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Chinese Physics B 2020年第8期29卷 133-136页

作者： Qi Hao Ji-Chao Qiao e v goncharova G v Afonin Min-Na Liu Yi-Ting Cheng v A Khonik School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Department of General Physics Voronezh State Pedagogical UniversityLenin Street 86Voronezh 394043Russia

A relationship between thermal effects and relaxation of the high-frequency shear modulus upon heat treatment of bulk Zr48(Cu5/6Ag1/6)44Al8 metallic glass is *** relationship is attributed to the relaxation of a interstitial-type defect system frozen-in from the melt upon glass *** data show that thermal effects occurring on heating include heat release below the glass transition temperature,heat absorption above it and heat release caused by *** equation derived within the Interstitialcy theory can be used to calculate the shear modulus relaxation using the calorimetric *** obtained results are used to trace the defect concentration as functions of temperature and thermal prehistory.

关键词： shear modulus metallic glass structural relaxation interstitialcy theory

Numerical Simulation of Thermocapillary Convection with evaporation Induced by Boundary Heating

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1667-1686页

作者： O.N.goncharova v.B.Bekezhanova Altai State University Institute of Mathematics and Information TechnologiesBarnaul656049Russia Institute of Computational Modelling SB RAS Department of Differential Equations of MechanicsKrasnoyarsk660036Russia

The dynamics of a bilayer system filling a rectangular cuvette subjected to external heating is *** influence of two types of thermal exposure on the flow pattern and on the dynamic contact angle is *** particular,the cases of local heating from below and distributed thermal load from the lateral walls are *** simulation is carried out within the frame of a two-sided evaporative convection model based on the Boussinesq approximation.A benzine–air system is considered as reference *** variation in time of the contact angle is described for both heating *** lateral heating,near-wall boundary layers emerge together with strong convection,whereas the local thermal load from the lower wall results in the formation of multicellular motion in the entire volume of the fluids and the appearance of transition regimes followed by a steady-state *** results of the present study can aid the design of equipment for thermal coating or drying and the development of methods for the formation of patterns with required structure and morphology.

关键词： Thermocapillary convection two-phase system numerical modeling contact angle

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara e Agko Marina N Kouliou Konstantinos e Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIe)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIe include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIe’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIe.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

Study of moisture migration in clay soils considering rate of freezing

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Research in Cold and Arid Regions 2014年第5期6卷 474-478页

作者： S.A.Kudriavtcev A.v.Kazharskii e.D.goncharova I.B.Berestianyi Far eastern State Transport University (FeSTU) Research Construction and engineering Company (Dv-GeOSYNTHeTICS)

The paper presents some methods of numerical modeling and a study of moisture changing in frozen clay soils considering rates of freezing in the base of *** impact assessment of moisture changes in clay soils affectin... 详细信息

关键词： numerical modeling permafrost soil freezing thawing

Combined effects of oncolytic vaccinia virus and dendritic cells on the progression of melanoma B16-F10 in mice

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 67-80页

作者： elena P.goncharova Tatiana A.Gamburg Oleg v.Markov Marina A.Zenkova Laboratory of Biochemistry of Nucleic Acid Institute of Chemical Biology and Fundamental Medicine SB RASNovosibirsk 630090Russia Faculty of natural science Novosibirsk State UniversityNovosibirsk 630090Russia

Aim:We aimed to test the hypothesis that loading of dendritic cells(DCs)with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic ***:vaccinia virus LIvP/GFP and melanoma B16-F10 were used in this *** were pulsed with various combinations of viral and tumor-associated *** maturation status of DCs was verified by expression of the markers CD80,CD86,and CCR7 and assessment of IL-6,TNF-α,and IL-12 *** most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T *** therapy using vaccinia virus LIvP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor ***:We found that loading of DCs with viral antigens,or with a combination of viral and tumor antigens,resulted in similar levels of expression of DC maturation *** maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia virus LIvP/GFP infected tumor *** results show that the combination of vaccinia virus LIvP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than ***:Combination therapy with oncolytic vaccinia virus LIvP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10,but no synergistic antitumor effects were *** propose that optimization of the therapy regimen could enhance the efficiency of combination therapy.

关键词： Oncolytic virus vaccinia virus melanoma B16 dendritic cells cytotoxic T lymphocytes cancer immunotherapy

Study of moisture migration in clay soils considering rate of freezing

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Journal of Groundwater Science and engineering 2014年第4期2卷 35-40页

作者： Kudryavtsev S A Kazharskii A v goncharova e D Berestianyi I B Far eastern State Transport University (FeSTU) Research Construction and engineering Company “Dv-GeOSYNTHeTICS”

The paper presents some methods of numerical modelling and a study of moisture changing in frozen clay soils considering rates of freezing in the foundation. An impact assessment of moisture changes in clay soils affe... 详细信息

关键词： Moisture Clay soil Freezing Numerical modelling

Photoluminescence properties of eu3+-doped MgAl2O4 nanoparticles in various surrounding media

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Journal of Rare earths 2019年第8期37卷 806-811,I0001页

作者： I.e.Kolesnikov e.v.Golyeva e.v.Borisov e.Yu Kolesnikov e.Lahderanta A.v.Kurochkin M.D.Mikhailov St.Petersburg State University St.PetersburgRussia Lappeenranta University of Technology LUT LappeenrantaFinland Peter the Great St.Petersburg Polytechnic University St.PetersburgRussia Scientific and Technological Institute of Optical Material Science VNTs S.I.Vavilov State Optical InstituteSt.PetersburgRussia volga State University of Technology Yoshkar-OlaRussia

eu3+-doped MgAl2O4 nanoparticles were prepared by modified Pechini method.X-ray diffraction analysis shows pure tetragonal spinel phase without any *** average size of synthesized nanoparticles was determined to be about 50-60 nm using scanning electron microscopy and static light scattering *** and excitation spectra as well as lifetimes of MgAl2O4:eu3+ nanophosphors were explored in surrounding media with different refractive *** medium does not affect luminescence bands position,whereas 5D0 lifetime monotonically decreases along with increase of medium refractive *** of surrounding media on radiative and nonradiative decay rates,which were calculated using 4f-4f intensity theory,was studied and *** factor of prepared nanoparticles is defined using both radiative and observed lifetimes.

关键词： eu3+ Nanoparticles Filling factor Luminescence Lifetime Rare earths

Cross section of the Coulomb excitation of ^(229m)Th by low energy muons

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Chinese Physics C 2021年第9期45卷 143-147页

作者： e.v.Tkalya P.N.Lebedev Physical Institute of the Russian Academy of Sciences 11999153 Leninskiy pr.MoscowRussia National Research Nuclear University MePhI 115409Kashirskoe shosse 31MoscowRussia Nuclear Safety Institute of RAS Bofshaya Tulskaya 52Moscow 115191Russia

The inelastic scattering cross section for muons,μ^(-),with energies e=9-100 ev from the ^(229)Th nuclei is calculated in the framework of the second order of the perturbation theory for quantum *** dominant contribution to the excitation of the low energy isomer ^(229m)Th(3/2^(+),8.19±0.12 ev)originates from the e2 *** excitation cross section reaches the value of 10^(-21) cm^(2) in the range e≈10 *** value is four to five orders of magnitude larger than the electron excitation cross section and is sufficient for the efficient excitation of ^(229m)Th on the muon beam at the next generation of muon colliders.

关键词： cross section muon Coulomb excitation Th-229

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling