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过敏煎通过Ige/FcεRⅠ途径抑制肥大细胞脱颗粒改善特应性皮炎的作用机制

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中华中医药学刊 2024年第9期42卷 135-140,I0025,I0026页

作者：高娟陈桂芳谭伟张洁饶高雄王睿睿张祎云南中医药大学中药学院云南昆明650500 云南省民族特色养生理论与健康产品工程实验室云南昆明650500 云南医药健康职业学院云南昆明650500

目的通过体内外实验,研究过敏煎改善特应性皮炎的作用机制。方法采用2,4-二硝基氯苯(2,4-dimethyl sulfoxide,DNCB)反复刺激皮肤建立特应性皮炎(Atopic dermatitis,AD)模型,给予氯雷他定片及过敏煎低、中、高剂量(1.32、2.64、5.28 g/kg... 详细信息

目的通过体内外实验,研究过敏煎改善特应性皮炎的作用机制。方法采用2,4-二硝基氯苯(2,4-dimethyl sulfoxide,DNCB)反复刺激皮肤建立特应性皮炎(Atopic dermatitis,AD)模型,给予氯雷他定片及过敏煎低、中、高剂量(1.32、2.64、5.28 g/kg)进行干预,eLISA法检测血清总Ige、IL-4、IL-13水平,IHC法测定皮损组织中IL-4、IL-13的表达水平。体外运用anti-DNP-Ige/DNP-HSA诱导RBL-2H3细胞复制脱颗粒模型,MTS法检测过敏煎对RBL-2H3活力,通过eLISA法检测细胞上清中β-hex酶释放率,Histamine、LTB4、IL-4、IL-13水平,RT-PCR法检测细胞Histamine、IL-4、IL-13mRNA表达,Western blotting法检测p-eRK/eRK、p-JNK/JNK、p-p38/p-38蛋白表达。结果与模型组比较,过敏煎各剂量组显著减轻AD小鼠血清总Ige、IL-4、IL-13水平(Pex酶释放率(Pe、LTB4、IL-4、IL-13水平(Pe、IL-4、IL-13mRNA表达(PeRK/eRK、p-JNK/JNK、p-p38/p38蛋白表达(Pe水平改善特应性皮炎,其作用机制可能是通过Ige/FcεRⅠ途径抑制肥大细胞脱颗粒。

关键词：过敏煎特应性皮炎 Ige/FcεRⅠ 肥大细胞脱颗粒

Ballistic behavior of boron carbide reinforced AA7075 aluminium alloy using friction stir processing-An experimental study and analytical approach

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Defence Technology（防务技术） 2016年第1期12卷 25-31页

作者： I.SUDHAKAR G.MADHUSUDHAN ReDDY K.SRINIVASA rao department of mechanical engineering mvgrceVizianagaramIndia defence metallurgical research laboratory HyderabadIndia department of metallurgical engineering andhra universityVisakhapatnamIndia

High strength-to-weight ratio of non-ferrous alloys, such as aluminium, magnesium and titanium alloys, are considered to be possible replacement of widely accepted steels in transportation and automobile sectors. Among these alloys, magnesium is self explosive and titanium is costlier, and aluminium is most likely to replace steels. Application of aluminium or its alloys is also thought of as an appropriate replacement in defence field, especially to enhance the easiness in mobility of combat vehicles while maintaining the same standard as that of conventional armour grade steels. Hence most of the investigations have been confined to aluminium or its alloys as base material and open an era of developing the newer composite materials to address the major limitation, i.e. tribological properties. The surface composites can be fabricated by incorporating the ceramic carbides like silicon carbide, carbides of transition metals and oxides of aluminium using surface modification techniques, such as high energy laser melt treatment, high energy electron beam irradiation and thermal spray process which are based on fusion route. These techniques yield the fusion related problems, such as interfacial reaction, pin holes, shrinkage cavities or voids and other casting related defects, and pave the way to need of an efficient technique which must be based on solid state. Recently developed friction stir processing technique was used in the present investigation for surface modification of AA7075 aluminum alloy, which is an alternative to steels. In the present investigation, 160 μm sized boron carbide powder was procured and was reduced to 60 μm and 30 μm using high energy ball mill. Subsequently these powders were used to fabricate the surface composites using friction stir *** performance testing as per the military standard(JIS.0108.01) was carried out. In the present work, an analytical method of predicting the ballistic behavior of surface composites was

