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Physical Activity Alters Superoxide Dismutase Activity and Intercellular Adhesion Molecule 1 Levels in Diabetes Mellitus Type 2 Patients

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Journal of Biosciences and Medicines 2023年第7期11卷 140-150页

作者： Anderson Martins tavares Leonardo Matta Jaslana Hainfellner da silva Christiane de Oliveira Bensusan Carla do Nascimento Giselle Fernandes Taboada Rodrigo Soares Fortunato Luciene de Carvalho Cardoso-Weide Postgraduate Program in Medical Sciences School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Carlos Chagas filho Institute of Biophysics UFRJ-Federal University of Rio de Janeiro Rio de Janeiro Brazil School of Biology University Salgado de Oliveira Rio de Janeiro Brazil Endocrinology Unit Department of Internal Medicine School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Luciene de Carvalho Cardoso Weide Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil

Background: Oxidative stress and inflammation are related to the pathophysiology of diabetes mellitus (DM), being involved in the development of micro-and macrovascular complications. Physical activity is beneficial for DM patients, but little is known about the relationship between redox and inflammation biomarkers and the level of physical activity in these patients. Based on this, this research aims to evaluate the effects of physical activity level on redox stress parameters and inflammatory markers in T2DM patients. Methods: Eighty-four patients with T2DM were divided according to their physical activity level: group A (n = 48), sedentary;group B (n = 11) active (3 times a week, 150 min) and group C (n = 25), highly active (5 times a week, 150 - 300 mins, at least). Anthropometric and biochemical parameters, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, as well as GSH, sRAGE and ICAM-1 levels were assessed. Results: Glycated haemoglobin, total cholesterol, and LDL-cholesterol levels were lower in the highly active group in comparison to other groups. Plasma SOD activity was higher in group C compared to Group A, while ICAM-1 levels were significantly higher in group B when compared to other groups. Conclusion: Our results suggest that the practice of physical activity is beneficial to T2DM patients, especially at high volume and frequency.

关键词： Cardiovascular Risk Exercise Health Inflammation Oxidative Stress

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