检索结果-南通市图书馆

Measurement of hepatic functional mass by means of ^(13)C-methacetin and ^(13)C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh score and serum bile acid levels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第1期11卷 142-148页

作者： D.Festi S.Capodicasa L.Sandri L.Colaiocco-Ferrante T.Staniscia e.Vitacolonna A.Vestito R.Simoni G.Mazzella P.Portincasa e.roda A.Colecchia Department of Internal Medicine and Gastroenterology Department of Medicine and Aging Department of Internal Medicine and Public Medicine

AIM: To evaluate and compare the clinical usefulness of 13C-phenylalanine and 13C-methacetin breath tests in quantitating functional hepatic mass in patients with chronic liver disease and to further compare these results with those of conventional tests, Child-Pugh score and serum bile acid ***: One hundred and forty patients (50 HCV-related chronic hepatitis, 90 liver cirrhosis patients) and 40 matched healthy controls were studied. Both breath test and routine liver test, serum levels of cholic and chenodeoxycholic acid conjugates were ***: Methacetin breath test, expressed as 60 min cumulative percent of oxidation, discriminated the hepatic functional capacity not only between controls and liver disease patients, but also between different categories of chronic liver disease patients. Methacetin breath test was correlated with liver function tests and serum bile ***, methacetin breath test, as well as serum bile acids, were highly predictive of Child-Pugh scores. The diagnostic power of phenylalanine breath test was always less than that of methacetin breath ***: Methacetin breath test represents a safe and accurate diagnostic tool in the evaluation of hepatic functional mass in chronic liver disease patients.

关键词： Chronic hepatitis c Liver cirrhosis Breath Tests Hepatic functional mass

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第8期17卷 1666-1674页

作者： Alejandro R.roda Gabriel Serra-Mir Laia Montoliu-Gaya Lidia Tiessler Sandra Villegas Protein Design and Immunotherapy Group Departament de Bioquímica i Biologia MolecularFacultat de BiociènciesUniversitat Autònoma de BarcelonaBellaterraBarcelonaSpain Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgSweden

Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral *** poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s *** occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of ***,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional *** mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both ***,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been *** others,the immune system seems to be strongly involved in amyloid-beta and tau *** factors,as the apolipoprotein eε4 isoform has been suggested to act as a link between amyloid-beta and tau ***,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical ***,it has been shown that tau-immunotherapy also reduces amyloid-beta ***,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapie

关键词： aggregation Alzheimer amyloid-beta dementia immunotherapy inflammation neurodegeneration tau

Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第14期19卷 2208-2216页

作者： Aldo roda Mara Mirasoli Massimo Guardigli Patrizia Simoni Davide Festi Boris Afonin Galina Vasilyeva Department of Chemistry "G.Ciamician" University of Bologna-Alma Mater Studiorum Department of Medical and Surgical Sciences University of Bologna-Alma Mater Studiorum State Scientific Center of Russian Federation-Institute of Biomedical Problems of the Russian Academy of Sciences(IBMP)

AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term ***:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 *** particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid *** addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal *** no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the ***:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external *** evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy *** contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same *** variability suggested that the H 2-breath

关键词： Breath test Gastrointestinal inflammation Gastrointestinal motility Spaceflight Stress

Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第8期18卷 1852-1856页

作者： Jesús Chato-Astrain Olga roda David Sánchez-Porras esther Miralles Miguel Alaminos Fernando Campos Óscar Darío García-García Víctor Carriel Department of Histology(Tissue engineering Group) University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain Department of Human Anatomy and embryology University of GranadaGranadaSpain Unit of Clinical Neurophysiology University Hospital San CecilioGranadaSpain

Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton *** have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone ***,the limited regenerative capacity of the central nervous system due to an inhibitory environment prevents major changes in neurite outgrowth and should be presumably associated with low levels of growth-associated protein 43 ***,central alterations due to peripheral nerve damage have never been assessed using the growthassociated protein 43 *** this study,we used the tubulization technique to repair 1 cm-long nerve gaps in the rat nerve injury/repair model and detected growth-associated protein 43 expression in the peripheral and central nervous ***,histological analysis of the regeneration process confirmed an active regeneration process of the nerve gaps through the conduit from 10 days *** growth-associated protein 43 expression profile varied across regions and follow-up times,from a localized expression to an abundant and consistent expression throughout the regeneration tissue,confirming the presence of an active nerve regeneration ***,spinal cord changes were also histologically assessed,and no apparent changes in the structural and cellular organization were observed using routine staining ***,remarkable differences and local changes appeared in growth-associated protein 43 expression at the spinal cord level,in particular at 20 days post-repair and ***-associated protein 43 protein was first localized in the gracile fasciculus and was homogeneously distributed in the left posterior *** findings differed from the growth-associated protein 43 pattern observed in the healthy control,which did not express growth-associated protein 43 at these *** results revealed a differential expression in growth-associate

关键词： growth-associated protein 43(GAP-43) immunohistochemistry nerve guide nerve tissue regeneration peripheral nerve repair spinal cord tissue engineering

Using Computer Vision and Intelligent Classification Techniques for the Classification and Selection of Brazilian Nuts

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Food Science and engineering 2016年第2期6卷 51-62页

作者： Raphael Gava de Andrade Valentin Oba roda Jose Dalton Cruz Pessoa Depto de engenharia eletrica e de Computagao EESC/USP Avenida Trabalhador Saocarlense 400 13566-590 Sao Carlos (SP)Brazil embrapa Instrumentagao - Rua XV de Novembro 1452 13560-970 Sao Carlos (SP) Brazil

Aiming to improve the processes involved in the industrial beneficiation of the Brazilian nuts, this work used a new methodology based on concepts of computer vision and intelligent classification, with a focus on two of the various stages of the processing： classification according to the origin and selection. Using the proposed methodology for the selection of the nuts it was possible to distinguish between intact and broken nuts and between good and spoiled nuts with a very high percentage of correct identifications. Also to evaluate the efficiency of the proposed methodology, visual tests by human subjects were performed for the classification of the nuts, the results demonstrated that the intelligent techniques performed the same or better than the visual classification.