关键词： AA7075 aluminium alloy Friction stir processing(FSP) Surface metal matrix composite(SMMC) Boron carbide(B4C) Ballistic performance Target

MeTAMODeLLING APPROACH TO DeSIGN THe ALLUVIAL CHANNeLS AT INCIPIeNT MOTION

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International Journal of Sediment Research 2007年第3期22卷 218-227页

作者： Achanta Ramakrishna rao Bimlesh KUMAR Gopu SReeNIVASULU Prof. Civil department IISc India Research Scholar Civil department IISc India

The design of an alluvial channel for critical conditions requires information about four basic parameters, i.e., particle size d, water depth y, energy slope Sf and average velocity u. Most of the investigators use a standard or modified form of the critical Shields’ parameter to define the incipient motion of a particular grain size. Shields’ diagram describes an iterative process of determining the incipient motion parameters. To design a process that does not require iteration, one must know the resistance relationship. The absence of a universal resistance equation increases the difficulty of defining the model. Metamodelling techniques are widely used in engineering designs to simulate a complex system. This article describes a Metamodel, which employs the radial basis function (RBF) network to predict the average velocity u and energy slope Sf based on experimental data of incipient condition. With the help of the Metamodel generated by the RBF network, design curves have been presented to predict the u and Sf based on known values of the particle size and water depth. It has been found that this model improves the predictability of incipient motion.

关键词： Incipient motion Metamodel Multiquadric Prediction error Radial-Basis function Sediment transport Shields’ diagram

High Performance Algorithms Based on a New Wavelet expansion for Time Dependent Acoustic Obstacle Scattering

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Communications in Computational Physics 2007年第6期2卷 1139-1173页

作者： Lorella Fatone Giuseppe rao Maria Cristina Recchioni Francesco Zirilli Dipartimento di Matematica Pura e Applicata Universit`a di Modena e Reggio EmiliaVia Campi 213/b41100 ModenaItaly Dipartimento di Matematica e Applicazioni Universit`a di PalermoVia Archirafi 3490123 PalermoItaly Dipartimento di Scienze Sociali“D.Serrani” Universit`a Politecnica delle MarchePiazza Martelli 860121 AnconaItaly Dipartimento di Matematica“G.Castelnuovo” Universit`a di Roma“La Sapienza”Piazzale Aldo Moro 200185 RomaItaly

This paper presents a highly parallelizable numerical method to solve time dependent acoustic obstacle scattering *** method proposed is a generalization of the“operator expansion method”developed by Recchioni and Zirilli[SIAM ***.,25(2003),1158-1186].The numerical method proposed reduces,via a perturbative approach,the solution of the scattering problem to the solution of a sequence of systems of first kind integral *** numerical solution of these systems of integral equations is challenging when scattering problems involving realistic obstacles and small wavelengths are solved.A computational method has been developed to solve these challenging problems with affordable computing *** this aim a new way of using the wavelet transform and new bases of wavelets are introduced,and a version of the operator expansion method is developed that constructs directly element by element in a fully parallelizable *** numerical experiments involving realistic obstacles and“small”wavelengths are proposed and high dimensional vector spaces are used in the numerical *** evaluate the performance of the proposed algorithm on parallel computing facilities,appropriate speed up factors are introduced and evaluated.

关键词： Time dependent acoustic scattering Helmholtz equation integral equation methods wavelet bases sparse linear systems.

First-Principles Study of Lithium and Sodium Atoms Intercalation in Fluorinated Graphite

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engineering 2015年第2期1卷 243-246页

作者： Fengya rao Zhiqiang Wang Bo Xu Liquan Chen Chuying Ouyang Department of Physics Jiangxi Normal University Laboratory for Solid State Ionics Institute of Physics Chinese Academy of Sciences

The structure evolution of fluorinated graphite （CFx） upon the Li/Na intercalation has been studied by first- principles calculations. The Li/Na adsorption on single CF layer and intercalated into bulk CF have been calculated. The better cycling performance of Na intercalation into the CF cathode, comparing to that of Li intercalation, is attributed to the different strength and characteristics of the Li-F and Na-F interactions. The interactions between Li and F are stronger and more localized than those between Na and e The strong and localized Coulomb attraction between Li and F atoms breaks the C-F bonds and pulls the F atoms away, and graphene sheets are formed upon Li intercalation.

