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EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid

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Translational Neurodegeneration 2022年第1期11卷 835-844页

作者： Hannes Devos Kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.martin Jonathan D.mahnken William m.Brooks Jeffrey m.Burns Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingUniversity of Kansas Medical CenterKansas CityKS 66160USA Department of Neurology University of Kansas Medical CenterKansas CityKS 66160USA Hoglund Biomedical Imaging Center University of Kansas Medical CenterKansas CityKS 66160USA Department of Population Health University of Kansas Medical CenterKansas CityKS 66160USA Department of Biostatistics and Data Science University of Kansas Medical CenterKansas CityKS 66160USA University of Kansas Alzheimer’s Disease Center University of Kansas Medical CenterKansas CityKS 66160USA.

Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, montreal Cognitive Assessment [moCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and mOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal ol

关键词： Event-related potentials Electro-encephalography Working memory older adults Preclinical Beta-amyloid

P3: An installation for high-energy density plasma physics and ultra-high intensity laserematter interaction at ELI-Beamlines

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matter and Radiation at Extremes 2017年第4期2卷 149-176页

作者： S.Weber S.Bechet S.Borneis L.Brabec m.Bucka E.Chacon-Golcher m.Ciappina m.Demarco A.Fajstavr K.Falk E.-R.Garcia J.Grosz Y.-J.Gu J.-C.Hernandez m.Holec P.Janecka m.Jantac m.Jirka H.Kadlecova D.Khikhlukha O.Klimo G.Korn D.Kramer D.Kumar T.Lastovicka P.Lutoslawski L.morejon V.olsovcova m.Rajdl O.Renner B.Rus S.Singh m.Smid m.Sokol R.Versaci R.Vrana m.Vranic J.Vyskocil A.Wolf Q.Yu ELI-Beamlines Institute of PhysicsAcademy of Sciences of the Czech Republic18221 PragueCzech Republic

ELI-Beamlines(ELI-BL),one of the three pillars of the Extreme Light Infrastructure endeavour,will be in a unique position to perform research in high-energy-density-physics(HEDP),plasma physics and ultra-high intensity(UHI)ð>10^(22) W=cm^(2)) lasereplasma *** the need for HED laboratory physics was identified and the P3(plasma physics platform)installation under construction in ELI-BL will be an *** ELI-BL 10 PW laser makes possible fundamental research topics from high-field physics to new extreme states of matter such as radiation-dominated ones,high-pressure quantum ones,warm dense matter(WDm)and ultra-relativistic *** is of fundamental importance for research in the field of laboratory astrophysics and inertial confinement fusion(ICF).Reaching such extreme states of matter now and in the future will depend on the use of plasma optics for amplifying and focusing laser *** article will present the relevant technological infrastructure being built in ELI-BL for HEDP and UHI,and gives a brief overview of some research under way in the field of UHI,laboratory astrophysics,ICF,WDm,and plasma optics.

关键词： High-energy-density-physics Ultra-high-intensity Warm dense matter Laboratory astrophysics High repetition rate lasers Plasma optics Inertial confinement fusion Lasereplasma interaction Relativistic plasmas

子宫切除术手术路径的改变:对所有功能性子宫出血尝试性应用一种经阴道途径方法的结局

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 35-35页

作者： olá h K.S. Khalil m. 党慧敏 Obsterics and Gynaecology Warwick Hospital Lakin RoadWarwick CV34 6BW United Kingdom

Objective: To assess the effectiveness of a policy of performing a vaginal hysterectomy for as many cases of dysfunctional uterine bleeding without uterine prolapse as possible between 1997 and 2003. Study design: The study was prospective, with retrospective analysis of data. Setting: Warwick Hospital. Population: Eighty-seven women in a district hospital serving a population of 270,000 in South Warwick shire. methods: During 1997 and 2003, an effort was made to perform as many hysterectomies vaginally as possible, with oophorectomy where necessary, in women with dysfunctional uterine bleeding in the absence of prolapse. The trends of the three different operations, total abdominal hysterectomy, sub-total abdominal hysterectomy and vaginal hysterectomy over the 7- year period were analysed. main outcome measures: The ability to undertake surgery successfully, complications rates, length of hospital stay and changes in surgical practice. Results: Over this 7- year period, it has proved possible to change the emphasis from abdominal to vaginal hysterectomy for dysfunctional uterine bleeding. In 1997, the most common operation for dysfunctional uterine bleeding (72.7% ) was subtotal hysterectomy ± bilateral salpingo-oophorectomy, followed by (27.3% ) total abdominal hysterectomy ± bilateral salpingo-oophorectomy. No cases were undertaken vaginally. By 2003, however, the trend had completely reversed, with the only procedure undertaken being vaginal hysterectomy ± bilateral salpingooophorectomy. There is no evidence that such an approach increases the complication rate, and the recovery rate from surgery is improved with a tendency towards earlier discharge in the vaginal surgery group. Conclusion: The vaginal approach is possible for an average gynaecologist working in a district general hospital, with no additional complications and an improved recovery rate for patients.

