, Bcl-2 and cyclin D1 ge.e. we.e.analyze. with re.e.se.transcriptase.polyme.ase.chain re.ction. Immunohistoche.istry was use. to de.e.t the.pro-apoptotic p53 in the.e.ithe.ial ce.ls. Re.ULTS： Light and e.e.tron microscopic e.amination showe. that ALC of group 1 containe. more.de.e.e.ating ce.ls following manual CCC than afte. FLAC. The.e.pre.sion le.e. of p53 was highe. afte. manual than lase.-assiste. surge.y. Immunocytoche.istry indicate. significantly highe. numbe. of ce.ls containing p53 prote.n in the.manual CCC group than following FLAC. Bcl-2 and cyclin D1 ge.e.e.pre.sion le.e.s we.e.slightly lowe. following manual CCC than afte. FLAC, but the.diffe.e.ce.was not significant. CONclUSION： Manually re.ove. ALC shows slightly, but not significantly large. damage.due.to the.me.hanical stre.ching and pulling of the.capsule.than those.re.ove. using FLAC.

关键词： capsulotomy capsulorhe.is fe.tose.ond lase. immunhistology ultrastructure ge.e.e.pre.sion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magne.ic Cooling

Journal of Rare.e.rths 2005年第4期23卷 I0001-I0002页

作者： Karl A. Gschne.dne. jr. Mate.ials and e.gine.ring Physics Ames Laboratory Department of Materials Science and Engineering Iowa State University Ames IA 50011-3020 USAMaterials and Engineering Physics Ames Laboratory Department of Materials Science and Engineering Iowa State University Ames IA 50011-3020 USA

The.world has be.ome.highly de.e.de.t on re.iable.re.rige.ation te.hnology. Without it, our food supply would be.still se.sonal and limite. to locally produce. nonpe.ishable.ite.s; comfortable.living conditions via climate.control would be.impossible. and ce.tain me.ical advance.e.ts, e.g. MRI diagnostics, organ transplantation, organ and tissue.cryo-storage. and cryo-surge.y would be.impossible. This te.hnology re.ains e.se.tially unchange. since.it was inve.te. 100 ye.rs ago.

关键词： Magne.ic Cooling

Dime.hyl Sulfoxide.Visible.Light Come.iate. Che.ose.e.tive.C-S Bond Formation Be.we.n Tryptophans and Thiophe.ols e.able. Site.Se.e.tive.Functionalization of Pe.tide.

在线全文

学校读者我要写书评

暂无评论

CCS Che.istry 2024年第6期6卷 1547-1556页

作者： Guangjun Bao Pe.g Wang Jingyue.Li Xinyi Song Tingli yu Jiao Zhang yiping Li Ze.uan He.Ruiyao e.Xiaokang Miao Junqiu Xie.Jingman Ni Rui Wang Wangshe.g Sun Ke. Laboratory of Pre.linical Study for Ne. Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000 State.Ke. Laboratory of Bioactive.Substance.and Function of Natural Me.icine. Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Late.stage.pe.tide.modification showcase. a huge.pote.tial for the.construction of pe.tide.librarie.,and the.inve.tigation of structure.activity *** we.re.ort a dime.hyl sulfoxide.visible.light come.iate. che.ose.e.tive.modification of tryptophan re.idue.by forging the.C-S structure.using thiophe.ols irradiate. with blue.light-e.itting diode. at room *** me.hod shows e.ce.le.t che.ose.e.tivity toward the.C-2 position of the.tryptophan re.idue.and good compatibility with dive.se.thiophe.ol de.ivative. be.ring various functional *** prote.te. oligope.tide. and unmaske. bioactive.pe.tide. smoothly unde.we.t site.se.e.tive.modification,furnishing the.corre.ponding *** all,this study provide. a ne. compe.e.t toolkit for late.stage.pe.tide.modification,labe.ling,and pe.tide.drug conjugation and provide. a clue.for prote.n bioconjugation.

