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Usefulness of duodenal biopsy during routine upper gastrointestinal endoscopy for diagnosis of celiac disease

World Journal of Gastroenterology 2006年第31期12卷 5028-5032页

作者： S Riestra F Domínguez e fernández-Ruiz e García-Riesco R Nieto e fernández L Rodrigo Gastroenterology Section and Gastroenterology ServiceHospital Central de Asturias Spain Gastroenterology Section and Pathology ServiceHospital Valle del Nalón Spain Gastroenterology Section and Biochemistry ServiceHospital de Cabuenes Spain

AIM： To describe the trend in duodenal biopsy performance during routine upper gastrointestinal endoscopy in an adult Spanish population, and to analyze its value for the diagnosis of celiac disease in clinical practice. MeTHODS： A 15 year-trend （1990 to 2004） in duodenal biopsy performed when undertaking upper gastrointestinal endoscopy was studied. We analysed the prevalence of celiac disease in the overall group, and in the subgroups with anaemia and/or chronic diarrhoea. ReSULTS： Duodenal biopsy was performed in 1033 of 13 678 upper gastrointestinal endoscopies （7.6%）; an increase in the use of such was observed over the study period （1.9% in 1990-1994, 5% in 1995-1999 and 12.8% in 2000-2004）. Celiac disease was diagnosed in 22 patients （2.2%）, this being more frequent in women than in men （3% and 1% respectively）. Fourteen out of 514 （2.7%） patients with anaemia, 12 out of 141 （8.5%） with chronic diarrhoea and 8 out of 42 （19%） with anaemia plus chronic diarrhoea had celiac disease. A classical clinical presentation was observed in 55% of the cases, 23% of the patients had associated dermatitis herpetiformis and 64% presented anaemia; 9% were diagnosed by familial screening and 5% by cryptogenetic hypertransaminasaemia. CONCLUSION： Duodenal biopsy undertaken during routine upper gastrointestinal endoscopy in adults, has been gradually incorporated into clinical practice, and is a useful tool for the diagnosis of celiac disease in high risk groups such as those with anaemia and/or chronic diarrhoea.

关键词： Duodenal biopsy Upper gastrointestinal endoscopy Celiac disease Anemia Chronic diarrhea

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Solar energy in Qinghai and Andalusia:the Role of the State in the Chinese Success

Solar Energy in Qinghai and Andalusia:the Role of the State ...

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作者： Désirée Nieto fernández 上海交通大学

学位级别：硕士

Sustainability is nowadays not only a concept for environmentalists,but a transformation goal for developed countries and the best development option for developing countries *** means going forward while being respectful with the planet,being *** seemingly contradictive nature of today’s capitalist world and a green lifestyle are still a matter of debate,for which this paper provides an answer: a green market economy stage fuelled by *** energy to power society’s development,while driving away the main cause of pollution,will be the key to a transition *** power,more specifically,will reign among the energy sources of the future *** only the current drops in solar prices are causing springs of new policies and incentives,but solar is the best solution for millions of people living in communities without access to a grid,who in turn generate more pollution by burning traditional unhealthy energy *** is considered as the equivalent of a market economy in this paper,without any other political connotation,since ecological capitalism simply aims to achieve green economic growth through use of the current global market practices,without challenging any political *** the success of green capitalism is of paramount importance for countries to believe in the green measures they are undertaking and the sustainable world they are aiming *** combination of a new statist approach where the government is the main driver of change shows that sustainability in the form of publicly supported capitalism can be green,as long as it acts as a transition towards a greener and more inclusive *** countries around the world can aim for a reality,and it starts with the energy system.

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Light Curve Analysis of the AP Dor Binary System using Ground-based and TeSS Observations

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Research in Astronomy and Astrophysics 2023年第9期23卷 114-128页

作者： A.Poro e.fernández-Lajús M.Madani G.Sabbaghian F.Nasrollahzadeh F.Jahediparizi Astronomy Department of the Raderon AI Lab. BurnabyBCCanada Instituto de Astrofísica de La Plata(CCT La Plata-CONICeT-UNLP) La PlataArgentina Facultad de Ciencias Astronómicas y Geofísicas Universidad Nacional de La PlataPaseo del BosqueB1900FWALa PlataArgentina BSN Project Transiting Exoplanets DepartmentTehranIran Department of Physics Shahid Bahonar University of KermanKermanIran

