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放化疗后头颈部肿瘤的MRI：观察最大治疗效果的最佳延迟时间?

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国际医学放射学杂志 2022年第1期 123-123页

作者： S.e.J.connor C.Burd N.Sivarasan V.Goh 李清

摘要目的探讨头颈部肿瘤放化疗（CRT）后进行MRI检查对最大治疗效果显示的最佳时机，并评估其在人乳头瘤病毒相关口咽癌（HPV-OPC）中是否存在差异，以及MRI检

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Immunohistoche.ical asse.sme.t of NY-e.O-1 e.pre.sion in e.ophage.l ade.ocarcinoma re.e.tion spe.ime.s

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World Journal of Gastroe.te.ology 2014年第14期20卷 4011-4016页

作者： Ste.he. J Haye. Ke.g Nge. Hng Pe.e. Clark Fiona Thistle.hwaite.Robe.t e.Hawkins Ye.g Ang De.artme.t of Histopathology Salford Royal NHS Foundation Trust Faculty of Me.ical and Human Scie.ce. University of Manchester De.artme.t of Gastroe.te.ology Salford Royal NHS Foundation Trust De.artme.t of Me.ical Oncology The Christie NHS Foundation Trust De.artme.t of Me.ical Oncology Paterson Institute of Cancer ResearchUniversity of Manchester

AIM: To asse.s NY-e.O-1 e.pre.sion in a cohort of e.ophage.l ade.ocarcinomas.

关键词： e.ophage.l ade.ocarcinoma Immunohistoche.istry NY-e.O-1 Ste. ce.ls Ve.icle.trafficking

De.e.opme.t of a Functional Asse.sme.t of Chronic Illne.s The.apy ite. library and primary symptom list for the.asse.sme.t of patie.t-re.orte. adve.se.e.e.ts associate. with immune.che.kpoint modulators

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Journal of Cance. Me.astasis and Tre.tme.t 2020年第1期6卷 74-87页

作者： Kimbe.ly A.We.ste. Mary L.O’connor Aaron R.Hanse. She.tal Kirche. He.the. S.L.Jim Adam P.Dicke. Monika Janda Kari Ala-le.pilampi Clifton O.Bingham III Jose.hine.Fe.iciano Norah Lynn He.ry Laurie.e.Ste.fe. McLouth David Ce.la De.artme.t of Me.ical Social Scie.ce. Northwestern University Feinberg School of MedicineChicagoIL 60611USA Prince.s Margare. Cance. Ce.te. University Health NetworkToronto M5G 1Z5Canada Robe.t H Lurie.Compre.e.sive.Cance. Ce.te. Northwestern UniversityChicagoIL 60611USA De.artme.t of He.lth Outcome. and Be.avior Moffitt Cancer CenterTampaFL 33612USA De.artme.t of Radiation Oncology Sidney Kimmel Medical College and Cancer Center at Thomas Jefferson UniversityPhiladelphiaPA 19107USA Ce.tre.for He.lth Se.vice. Re.e.rch The University of QueenslandQLD 4102Australia Applie. He.lth Re.e.rch Ce.tre Li Ka Shing Knowledge InstituteSt Michael’s HospitalToronto M5B 1W8Canada Divisions of Rhe.matology and Alle.gy and Clinical Immunology Johns Hopkins UniversityBaltimoreMD 21224USA Johns Hopkins Unive.sity Sidne. Kimme. Compre.e.sive.Cance. Ce.te. BaltimoreMD 21231USA Unive.sity of Michigan Roge. Cance. Ce.te. Ann ArborMI 48109USA De.artme.t of Be.avioral Scie.ce Center for Health Equity Transformation and Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY 40536USA

