检索结果-南通市图书馆

Synthesis, characterization, spectroscopic and crystallographic investigation of Cobalt(Ⅲ) schiff base complex with two perpendicular diamine coumarin ligands

在线全文

学校读者我要写书评

暂无评论

Open Journal of Inorganic Chemistry 2012年第2期2卷 33-39页

作者： Imen Ketata Lassad Mechi Taicir Ben Ayed michal dusek Vaclav Petricek Rached Ben Hassen Unite de Recherche de Chimie des Materiaux et de l’Environnement Universite de Tunis El ManarTunisTunisia INSAT Universite de CarthageTunisTunisia Institute of Physics Academy of Sciences of the Czech RepublicPrahaCzech Republic

New transition metal complex of Cobalt(III) of the ligand (E)-3-(1-(2-aminoethylimino)ethyl)-4-hydroxy-2H-chromen-2-one, derived from condensation of ethylene diamine with 3-acetyl-4-hydroxy-chromene-2-one have been synthesized by reaction of cobalt(III) salt and the ligand, in amounts equal to metal-ligand molar ratio of 1:2. Both the Schiff base and the complex of Co(III) were characterized by IR, UV-Vis, 1H NMR- and 13C NMR-spectroscopy techniques. Single crystal X-ray diffraction investigation, at low temperature T = 120 K, shows that the cobalt complex is triclinic P-1, a = 10.426(5) ?, b = 11.3234(2) ?, c = 15.729(5) ?, α(°) = 70.102(4), β(°) = 86.049(4), γ(°) = 82.497(4), Z = 2, and its structure consists of isolated [Co(III)(C13H13N2O3)2]+ complex cations with distorted octahedral geometry, ClO-4 counter anions, acetone solvent and water molecules. The crystal cohesion is stabilized by hydrogen bonds between ligands and water molecules, and ionic interactions between complex cations and counter anions.

关键词： Hydroxycoumarin Derivative Co^(Ⅲ) Complex ^(1)H NMR UV-Visible Single Crystal X-Ray Diffraction

Clinical outcomes of radiofrequency catheter ablation of atrial fibrillation in octogenarians lO-year experience of a one high-volume center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第9期14卷 575-581页

作者： Alan Bulava Jiri Hanis Ladislav dusek Department of Cardiology Ceske Budejovice Hospital Ceske Budejovice Czech Republic Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic Faculty of Health and Social Sciences University of South Bohemia in Ceske Budejovice Czech Republic Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic

Background Prevalence of atrial fibrillation （AF） increases with age. Radiofrequency catheter ablation （RFCA） is an establishedtreatment option superior to antiarrhythmics （AAs）. In this study, we investigated safety and efficacy of RFCA of AF in *** From our database, we extracted procedural and follow-up data for patients 〉 80 years with symptomatic AF undergoing RFCAand compared this population to RFCA patients 〈 50 years. All patients underwent pulmonary vein isolation （PVI） supplemented by linearlesions in PVI-nonresponders. Arrhythmia-free survival was assessed using seven day Holter every three months post procedure. All patientscompleted their 12 months follow-up. Results Fifty patients aged ≥80 years （80.5 ± 1.6 years） were compared to 259 patients aged 〈 50years （43.5±5.5 years）. The RFCA complication rate did not vary between groups. No differences in procedural characteristics were seenafter being analyzed by type of AF. Among patients with paroxysmal AF, 71.4% octogenarian vs. 84.7% young patients was free of anyarrhythmia, without AAs, after single procedure. For non-paroxysmal AF, arrhythmia-free survival without AAs, was considerably lower（58.6% octogenarians vs. 81.2% younger patients, P = 0.023）. If AAs were used, arrhythmia-free survival for paroxysmal AF increased to90.5% and 92.1% in octogenarians and younger patients, respectively; and in non-paroxysmal AF it increased to 79.3% vs. 88.4%. ConclusionsRFCA is a safe and effective strategy to achieve normal sinus rhythm in a highly selected group of octogenarians. Paroxysmal AF ablation inoctogenarians has similar clinical effectiveness as that seen in much younger patients. Non-paroxysmal AF ablation has lower, but still rea-sonable clinical effectiveness.

