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Chemotactic signaling and beyond: link between interleukin-16 and axonal degeneration in multiple sclerosis

Neural Regeneration Research 2015年第11期10卷 1761-1763页

作者： dusanka s.skundric Department of Immunology and Microbiology School of MedicineWayne State University

Multiple sclerosis（Ms）is a progressive inflammatory,and chronic demyelinating,neurodegenerative disease of central nervous system（CNs）.Autoimmune responses to myelin and other CNs antigens mediated by cluster of differentiation 4（CD4＋）T cells are critical for initiation and progression of *** of autoimmune T cells from the peripheral lymph organs into CNs parenchyma leads to inflammation,demyelination and damage of axonal cytoskeleton, which manifest in decreased impulse conduction velocity of motor and sensory nerves. Myelin and axonal pathology causes motor, sensory and autonomic nerve dysfunction, including optic nerve damage leading to double or distorted vision; paresis and paralysis of extremities, painful sensations, and bladder sphincter dysfunction, manifested as bladder incontinence. Gray matter pa- thology in cortical and subcortical regions, including cerebellum and hippocampus underlies cognitive and behavioral dysfunction consisting of memory deficits, depression, and ataxic gait and tremor.

关键词： cell IL Chemotactic signaling and beyond link between interleukin-16 and axonal degeneration in multiple sclerosis EAE MOG

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Functional phenotypes of CCR5 on CD4+ T cells of relevance to its genetic and epigenetic associations with HIV infection

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Cellular & Molecular Immunology 2020年第7期17卷 680-681页

作者： dusanka s.skundric Harley Y.Tse Paul C.Montgomery Department of Biochemistry Microbiology and ImmunologyWayne State UniversitySchool of MedicineDetroitMIUSA

The article by Kulkarni et *** a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5,which is critical to human immunodeficiency virus type 1(HIV-1)infection.1 significant advances in the genetic regulation of human diseases have been made through the use of genome-wide association studies(GWAss)over the past several *** daunting task of elucidating the cellular pathways that are critical to human disease regulation remains for many disease-associated coding genetic variants.

关键词： CCR5 epigenetic al.

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