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Cu,N codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai Feng Min Yu Minjia Meng Lei Liu Dewei rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(NPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-N-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)NPs in Cu@Cu-N-C have high PDO dehydrogenation activity while N-coordinated Cu(Cu-N)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-N-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

Simulation Study on Constraining Gravitational Wave Propagation Speed by Gravitational Wave and Gamma-ray Burst Joint Observation on Binary Neutron Star Mergers

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Research in Astronomy and Astrophysics 2024年第8期24卷 44-53页

作者： Jin-Hui rao Shu-Xu Yi Lian Tao Qing-Wen Tang Department of Physics School of Physics and Materials ScienceNanchang University Institute of High energy Physics Chinese Academy of Sciences

Theories of modified gravity suggest that the propagation speed of gravitational waves （GW） vgmay deviate from the speed of light c.A constraint can be placed on the difference between c and vgwith a simple method that uses the arrival time delay between GW and electromagnetic wave simultaneously emitted from a burst *** simulated the joint observation of GW and short gamma-ray burst signals from binary neutron star merger events in different observation campaigns,involving advanced LIGO （aLIGO） in design sensitivity and einstein Telescope（eT） joint-detected with Fermi/*** a result,the relative precision of constraint on vgcan reach～10-17（aLIGO） and～10-18（eT）,which are one and two orders of magnitude better than that from GW170817,*** continue to obtain the bound of graviton mass mg≤7.1（3.2）×10-20eV with aLIGO （eT）.Applying the Standard-Model extension test framework,the constraint on vgallows us to study the Lorentz violation in the nondispersive,nonbirefringent limit of the gravitational *** obtain the constraints of the dimensionless isotropic coefficients ■at mass dimension d=4,which are■for aLIGO and■for eT.

关键词： (stars:) gamma-ray burst: general gravitational waves stars: neutron

Revolutionizing genetic disease treatment: The case of exagamglogene autotemcel

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The Innovation 2024年第3期5卷 5-6页

作者： Shuquan rao Yao Yao Wenxuan Huo Yang Cao Lihua e.Budde State Key Laboratory of experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020 China 2Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing 100044 China 3Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences(2019RU029)Beijing 100044 China 4Department of Hematology&Cancer Biology Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China 5Department of Hematology&Hematopoietic Stem Cell Transplantation City of Hope National Medical CenterDuarteCA 91010USA

Recent approval of exagamglogene autotemcel(exa-cel)on November 16,2023,in the United Kingdom,developed by Vertex Pharmaceuticals and CRISPR Therapeutics,represents the first cell-based therapy for treatment of sickle cell disease(SCD)with recurrent vaso-occlusive crises(VOCs)or transfusion-dependentβ-thalassemia(TDT)in patients aged 12 and *** suit,the US Food and Drug Administration authorized exa-cel for the same indications on December 8,***-cel represents the first commercially approved CRISPR-based gene therapy,offering hope to approximately 25,000 eligible patients in the US and *** significance of exa-cel extends beyond revolutionizing therapeutic intervention in genetic medicine;it also raises profound ethical considerations and societal implications related to genome manipulation.

关键词： transfusion treatment manipulation

High-Value-Added Utilization of Turpentine:Screening of Anti-Influenza Virus Agents fromβ-Pinene Derivatives

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Journal of Renewable Materials 2024年第1期12卷 45-56页

作者： Yiwen Li Hongyan Si Peng Wang Hai Luo Minggui Shen Xiaoping rao Zhanqian Song Shibin Shang Zongde Wang Shengliang Liao east China Woody Fragrance and Flavor engineering Research Center of National Forestry and Grassland Administration Camphor Engineering Research Center of National Forestry and Grassland AdministrationCollege of ForestryJiangxi Agricultural UniversityNanchang330045China Institute of Chemical Industry of Forestry Products China Academy of ForestryNational Engineering Laboratory for Biomass Chemical UtilizationKey and Open Laboratory of Forest Chemical EngineeringState Forestry AdministrationKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing210042China College of Chemical engineering Huaqiao UniversityXiamen361021China