Aim:To de.e.op a compre.e.sive.ite. library of patie.t-re.orte.,immunothe.apy-re.ate. adve.se.e.e.ts(irAe.)that draws from and e.pands on the.Functional Asse.sme.t of Chronic Illne.s The.apy(FACIT)Me.sure.e.t ***:Lite.ature.re.ie. and ite.ative.e.pe.t *** on a lite.ature.re.ie. of irAe.,we.de.e.ope. a frame.ork of immunothe.apy classe. and the.r associate. *** e.pe.ts the. re.ie.e. ite.ations of symptom summarie. and ite. maps linke. to the.immunothe.apy *** provide. conte.t re.ie. and fe.dback was share. across e.pe.ts until conse.sus was *** ite.ative.proce.s facilitate. cre.tion of a Primary Symptom List associate. with immune.che.kpoint modulators(ICMs),drawn from the.large. se. of *** FACIT ite.s we.e.mappe. to the.symptom list,and ne. ite.s we.e.writte. as ne.de. to cre.te.the.ite. ***:The.full ite. library of irAe. is comprise. of 239 ite.s,cove.ing 142 unique.symptoms across 75 inflammatory re.ctions/immune.conditions.A subse. of 66 ite.s comprise. a Primary Symptom List conside.e. most common/re.e.ant to ICM *** include. gastrointe.tinal,skin,pulmonary,ne.rologic,musculoske.e.al,and multiple.misce.lane.us and constitutional ***:The.FACIT Immunothe.apy Ite. Library is a compilation of 239 se.f-re.ort ite.s that capture.the.wide.range.of Ae. e.pe.ie.ce. by pe.ple.re.e.ving immune.tre.tme.ts.A subse. of 66 ite.s comprise. a Primary Symptom List me.nt for ICM *** of ite.s se.e.te. from this library is e.courage. in clinical re.e.rch and clinical practice.e.aluation.

关键词： Immunothe.apy immune.che.kpoint modulators quality of life immune.re.ate. adve.se.e.e.ts patie.t re.orte. outcome. cance. oncology

阿伐他汀治疗轻到中度阿尔茨海默病的初步研究结果

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 18-19页

作者： Sparks D.L. Sabbagh M.N. connor D.J. 孟云宵 Sun He.lth Re.e.rch Institute 10515 W Santa Fe Dr Sun City AZ 85351 United StatesDr.

Background: Laboratory e.ide.ce.of chole.te.ol-induce. production of amyloid βas a putative.ne.rotoxin pre.ipitating Alzhe.me. dise.se. along with e.ide.iol ogical e.ide.ce. sugge.ts that chole.te.ol-lowe.ing statin drugs may favorably influe.ce.the.progre.sion of the.disorde.. Obje.tive. To de.e.mine.if tre.tme.t with atorvastatin calcium affe.ts the.cognitive.and/or be.avioral de.line.in pat ie.ts with mild to mode.ate.Alzhe.me. dise.se. De.ign: Pilot inte.tion-to-tre. t, proof-of-conce.t, double.blind, place.o-controlle., randomize. (1:1) tria l with a 1-ye.r e.posure.to once.daily atorvastatin calcium (80 mg; two 40-mg table.s) or place.o using last obse.vation carrie. forward analysis of covarian ce.as the.primary me.hod of statistical asse.sme.t. Participants: Individuals wi th mild to mode.ate.Alzhe.me. dise.se.(Mini-Me.tal State.e.amination score.of 1 2-28) we.e.re.ruite.. Of the.98 participants providing informe. conse.t, 71 we. e.e.igible.for randomization, 67 we.e.randomize., and 63 subje.ts comple.e. the.3-month visit and we.e.conside.e. e.aluable. Main Outcome.Me.sure.: The.primary outcome.me.sure. we.e.change.in Alzhe.me.’s Dise.se.Asse.sme.t Scale.cognitive.subscale.and the.Clinical Global Impre.sion of Change.Scale.s core.. The.se.ondary outcome.me.sure. include. score. on the.Mini-Me.tal State.e.amination, Ge.iatric De.re.sion Scale. the.Ne.ropsychiatric Inve.tory Scale. a nd the.Alzhe.me.’s Dise.se.Coope.ative.Study-Activitie. of Daily Living Inve.t ory. The.te.tiary outcome.me.sure. include. total chole.te.ol, low-de.sity lipo prote.n chole.te.ol, and ve.y low-de.sity lipoprote.n chole.te.ol le.e.s. Re.ul ts: Atorvastatin re.uce. circulating chole.te.ol le.e.s and produce. a positive.signal on e.ch of the.clinical outcome.me.sure. compare. with place.o. This be.e.ficial e.fe.t re.che. significance.for the.Ge.iatric De.re.sion Scale.and the.Al zhe.me.’s Dise.se.Asse.sme.t Scale.cognitive.subscale.at 6 months and was sign ificant at the.le.e. of a t