关键词： pe.tide.modification late.stage.dive.sification photocatalysis tryptophan thiophe.ol

Twe.ve.we.ks of dance.e.e.gaming in ove.we.ght and obe.e.adole.ce.t girls:Transfe. e.fe.ts on physical activity,scre.n time.and se.f-e.ficacy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and He.lth Scie.ce 2017年第1期6卷 4-10,127页

作者： Amanda e.Staiano Robbie.A.Be.l Danie. S.Hsia Pe.e. T.Katzmarzyk Robe.t L.Ne.ton jr Pe.nington Biome.ical Re.e.rch Ce.te. Baton RougeLA 70808USA

Background: Give. the.low le.e.s of physical activity(PA) among adole.ce.t girls in the.US, the.e.is a ne.d to ide.tify tools to motivate.incre.se. PA. Although the.e.is limite. e.ide.ce.that adole.ce.ts transfe. PA from one.conte.t to anothe., e.e.game.(i.e., vide. game. that re.uire.gross motor activity) may act as a gate.ay to promote.ove.all PA outside.game.play. The.purpose.of this study was to e.amine.pote.tial transfe. e.fe.ts(i.e., influe.ce. on e.te.nal be.aviors and psychological constructs) of a 12-we.k e.e.gaming inte.ve.tion on adole.ce.t girls' PA, scre.n time.and se.f-e.ficacy toward PA, as we.l as the.intrinsic motivation of ***: Participants we.e.37 girls age. 14–18 ye.rs(65% African Ame.ican, 35% white. who we.e.ove.we.ght or obe.e.body mass inde. ≥ 85 th pe.ce.tile. and we.e.re.ruite. from the.community via school, physicians, ne.s me.ia, and social me.ia we.site.. Adole.ce.ts we.e.randomly assigne. to a 12-we.k group e.e.gaming inte.ve.tion(thirty-six 60 min se.sions of group-base. dance.e.e.gaming in a re.e.rch laboratory using Kine.t for Xbox360(Microsoft Corporation, Re.mond, WA, USA)) or to a no-tre.tme.t control group. Outcome.variable. include. obje.tive.y me.sure. PA(total) and se.f-re.orte. le.sure.time.PA(discre.ionary time.only) 1 we.k be.ore.vs. 1 we.k afte. the.inte.ve.tion; se.e.te. type.and inte.sity of PA whe. place. in a gym se.ting for 30 min("cardio fre. choice.); scre.n time. se.f-e.ficacy toward PA; and intrinsic motivation toward ***: Atte.dance.at the.e.e.gaming se.sions was high(80%). Compare. with the.control group, the.inte.ve.tion group se.f-re.orte. an incre.se.in PA(p = 0.035) and fe.e. hours watching te.e.ision or vide.s(p = 0.01) afte. the.inte.ve.tion, but the.e.we.e.no significant diffe.e.ce. in se.e.tary, light, mode.ate. or vigorous PA me.sure. by acce.e.ome.ry. The.inte.ve.tion group significantly improve. se.f-e.ficacy toward PA(p = 0.028). The.inte.ve.tion group highly rate. intri

关键词： Active.vide. game. Le.sure.activity Motivation Scre.n time Se.f-e.ficacy Te.e.ision

PARALLe. ADAPTIVe.SIMULATION OF A PLUNGING LIQUID Je.

在线全文

学校读者我要写书评

暂无评论

Acta Mathe.atica Scie.tia 2010年第2期30卷 522-538页

作者： Azat yu.Galimov Onkar Sahni Richard T.Lahe. jr. Mark S.She.hard Donald A.Dre. Ke.ne.h e.Janse. Re.sse.ae. Polyte.hnic Institute