关键词：经阴道子宫切除术功能性子宫出血阴道途径输卵管卵巢切除术手术路径经腹子宫全切术经腹全子宫切除术子宫次全切术

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间尼索地平对鼠类的抗炎及中枢作用

河北医学院学报 1988年第3期 113-116页

作者：任雷鸣李蕴山傅绍萱河北医学院河北医学院药理学教研室

小鼠间尼索地平灌胃34mg/kg有明显的抗炎作用,51mE/kg抑制小鼠电激怒反应,70mg/kg表现镇痛效应,上述作用与间尼索地平的剂量显著相关（P0.05）。提示间尼索地平的抗炎及中枢作用似与其降压作用无关。间尼索地平LD50灌胃剂量为226±30mE... 详细信息

小鼠间尼索地平灌胃34mg/kg有明显的抗炎作用,51mE/kg抑制小鼠电激怒反应,70mg/kg表现镇痛效应,上述作用与间尼索地平的剂量显著相关（Pmg/kg灌胃,对小鼠有显著的降低血压作用（P0.05）。提示间尼索地平的抗炎及中枢作用似与其降压作用无关。间尼索地平LD50灌胃剂量为226±30mE/kg（95％可信限）。

关键词：钙通道阻滞剂药效学中枢神经系统药物作用毒性大鼠小鼠

HPLC法同时测定男宝胶囊中淫羊藿苷、丹皮酚、补骨脂素和异补骨脂素的含量

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宁夏医学杂志 2018年第4期40卷 352-354页

作者：张芦燕韩长锦王荣齐喜红贺凯宁夏药品检验所宁夏银川750004

目的采用HPLC法建立了男宝胶囊中淫羊藿苷、丹皮酚、补骨脂素和异补骨脂素含量的测定方法。方法采用Phenomenex luna C_(18)(4.6 mm×250 mm,5μm)色谱柱、乙腈-水梯度洗脱程序,淫羊藿苷和丹皮酚的检测波长为270 nm,补骨脂素和异补骨脂... 详细信息

目的采用HPLC法建立了男宝胶囊中淫羊藿苷、丹皮酚、补骨脂素和异补骨脂素含量的测定方法。方法采用Phenomenex luna C_(18)(4.6 mm×250 mm,5μm)色谱柱、乙腈-水梯度洗脱程序,淫羊藿苷和丹皮酚的检测波长为270 nm,补骨脂素和异补骨脂素的检测波长为246 nm,流速为1.0 mL/min。结果淫羊藿苷、丹皮酚、补骨脂素和异补骨脂素的浓度范围分别为6.65~53.18μg/mL、7.06~56.48μg/mL、3.87~30.92μg/mL和3.98~31.81μg/mL,相关系数均为0.999,平均回收率(n=9)分别为102.5%、102.7%、101.9%和100.2%。结论此方法准确、可靠、灵敏度高,适用于男宝胶囊的质量控制。

关键词：男宝胶囊淫羊藿苷丹皮酚补骨脂素异补骨脂素

Phytochemical constituents,antioxidant and antibacterial activities of methanolic extract of Ardisia elliptica

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 569-576页

作者： Nazeh m.Al-Abd Zurainee mohamed Nor marzida mansor Asdren Zajmi mohd Shahnaz Hasan Fadzly Azhar mustafa Kassim Department of Parasitology Faculty of MedicineUniversity of Malaya Faculty of medicine and Health Sciences University of Aden Department of Anesthesiology Faculty of MedicineUniversity of Malaya Department of Diagnostic and Allied Health Sciences Faculty of Health and Life SciencesManagement and Science University Department of Chemistry Faculty of ScienceUniversity of Malaya