关键词： Atrial fibrillation Catheter ablation Effectiveness Octogenarians Safety The elderly

Colorectal cancer screening in Europe

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第47期15卷 5907-5915页

作者： Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav dusek Jan Muzik Bohumil Seifert Premysl Fric Clinic of Medicine Central Military Hospital1st Faculty of MedicineCharles UniversityPragueCZ16902Czech Republic Institute of Biostatistics and Analyses Masaryk UniversityBrnoCZ60200Czech Republic Institute of General Medicine 1st Faculty of MedicineCharles UniversityPragueCZ12800Czech Republic

Colorectal cancer(CRC)is the second most frequent malignant disease in *** year,412 000people are diagnosed with this condition,and 207 000patients die of *** 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC *** manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 *** most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic).

关键词：欧洲联盟理事会大肠癌筛查筛选程序捷克共和国 CRC 隐匿性结肠镜

The 3’-untranslated region contributes to the pregnane X receptor(PXR) expression downregulation by PXR ligands and up-regulation by glucocorticoids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2020年第1期10卷 136-152页

作者： Tomas Smutny Jan dusek Lucie Hyrsova Jana Nekvindova Alzbeta Horvatova Stanislav Micuda Sabine Gerbal-Chaloin Petr Pavek Department of Pharmacology and Toxicology Faculty of Pharmacy in Hradec KraloveCharles UniversityHradec Kralove CZ-50005Czech Republic Institute of Clinical Biochemistry and Diagnostics University Hospital Hradec KraloveHradec Kralove CZ-50005Czech Republic Department of Pharmacology Faculty of Medicine in Hradec KraloveCharles UniversityHradec Kralove CZ-50003Czech Republic IRMB INSERMUniversity MontpellierMontpellierFrance

Pregnane X receptor(PXR)is the major regulator of xenobiotic *** itself is controlled by various signaling molecules including ***,negative feed-back regulation has been proposed at the transcriptional *** examined the involvement of the 3’-untranslated region(3’-UTR)of NR1I2 mRNA and microRNAs in PXR-and glucocorticoid receptor(GR)-mediated regulation of NR1I2 gene *** ligands were found to significantly downregulate NR1I2 mRNA expression in a set of 14 human hepatocyte ***,PXR was downregulated by PCN in the C57/BL6 mice *** mechanistic studies with the full-length 3’-UTR cloned into luciferase reporter or expression vectors,we showed that the 3’-UTR reduces PXR *** the miRNAs tested,miR-18a-5p inhibited both NR 112 expression and CYP3A4 gene ***,we observed significant upregulation of miR-18a-5p expression 6 h after treatment with the PXR ligand rifampicin,which indicates a putative mechanism underlying NR1I2 negative feed-back regulation in hepatic ***,glucocorticoids upregulated NR1I2 expression not only through the promoter region but also via 3’-UTR regulation,which likely involves downregulation of *** conclude that miR-18a-5p is involved in the down-regulation of NR1I2expression by its ligands and in the upregulation of NR1I2 mRNA expression by glucocorticoids in hepatic cells.

关键词： Gene expression MicroRNA Glucocorticoid Regulation Pregnane X receptor Cytochrome P4503A4

A Lack of Evidence for Global Ram-Pressure Induced Star Formation in the Merging Cluster Abell 3266

在线全文

学校读者我要写书评

暂无评论

International Journal of Astronomy and Astrophysics 2021年第1期11卷 95-132页

作者： Mark J. Henriksen Scott dusek Physics Department University of Maryland Baltimore MD USA

