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HPV Vaccine: Integrative Review of National and International Guidelines

Health 2022年第12期14卷 1287-1298页

作者： durval silva tavares filho Camille Marcele Resende Rocha Elizabeth Bacha Marcela Curvello Beltrão Lusitânia Maria de Barros Ádamo Newton Marinho Andrade Fabiana Torres Valadares Yasmin Nunes Machado Centro Universitário Tiradentes (UNIT) Maceió Brasil

HPV (Human Papillomavirus) is an adenovirus of the Papillomaviridae family with approximately 200 subtypes (subdivided into low and high oncogenic risk groups), responsible for almost 99% of cervical cancers. Worldwide, there are more than 570,000 new cases and more than 311,000 women die each year from cervical cancer;for Brazil, the estimate is of more than 16,000 new cases per year. It is known that cervical cancer is one of the most easily preventable forms of cancer, as there is a highly effective vaccine against HPV. However, the morbidity and mortality rates correlated with human papillomavirus are still concerning, especially in less developed countries. In 2020, the WHO (World Health Organization) presented three goals to achieve by 2030 the worldwide extermination of cervical cancer;among these goals is vaccination. Is the world preparing for this battle? The present work is an integrative review, comparing national and international guidelines for HPV vaccination published in the last five years in the consulted databases, using the descriptors “cervical cancer”, “prevention” and “guideline” and the boolean operator “and”, from which nine articles were selected. The study made it possible to compare international and national guidelines for vaccination against HPV, showing that developed countries implemented the HPV vaccine longer ago and follow the WHO recommendations more rigorously and effectively than underdeveloped or developing countries. Adopting a single dose as a strategy, as suggested by the WHO in April 2022, could be an important step towards increasing coverage and providing protection for a greater number of girls who do not have access to HPV immunization.

关键词： Immunization Prevention Guidelines HPV Cervical Cancer

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Current HPV Vaccination Strategies in Brazil

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Health 2023年第2期15卷 107-121页

作者： durval silva tavares filho Camille Marcele Resende Rocha Elizabeth Bacha Ádamo Newton Marinho Andrade Daniel Diniz Porto Pereira Letícia Mayer Nunes Luma Dória Passos Pollyana Thaise Santos Braz Paula Andreia Santos Braz Antônia Iva Sampaio Bisneta Francisco Expedito Ramos Aguiar Sobrinho Centro Universitário Tiradentes (UNIT) Maceió Brazil Universidade de Pernambuco (UPE) Recife Brazil

Cervical cancer is one of the most preventable and treatable malignancies, however, it still has high incidence and mortality rates, especially in less developed countries. For Brazil, the estimate is more than 16,000 new cases and more than 6000 deaths annually. Despite this, vaccines against HPV (responsible for cervical cancer) are effective and promote a significant decrease in infections and neoplastic lesions of the cervix. As recommended by the World Health Organization, girls aged 9 to 14 should be vaccinated before becoming sexually active. Although the vaccine was developed in 2006, in Brazil immunization only started to be carried out in 2014, initially only for girls between 9 and 11 years old. The present work is an integrative review, with the objective of explaining the current situation of vaccination against HPV throughout the country. Using the PubMed, MED-LINE and Google Scholar databases, a search for scientific articles was carried out during the year 2022, using the descriptors “Vaccine”, “HPV” and “Brazil”, simultaneously selecting 17 articles. The Brazilian recommendations for vaccination against HPV have undergone several strategic changes over time, in the following points: age group and gender of the target population, major site of application of vaccines and number of doses to be applied. Currently, in Brazil, the recommendation for vaccination against HPV is neutral in gender, between 9 and 14 years old and in immunosuppressed people up to 45 years old, with a vaccination schedule of 2 doses with an interval of 6 months between them, and 3 doses for those from 15 years and immunocompromised individual (0 - 2 - 6 months). The tetravalent vaccine offered by public funding continues to be applied at health centers, despite several favorable criticisms of the return of application in schools. Even though the vaccine is available free of charge, studies point to the difficulty in achieving and maintaining vaccination coverage, especially for

关键词： Brazil HPV Vaccine Update Cervical Cancer

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HPV Vaccine: Integrative Review of National and International Guidelines

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Health（健康） 2022年第12期

作者： durval silva tavares filho Elizabeth Bacha Marcela Curvello Beltrão Lusitânia Maria de Barros Ádamo Newton Marinho Andrade Fabiana Torres Valadares Yasmin Nunes Machado

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Current HPV Vaccination Strategies in Brazil

