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Human papillomavirus 16 e6 is associated with the nuclear matrix of esophageal carcinoma cells

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World Journal of Gastroenterology 2001年第6期7卷 788-791页

作者： S.B.cheng e.c.chew Department of Physiology and The chinese University of Hong Kong ShatinNT.Hong KongChina Department of Anatomy The Chinese University of Hong KongShatinNT.Hong KongChina

AIM: To explore the etiologic role of HPV infection in esophageal carcinoma, and the association of HPV-16 e6with the nuclear metrix of carcinoma cells.MeTHODS: Two esophageal carcinoma cell lines, ec/cUHK1 and ec/cUHK2, were tested for HPV-16 e6subgenetic fragment by polymerase chain reaction amplification of virus DNA associated nuclear matrix. RT-PcR and immunocytochemistry were also used to visualizethe expression of e6 subgene in the cells.ReSULTS: The HPV-16 e6 subgenetic fragment wes found to be present in nuclear metrix-associeted DNA, e6oncoprotein localized in the nucleus where it is tightly associated with nuclear matrix after sequential extraction in ec/cUHK2 cells. It was not detected, however, in ec/cUHK1 cells.cONcLUSION: The interaction between HPV-16 e6 and nuclear matrix may contribute to the virus induced carcinogenesis in esophageal carcinoma.

关键词： esophageal neoplasms/virology esophaheal neoplasms/pathology Tumor cells, cultured Papillomavirus, human Nuclear matrix

Nucleophasmin／B23是肝再生和肝细胞增生的标记物

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Nucleophasmin／B23是肝再生和肝细胞增生的标记物

Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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作者：云径平 e c chew c T Liew 中山医科大学肿瘤防治中心病理科香港中文大学解剖系香港中文大学病理系

＜正＞目的用Nucleophasmin／B23的单克隆抗体观察B23在鼠肝大部分切除后再生过程中增殖肝细胞表达的动态变化,从而探讨B23可以作为肝再生和肝细胞干部管理的标记物。材料与方法Wistar大白鼠肝大部切除术后第1,2,3,4和7天收取再生肝组织...

＜正＞目的用Nucleophasmin／B23的单克隆抗体观察B23在鼠肝大部分切除后再生过程中增殖肝细胞表达的动态变化,从而探讨B23可以作为肝再生和肝细胞干部管理的标记物。材料与方法Wistar大白鼠肝大部切除术后第1,2,3,4和7天收取再生肝组织,采用1323的单克隆抗体和Westem Blot及免疫组化方法检测B23在不同时间再生肝组织的表达,并与PcNA的表达相比较。结果 B23在静止期肝细胞中几乎检测不到,但在

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.M.Saporetti L.c.Oliveira e.Pereira Department of computational and Applied Mechanics Federal University of Juiz de Fora Department of computational Modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. Machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning evolutionary algorithms Geology

Review on laser directed energy deposited aluminum alloys

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International Journal of extreme Manufacturing 2024年第2期6卷 84-131页

作者： Tian-Shu Liu Peng chen Feng Qiu Hong-Yu Yang Nicholas Tan Yew Jin Youxiang chew Di Wang Ruidi Li Qi-chuan Jiang chaolin Tan Singapore Institute of Manufacturing Technology(SIMTech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore State Key Laboratory of Automotive Simulation and control Jilin UniversityChangchun 130025People’s Republic of China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025People’s Republic of China School of Mechanical&Automotive engineering South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Lightweight aluminum(Al)alloys have been widely used in frontier fields like aerospace and automotive industries,which attracts great interest in additive manufacturing(AM)to process high-value Al *** a mainstream AM technique,laser-directed energy deposition(LDeD)shows good scalability to meet the requirements for large-format component manufacturing and ***,LDeD Al alloys are highly challenging due to their inherent poor printability(*** laser absorption,high oxidation sensitivity and cracking tendency).To further promote the development of LDeD high-performance Al alloys,this review offers a deep understanding of the challenges and strategies to improve printability in LDeD Al *** porosity,cracking,distortion,inclusions,element evaporation and resultant inferior mechanical properties(worse than laser powder bed fusion)are the key challenges in LDeD Al *** parameter optimizations,in-situ alloy design,reinforcing particle addition and field assistance are the efficient approaches to improving the printability and performance of LDeD Al *** underlying correlations between processes,alloy innovation,characteristic microstructures,and achievable performances in LDeD Al alloys are *** benchmark mechanical properties and primary strengthening mechanism of LDeD Al alloys are *** review aims to provide a critical and in-depth evaluation of current progress in LDeD Al *** opportunities and perspectives in LDeD high-performance Al alloys are also outlined.