Turpentine is a renewable and resourceful forest *** deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread *** study aimed to synthesize 40 derivatives ofβ-pinene,including nopinone,3-cyanopyridines of nopinone,myrtanyl acid,myrtanyl acylthioureas,and myrtanyl *** assessed the antiviral activities of theseβ-pinene derivatives against influenza virus A/Puerto Rico/8/34(H1N1)using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ***β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 *** results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration(IC50)value of 47.6μmol/*** the compounds,4e,4i,and 4l demonstrated therapeutic effects against cellular infection,with compound 4e displaying the most potent therapeutic effect(IC50=17.5μmol/L),comparable to the positive control *** findings indicated that certainβ-pinene derivatives exhibited in vitro antiviral activity against the H1N1 influenza A virus,warranting further investigation as potential anti-influenza agents.

关键词： Antiviral activity β-pinene derivative 3-cyanopyridine influenza virus

First spectroscopic study of HFRC plasma

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Plasma Science and Technology 2024年第8期26卷 18-24页

作者：毛安程芝峰饶波杨菁珉张明 International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic TechnologyWuhan 430074People’s Republic of China School of electrical and electronic engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

An advanced spectral diagnostic system was developed to measure the electron temperature(T_(e)),electron density(N_(e)),and ion temperature(T_(i))of the Huazhong University of Science and Technology field-reversed configuration *** system consists of an optic fiber spectrometer with a wide spectral band and a 670 mm focal length high throughout Czerny-Turner monochromator equipped with both a 3600 g mm^(-1)grating and a 2400 g mm^(-1)grating to measure the line *** these components is an electronmultiplying charge-coupled device camera to capture spectral *** relative intensity of the optical fiber spectrometer was calibrated using a standard luminance source,and the wavelength calibration of the spectrometer was accomplished using a Hg/Ar *** diagnostic setup was configured to measure electron density based on the Stark effect of H_γ(n=5→n=2;434.04 nm).Doppler broadening of an OⅢ(2s^(2)2p(^(2)P^(0))3p→2s^(2)2p(^(2)P^(0))3s;375.988 nm)emission line was measured and analyzed to obtain the ion temperature,and electron temperatures were estimated from the relative strength of H_(β)(n=4→n=2;486.14 nm)(D_(β))and H_(γ)(D_(γ))spectral lines when the electron density was obtained from Stark effect *** initial experimental results indicate that the highest electron temperature of the formation region was approximately 8 eV,the electron density of the colliding-and-merging region was approaching 10^(20)m^(-3),and the ion temperature reached about 40 eV.

关键词： Stark effect Doppler effect ion temperature electron density electron temperature

In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： Jin Liu Yike Gui Jingxin rao Jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu Zhiyi Chene Xia Sheng Yitian Wang Mingyue Zheng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

Ultra-broadband microwave absorber and high-performance pressure sensor based on aramid nanofiber,polypyrrole and nickel porous aerogel

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1912-1921页

作者： Leyi Zhang Hongyu Jin Hanxin Liao rao Zhang Bochong Wang Jianyong Xiang Congpu Mu Kun Zhai Tianyu Xue Fusheng Wen State Key Laboratory of Metastable Materials Science&Technology Yanshan UniversityQinhuangdao 066004China Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

electronic devices have become ubiquitous in our daily lives,leading to a surge in the use of microwave absorbers and wearable sensor devices across various sectors.A prime example of this trend is the aramid nanofibers/polypyrrole/nickel(APN)aerogels,which serve dual roles as both microwave absorbers and pressure *** this work,we focused on the preparation of aramid nanofibers/polypyrrole(AP15)aerogels,where the mass ratio of aramid nanofibers to pyrrole was 1:*** employed the oxidative polymerization method for the preparation *** this,nickel was thermally evaporated onto the surface of the AP15 aerogels,resulting in the creation of an ultralight(9.35 mg·cm^(-3)).This aerogel exhibited a porous *** introduction of nickel into the aerogel aimed to enhance magnetic loss and adjust impedance matching,thereby improving electromagnetic wave absorption *** minimum reflection loss value achieved was-48.7 dB,and the maximum effective absorption bandwidth spanned 8.42 GHz with a thickness of 2.9 *** impressive metrics can be attributed to the three-dimensional network porous structure of the aerogel and perfect impedance ***,the use of aramid nanofibers and a three-dimensional hole structure endowed the APN aerogels with good insulation,flame-retardant properties,and compression *** under a compression strain of 50%,the aerogel maintained its resilience over 500 *** incorporation of polypyrrole and nickel particles further enhanced the conductivity of the ***,the final APN aerogel sensor demonstrated high sensitivity(10.78 kPa-1)and thermal *** conclusion,the APN aerogels hold significant promise as ultra-broadband microwave absorbers and pressure sensors.

