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Three-dimensional magnetization reconstruction from electron optical phase images with physical constraints

science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 122-132页

作者： Boyao Lyu shihua Zhao Yibo Zhang Weiwei Wang Fengshan Zheng Rafal e.dunin-Borkowski Jiadong Zang Haifeng du Anhui Province Key Laboratory of Low-energy Quantum Materials and devices High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230026China department of Physics and Astronomy University of New HampshireDurham 03824USA department of Physics The City College of New YorkNew York 10031USA Physics Program Graduate Center of the City University of New YorkNew York 10016USA department of Chemistry University of New HampshireDurham 03824USA Institutes of Physical science and Information Technology Anhui UniversityHefei 230601China spin-X Institute Center for Electron MicroscopySchool of Physics and OptoelectronicsState Key Laboratory of Luminescent Materials and DevicesGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsSouth China University of TechnologyGuangzhou 511442China ernst Ruska-Centre for Microscopy and spectroscopy with electrons Forschungszentrum JülichJülich 52425Germany

The ability to characterize three-dimensional(3d)magnetization distributions in nanoscale magnetic materials and devices is essential to fully understand their static and dynamic magnetic *** contrast techniques in the transmission electron microscope(TeM),such as electron holography and electron ptychography,can be used to record two-dimensional(2d)projections of the in-plane magnetic induction of 3d nanoscale *** the 3d magnetic induction can in principle be reconstructed from one or more tilt series of such 2d projections,conventional tomographic reconstruction algorithms do not recover the 3d magnetization within a sample ***,we use simulations to describe the basis of an improved model-based algorithm for the tomographic reconstruction of a 3d magnetization distribution from one or more tilt series of electron optical phase images recorded in the *** algorithm allows a wide range of physical constraints,including a priori information about the sample geometry and magnetic parameters,to be *** also makes use of minimization of the micromagnetic energy in the loss *** demonstrate the reconstruction of the 3d magnetization of a localized magnetic soliton—a hopfion ring—and discuss the influence of noise,choice of magnetic constants,maximum tilt angle and number of tilt axes on the *** algorithm can in principle be adapted for other magnetic contrast imaging techniques in the TeM,as well as for other magnetic characterization techniques,such as those based on X-rays or neutrons.

关键词： three-dimensional magnetization vector field tomography differentiable programming electron holography micromagnetism

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Understanding the catalysis of chromium trioxide added magnesium hydride for hydrogen storage and Li ion battery applications

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Journal of Magnesium and Alloys 2024年第3期12卷 1117-1130页

作者： d.Pukazhselvan IhsanÇaha Catarina de Lemos sergey M.Mikhalev Francis Leonard deepak duncan Paul Fagg department of Mechanical engineering TEMA-Centre for Mechanical Technology and AutomationUniversity of AveiroAveiro 3810-193Portugal LAsI-Intelligent systems Associate Laboratory Guimarães 4800-058Portugal Nanostructured Materials Group International Iberian Nanotechnology Laboratory(INL)Avenida Mestre Jose VeigaBraga 4715-330Portugal

This study explores how the chemical interaction between magnesium hydride(MgH_(2))and the additive CrO_(3) influences the hydrogen/lithium storage characteristics of MgH_(2).We have observed that a 5 wt.%CrO_(3) additive reduces the dehydrogenation activation energy of MgH_(2) by 68 kJ/mol and lowers the required dehydrogenation temperature by 80℃.CrO_(3) added MgH_(2) was also tested as an anode in an Li ion battery,and it is possible to deliver over 90%of the total theoretical capacity(2038 mAh/g).evidence for improved reversibility in the battery reaction is found only after the incorporation of additives with MgH_(2).In depth characterization study by X-ray diffraction(XRd)technique provides convincing evidence that the CrO_(3) additive interacts with MgH_(2) and produces Cr/MgO *** free energy analyses confirm the thermodynamic feasibility of conversion from MgH_(2)/CrO_(3) to MgO/Cr,which is well supported by the identification of Cr(0)in the powder by X ray photoelectron spectroscopy(XPs)*** high resolution transmission electron microscopy(HRTeM)and energy dispersive spectroscopy(eds)we found evidence for the presence of 5 nm size Cr nanocrystals on the surface of MgO rock salt *** is also convincing ground to consider that MgO rock salt accommodates Cr in the *** observations support the argument that creation of active metal–metal dissolved rock salt oxide interface may be vital for improving the reactivity of MgH_(2),both for the improved storage of hydrogen and lithium.

关键词： Hydrogen storage Rechargeable batteries Binary hydrides Metal oxides Catalytic mechanism.

