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Methyl-salicylate:A surveillance system fortriggering immunity in neighboring plants

Journal of Integrative Plant Biology 2024年第2期66卷 163-165页

作者： Saumya Jaiswal durgesh kumar Tripathi Ravi Gupta JingHe Zhong-Hua Chen Vijay Pratap Singh Plant Physiology Laboratory Department of Botany C.M.P.Degree CollegeA Constituent Post Graduate College ofUniversity of AllahabadPrayagraj 211002India Crop Nanobiology and Molecular Stress Physiology LabAmity Institute of Organic Agriculture Amity University UttarPradeshNoida 201313India College of General Education Kookmin UniversitySeoul 02707South Korea School of Science Western Sydney UniversitySydney 2751New South WalesAustralia Hawkesbury Institute for the Environment Western SydneyUniversitySydney 2751New South WalesAustralia

Plant behavioral actions have been one of the major topicsof research in plant biology and *** actionsfrom plants are determined by their instant structural andphysical reactions to the circumstances(Bouwmeester et al.,2019).Upon sensing abiotic factors such as salinity,flooding,high temperature,drought,plants make suitable changes intheir physiology and behavior to survive such harsh conditions.

关键词： immunity neighboring salinity

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Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis

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Genes & Diseases 2023年第2期10卷 480-494页

作者： Harsh Vardhan Charan durgesh kumar Dwivedi Sabbir Khan Gopabandhu Jena Facility for Risk Assessment and Intervention Studies Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and ResearchSector-67S.A.S. NagarPunjab 160062India Department of Neuro-Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

The liver injury leads to an inflammatory response, which causes the activation of hepatic stellate cells (HSCs) that further secrete ECM proteins and play an important role in liver fibrosis. Moreover, the inflammatory response is a driving force for fibrogenesis, which is triggered by many types of injuries. Exaggerated inflammatory immune responses are mediated by cytoplasmic protein complexes known as inflammasomes, which are involved in many chronic liver diseases. Inflammasomes are pattern recognition receptors (PRRs) that can sense any microbial motifs known as pathogen-associated molecular patterns (PAMPs), and host- or environmental-derived stress signals known as damage-associated molecular patterns (DAMPs). The inflammasomes cause caspase-mediated proteolytic cleavage of pro-IL-1β and pro-IL-18 into active IL-1β and IL-18. In this review, we provide a comprehensive summary of the important roles of NLRP3 inflammasome in the pathogenesis of liver fibrosis with an emphasis on several direct and indirect pathways responsible for the NLRP3 inflammasome-mediated HSCs activation and fibrogenesis. In addition, we discuss the general pharmacological and genetics strategies for the inhibition of NLRP3 inflammasome activation and its downstream signaling with examples of emerging pharmacotherapeutics, targeting the NLRP3 inflammasome signaling as well as a possible way to develop effective and safer NLRP3 inflammasome inhibitors.

关键词： Hepatic stellate cells Liver fibrosis NLRP3 activation NLRP3 inflammasome NLRP3 inhibitors

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Organo-Petrographic and Pore Facets of Permian Shale Beds of Jharia Basin with Implications to Shale Gas Reservoir

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Journal of Earth Science 2017年第5期28卷 897-916页

作者： Vinod Atmaram Mendhe Subhashree Mishra Ranjit G.Khangar Alka Damodhar Kamble durgesh kumar Atul kumar Varma H.Singh Sujeet kumar Mollika Bannerjee CSIR-Central Institute of Mining and Fuel Research GSI-Geological Survey of India Central Region IIT (ISM)-Department of Chemical Engineering Indian Institute of Technology (ISM) IIT (ISM)-Department of Applied Geology Indian Institute of Technology (ISM)