Interaction between the intracluster medium and the interstellar media of galaxies via ram-pressure stripping (RPS) has ample support from both observations and simulations of galaxies in clusters. Some, but not all of the observations and simulations show a phase of increased star formation compared to normal spirals. Examples of galaxies undergoing RPS induced star formation in clusters experiencing a merger have been identified in high resolution optical images supporting the existence of a star formation phase. We have selected Abell 3266 to search for ram-pressure induced star formation as a global property of a merging cluster. Abell 3266 (z = 0.0594) is a high mass cluster that features a high velocity dispersion, an infalling subcluster near to the line of sight, and a strong shock front. These phenomena should all contribute to making Abell 3266 an optimum cluster to see the global effects of RPS induced star formation. Using archival X-ray observations and published optical data, we cross-correlate optical spectral properties ([OII, Hβ]), indicative of starburst and post-starburst, respectively with ram-pressure, ρv2, calculated from the X-ray and optical data. We find that post-starburst galaxies, classified as E + A, occur at a higher frequency in this merging cluster than in the Coma cluster and at a comparable rate to intermediate redshift clusters. This is consistent with increased star formation due to the merger. However, both starburst and post-starburst galaxies are equally likely to be in a low or high ram pressure environment. From this result, we infer that the duration of the starburst phase must be very brief so that: 1) at any time only a small fraction of the galaxies in a high ram pressure environment show this effect, and 2) most post-starburst galaxies are in an environment of low ram pressure due to their continued orbital motion in the cluster.

关键词： X-Ray High Energy Galaxy Evolution Clusters of Galaxies

Colorectal cancer screening:20 years of development and recent progress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第14期20卷 3825-3834页

作者： Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav dusek Department of Medicine 1st Faculty of MedicineMilitary University HospitalCharles University Institute of Biostatistics and Analyses Masaryk University Genomac Research Institute Centre for Applied Genomics of Solid Tumors Institute of General Medicine 1st Faculty of MedicineCharles University

Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily *** trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality *** year,approximately 8000 people are diagnosed with CRC and some 4000 die from this *** years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in ***,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT *** program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of *** the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening *** overall program expanded to cover 25.0%of the target population by ***,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared.

关键词： Colorectal cancer Population-based screening progr

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

5m宽厚板试样处理自动化系统

电气传动自动化 2005年第5期27卷 33-37页

作者：方英裴瑞琳刘豪 dusek 宝山钢铁股份有限公司厚板厂设备管理室上海201900 Headquarter of Siemens A utomation & DriveErlangen Germany

随着工业控制技术的不断发展,高性能的PLC在工业控制领域用得越来越广泛,5m宽厚板试样处理自动化系统,运用一个完整的工业控制系统,包括PCS7、编程工程师站、WinCC、HMI画面、PDA跟踪系统、ITV工业监视电视,并结合现场调试经验,对试样... 详细信息

随着工业控制技术的不断发展,高性能的PLC在工业控制领域用得越来越广泛,5m宽厚板试样处理自动化系统,运用一个完整的工业控制系统,包括PCS7、编程工程师站、WinCC、HMI画面、PDA跟踪系统、ITV工业监视电视,并结合现场调试经验,对试样处理自动化系统工业控制的系统设计、自动化编程、联动测试、现场调试等进行了描述。

关键词：试样处理自动化系统 HMI PDA 自动化

在线全文

学校读者我要写书评

暂无评论

东南欧医学院校课程改革的分析与展望

复旦教育论坛 2006年第1期4卷 85-88页

作者： Robert Likic Tina dusek Drago Horvat 梅人朗萨格勒布大学医学院复旦大学公共卫生学院上海200032

为阐明东南欧地区6个国家16所医学院的课程改革状况,作者通过电子邮件收集了各医学院有关课程的信息,包括注册学生数、课程门类、学时分配等。结果表明,这一地区的课程发展还有很大的潜力。在改革过程中应当十分注意教师培训、学生参与... 详细信息

为阐明东南欧地区6个国家16所医学院的课程改革状况,作者通过电子邮件收集了各医学院有关课程的信息,包括注册学生数、课程门类、学时分配等。结果表明,这一地区的课程发展还有很大的潜力。在改革过程中应当十分注意教师培训、学生参与、认定核心能力,以及新方法的引进等。该研究原文发表在英国医学教育杂志上(***2005,39:833-840)。

关键词：医学教育课程改革欧洲

How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第36期22卷 8103-8111页

作者： Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic Bohumil Seifert Ladislav dusek Miroslav Zavoral Department of Internal Medicine 1st Faculty of Medicine Charles University Military University Hospital Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Institute of General Medicine 1st Faculty of Medicine Charles University

The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations.

关键词： Metabolic syndrome Diabetes mellitus type 2 Heart ischemic disease Colorectal neoplasia