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Influence of the safety factor profile on the particle and heat transport in the Globus-M spherical tokamak

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Plasma Science and Technology 2019年第11期21卷 1-6页

作者： A YU TeLNoVA G S KURSKIeV e o kiselev N N BAKHAReV V K GUSeV N A KHRoMoV S YU MeDVeDeV V B MIINAeV I V MIRoSHNIKoV M I PATRoV Yu V PeTRoV N V SAKHARoV A D SLADKoMeDoVA P B SHCHeGoLeV V V SoLoKHA V A ToKAReV S YU ToLSTYAKoV e A TUKHMeNeVA Ioffe Institute Saint-Petersburg 194021Russia Keldysh Institute Russian Academy of SciencesMoscow 125047Russia NRC'Kurchatov Institute’ Moscow 123098Russia

The advanced tokamak scenario is a promising operation scenario for ITeR and fusion neutron *** this scenario the minimum value of the safety factor in the center of the plasma exceeds *** the compact spherical tokamak Globus-M,the formation of such conditions is possible with neutral beam injection at the current ramp-up *** to the slower diffusion of current inside the plasma,a zone is formed with reduced heat and particle transport across the magnetic field,which affects the temperature and density profiles of the *** leads to the peaked density profile formation and improvement of the energy confinement *** achieve a high fraction of the bootstrap current,it is necessary to increase the plasma *** the same time,the maximum allowable pressure is limited to the normalized beta limit.

关键词： advanced tokamak mode transport analysis internal transport barriers

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Universality test of short range nucleon-nucleon correlations in nuclei with strange and charmed probes

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Chinese Physics C 2022年第1期46卷 124-128页

作者： Yu.T.kiselev NRC"Kurchatov Institute"-ITeP Moscow 117218 Russia

Understanding the eMC effect and its relation to the short-range nucleon-nucleon correlations(SRC)in nuclei is a major challenge for modem nuclear *** of the key aspects of the connection between these phenomena is the *** universality states that the SRC is responsible for the eMC effect and that the modification of the partonic structure of the SRC is the same in different *** flavor dependence of the universal-ity is one of the unanswered *** investigations conducted to date have demonstrated the existence and universality of the SRC for light u and d ***,it was suggested that the universality for heavy flavors can be studied through their deep subthreshold production in yA and eA *** this paper,we discuss an alternative possibility to access the strange and gluon high-A"structure of the SRC and to establish universality for heavy flavors using nuclear semi-inclusive deep inelastic scattering(nSIDIS),which probes different quark flavor combinations depending on the final state *** specific reaction can be"tagged"by observation of a strange or charmed particle registered in coincidence with the scattering *** universality of the SRC can be tested in the kinematic region,i.e.,X>1,where the contribution to the cross section from SRC becomes *** the strangeness,charmonium,and open charm will shed light on the role of quarks and gluons in nuclei,thereby developing an understanding of how nuclei emerge within QCD.

关键词： eMC effect strange and charm quarks in nuclei short-range nucleon correlation in nuclei

Medium effects in ΛK~＋ pair production by 2.83 GeV protons on nuclei

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Chinese Physics C 2017年第12期41卷 88-105页

作者： e. Ya. Paryev M. Hartmann Yu. T. kiselev Institute for Nuclear Research Russian Academy of Sciences Moscow 117312 Russia Institute for Theoretical and experimental Physics Moscow 117218 Russia Institut für Kernphysik and Jülich Centre for Hadron Physics Forschungszentrum Jiilich D-52425 Jiilich Germany

We study ΛK~＋ pair production in the interaction of protons of 2.83 GeV kinetic energy with C, Cu,Ag, and Au target nuclei in the framework of the nuclear spectral function approach for incoherent primary proton–nucleon and secondary pion–nucleon production processes, and processes associated with the creation of intermediate Σ~0K~＋ pairs. The approach accounts for the initial proton and final Λ hyperon absorption, final K~＋ meson distortion in nuclei, target nucleon binding, and Fermi motion, as well as nuclear mean-field potential effects on these *** calculate the Λ momentum dependence of the absolute ΛK~＋ yield from the target nuclei considered, in the kinematical conditions of the ANKe experiment, performed at CoSY, within the different scenarios for the Λ-nucleus effective scalar potential. We show that the above observable is appreciably sensitive to this potential in the low-momentum region. Therefore, direct comparison of the results of our calculations with the data from the ANKe-at-CoSY experiment can help to determine the above potential at finite momenta. We also demonstrate that the two-step pion–nucleon production channels dominate in the low-momentum ΛK~＋ production in the chosen kinematics and, therefore, they have to be taken into account in the analysis of these data.