关键词： additive manufacturing laser directed energy deposition(LDeD) aluminum alloys printability aluminum matrix composite auxiliary fields mechanical properties

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effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of coal Science & Technology 2024年第3期11卷 86-101页

作者： F.Animah c.Keles W.R.Reed e.Sarver Department of Mining and Minerals engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of Occupational Safety and Health(NIOSH) PittsburghPAUSA

control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of Occupational Safety and Health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(cAcs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter cAc on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and cAc appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SeM–eDX Scrubber canopy air curtain Silica

Investigations of nuclear chirality at iThemba LABS

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Frontiers of physics 2024年第2期19卷 7-38页

作者： R.A.Bark e.A.Lawrie c.Liu S.Y.Wang iThemba Laboratory for Accelerator Based Sciences National Research FoundationP.O.Box 722Somerset-West 7129South Africa Department of Physics University of the Western CapePrivate Bag X177535BellvilleSouth Africa Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial environment Institute of Space SciencesShandong UniversityWeihai 264209China

Progress in the studies of chirality in atomic nuclei at iThemba LABS is *** regions of chirality,around mass 80 and 190 have been discovered using the AFRODITe array,specifically in the nuclei^(74)As,^(78,80,82)Br,^(81)Kr,and^(193,194,198)*** phenomena have been observed,including multiple chiral bands in the same nucleus,the coexistence of octupole correlations and nuclear chirality,and the coexistence of pseudo spin and nuclear *** best example of chiral degeneracy to date was found in ^(194)*** level scheme of ^(106)Ag has been revisited and interpreted in terms of two-and four-quasiparticle *** using the particle-rotor model have shown that the fingerprints of chirality in the two-quasiparticle system only can occur in an idealised model *** systems with a higher number of quasiparticles,the calculations showed that nuclear chirality can persist.

关键词： chirality high-spin states particle-rotor model

All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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chinese Physics B 2024年第8期33卷 238-246页

作者： c.S.Gomes F.e.Jorge A.canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-ccSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe ccSD(T)method atomic and molecular properties

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Slope stability of reclaimed coal mines through a new water filling index

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Journal of Rock Mechanics and Geotechnical engineering 2024年第3期16卷 828-839页

作者： Antonios Mikroutsikos Alexandros I.Theocharis Nikolaos c.Koukouzas Ioannis e.Zevgolis chemical Process&energy Resources Institute Centre for Research&Technology HellasAthensGreece School of Mining and Metallurgical engineering National Technical University of AthensAthensGreece

A common reclamation practice for closed coal surface mines is filling them with water to form pit *** creation and sustainability of these lakes are significantly affected by the stability of the corresponding *** present study provides a general framework for analyzing the water filling’s effect on slope stability based on a new water filling index,which can indirectly consider the factors affecting the process and efficiently quantify the filling speed’s *** assumptions of the proposed approach are thoroughly discussed,and the range of the water filling index is ***,the safety factor is calculated using the finite element method with the shear strength reduction technique during the filling process for various conditions(soil properties,slope geometry,hydraulic conditions,and water filling speed).Results are presented as normalized stability charts for practical *** the water filling,the stability gradually decreases until the reservoir reaches a critical level of 10%e40%of the total height;it then increases to even more stable conditions than the initial ***,the present analysis allows for the preliminary stability evaluation of a coal mine during the formation of a pit lake and the appropriate quantification of the water filling’s effect.

关键词： Post-coal era Open-pit flooding Stability charts critical level

comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

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ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.eggleton cody J.Salzmann Joseph e.Kaiser Shannon c.F.Smith Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish commission Virginia Institute of Marine Science

Background Since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. Fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P e post-carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp Silver carp Aquatic nuisance species Fish assemblage Oxbow lake Large river