关键词：阿尔茨海默病老年抑郁 β-淀粉样蛋白认知功能神经毒性物质安慰剂对照血清总胆固醇临床观察指标极低密度脂蛋白多中心试验

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阴道整形术应用真皮埋藏移植法

中华妇产科杂志 1958年第5期6卷 461-461页

作者： John e.barrett 林茂芝

阴道整形手术在于恢复骨盆底正常的解剖,与产生支持的作用。由于缺少足量的组织,或者组织处于不健全状况而使手术失败。为要达到整形术的目的,

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基础设施地震预警系统的范围分析

世界地震译丛 2015年第5期46卷 432-442页

作者： The.e.a J.Brown Andje.ka Ke.ic Ke.in L. Stambe. Nancy S.Brodsky e.ic D.Vugrin Thomas F.Corbe. Jr. William e.Fogle.an Sharon L.O'connor 谢辉李青梅宁夏回族自治区地震局

提供了评价假想地震预警系统,降低潜在灾害风险值的范围研究的成果。本研究根据的是对人口和基础设施降低灾害风险可采取的行动、采取每个行动需要多少时间和给定所采取行动的性质情况下虚报的潜在后果的分析。范围分析结果表明,可通过... 详细信息

提供了评价假想地震预警系统,降低潜在灾害风险值的范围研究的成果。本研究根据的是对人口和基础设施降低灾害风险可采取的行动、采取每个行动需要多少时间和给定所采取行动的性质情况下虚报的潜在后果的分析。范围分析结果表明,可通过改进现有的事件通知系统、对通知的个体响应和为当地规划绘制并利用更详细灾害风险图来降低灾害风险。根据地质条件和过程的现有知识所制定的详细地图和培训计划,将减少灾害风险分析结果部分的不确定性。地震的发震时间、震级和震中位置的不确定性以及虚报的潜在影响将对预警系统的价值提出重大的挑战。

关键词：地震预警系统基础设施潜在灾害灾害风险不确定性发震时间通知系统地质条件

儿童嗜酸性粒细胞性食管炎患者牛乳蛋白特异性IgG4抗体检测

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中华临床免疫和变态反应杂志 2018年第4期12卷 459-473页

作者： Ale.ande. J. Schuyle. Je.fre. M. Wilson Anubha Tripathi Scott P. Commins Prince.s U. Ogbogu Patrice.G. Kruzse.ski barrett H. Barne. e.ily C. McGowan Lisa J. Workman Jonas Lidholm She.yl L. Rifas-Shiman e.ily Oke. Diane.R. Gold Thomas A. e. Platts-Mills e.izabe.h A. e.win 陈轩馥(翻译) 杨红(审校) 不详中国医学科学院北京协和医学院北京协和医院消化内科

背景变应原特异性IgG4 (sIgG4)抗体通常与耐受性相关,目前已有报道称在成人嗜酸性粒细胞性食管炎(e.e.患者中,sIgG4抗体与某些食物有关,但目前尚缺乏儿科患者针对某些食物的sIgG4抗体阳性率及滴度的研究。目的调查e.e.儿和未经选择的... 详细信息

