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Current advances in the application of proteomics in apoptosis research

Science china(Life Sciences) 2011年第3期54卷 209-219页

作者： WANG LiShun & CHeN GuoQiang Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Ministry of education of china e-institutes of shanghai municipal education commission chemical biology division,shanghai jiao tong university school of medicine,shanghai 200025.china 1. Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China e-institutes of shanghai municipal education commission chemical biology division Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular *** of apoptosis has been implicated in a number of diseases,including cancer and autoimmune ***,the investigation of apoptotic regulation has evoked considerable *** apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic ***,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the *** review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.

关键词： apoptosis proteomics small compound oncogene tumor suppressor

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Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and chemical biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

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Structurally reconfigurable designer RNA structures for nanomachines

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Biophysics Reports 2021年第1期7卷 21-34页

作者： Kai jiao Yaya Hao Fei Wang Lihua Wang Chunhai Fan Jiang Li division of Physical biology CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences The Interdisciplinary Research Center Shanghai Synchrotron Radiation Facility Zhangjiang Laboratory Shang-hai Advanced Research Institute Chinese Academy of Sciences university of Chinese Academy of Sciences school of Chemistry and chemical engineering Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine Shanghai Jiao Tong University

Structurally reconfigurable RNA structures enable dynamic transitions of the functional states in response to diverse molecular stimuli, which are fundamental in genetic and epigenetic regulations. Inspired by nature, rationally designed RNA structures with responsively reconfigurable motifs have been developed to serve as switchable components for building engineered nanomachines, which hold promise in synthetic biological applications. In this review, we summarize recent progress in the design, synthesis, and integration of engineered reconfigurable RNA structures for nanomachines. We highlight recent examples of their targeted applications such as biocomputing and smart *** also discuss their advantages, challenges as well as possible solutions. We further provide an outlook of their potential in future synthetic biology.

关键词： Structure Reconfiguration Theranostics RNA nanomachine Biocomputing

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USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

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Signal Transduction and Targeted Therapy 2018年第1期3卷 52-61页

作者： Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin tong Li Zhou Hanzhang Xu Yingli Wu Hongqiao International Institute of medicine Shanghai Tongren Hospital/Faculty of Basic MedicineChemical Biology Division of Shanghai Universities E-InstitutesKey Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Hematology Rui-Jin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin Er RoadShanghaiChina shanghai university of medicine&Health Sciences No.279Zhouzhu RoadShanghaiChina Department of Hematology Shanghai First People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling *** studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and ***,the specific deubiquitinase that affects NOTCH1 protein stability remains ***,we report that ubiquitin-specific protease 7(USP7)can stabilize ***7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of ***7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this *** of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein ***,pharmacologic inhibition of USP7 led to apoptosis of T-ALL *** importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these ***,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes ***,USP7 may be a promising therapeutic target in the currently incurable T-ALL.

关键词： ubiquitin USP7 lymphoblastic

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