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The study of Muscle,Mobility and Aging(sOMMA)

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Journal of sport and Health science 2024年第5期13卷 621-630页

作者： Yujia(susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen steven R.Cummings Giovanna distefano samaneh Farsijani daniel e.Forman Bret H.Goodpaster stephen B.Kritchevsky Theresa Mau Frederico G.s.Toledo Anne B.Newman Nancy W.Glynn department of epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA san Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA department of epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA division of endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(sB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±sd;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOs))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for seniors(CHAMPs)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOs and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(ps not associated with maxOXPHOs or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOs and0.

关键词： Aging exercise Mitochondria

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enhanced asphalt dynamic modulus prediction: A detailed analysis of artificial hummingbird algorithm-optimised boosted trees

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Journal of Road engineering 2024年第2期4卷 224-233页

作者： Ikenna d.Uwanuakwa Ilham Yahya Amir Lyce Ndolo Umba department of Civil engineering Near East UniversityMersin 10Turkey Faculty of sciences University of LubumbashiLubumbashiThe Democratic Republic of Congo

This study introduces and evaluates a novel artificial hummingbird algorithm-optimised boosted tree(AHAboosted)model for predicting the dynamic modulus(e*)of hot mix asphalt *** a substantial dataset from NCHRP Report-547,the model was trained and rigorously *** metrics,specifically RMse,MAe,and R2,were employed to assess the model's predictive accuracy,robustness,and *** benchmarked against well-established models like support vector machines(sVM)and gaussian process regression(GPR),the AHA-boosted model demonstrated enhanced *** achieved R2 values of 0.997 in training and 0.974 in testing,using the traditional Witczak NCHRP 1-40d model *** features such as test temperature,frequency,and asphalt content led to a 1.23%increase in the test R2,signifying an improvement in the model's *** study also explored feature importance and sensitivity through sHAP and permutation importance plots,highlighting binder complex modulus|G*|as a key *** the AHA-boosted model shows promise,a slight decrease in R2 from training to testing indicates a need for further ***,this study confirms the AHA-boosted model as a highly accurate and robust tool for predicting the dynamic modulus of hot mix asphalt concrete,making it a valuable asset for pavement engineering.

关键词： Asphalt dynamic modulus Prediction Artificial hummingbird algorithm Boosted tree

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美国页岩油气地质特征及勘探开发进展

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石油勘探与开发 2024年第4期51卷 807-828页

作者： MCMAHON T P LARsON T e ZHANG T sHUsTeR M 美国德克萨斯大学奥斯汀分校杰克逊地质科学学院经济地质局奥斯汀78758-4445德克萨斯州美国

基于美国页岩油气勘探开发历程的回顾,对主要页岩盆地的地质演化、主要页岩层系的油气地质特征及勘探开发进展进行系统梳理和总结。美国重要页岩盆地的富烃页岩主要发育于6个地质时期:中奥陶世、中—晚泥盆世、早石炭世(中—晚密西西比... 详细信息

基于美国页岩油气勘探开发历程的回顾,对主要页岩盆地的地质演化、主要页岩层系的油气地质特征及勘探开发进展进行系统梳理和总结。美国重要页岩盆地的富烃页岩主要发育于6个地质时期:中奥陶世、中—晚泥盆世、早石炭世(中—晚密西西比世)、早二叠世、晚侏罗世和晚白垩世(塞诺曼期—土伦期),构造沉积环境主要包括克拉通内盆地、前陆盆地和被动大陆边缘盆地。古生界富烃页岩主要分布于以下6个盆地:阿巴拉契亚盆地(尤蒂卡页岩和马塞勒斯页岩)、阿纳达科盆地(伍德福德页岩)、威利斯顿盆地(巴肯页岩)、阿卡马盆地(费耶特维尔页岩)、沃思堡盆地(巴内特页岩)和二叠盆地(狼营组和斯帕瑞组/骨泉组页岩)。中生界富烃页岩主要发育在西墨西哥湾盆地(海恩斯维尔组和鹰滩组)和落基山盆地群(以丹佛和粉河盆地的尼尔布拉勒组页岩为主)。通过对各页岩区带的详细分析发现,页岩的岩相和矿物成分存在差异,“页岩储层”并非只是页岩,很多情况下页岩油气还产自粉砂岩和碳酸盐岩等多种岩石类型。美国的页岩油气资源丰富,页岩油地质资源量超过0.246×1012 t,页岩气地质资源量超过290×1012 m3。在开启“页岩革命”的水平井水力压裂技术出现之前,美国经过了长达20年的勘探开发实践和理论技术积累。自2007年至2023年,美国页岩油气产量从约11.2×104t/d油当量增加到超过300.0×104t/d油当量,2017年页岩油气产量超过了常规油气,2023年在油气总产量中的占比增加到60%以上。页岩油气的开发主要得益于钻完井技术的改进,“立体开发”的攻关,以及重复压裂、提高原油采收率和“U”形井等技术的应用。基于美国丰富的页岩资源基础和技术的不断进步,页岩油气的产量将继续为全美的油气生产做出更大贡献。