The short-period eclipsing binary AP Dor’s first in-depth and multiband photometric solutions are *** made use of our eight nights of ground-based opportunity at a southern hemisphere observatory,and twelve sectors of TeSS *** extracted eight and 1322 minima from our observations and TeSS,*** suggest a new linear ephemeris based on the trend of orbital period variations using the Markov chain Monte Carlo(MCMC)*** PHysics Of eclipsing Binaries(PHOeBe)Python code and the MCMC approach were utilized for the light curve *** system did not require a starspot for the light curve *** calculated the absolute parameters of the system by applying the Gaia DR3 parallax *** orbital angular momentum(J_(0))of AP Dor indicates that this system is located in a region corresponding to contact *** to our results,this system is an overcontact binary system with a mass ratio of 0.584,a fillout factor of 48%,and an inclination of 53°.The positions of component stars in the AP Dor system on the Hertzsprung–Russell diagram are found.

关键词： (stars )binaries eclipsing-methods observational-stars individual(AP Dor)

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GM3-containing nanoparticles in immunosuppressed hosts:effect on myeloid-derived suppressor cells

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World Journal of Immunology 2014年第2期4卷 98-106页

作者： Audry fernández Liliana Oliver Rydell Alvarez Luis e fernández Circe Mesa Immunobiology Division Center of Molecular Immunology Innovation Division Center of Molecular Immunology

Cancer vaccines to date have not broadly achieved a significant impact on the overall survival of patients. The negative effect on the immune system of the tu-mor itself and conventional anti-tumor treatments such as chemotherapy is, undoubtedly, a key reason for these disappointing results. Myeloid-derived suppres-sor cells （MDSCs） are considered a central node of the immunosuppressive network associated with tumors. These cells inhibit the effector function of natural killer and CD8＋ T cells, expand regulatory T cells and can differentiate into tumor-associated macrophages within the tumor microenvironment. Thus, overcoming the suppressive effects of MDSCs is likely to be criti-cal for cancer immunotherapy to generate effective anti-tumor immune responses. However, the capacity of cancer vaccines and particularly their adjuvants to overcome this inhibitory population has not been well characterized. Very small size proteoliposomes （VSSP） is a nanoparticulated adjuvant specifcally designed to be formulated with vaccines used in the treatment of immunocompromised patients. This adjuvant contains immunostimulatory bacterial signals together with GM3 ganglioside. VSSP promotes dendritic cell maturation, antigen cross-presentation to CD8＋ T cells, Th1 polar-ization, and enhances CD8＋ T cell response in tumor-free mice. Currently, four cancer vaccines using VSSP as the adjuvant are in Phase？Ⅰ？and Ⅱ clinical trials. In this review, we summarize our work characterizing the unique ability of VSSP to stimulate antigen-specifc CD8＋ T cell responses in two immunocompromised sce-narios; in tumor-bearing mice and during chemother-apy-induced leukopenia. Particular emphasis has been placed on the interaction of these nanoparticles with MDSCs, as well as comparison with other cancer vac-cine adjuvants currently in preclinical or clinical studies.

关键词： Very small size proteoliposomes Adjuvants Tumors Myeloid-derived suppressor cells Leukopenia Chemotherapy

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Gas-phase electrocatalytic conversion of CO_2 to chemicals on sputtered Cu and Cu–C catalysts electrodes

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Journal of energy Chemistry 2019年第4期28卷 46-53页

作者： N.Gutiérrez-Guerra J.A.González J.C.Serrano-Ruiz e.López-fernández J.L.Valverde A.de Lucas-Consuegra Departamento de Ingeniería Química Facultad de Ciencias y Tecnologías Químicas Universidad de Castilla-La Mancha Instituto Regional de Investigación Científica Aplicada (IRICA) and Departamento de Física Aplicada Universidad de Castilla-La Mancha Departamento de Ingeniería Universidad Loyola Andalucía