关键词： porous aerogel aramid nanofibers microwave absorbers pressure sensor porous structure

不均衡小样本下多特征优化选择的生命体触电故障识别方法

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电工技术学报 2024年第7期39卷 2060-2071页

作者：高伟饶俊民全圣鑫郭谋发福州大学电气工程与自动化学院福州350108 智能配电网装备福建省高校工程研究中心福州350108

针对现有的剩余电流保护装置无法有效识别触电事故的问题,该文提出了一种不均衡小样本下多特征优化选择的生命体触电故障识别方法。首先通过变分自编码器(VAe)对实验收集到的生命体触电小样本数据进行增殖以实现正负样本均衡;然后在时... 详细信息

针对现有的剩余电流保护装置无法有效识别触电事故的问题,该文提出了一种不均衡小样本下多特征优化选择的生命体触电故障识别方法。首先通过变分自编码器(VAe)对实验收集到的生命体触电小样本数据进行增殖以实现正负样本均衡;然后在时域上提取能够反映波形动态变化特性的23个特征量,并利用高斯核Fisher判别分析(GKFDA)与最大信息系数(MIC)法从中选择最优表达特征组;最后,提出基于遗忘因子的在线顺序极限学习机(FOS-eLM)算法实现生命体触电行为的鉴别。实验结果表明,所提方法利用不均衡小样本触电数据集就可以训练出一个优秀的分类模型,诊断准确率可达98.75%,诊断时间仅为1.33 ms。其优良的性能结合在线增量式学习分类器设计,使得模型具备新知识学习能力,具有极好的工程应用前景。

关键词：剩余电流保护装置生命体触电故障多特征优化选择基于遗忘因子的在线顺序极限学习机(FOS-eLM) 不均衡小样本

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双螺杆压缩机工作性能参数仿真及试验研究

压缩机技术 2024年第1期 38-43页

作者：饶静信阳学院外国语学院河南信阳464000

双螺杆压缩机是将低压气体转换为高压气体的一种旋转机械装置,现阶段存在着影响双螺杆压缩机内部流场性能参数的研究不够全面,缺少相关试验分析,并且四大工作性能参数对双压缩机性能的影响尚未系统化、定性化描述的问题。以5~6齿双螺杆... 详细信息

双螺杆压缩机是将低压气体转换为高压气体的一种旋转机械装置,现阶段存在着影响双螺杆压缩机内部流场性能参数的研究不够全面,缺少相关试验分析,并且四大工作性能参数对双压缩机性能的影响尚未系统化、定性化描述的问题。以5~6齿双螺杆压缩机为研究对象,利用Pro.e和Pumplinx软件为研究手段,建立双螺杆压缩机3D流体域模型,采用动网格技术分析了功率、流量、比功率、压力四大工作性能参数在瞬态流场特性下的变化规律,同时,进行了试验验证。结果表明,功率仿真数据与试验数据相比较,差异率为0.13%,排气量差异率为0.933%,比功率差异率为4.92%,压力差异率为0.388%。由此可知仿真值与试验值差异率均小于5%,吻合度较好,研究结果完善了双螺杆压缩机性能参数评价标准,为后续双螺杆压缩机性能优化提供了一种新方法。

关键词：双螺杆压缩机瞬态流场特性动网格技术工作参数试验验证