关键词：美国页岩油页岩气页岩储层非常规储层油气产量资源评价

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Photosynthetic response to a winter heatwave in leading and trailing edge populations of the intertidal red alga Corallina offi-cinalis(Rhodophyta)

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Acta Oceanologica sinica 2024年第7期43卷 70-77页

作者： Regina Kolzenburg Federica Ragazzola Laura Tamburello Katy R.Nicastro Christopher d.McQuaid Gerardo I.Zardi UmeåMarine sciences Centre UmeåUniversity90571 NorrbynSweden University of Portsmouth Institute of Marine SciencePortsmouth PO49LYUK stazione Zoologica Anton dohrn Genova Marine CenterGenova 16126Italy stazione Zoologica Anton dohrn Sicily Marine CenterPalermo 90149Italy department of Zoology and entomology Rhodes UniversityMakhanda(Grahamstown)6139South Africa Centre of Marine sciences University of AlgarveFaro 8005-139Portugal Laboratoire d’Océanologie et de Géosciences Universitéde LilleLille 59000France Universitéde Caen Normandie Laboratoire de Biologie des Organismes et des Ecosystèmes AquatiquesCaen 14032France

Marine heatwaves(MHWs)caused by anthropogenic climate change are becoming a key driver of change at the ecosystem *** conditions experienced by marine organisms across their distribution,particularly towards the equator,are likely to approach their physiological limits,resulting in extensive mortality and subsequent changes at the population *** at the margins of their species’distribution are thought to be more sensitive to climate-induced environmental pressures than central populations,but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is *** a laboratory simulation study,we tested whether two leading(Iceland)and two trailing(spain)peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency(Fv/Fm)resilience to current and future winter MHWs *** study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of ***,which exhibited stable photosynthetic efficiency throughout the *** edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs *** and equatorward populations did not produce significantly different results,with winter MHWs having no negative affect on Fv/Fm of either ***,we found no long-term regional or population-level influence of a winter MHWs on this species’photosynthetic ***,we found no statistically significant difference in thermal stress responses between leading and trailing ***,*** showed a trend towards higher stress responses in southern than northern *** responses rest on a variety of local population traits,they are difficult to predict based solely on thermal pressures.

关键词： marginal population coralline algae climate change ecophysiology photophysiology macroalgae Fv/Fm

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THe eFFeCT OF dUAL-PHAse-LAG MOdeL ON ReFLeCTION OF THeRMOeLAsTIC WAVes IN A sOLId HALF sPACe WITH VARIABLe MATeRIAL PROPeRTIes

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Acta Mechanica solida sinica 2013年第6期26卷 659-670页

作者： A.M.Zenkour d.s.Mashat A.e.Abouelregal department of Mathematics Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia department of Mathematics Faculty of ScienceKafrelsheikh UniversityKafr El-Sheikh 33516Egypt department of Mathematics Faculty of ScienceMansoura UniversityMansoura 35516Egypt department of Mathematics College of Science and ArtsUniversity of AljoufEl-QurayatSaudi Arabia

The present article represents an analysis of reflection of P-wave and sV-wave on the boundary of an isotropic and homogeneous generalized thermoelastic half-space when the boundary is stress-free as well as isothermal. The modulus of elasticity is taken as a linear function of reference temperature. The basic governing equations are applied under four theories of the generalized thermoelasticity： Lord-shulman （L-s） theory with one relaxation time, Green-Naghdi （G-N） theory without energy dissipation and Tzou theory with dual-phase-lag （dPL）, as well as the coupled thermoelasticity （CTe） theory. It is shown that there exist three plane waves, namely, a thermal wave, a P-wave and an sV-wave. The reflection from an isothermal stress-free surface is studied to obtain the reflection amplitude ratios of the reflected waves for the incidence of P- and sV-waves. The amplitude ratios variations with the angle of incident are shown graphically. Also the effects of reference temperature of the modulus of elasticity and dual-phase lags on the reflection amplitude ratios are discussed numerically.

关键词： generalized thermoelasticity dual-phase-lag variable material properties reflection waves

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Taxonomy,phylogeny,molecular dating and ancestral state reconstruction of Xylariomycetidae(sordariomycetes)

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Fungal diversity 2022年第1期112卷 1-88页

作者： milan C.samarakoon Kevin d.Hyde sajeewa s.N.Maharachchikumbura Marc stadler e.B.Gareth Jones Itthayakorn Promputtha Nakarin suwannarach erio Camporesi Timur s.Bulgakov Jian-Kui Liu school of Life science and Technology Center for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Research Center in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Institute of Microbiology Technische Universität BraunschweigSpielmannstraße 738106 BrunswickGermany department of Botany and Microbiology College of ScienceKing Saud UniversityP.O Box 2455Riyadh 11451Kingdom of Saudi Arabia Research Center of Microbial diversity and sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand A.M.B.Gruppo Micologico Forlivese"Antonio Cicognani"Via Roma 18ForliItaly department of Plant Protection Federal Research Centre the Subtropical Scientific Centre of the Russian Academy of SciencesYana Fabritsiusa Street 2/28SochiKrasnodar RegionRussia 354002