A novel gas-phase electrocatalytic cell containing a low-temperature proton exchange membrane(PeM)was developed to electrochemically convert CO_2into organic *** different Cu-based cathode catalysts(Cu and Cu–C)were prepared by physical vapor deposition method(sputtering)and subsequently employed for the gas-phase electroreduction of CO_2at different temperatures(70–90°C).The prepared electrodes Cu and Cu–C were characterized by X-ray diffraction(XRD),X-ray photoemission spectroscopy(XPS)and scanning electron microscopy(SeM).As revealed,Cu is partially oxidized on the surface of the samples and the Cu and Cu–C cathodic catalysts were comprised of a porous,continuous,and homogeneous film with nanocrystalline Cu with a grain size of 16 and 8 nm,*** influence of the applied current and temperature on the electro-catalytic activity and selectivity of these materials was *** the two investigated electrodes,the pure Cu catalyst film showed the highest CO_2specific electrocatalytic reduction rates and higher selectivity to methanol formation compared to the Cu–C electrode,which was attributed to the higher particle size of the former and lower Cu O/Cu *** obtained results show potential interest for the possible use of electrical renewable energy for the transformation of CO_2into valuable products using low metal loading Cu based electrodes(0.5 mg Cu cm^(-2))prepared by sputtering.

关键词： CO_2 valorization electro-reduction Cu catalyst PeM Selectivity Methanol production

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Cyclooxygenase Inhibition in Cancer Immunotherapy: Combination of Indomethacin with Cancer Vaccines Is Not Always Beneficial

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Journal of Cancer Therapy 2017年第2期8卷 188-209页

作者： Giselle Hevia Isabel Pablos Marilyn Clavell Judith Raymond Mayrel Labrada Luis e. fernández Immunobiology Division Center of Molecular Immunology (CIM) Havana Cuba Deparment of Molecular Biology University of Salzburg Salzburg Austria

Cyclooxygenase (COX)-1, but preferable COX-2 catalyzes the synthesis of PGe2 in several tumors, promoting angiogenesis and a suppressive inflammation in their microenvironments. Different types of cancer vaccines have been combined with COX-2 inhibitors, assuming that its particular mechanism of action will not influence the overall results of the combination. In this research, a possible relationship between the type of cancer vaccine and the outcome of the combination with a COX inhibitor was experimentally addressed. We investigated whether nonsteroidal anti-inflammatory drugs (NSAIDs) affect the immune response to vaccination. Three adjuvants were evaluated for humoral and cellular response using ovalbumin (OVA) as antigen. We evaluated also the impact of indomethacin in five tumor models and the correlation of this effect with the secretion of prostaglandin e2 (PGe2) of these cells. We finally studied the combination of indomethacin with two cancer vaccines in three different experimental settings. COX inhibitor did not interfere with dendritic cells maturation in vitro and did not affect the frequency of splenic immune cell populations in mice. However, the induction of OVA-specific antibodies is affected by the COX inhibitor but its impact on cytotoxic CD8+ T cell response is adjuvant-dependent. In contrast, the antitumor effect of the COX inhibitor in the 3LL-D122 tumor model is not mediated by CD4+ or CD8+ T cells. Interestingly, the in vivo effect observed in this model and others didn’t correlate with levels of PGe2 secretion by the tumor cell lines in vitro. Finally, the combination of a COX inhibitor with cancer vaccines may depend on the type of the cancer vaccine.

关键词： Cyclooxygenase Inhibitors Cancer Vaccines Combination Therapy

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Towards Urban Resource Flow estimates in Data Scarce environments: The Case of African Cities

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Journal of environmental Protection 2015年第9期6卷 1066-1083页

作者： Paul Currie ethan Lay-Sleeper John e. fernández Jenny Kim Josephine Kaviti Musango School of Public Leadership Stellenbosch University Stellenbosch South Africa Department of Architecture Massachusetts Institute of Technology Cambridge USA School of Public Leadership and the Centre for Renewable and Sustainable Energy Studies (CRSES) Stellenbosch South Africa

Data sourcing challenges in African nations have led many African urban infrastructure developments to be implemented with minimal scientific backing to support their success. In some cases this may directly impact a city’s ability to reach service delivery, economic growth and human development goals, let alone the city’s ability to protect ecosystem services upon which it relies. As an attempt to fill this gap, this paper describes an exploratory process used to determine city-level demographic, economic and resource flow data for African nations. The approach makes use of scaling and clustering techniques to form acceptable and utilizable representations of selected African cities. Variables that may serve as the strongest predictors for resource consumption intensity in African nations and cities were explored, in particular, the aspects of the Koppen Climate Zones, estimates of average urban income and GDP, and the influence of urban primacy. It is expected that the approach examined will provide a step towards estimating and understanding African cities and their resource profiles.