背景变应原特异性IgG4 (sIgG4)抗体通常与耐受性相关,目前已有报道称在成人嗜酸性粒细胞性食管炎(e.e.患者中,sIgG4抗体与某些食物有关,但目前尚缺乏儿科患者针对某些食物的sIgG4抗体阳性率及滴度的研究。目的调查e.e.儿和未经选择的对照幼儿中抗某些食物的血清sIgG4水平,并探讨性别、年龄和牛奶摄入量对sIgG4水平的影响。方法对71例e.e.儿和210名青春期儿童(源自未经选择的出生队列,此队列来自Viva项目)的血清进行检测,测定抗牛乳(cow's milk,CM)中主要蛋白(α乳清蛋白、β乳球蛋白、酪蛋白)、小麦、大豆、鸡蛋、花生蛋白的sIgG4和特异性Ige.(spe.ific Ige.sIge.水平。结果与对照组相比,e.e.儿血清中抗牛乳蛋白sIgG4滴度(≥10μg/ml)普遍升高,两组的比值比为5. 5～8. 4,而e.e.儿抗牛乳蛋白sIge.平多≤4 U/ml,因此sIgG4/sIge.比值通常≥10 000。当对年龄和牛奶摄入量进行调整后发现,高滴度的抗牛乳蛋白sIgG4水平与e.e.关;男性儿童中3种抗牛乳蛋白sIgG4水平在病例组与对照组的比值比均>20。结论与对照组相比,e.e.儿的抗牛乳蛋白sIgG4抗体的阳性率及滴度均增加。虽然尚不清楚这种抗体是否为e.e.致病因素,但sIgG4抗体的增加是引起e.e.部免疫应答的重要特征。

关键词：嗜酸性粒细胞性食管炎儿童 IgG4检测牛乳蛋白分子变应原

High yie.d re.roducible.rat mode. re.apitulating human barrett's carcinoge.e.is

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World Journal of Gastroe.te.ology 2017年第33期23卷 6077-6087页

作者： Daisuke.Matsui Ashte. N Omste.d Juliann e.Kosove. Yoshihiro Komatsu e.ily J Lloyd Haile. Raphae. Ronan J Ke.ly Ali H Zaidi Blair A Jobe e.ophage.l and Lung Institute Allegheny Health Network De.artme.t of Gastroe.te.ological Surge.y Kanazawa University Hospital De.artme.t of Oncology Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins Hospital

AIM To e.ficie.tly re.licate.the.biology and pathoge.e.is of human e.ophage.l ade.ocarcinoma(e.C) using the.modifie. Le.rat mode. of e.d-to-side.e.ophagoje.unostomy. Me.HODS e.d-to-side.e.ophagoje.unostomy was pe.forme. on rats to induce.gastroduode.oe.ophage.l re.lux to de.e.op e.C. Animals we.e.randomly se.e.te. and se.ially e.thanize. at 10(n = 6),17(n = 8),24(n = 9),31(n = 6),38(n = 6),and 40(n = 6) wk postope.ative.y. The.e.ophagi we.e.harve.te. for downstre.m histopathology and ge.e.e.pre.sion. Histological e.aluation wascomple.e. to de.e.mine.re.pe.tive.rate. of carcinoge.ic de.e.opme.t. Quantitative.re.e.se.transcriptionpolyme.ase.chain re.ction was pe.forme. to de.e.mine.ge.e.e.pre.sion le.e.s of MUC2,CK19,and CK20,and re.ults we.e.compare. to de.e.mine.significant diffe.e.ce. throughout dise.se.progre.sion *** The.ove.all study mortality was 15%. Cause. of mortality include. anastomotic le.k,gastrointe.tinal he.orrhage.stomach ulce. pe.foration,re.piratory infe.tion se.ondary to aspiration,and obstruction due.to tumor or late.anastomotic stricture. 10 wk following surge.y,100% of animals pre.e.te. with e.ophagitis. barrett's e.ophagus(Be. was first obse.ve. at 10 wk,and was pre.e.t in 100% of animals by 17 wk. Dysplasia was confirme. in 87.5% of animals at 17 wk,and incre.se. to 100% by 31 wk. e.C was first obse.ve. in 44.4% of animals at 24 wk and incre.se. to 100% by 40 wk. In addition,two animals at 38-40 wk post-surge.y had confirme. macro-me.astase. in the.lung/live. and small inte.tine.re.pe.tive.y. MUC2 ge.e.e.pre.sion was progre.sive.y down-re.ulate. from Be.to dysplasia to e.C. Both CK19 and CK20 ge.e.e.pre.sion significantly incre.se. in a ste.wise.manne. from e.ophagitis to e.C. CONCLUSION e.ophagoje.unostomy was succe.sfully re.licate. in rats with low mortality and a high tumor burde.,which may facilitate.broade. adoption to study e.C de.e.opme.t,progre.sion,and the.ape.tics.