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Health（健康） 2023年第2期

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Peroxisome proliferator-activated receptors as targets to treat metabolic diseases:Focus on the adipose tissue,liver,and pancreas

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World Journal of Gastroenterology 2023年第26期29卷 4136-4155页

作者： Henrique Souza-tavares Carolline Santos Miranda Isabela Macedo Lopes Vasques-Monteiro Cristian Sandoval Daiana Araujo Santana-Oliveira Flavia Maria silva-Veiga Aline Fernandes-da-silva Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Escuela de Tecnología Médica Facultad de SaludUniversidad Santo TomásOsorno 5310431Chile Departamento de Ciencias Preclínicas Universidad de la FronteraTemuco 4780000Chile

The world is experiencing reflections of the intersection of two pandemics:Obesity and coronavirus disease *** prevalence of obesity has tripled since 1975 worldwide,representing substantial public health costs due to its *** adipose tissue is the initial site of obesity *** excessive energy intake,it undergoes hyperplasia and hypertrophy until overt inflammation and insulin resistance turn adipocytes into dysfunctional cells that send lipotoxic signals to other *** pancreas is one of the organs most affected by *** lipotoxicity becomes chronic,there is an increase in insulin secretion by pancreatic beta cells,a surrogate for type 2 diabetes mellitus(T2DM).These alterations threaten the survival of the pancreatic islets,which tend to become dysfunctional,reaching exhaustion in the long *** for the liver,lipotoxicity favors lipogenesis and impairs beta-oxidation,resulting in hepatic *** silent disease affects around 30%of the worldwide population and can evolve into end-stage liver *** therapy for hepatic steatosis remains to be defined,peroxisome proliferator-activated receptors(PPARs)activation copes with T2DM *** PPARs are transcription factors found at the intersection of several metabolic pathways,leading to insulin resistance relief,improved thermogenesis,and expressive hepatic steatosis mitigation by increasing mitochondrial *** review aimed to update the potential of PPAR agonists as targets to treat metabolic diseases,focusing on adipose tissue plasticity and hepatic and pancreatic remodeling.

关键词： Obesity Insulin resistance Peroxisome proliferator-activated receptors Pancreas Hepatic steatosis Adipose tissue

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Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice

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World Journal of Gastroenterology 2022年第17期28卷 1814-1829页

作者： Flavia Maria silva-Veiga Carolline Santos Miranda Isabela Macedo Lopes Vasques-Monteiro Henrique Souza-tavares Fabiane Ferreira Martins Julio Beltrame Daleprane Vanessa Souza-Mello Department of Anatomy Institute of BiologyState University of Rio de JaneiroLaboratory of MorphometryMetabolism and Cardiovascular DiseasesRio de Janeiro 20551-030Brazil Department of Clinical and Toxicology Analysis State University of Rio de JaneiroNutrition InstituteState University of Rio de JaneiroNutrition InstituteUniversity of Sao PauloRio de Janeiro 20551-030Brazil

BACKGROUND Obesity and comorbidities onset encompass gut dysbiosis,altered intestinal permeability,and *** that target gut dysbiosis can cope with obesity and nonalcoholic fatty liver disease(NAFLD)*** proliferator-activated receptor(PPAR)-alpha activation and dipeptidyl-peptidase-4(DPP-4)inhibition alleviate NAFLD,but the mechanism may involve gut microbiota modulation and merits further *** To address the effects of PPAR-alpha activation and DPP-4 inhibition(isolated or combined)upon the gut-liver axis,emphasizing inflammatory pathways in NAFLD management in high-fat-fed C57BL/6J *** Male C57BL/6J mice were fed a control diet(C,10%of energy as lipids)or a highfat diet(HFD,50%of energy as lipids)for 12 wk,when treatments started,forming the groups:C,HF,HFA(HFD+PPAR-alpha agonist WY14643,2.5 mg/kg body mass),HFL(HFD+DPP-4 inhibitor linagliptin,15 mg/kg body mass),and HFC(HFD+the combination of WY14643 and linagliptin).RESULTS The HFD was obesogenic compared to the C *** treatments elicited significant body mass loss,and the HFC group showed similar body mass to the C *** treatments tackled oral glucose intolerance and raised plasma glucagon-like peptide-1 *** metabolic benefits restored Bacteroidetes/Firmicutes ratio,resulting in increased goblet cells per area of the large intestine and reduced lipopolysaccharides concentrations in treated *** the gene level,treated groups showed higher intestinal Mucin 2,Occludin,and Zo-1 expression than the HFD *** reduced endotoxemia suppressed inflammasome and macrophage gene expression in the liver of treated *** observations complied with the mitigation of liver steatosis and reduced hepatic triacylglycerol,reassuring the role of the proposed treatments on NAFLD *** PPAR alpha activation and DPP-4 inhibition(isolated or combined)tackled NAFLD in dietinduced obese mice by restoration of gut-liver axis