关键词： first-principles Li/Na rechargeable batteries fluorinated graphite.

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江西龙虎山铁皮石斛对胃阴虚小鼠的作用机制

中国中西医结合杂志 2024年第9期44卷 1100-1108页

作者：赵益卢雪凤方红吴柳瑾陈丽华朱培林饶毅江西中医药大学中医基础理论分化发展研究中心南昌330004 江西中医药大学中药固体制剂制造技术国家工程研究中心南昌330004 江西中医药大学现代中药制剂教育部重点实验室南昌330004 江西省林业科学院南昌330013

目的基于环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/水通路蛋白(AQPs)通路以及胃肠紧密功能,观察江西龙虎山铁皮石斛不同提取工艺(水提、醇提、多糖)对胃阴虚小鼠模型干预作用机制。方法将雄性ICR小鼠120只随机分为正常组、模型组、益胃汤组(15 ... 详细信息

目的基于环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/水通路蛋白(AQPs)通路以及胃肠紧密功能,观察江西龙虎山铁皮石斛不同提取工艺(水提、醇提、多糖)对胃阴虚小鼠模型干预作用机制。方法将雄性ICR小鼠120只随机分为正常组、模型组、益胃汤组(15 g/kg)、奥美拉唑组(1.7 mg/kg)、不同提取工艺铁皮石斛高剂量组(4.2 g/kg)、不同提取工艺铁皮石斛低剂量组(2.1 g/kg),每组12只。采用白酒和辣椒液的混合液灌胃建立胃阴虚小鼠模型,造模至第30天开始给药,持续至第70天,实验过程中小鼠每3天测定体重、饮水量、饮食量。实验结束后计算颌下腺指数、测定粪便含水量与唾液分泌量;He染色观察胃组织变化;eLISA测定血清中血管活性肠多肽(VIP)、cAMP的含量;Western Blot检测cAMP/PKA/AQPs通路中PKA以及磷酸化PKA蛋白(p-PKA)、AQP3、AQP4、AQP5蛋白表达及紧密连接蛋白(ZO-1)、e-钙粘素(e-cadherin)表达。结果与正常组比较,模型组小鼠饮水量、体重、唾液分泌量、粪便含水率均下降(Pe染色显示胃黏膜组织变薄、缺损,肌层丢失、腺体排列紊乱、炎性细胞浸润;血清中VIP、cAMP含量降低(Pe-cadherin表达上调(Pe-cadherin蛋白表达下调(P<0.05,P<0.01);奥美拉唑组及水提物、多糖高剂量组AQP3蛋白表达上调(P<0.05,P<0.01),3种提取物的高剂量AQP4蛋白表达均上调(P<0.01),多糖组AQP5蛋白表达下调(P<0.01,P<0.05)。结论江西龙虎山铁皮石斛能够改善胃阴虚小鼠模型的症状,其作用机制与cAMP/PKA/AQPs通路以及紧密连接有关,其中水提及多糖的高剂量在促进唾液分泌量以及促进AQP3、AQP4表达上有优势,多糖在下调AQP5表达上有优势。

关键词：铁皮石斛铁皮石斛多糖胃阴虚水通道蛋白紧密连接蛋白中药

An improved data space inversion method to predict reservoir state fields via observed production data

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Petroleum Science 2021年第4期18卷 1127-1142页

作者： Deng Liu Xiang rao Hui Zhao Yun-Feng Xu Ru-Xiang Gong Cooperative Innovation Center of Unconventional Oil and Gas(Ministry of education&Hubei Province) Yangtze UniversityWuhan434023HubeiPR China School of Petroleum engineering Yangtze UniversityWuhan434023HubeiPR China CNOOC Oilfield Services Co. Ltd.Tianjin30000PR China

