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Ibuprofen-Induced Toxic Epidermal Necrolysis:A Case Report

International Journal of Dermatology and Venereology 2024年第2期7卷 108-110页

作者： Nevin Kannappilly Mohamed Z.peediyakkal Mohamad Y.Khatib Dore C.Ananthegowda Moustafa S.Elshafei Hani El Zeer Karimulla S.Shaik Moayad M.AlFayoumi dyaneshwar p.mutkule Ahmed A.Soliman Abdulqadir J.Nashwan Critical Care Department Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epidermal necrolysis(TEN)is a medical emergency that most commonly occurs as an adverse effect of certain ***,we describe a case of a 41-year-old man with no comorbid illness who developed *** presentation:The patient had been prescribed ibuprofen for myalgia and developed skin lesions after the single *** lesions were erythematous papules and macules distributed all over the body after ibuprofen *** was diagnosed based on the patient’s clinical presentation and laboratory *** was treated with intravenous dexamethasone,intravenous immunoglobulin,and *** dressing changes and skin care was done with saline,chlorhexidine,and liquid *** patient was intubated and tracheostomized,and he gradually improved and ***,he developed septicemia in the intensive care unit and was treated ***:The management of TEN includes cessation of the causative cause,multidisciplinary intensive care unit(ICU)care,prevention and early detection of sepsis,fluid and electrolyte balance,adequate analgesia and temperature control,proper organ support,aggressive nutritional management,and good psychological *** pharmacological therapy for TEN includes corticosteroids,intravenous immunoglobulin,and *** key elements of management are aseptic care and proper dressing of the ***:TEN is associated with high mortality if not managed in a systemic and protocolized way.

关键词： ibuprofen toxic epidermal necrolysis erythema drug-induced erythema

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