关键词： proton-nucleus reactions medium effects hyperon nuclear potential

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Features of the long-term transformation of the Krasnodar reservoir,near the mouth of the Kuban River,Russia

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Journal of Geographical Sciences 2021年第12期31卷 1895-1904页

作者： PoGoReLoV Anatoly LAGUTA Andrey kiselev evgeny LIPILIN Dmitry Kuban State University Krasnodar 350040Russia Aerogematica LLC Krasnodar 350063Russia Kuban State Agrarian University Named after I.T.Trubilin Krasnodar 350044Russia Tuapse Branch of the Russian State Hydrometeorological University Krasnodar RegionTuapse 352800Russia

The article considers the long-term(1941-2018)transformation of the Krasnodar valley reservoir,the largest in the North *** main functions of the Krasnodar reservoir are irrigation of rice systems and flood protection of land in the Krasnodar reservoir region and the Republic of *** to topographic maps,Landsat satellite images(1974-2018)and field observations(2016-2018),four stages of transformation of the floodplain reservoir are *** selected stages are characterized by both natural causes(the transformation of the filling deltas into the extended deltas,etc.)and man-made causes(runoff diversions in the delta areas,etc.).The key factor of transformation is the formation of deltas of rivers flowing into the *** of the selected stages,against the background of a gradual reduction in the area and volume of the reservoir,is characterized by the peculiarities of the formation of river deltas with the formation of genetically homogeneous sections of delta *** the period of operation of the reservoir,the delta of the main Kuban River moved up to 32.4 km and took away an area of 35.4 km^(2) of the *** the formation of the deltas of the Kuban and Belaya rivers,a bridge was formed on the Krasnodar *** evolution of the delta regions led to the division of the reservoir into two autonomous *** total area of the delta regions was 85.9 km^(2) by 2018,i.e.,21% of the initial area of the *** transformation of the Krasnodar reservoir leads to a decrease in its regulated volume and gradual degradation.

关键词： Krasnodar reservoir sedimentation siltation transformation delta formation Landsat

Recent Advancements in the optimization Capacity Configuration and Coordination operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MoGA)and state of charge(SoC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

ANALYSIS MoDeL To SIMULATe THe CRACKeD PIPe BURIeD IN SoIL

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Acta Mechanica Sinica 1998年第2期14卷 147-156页

作者：庄茁 P.e.o’Donoghue Department of engineering Mechanics Tsinghua University Beijing China 100084 Department of Civil engineering University College Dublin Earlsfort Terrace Dublin 2 Ireland

The finite element method was used to simulate the crack propagation in a pipeline in the presence of soil backfill. Since typical values for soil modulus are known, a spring element can be used to simulate the effects of backfilled soil on crack propagation. This consists of the relationship between the soil property and the stiffness of the spring element, and the effect of backfill depth on the crack propagation in the pipes. By equating crack driving force, G, in the presence of soil, to the dynamic fracture toughness of the pipeline material, a theoretical predictive capability was obtained for the gas transmission and distribution pipelines. Numerical calculations had also been carried out for the cracked pipe with backfill and without backfill. (edited author abstract) 9 Refs.

关键词： fracture mechanics finite element simulation pipeline soil

Generic sensor platform based on electro- responsive molecularly imprinted polymer nanoparticles (e-NanoMIPs)

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Microsystems & Nanoengineering 2020年第1期6卷 266-274页

作者： A.Garcia-Cruz o.S.Ahmad K.Alanazi e.Piletska S.A.Piletsky School of Chemistry University of LeicesterLeicesterUK

The present research describes the design of robust electrochemical sensors based on electro-responsive molecularly imprinted polymer nanoparticles(e-MIPs).The e-MIPs,tagged with a redox probe,combine both recognition and reporting *** system replaces enzyme-mediator pairs used in traditional *** analyte recognition process relies on the generic actuation phenomenon when the polymer conformation of e-MIPs is changing in response to the presence of the template *** analyte concentration is measured using voltammetric *** an exemplification of this technology,electrochemical sensors were developed for the determination of concentrations of trypsin,glucose,paracetamol,C4-homoserine lactone,and *** present technology allows for the possibility of producing generic,inexpensive,and robust disposable sensors for clinical,environmental,and forensic applications.

关键词： functions. methods. polymer