A data-space inversion(DSI)method has been recently proposed and successfully applied to the history matching and production prediction of *** on Bayesian theory,DSI can directly and effectively obtain good posterior flow predictions without inversion of geological parameters of reservoir *** paper presents an improved DSI method to fast predict reservoir state fields(*** and pressure profiles)via observed production ***,a large number of production curves and state data are generated by reservoir model simulation to expand the data space of original ***,efficient history matching only on the observed production data is carried out via the original DSI to obtain related parameters which reflects the weight of the real reservoir model relative to prior reservoir ***,those parameters are used to predict the oil saturation and pressure profiles of the real reservoir model by combining large amounts of state data of prior reservoir *** examples including conventional heterogeneous and unconventional fractured reservoir are implemented to test the performances of predicting saturation and pressure profiles of this improved DSI ***,this method is also tested in a real field and the obtained results show the high computational efficiency and high accuracy of the practical application of this method.

关键词： Fossil fuels Oil and gas reservoirs Reservoir state fields Production data Data inversion method

Platinum Wire Implants Coated with PeDOT/Carbon Nanotube Conducting Polymer Films in the Brain of Rats: A Histological evaluation

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Journal of Wuhan University of Technology(Materials Science) 2012年第6期27卷 1053-1057页

作者：程璇 LI Chengyan rao Li ZHOU Haihan 李涛段晏文 Department of Neurology Renmin Hospital of Wuhan University College of Chemistry and Molecular Sciences Wuhan University

Platinum （Pt） implants coated with poly （3, 4-ethylenedioxythiophene）/carbon nanotube （PeDOT/CNT） composite films were implanted into the brain of rats, and the brain response was evaluated 6 weeks after the implantation. The surface morphology of Pt implants with and without the PeDOT/CNT coating was studied using scanning electron microscopy （SeM）. After 6 weeks post-implantation, the expression of laminin （vascular endothelial marker） and neuronal nuclei （NeuN, neuronal marker） were evaluated by immnohistochemistry. It is revealed that the obvious improvements of the surface density of blood vessels and neurons aound the Pt implants with the coating, which were evidenced by laminin and NeuN staining in the zone within the distance of 150 μm to the implant interface. These results suggest the PeDOT/CNT composite films can improve the biocompatibility of the Pt electrodes while it is implanted in brain.

关键词： neural electrodes biocompatibility poly (3, 4-ethylenedioxythiophene) (PeDOT) carbon nanotube (CNT) laminin neuronal nuclei

electronic characteristic,tensile cracking behavior and potential energy surface of TiC(111)/Ti(0001)interface:A first principles study

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中国航空学报:英文版 2023年第9期36卷 451-463页

作者： Silong ZHANG Jibo WANG Lixiang rao Qizhen He Xiaolei XING Yefei ZHOU Qingxiang YANG State Key Lab of Metastable Materials Science&Technology Hebei Key Lab for Optimizing Metal Product Technology and PerformanceCollege of Materials Science&EngineeringYanshan UniversityQinhuangdao 066004China College of Physics and Mechanical&electrical engineering Longyan UniversityLongyan 364012China College of Mechanical engineering Yanshan UniversityQinhuangdao 066004China

The preparation of TiC coating on Ti alloy surface to improve the wear resistance has attracted attention from researchers in aerospace *** service life of TiC coating is related to the interfacial adhesion properties between TiC coating and Ti alloy ***,it is difficult to explain its interfacial adhesion mechanism by experimental *** on the termination of atoms on the TiC surface,two TiC/Ti interface models named as the C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(11)/Ti(0001) interface were constructed by *** interfacial electronic characteristic of C-Ti bond is a mixture of polar covalent and metal bonds,and that of Ti-Ti bond is the metal *** tensile strains of both C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface in the fracture stage are ranged from 12% to 14%.Their maximum tensile stresses are 16.201 GPa and 15.590GPa,*** sliding potential energy surface maximum of C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface are 5.387 J/m^(2) and 0.271 J/m^(2),*** the sliding potential barriers on the minimum energy path are 2.094 J/m2and 0.136 J/m^(2) with an ideal shear strength of 20.32 GPa and 1.61 GPa,*** summary,the interfacial adhesion property of C-terminated-TiC(111)/Ti(0001) interface is better than that of Ti-terminated-TiC(111)/Ti(0001) interface.

关键词： electronic First-principles Potential energy surface Tensile TiC/Ti interface