关键词： Brazilian nuts classification techniques computer vision intelligent systems.

Production of reactive oxygen species and expression of inducible nitric oxide synthase in rat isolated Kupffer cells stimulated by Leptospira interrogans and Borrelia burgdorfen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第19期12卷 3077-3081页

作者： Antonella Marangoni Silvia Accardo Rita Aldini Massimo Guardigli Francesca Cavrini Vittorio Sambri Marco Montagnani Aldo roda Roberto Cevenini Sezione di Microbiologia DMCSS University of Bologna BolognaItaly Istituto di Scienze Chimiche University of Bologna BolognaItaly Dipartimento di Scienze Farmaceutiche University of Bologna BolognaItaly Dipartimento di Medicina Interna e Gastroenterologia University of Bologna BolognaItaly

AIM： To evaluate the production of reactive oxygen species （ROS） and the expression of inducible nitric oxide synthase （iNOS） in rat isolated Kupffer cells （KCs） stimulated by Leptospira interrogans and Borrelia burgdorferi. MeTHODS： Rat Kupffer cells were separated by perfusion of the liver with 0.05% collagenase, and purified by Percoll gradients. Pudfied Kupffer cells were tested in vitro with alive *** and B. burgdorferi preparations. The production of ROS was determined by chemiluminescence, whereas iNOS protein expression was evaluated by Western blot assay using anti-iNOS antibodies. ReSULTS： B. burgdorferi and to a less extent L. interrogans induced ROS production with a peak 35 min after infection. The chemiluminescence signal progressively diminished and was undetectable by 180 min of incubation. Leptospirae and borreliae induced an increased iNOS expression in Kupffer cells that peaked at 6 hours and was still evident 22 h after infection. CONCLUSION： Both genera of spirochetes induced ROS and iNOS production in rat Kupffer cells. Since the cause of liver damage both in leptospiral as well as in borrelial infections are still unknown, we suggest that leptospira and borrelia damage of the liver can be initially mediated by oxygen radicals, and is then maintained at least in part by nitric oxide.

关键词： Leptospira interrogans Borrelia burgdorferi Inducible nitric oxide synthase Nitric oxide Reactive oxygen species Kupffer cells Chemiluminescence

Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第16期23卷 2995-3002页

作者： Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein Department of Gastroenterology Sheba Medical CenterSackler School of MedicineTel-Aviv UniversityRamat-Gan 52621Israel the First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510700Guangdong provinceChina Department of Gastroenterology and Hepatology Inflammatory Bowel Disease ServiceRoyal Adelaide HospitalSchool of MedicineUniversity of AdelaideAdelaideSA 5005Australia Division of Gastroenterology School of Health SciencesUniversity of IoanninaIoannina 45500Greece Department of Gastroenterology Hepatology and NutritionDigestive Disease Diseases and Surgery InstituteCleveland Clinic FoundationClevelandOH 44109United States Unit of Inflammatory Bowel Disease Hospital Israelita Albert EinsteinSao PauloSP 05652-900Brazil Department of Gastroenterology Venizeleio General HospitalHeraklion71409 CreteGreece Department of Internal Medicine Yonsei University College of MedicineSeoul 03722South Korea NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of NottinghamNottingham NG7 2UHUnited Kingdom Dipartimento di Medicina Interna e SpecialitàMediche “Sapienza”University of Rome00185 RomaItaly Comprehensive Digestive Institute of Nevada Las VegasNV 89113United States Department of Gastroenterology and Hepatology Soroka University Medical CenterBeer-Sheva 6400111Israel Department of Gastroenterology University Hospital ZvezdaraBelgrade 11000Serbia Department of Gastroenterology University-Hospital of Saint-Etienne42100 Saint EtienneFrance Gastroenterology Unit S.Orsola-Malpighi40138 BolognaItaly IBD Clinical and Research Centre University of ManitobaWinnipegMB R3T2N2Canada

AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). MeTHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. ReSULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P e undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.

关键词： Inflammatory bowel disease Corticosteroids 5-aminosalicylates Ulcerative colitis

Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第9期18卷 930-937页

作者： Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini edoardo Poli Adriano De Santis Aldo roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili Gastroenterology Division Department of Clinical MedicineSapienza University of RomeViale dell' Universita' 37 Department of Medical Sciences and Biotechnology Vascular Medicine and Atherothrombosis LaboratorySapienza University of Rome Direzione Sanitaria Terme di Chianciano Department of Pharmaceutical Science Alma Mater-University of Bologna Department of Clinical Medicine Alma MaterUniversity of Bologna

AIM： To investigate the effect of drinking sulphate-bi- carbonate-calcium thermal water （TW） on risk factors for atherosclerosis and cholesterol gallstone disease.

关键词： Thermal water Gallstones Oxidative stress Body weight Bile acid

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony e. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce e. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker e. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian e.M. Baldin P. Balek e. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz e. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat e.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JeT QUARK GLUON TAGGING