Xylariomycetidae(Ascomycota)is a highly diversified group with variable stromatic *** research focused on inconspicuous stromatic xylarialean taxa from China,Italy,Russia,Thailand and the United *** morpho-logical descriptions,illustrations and combined ITs-LsU-rpb2-tub2-tef1 phylogenies revealed 39 taxa from our collections belonging to Amphisphaeriales and Xylariales.A new family(Appendicosporaceae),five new genera(Magnostiolata,Mela-nostictus,Neoamphisphaeria,Nigropunctata and Paravamsapriya),27 new species(Acrocordiella photiniicola,Allocryp-tovalsa sichuanensis,Amphisphaeria parvispora,Anthostomella lamiacearum,Apiospora guiyangensis,***,Biscogniauxia magna,eutypa camelliae,Helicogermslita clypeata,Hypocopra zeae,Magnostiolata mucida,Melanostictus longiostiolatus,***,Nemania longipedicellata,***,***,***,Neoamphispha-eria hyalinospora,Neoanthostomella bambusicola,Nigropunctata bambusicola,***,***,Occul-titheca rosae,Paravamsapriya ostiolata,Peroneutypa leucaenae,seiridium italicum and Vamsapriya mucosa)and seven new host/geographical records are introduced and *** time estimates indicate that delonicicolales diverged from Amphisphaeriales+Xylariales at 161(123-197)*** and Xylariales diverged 154(117-190)MYA with a crown age of 127(92-165)MYA and 147(111-184)MYA,***(Amphisphaeriales)has a stem age of 89(65-117)*** character state reconstruction indicates that astromatic,clypeate ascomata with aseptate,hyaline ascospores that lack germ slits may probably be ancestral Xylariomycetidae having plant-fungal endo-phytic *** Amphisphaeriales remained mostly astromatic with common septate,hyaline *** variations may have developed mostly during the Cretaceous *** ascospores are common in Xylariales,but they first appeared in Amphisphaeriaceae,Melogrammataceae and sp

关键词： 33 new taxa Amphisphaeriales Appendicosporaceae evolution stromata Xylariales

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satellite-enabled enviromics to enhance crop improvement

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Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee Hickey Cibele H.Amaral Lucas L.Peixoto Gustavo e.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA environmental data science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LidAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling

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Journal of environmental sciences 2024年第3期137卷 443-454页

作者： Zhihua Ren Xiaoxi Yang Tingting Ku Qian s.Liu Jiefeng Liang Qunfang Zhou Francesco Faiola Guibin Jiang state Key Laboratory of environmental Chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and environment University of Chinese Academy of SciencesBeijing 100049China College of environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China College of sino-danish University of Chinese Academy of SciencesBeijing 100049China

Investigating the development toxicity of perfuorinated iodine alkanes(PFIs)is critical,given their estrogenic effects through binding with estrogen receptors(eRs).In the present study,two PFIs,including dodecafuoro-1,6-diiodohexane(PFHx dI)and tridecafuorohexyl iodide(PFHx I),with binding preference to eRαand eRβ,respectively,were selected to evaluate their effects on proliferation and differentiation of the mouse embryonic stem cells(m esCs).The results revealed that,similar to e_(2),50μmol/L PFHx dI accelerated the cell proliferation of the m *** PFI stimulation at the exposure concentrations of 2–50μmol/L promoted the differentiation of the m esCs as characterized by the upregulation of differentiation-related biomarkers(i.e.,Otx2 and dnmt3β)and downregulation of pluripotency genes(i.e.,Oct4,Nanog,sox2,Prdm14 and Rex1).Comparatively,PFHx dI exhibited higher induction effect on the differentiation of the m esCs than did PFHx *** tests on eR signaling indicated that both PFI compounds induced exposure concentration-dependent expressions of eR signaling-related biomarkers(i.e.,eRα,eRβand Caveolin-1)in the m esCs,and the downstream eR responsive genes(i.e.,c-fos,c-myc and c-jun)well responded to PFHx I *** role of eR in PFI-induced effects on the m esCs was further validated by the antagonistic experiments using an eR inhibitor(ICI).The findings demonstrated that PFIs triggered eR signaling,and perturbed the differentiation program of the m esCs,causing the potential health risk during early stage of development.

关键词： Perfuorinated iodine alkanes(PFIs) embryonic stem cells(esCs) developmental toxicity Cell differentiation estrogen receptor-related signaling

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