关键词： Nonalcoholic fatty liver disease High-fat diet Peroxisome proliferator-activated receptor-alpha Dipeptidyl-peptidase-4-inhibitor Dysbiosis Inflammation

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Lithic soils in the semi-arid region of Brazil:edaphic characterization and susceptibility to erosion

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Journal of Arid Land 2022年第1期14卷 56-69页

作者： Carlos R PINHEIRO JUNIOR Conan A SALVADOR Tiago R tavares Marcel C ABREU Hugo S FAGUNDES Wilk S ALMEIDA Eduardo C silva NETO Lúcia H C ANJOS Marcos G PEREIRA Federal Rural University of Rio de Janeiro(UFRRJ) Department of SoilsSeropédicaRio de Janeiro 23890Brazil Center for Nuclear Energy in Agriculture(CENA) University of São Paulo(USP)PiracicabaSão Paulo 13416Brazil Federal Institute of Education Science and Technology of Rondônia(IFRO)Rural ZoneAriquemesRondônia 78930Brazil

Soils(Leptosols or Epileptic Regosols)with lithic contact at a depth of 50 cm occupy almost 20%of the Brazilian semi-arid *** lithic soils are susceptible to erosion due to faster saturation of water-holding capacity during rainfall,which accelerates the beginning of ***,erosion traits of lithic soils in the semi-arid region of Brazil are less *** aim of this study was to characterize the soil and landscape attributes in areas with Neossolos Litólicos(Entisols)in the Caatinga biome to identify region of high susceptibility to *** showed that the soils were characterized by a sandy texture,soil structure with poor development and low content of organic *** attributes increase susceptibility to erosion and reduce water storage capacity,especially in the states of Cearáand *** these states,the content of rock fragments in the soil reaches 790 g/*** contents of silt and fine sand,high silt/clay ratio,predominance of Leptosols and strong rainfall erosivity were observed in Piauíand northwestern Ceará.A very high degree of water erosion was observed in the states of Pernambuco and Paraí*** the low degree of erosion observed in the state of Bahia,it is highly susceptible to erosion due to the predominance of very shallow soils,rugged relief and high values of rainfall *** vulnerability was observed in the state of Alagoas because of its more smoothed relief,greater effective soil depth,thicker A horizon of soil and lower rainfall *** general,the characteristics that intensify the susceptibility to erosion in the Caatinga biome are those soil structures with poor development or without aggregation,low contents of organic carbon,high contents of silt and fine sand,high values of silt/clay ratio and rugged relief in some *** study collected information contributing to a better characterization of soils with lithic contact in the semi-arid region of *** addition,regions with

关键词： Caatinga biome drylands erosive processes leptosols soil degradation

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Physical Activity Alters Superoxide Dismutase Activity and Intercellular Adhesion Molecule 1 Levels in Diabetes Mellitus Type 2 Patients

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Journal of Biosciences and Medicines 2023年第7期11卷 140-150页

作者： Anderson Martins tavares Leonardo Matta Jaslana Hainfellner da silva Christiane de Oliveira Bensusan Carla do Nascimento Giselle Fernandes Taboada Rodrigo Soares Fortunato Luciene de Carvalho Cardoso-Weide Postgraduate Program in Medical Sciences School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Carlos Chagas filho Institute of Biophysics UFRJ-Federal University of Rio de Janeiro Rio de Janeiro Brazil School of Biology University Salgado de Oliveira Rio de Janeiro Brazil Endocrinology Unit Department of Internal Medicine School of Medicine UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil Luciene de Carvalho Cardoso Weide Medical School Department of Pathology UFF-Universidade Federal Fluminense Rio de Janeiro Brazil