关键词： Urban Metabolism Resource Flows African Cities Data Scaling City Clustering

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1996—2005年西班牙加利西亚省结核病流行病学

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国际结核病与肺部疾病杂志 2008年第1期3卷 16-22页

作者： e.Cruz-Ferro e.fernández-Nogueira 李波王雪静 Galicia Programme for the Prevention and Control of Tuberculosis Government of GaliciaSantiago de CompostelaSpain

地点:西班牙加利西亚省目的:描述1996—2005年间,加利西亚省10年的结核病流行病学进展及特点。设计:利用加利西亚省结核病登记中心的数据进行的一项描述性和观察性的回顾性研究。结果:加利西亚省的结核病发病率从1996年的72.3/10万下降... 详细信息

地点:西班牙加利西亚省目的:描述1996—2005年间,加利西亚省10年的结核病流行病学进展及特点。设计:利用加利西亚省结核病登记中心的数据进行的一项描述性和观察性的回顾性研究。结果:加利西亚省的结核病发病率从1996年的72.3/10万下降至2005年的37.7/10万,平均年递降率为7.0%。2005年,51.6%的结核病患者年龄在15～44岁之间,61.6%为男性,59.2%为单纯性肺结核。在肺结核患者中,63.4%未发现空洞病变,50.3%为痰涂片阳性,77.3%为培养阳性。4.4%的结核病患者感染了HIV,3.5%为吸毒者,3%为移民。将80%的痰涂片阳性病人作为指示病例,对其至少1名接触者进行了筛查。治疗成功率接近90%。结论:自结核病控制规划实施以来,加利西亚省的结核年发病率逐步下降,但仍然高于西班牙的其他地区及周边国家,结核病控制工作还需进一步加强。

关键词：结核规划流行病学进展

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Variability and change of climate extremes from indigenous herder knowledge and at meteorological stations across central Mongolia

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Frontiers of earth Science 2020年第2期14卷 286-297页

作者： Sukh TUMeNJARGAL Steven RFASSNACHT Niah BHVeNABLe Alison PKINGSTON Maria efernAndez-GIMeNeZ Batjav BATBUYAN Melinda JLAITURI Martin KAPPAS GADYABADAM eSS-Watershed Science Colorado State UniversityFort Collins ColoradoCO 80523-1476USA Cabinet Secretariat of Government of Mongolia State HouseUlaanbaatar City 14201Mongolia Natural Resources ecology Laboratory Fort Collins ColoradoCO 80523-1499USA Cooperative Institute for Research in the Atmosphere Fort Collins ColoradoCO 80523-1375USA Cartography GIS and Remote Sensing DepartmentInstitute of GeographyGeorg-August Universität GöttingenGöttingen 37007Germany FRS-Rangeland Science Colorado State UniversityFort Collins ColoradoCO 80523-1472USA Center for Nomadic Pastoralism Studies Ulaanbaatar 210620Mongolia Institute of Meteorology Hydrology and the EnvironmentUlaanbaatar 210620Mongolia

In semi-arid regions,air temperatures have increased in the last decades more than in many other parts of the *** has an arid/semi-arid climate and much of the population are herders whose livelihoods depend upon limited water resources that fluctuate with a variable *** were surveyed to identify their observations of changes in climate extremes for two soums of central Mongolia,Ikh-Tamir in the forest steppe north of the Khangai Mountains and Jinst in the desert steppe south of the *** herders’indigenous knowledge of changes in climate extremes mostly aligned with the station-based analyses of *** were warming with more warm days and nights at all *** were fewer cool days and nights observed at the mountain stations both in the summer and winter,yet more cool days and nights were observed in the winter at the desert steppe *** number of summer days is increasing while the number of frost days is decreasing at all *** results of this study support further use of local knowledge and meteorological observations to provide more holistic analysis of climate change in different regions of the world.

关键词： climate change climate extreme indices indigenous knowledge systems temperature precipitation

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颈椎病和长时间脊髓压迫病人脑萎缩、白质损伤和功能适应性改变的MRI证据

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国际医学放射学杂志 2020年第2期 245-246页

作者： á.Bernabéu-Sanz J.V.Mollá-Torró S.López-Celadal P.M.López e.fernández-Jover 胡现宁 Magnetic Resonance Department Inscanner SL C/San Pedro Poveda

目的采用多种先进神经影像技术探讨颈椎病(CS)对脑的影响。方法纳入27例CS和24名年龄及性别匹配的健康对照者。采用改良的日本骨科协会评分系统

关键词：功能适应性 MRI 感觉运动皮质白质损伤颈椎病

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