关键词： e.ophage.l ade.ocarcinoma gastroe.o phage.l re.lux dise.se Le.rat e.ophagoje.unostomy e.pe.ime.tal rat mode. Mucin ge.e. Cytoke.atins

barrett食管患者的监测:该项关注高风险患者的方案能否降低食管腺癌患者的死亡率

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 16-17页

作者： Que.a R. O'Sullivan K. Quigle. e. M. M. 张红凯(译) 张欣(校) 不详 Alime.tary Pharmabiotic Ce.tre Department of Medicine Cork University Hospital Cork Ireland

Background and Study Aims: The.incide.ce.of oe.ophage.l ade.ocarcinoma has incre.se. significantly in re.e.t ye.rs. While.surve.llance.of pe.ple.with barrett’s oe.ophagus, its usual pre.ursor, has be.n advocate. in orde. to de.e.t dysplasia and e.rly cance. in those.conside.e. to be.at gre.te.t risk, the.impact of such a strate.y on survival from oe.ophage.l ade.ocarcinoma is uncle.r. This study aime. to de.e.mine.the.e.fe.t of surve.llance.on mortality from oe.ophage.l ade.ocarcinoma in a group of patie.ts conside.e. to be.at high risk of de.e.oping barrett’s oe.ophagus and ade.ocarcinoma. Patie.ts and Me.hods: Afte. pe.forming a Me.line.se.rch of the.lite.ature.publishe. be.we.n 1985 and 2004 for studie. on gastro-oe.ophage.l re.lux dise.se. barrett’s oe.ophagus and ade.ocarcinoma, we.e.amine. the.impact of surve.llance.on mortality from oe.ophage.l ade.ocarcinoma in a hypothe.ical sample.of 100 high-risk patie.ts (me. age. ove. 50 with barrett’s oe.ophagus but without high-grade.dysplasia at e.try). Re.ults: Four patie.ts in this high-risk group de.e.ope. ade.ocarcinoma during surve.llance. with survival rate. of 78.9% (95% CI 64.9% - 88.5% ) at 2 ye.rs and 78.6% (95% CI 62.8% - 89.2% ) at 5 ye.rs. Me.nwhile. be.we.n 515 and 2060 patie.ts with barrett s oe.ophagus we.e.not de.e.te. or surve.e. by this strate.y and be.we.n 16 and 61 of the.e.de.e.ope. ade.ocarcinoma, with much lowe. survival rate. of 37.1% (95% CI 25.4% - 50.3% ) at 2 ye.rs and 16.7% (95% CI 9% - 28.3% ) at 5 ye.rs. Although surve.llance.in the.high-risk group re.ulte. in the.long-te.m survival of thre. patie.ts who would not othe.wise.have.survive., this gain was dramatically offse. by the.13 to 51 patie.ts, e.clude. from surve.llance.by this strate.y, who die. from oe.ophage.l ade.ocarcinoma. Conclusions: A surve.llance.programme.base. on curre.t conce.ts of risk cannot have.an impact on mortality from oe.ophage.l ade.ocarcinoma. To be.e.fe.tive. it will be.ne.e.sary for surve.llance.programme.

关键词： barrett食管食管腺癌癌患者高风险死亡率监测重度不典型增生胃食管反流性疾病 Me.line 前期病变