Background: Oxidative stress and inflammation are related to the pathophysiology of diabetes mellitus (DM), being involved in the development of micro-and macrovascular complications. Physical activity is beneficial for DM patients, but little is known about the relationship between redox and inflammation biomarkers and the level of physical activity in these patients. Based on this, this research aims to evaluate the effects of physical activity level on redox stress parameters and inflammatory markers in T2DM patients. Methods: Eighty-four patients with T2DM were divided according to their physical activity level: group A (n = 48), sedentary;group B (n = 11) active (3 times a week, 150 min) and group C (n = 25), highly active (5 times a week, 150 - 300 mins, at least). Anthropometric and biochemical parameters, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, as well as GSH, sRAGE and ICAM-1 levels were assessed. Results: Glycated haemoglobin, total cholesterol, and LDL-cholesterol levels were lower in the highly active group in comparison to other groups. Plasma SOD activity was higher in group C compared to Group A, while ICAM-1 levels were significantly higher in group B when compared to other groups. Conclusion: Our results suggest that the practice of physical activity is beneficial to T2DM patients, especially at high volume and frequency.

关键词： Cardiovascular Risk Exercise Health Inflammation Oxidative Stress

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Effect of Ultra-Turrax on Nanocellulose Produced by Acid Hydrolysis and Modified by Nano ZnO by Sol-Gel Method

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Materials Sciences and Applications 2020年第2期11卷 150-166页

作者： Amanda Ramos Aragao Melo Jose Carlos Dutra filho Roberto Pinto Cucinelli Neto Wellington silva Ferreira Braulio Soares Archanjo Raphael Verdan Curti Maria Ines Bruno tavares Instituto de Macromoléculas Professora Eloisa Mano Universidade Federal do Rio de JaneiroBl J do Centro de TecnologiaIlh do FundaoRio de JaneiroRJBrasil Instituto SENAI de Inovacao em Biossintéticos e Fibras Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Instituto de Biofísica Carlos Chagas Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Divisao de Metrologia de Materiais Instituto Nacional de MetrologiaQualidade e Tecnologia(INMETRO)Duque de CaxiasBrasil

Cellulose nanocrystals (NCC) and cellulose nanofibrils (CNF) were obtained by a single step process, with synergy between 64% sulfuric acid hydrolysis and high shear from ultra-turrax stirring, which is an advantageous process for disintegrating cellulose microcrystalline and also may improve the hydrolysis process. The surface modification on the cellulose was performed by the sol-gel process, in which the sulfate groups from hydrolysis were replaced by nanoparticles of zinc oxide, which led to the increase of up to 54°C Tonset, according to thermogravimetric analysis (TGA) results. The morphology and crystallinity degree were characterized by Helium Ion Microscopy (HIM), atomic force microscopy (AFM) and X-ray diffraction. In addition, the ZnO band was observed in Fourier transform infrared spectroscopy, furthermore, the change in the zeta potential confirmed the cellulose modification. The changes in the values of proton spin-spin relaxation time for the systems showing the confined hydrogen in the rigid domains, confirmed the results observed with the aforementioned techniques, for both cellulose after hydrolysis and ZnO modified cellulose, suggesting that ZnO disrupted crystal formation in cellulose.

关键词： Cellulose Nanocrystal Cellulose Nanofibril Nano Zinc Oxide Acid Hydrolysis Sol-Gel

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Public Use and Landscape Analysis in the Serra da Canastra National Park, Brazil: A Geospatial Approach

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Natural Resources 2016年第2期7卷 93-101页

作者： Marcos Cicarini Hott Luiz Otávio Moras filho Marco Aurélio Leite Fontes Aline Aparecida silva Pereira Cláudia de Oliveira Gonçalves Nogueira Luis Marcelo tavares de Carvalho Luís Antônio Coimbra Borges João Cesar de Resende Mauro Antonio Homem Antunes Department of Forest Sciences Federal University of Lavras Lavras Brazil Brazilian Agricultural Research Corporation—Embrapa Juiz de Fora Brazil Department of Engineering Federal Rural University of Rio de Janeiro Seropédica Brazil

The Conservation Units (CU) were created to protect natural environments from growing degradation and to impede the expansion of urbanization and agricultural crops. The Serra da Canastra National Park, established to protect the headwaters of the S?o Francisco River and other places of scenic and ecological interest, is extensively visited due to its many tourist attractions, such as waterfalls, fauna and flora. An analysis of the park’s geography is needed to assess the risk involved in and its suitability for public use due to its territorial extension and environmental complexities. Thus, this study aimed to investigate the background of issues of interest to CU management. Additionally, we used high-resolution RapidEye imagery, altimetry and database of park infrastructure to build geospatial database and estimate classes of suitability for and risk in public use through GIS tools. The resulting cartographic data can support the planning of policies concerning the landscape and park’s territorial management.

关键词： Conservation Units Environment GIS RapidEye Imagery

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