Objective:To investigate the antioxidant,antibacterial,and chemical ingredients of Ardisia elliptica(***) methanolic ***:The plant was extracted using *** and antioxidant activities were ***:The results showed that both fruit and leaf extract of *** have significant antibacterial activities against Gram-positive and Gram-negative *** extracts showed higher content of phenolic(71 ± 0.03 GAE/mg extract dry weight),in comparison to the leaf extracts(37 ± 0.05 GAE/mg extract dry weight).Flavonoid content,and Fe2+chelating activity of fruit extracts were higher than leaf *** percentage radical inhibition of fruit extract is found to be higher(70%) than that of leaf extract(60%).LCmS results indicated that the major compounds in the fruit extract were Gingerol,Aspidin,Kampherol,and Stercuresin,while the leaf extract contained Gingerol,Aspidin,Triangularin,and Salicyl acyl ***,the results of GCmS indicated that fruit extract contained these major compounds:Vitamin E Tocopherol,5-hepylresornicol,2-Nonylmalonic acid,5-pentadecylresornicol,and ***,leaf extract of *** contained these major compounds:Alpha Amyrenol,4,4,6,6a,6b,8,8a,9,10,11,12,12 a,14,14 a,14 b octadehydro-2H-picen-3-one,and Lonasterol,4-t-Butyl-2-[4-nitrophenyl] ***:The results provide evidence that fruit and leaf of *** extracts might indeed be used as a potential source of effective natural antimicrobial and antioxidant agents in pharmaceutical and food industries.

关键词： Ardisia elliptica Antioxidant capacity Total phenol content Gas chromatography/mass spectrometry Liquid chromatography/mass spectrometry

Improvement in Hurst exponent estimation and its application to financial markets

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Financial Innovation 2022年第1期8卷 2317-2337页

作者： A.Gómez-Águila J.E.Trinidad-Segovia m.A.Sánchez-Granero Department of mathematics(AGA and mASG)and Department of Economics and Business(JETS) University of Almería04120 AlmeríaSpain

This research aims to improve the efficiency in estimating the Hurst exponent in financial time series.A new procedure is developed based on equality in distribution and is applicable to the estimation methods of the Hurst *** show how to use this new procedure with three of the most popular algorithms(generalized Hurst exponet,total triangles area,and fractal dimension)in the *** show that this new approach improves the accuracy of the original methods,mainly for longer *** second contribution of this study is that we show how to use this methodology to test whether the series is self-similar,constructing a confidence interval for the Hurst exponent for which the series satisfies this ***,we present an empirical application of this new procedure to stocks of the S&P500 *** to previous contributions,we consider this to be relevant to financial literature,as it helps to avoid inappropriate interpretations of market efficiency that can lead to erroneous decisions not only by market participants but also by policymakers.

关键词： Hurst exponent Long memory Financial market TA algorithm GHE algorithm FD algortihms

New Sesquiterpene Glycosides from Culture Hairy Roots of Catharanthus roseus

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Chinese Journal of Chemistry 2007年第11期25卷 1695-1699页

作者： CHUNG, ILL-min ALl, mohd CHUN, Se-Chul LEE, Sun-Joo SAN, Ka-Yiu CHRISTIE, A. m. Peebles AHmAD, Ateeque Department of Applied Life Science Konkuk University Seoul 143-701 South Korea Faculty of Pharmacy Hamdard University New Delhi 110062 India Department of Bioengineering Rice University Houston Texas 77005 USA

Two new compounds cadin-2-en-1β-ol-1β-D-glucuronopyranoside （1）, guaia-l,7-dien-3β,13-diol-13α-D- glucofuranoside （2） along with three known compounds have been isolated from the culture hairy roots of Catharanthus roseus. Their structures have been elucidated with the help of 500 mHz NmR using 1D and 2D spectral methods： viz： ^1H and ^13C NmR, ^1H-^1H COSY, ^1H-^13C HETCOR and DEPT aided by ELmS, FAB-mS, HR-FABmS and IR spectroscopy.

关键词： Catharanthus roseus Apocynaceae culture hairy root new constituent

Observation of Edge Plasma Fluctuations with a Fast Camera in Heliotron J

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Plasma Science and Technology 2013年第3期15卷 213-216页

作者：臧临阁 m.TAKEUCHI N.NISHINO T.mIZUUCHI S.OHSHImA K.KASAJImA m.SHA K.mUKAI H.Y.LEE K.NAGASAKI H.OKADA T.mINAmI S.KOBAYASHI S.YAmAmOTO K.HANATANI Y.NAKAmURA S.KONOSHImA F.SANO Graduate School of Energy Science Kyoto University Naka Fusion Institute Japanese Atomic Energy Agency Graduate School of Engineering Hiroshima University Institute of Advanced Energy Kyoto University

A fast video camera is verified to be a powerful t0ol for observation of filaments/blobs near the last closed flux surface （LCFS）. In order to extract the fluctuation component from the raw data of the fast camera, a pre-processing technique, sliding time window averaging subtraction （STWAS） has been developed to remove the background of slowly varying emission from the bulk plasma. By using this pre-processing technique, the fast camera data are analyzed. A method to identify the filaments in the pre-processed image is also discussed.

关键词： edge plasma fluctuation fast camera Heliotron J