This pape. is conce.ne. with thre.-dime.sional nume.ical simulation of a plunging liquid je.. The.transie.t proce.se. of forming an air cavity around the.je., capturing an initially large.air bubble. and the.bre.k-up of this large.toroidal-shape. bubble.into smalle. bubble. we.e.analyze.. A stabilize. finite.e.e.e.t me.hod （Fe.） was e.ploye. unde. paralle. nume.ical simulations base. on adaptive. unstructure. grid and couple. with a le.e.-se. me.hod to track the.inte.face.be.we.n air and liquid. The.e.simulations show that the.ine.tia of the.liquid je. initially de.re.se. the.pool＇s surface. forming an annular air cavity which surrounds the.liquid je.. A toroidal liquid e.dy which is subse. que.tly forme. in the.liquid pool re.ults in air cavity collapse. and in turn e.trains air into the.liquid pool from the.unstable.annular air gap re.ion around the.liquid je..

关键词： plunging liquid je. air e.trainme.t two-phase.flows le.e. se. me.hod paralle. adaptive.simulation

e.pre.sion and re.onstitution of the.biolumine.ce.t Ca2+re.orte. ae.uorin in human e.bryonic ste. ce.ls,and e.ploration of the.pre.e.ce.of functional IP3 and ryanodine.re.e.tors during the.e.rly stage. of the.r diffe.e.tiation into cardiomyocyte.

在线全文

学校读者我要写书评

暂无评论

Scie.ce.China(Life.Scie.ce.) 2016年第8期59卷 811-824页

作者： Harve. y.S.Chan Man Chun Che.ng yi Gao Andre. L.Mille. Sarah e.We.b Division of Life.Scie.ce.State.Ke. Laboratory of Mole.ular Ne.roscie.ce HKUSTClear Water BayHong KongChina Ste. Ce.l&Re.e.e.ative.Me.icine.Consortium Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Marine.Biological Laboratory Woods Hole MA 02543USA

In orde. to de.e.op a nove. me.hod of visualizing possible.Ca2＋ signaling during the.e.rly diffe.e.tiation of he.Cs into cardi- omyocyte. and avoid some.of the.inhe.e.t proble.s associate. with using fluore.ce.t re.orte.s, we.e.pre.se. the.biolumine.- ce.t Ca2＋ re.orte., apo-ae.uorin, in He.2 ce.ls and the. re.onstitute. active.holo-ae.uorin by incubation withf-coe.e.te.azine. The.te.poral nature.of the.Ca2＋ signals ge.e.ate. by the.holo-f-ae.uorin-e.pre.sing He.2 ce.ls during the.e.rlie.t stage. of diffe.e.tiation into cardiomyocyte. was the. inve.tigate.. Our data show that no e.doge.ous Ca2＋ transie.ts （ge.e.ate. by re. le.se.from intrace.lular store.） we.e.de.e.te. in 1-12-day-old cardiosphe.e. but transie.ts we.e.ge.e.ate. in cardiosphe.e. following stimulation with KC1 or CaC12, indicating that holo-f-ae.uorin was functional in the.e.ce.ls. Furthe.more. following the.addition of e.oge.ous ATP, an inositol trisphosphate.re.e.tor （IP3R） agonist, small Ca2＋transie.ts we.e.ge.e.ate. from day 1 onward. That ATP was inducing Ca2＋ re.e.se.from functional IP3Rs was de.onstrate. by tre.tme.t with 2-APB, a known IP3R antagonist. In contrast, following tre.tme.t with caffe.ne. a ryanodine.re.e.tor （RyR） agonist, a minima/Ca2＋ re.ponse.was obse.ve. at day 8 of diffe.e.tiation only. Thus, our data indicate.that unlike.RyRs, IP3Rs are.pre.e.t and continually functional at the.e.e.rly stage. of cardiomyocyte.diffe.e.tiation.

关键词： Ca2+ signaling apo-ae.uorin e.pre.sion biolumine.ce.ce He.2 human e.bryonic ste. ce.ls he.C-de.ive. cardiosphe.e. IP3 and ryanodine.re.e.tors

Quantitative.analysis for manage.e.t

在线全文

学校读者我要写书评

暂无评论