The shale deposits of Damodar Valley have received great attention since preliminary studies indicate their potential for shale gas. However, fundamental information allied to shale gas re- servoir characteristics are still rare in India, as exploration is in the primary stage. In this study, Ba- rakar shale beds of eastern part of Jharia Basin are evaluated for gas reservoir characteristics. It is evident that Barakar shales are carbonaceous, silty, contains sub-angular flecks of quartz and mica, irregular hair-line fractures and showing lithological variations along the bedding planes, signifying terrestrial-fluviatile deposits under reducing environment. The values of TOC varies from 1.21 wt.% to 17.32 wt.%, indicating good source rock potentiality. The vitrinite, liptinite, inertinite and mineral matter ranging from 0.28 vol.% to 12.98 vol.%, 0.17 vol.% to 3.23 vol.%, 0.23 vol.% to 9.05 vol.%, and 74.74 vol.% to 99.10 vol.%, respectively. The ternary facies plot of maceral composition substan- tiated that Barakar shales are vitrinite rich and placed in the thermal-dry gas prone region. The low values of the surface area determined following different methods point towards low methane storage capacity, this is because of diagenesis and alterations of potash feldspar responsible for pore blocking effect. The pore size distribution signifying the micro to mesoporous nature, while Type II sorption curve with the H2 type of hysteresis pattern, specifies the heterogeneity in pore structure mainly combined-slit and bottle neck pores.

关键词： shale gas petrographic composition surface area pore disposition pore volume.

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An epidemiological study on delay in treatment initiation of cancer patients

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Health 2012年第2期4卷 66-79页

作者： Alok kumar Dwivedi Sada Nand Dwivedi Suryanarayana Deo Rakesh Shukla Arvind Pandey durgesh kumar Dwivedi Center for Biostatistical Services Division of Biostatistics and Epidemiology Department of Environmental Health College of Medicine University of Cincinnati Cincinnati USA Department of Biostatistics All India Institute of Medical Sciences New Delhi India Department of NMR & MRI Facility All India Institute of Medical Sciences New Delhi India Department of Surgical Oncology All India Institute of Medical Sciences New Delhi India National Institute of Medical Statistics Indian Council of Medical Research New Delhi India

Early diagnosis and timely initiation of treatment of cancer patients may improve survival and quality of life. Various measures of delay can be made during diagnosis and treatment initiation. Most of the studies were based on single type of cancer with different definitions and measurements of delay in diagnosis and treatment. Thus, it has been difficult to synthesize results and generalize to other types of cancer. The study proposes to measure total duration between onsets of symptom to start of treatment into three components, namely primary, secondary and tertiary delays. Primary delay is defined as onset of symptoms to contacting the first medical person, secondary delay is from first medical contact to confirmed diagnosis, and tertiary delay is from confirmed diagnosis to treatment initiation. The aim of this study is to determine factors associated with primary, secondary and tertiary delays in cancer patients. This study was planned as a cross-sectional study. Data was collected from patients admitted to the surgical wards of Department of Surgical Oncology, Institute Rotary Cancer Hospital, New Delhi during 2006-2007. Gamma regression and quantile regressions at 25th, 50th and 75th percentile of each of the delays were used to determine related factors. A total of 403 patients were included in the analysis. The median tertiary delay was found almost two folds (59;Interquartile range: 26 - 101 days) than the primary and secondary delays. Extremity cancer patients had longest primary, secondary and tertiary delays. Shortest primary, secondary and tertiary delays were observed for gastrointestinal cancer, breast and genitourinary cancer respectively. There is an urgent need and scope to reduce delay at each level primary, secondary and tertiary delay. Intervention studies are needed through information, education and communication/screening programs to reduce the diagnostic and treatment delays in cancer patients.

关键词： Delay Cancer Log Gamma Regression Quantile Regression

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Autochthonous halotolerant plant growth-promoting rhizobacteria promote bacoside A yield of Bacopa monnieri(L.)Nash and phytoextraction of salt-affected soil

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Pedosphere 2020年第5期30卷 671-683页

作者： Umesh PANKAJ durgesh Narain SINGH Pooja MISHRA Pooja GAUR C.S.Vivek BABU Karuna SHANKER Rajesh kumar VERMA Department of Soil Science CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015(India) Division of Biotechnology CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015(India) Division of Microbial Technology CSIR-Central Institute o f Medicinal and Aromatic PlantsLucknow 226015(India) Analytical Chemistry Department CSIR-Central Institute o f Medicinal and Aromatic PlantsLucknow 226015(India) Research Centre CSIR-Central Institute of Medicinal and Aromatic PlantsBangalore 560065(India)

Phytoremediation is a promising approach for reclamation of salt-affected *** is the most commonly used process,which exploits plants to absorb,immobilize,and accumulate salt in their *** this study,halotolerant plant growth-promoting rhizobacteria(PGPR)were isolated from the rhizosphere of wild grasses growing naturally in salt-affected areas of Lucknow,Uttar Pradesh(India)and were tested for their efficacies of salt-tolerance and plant growth-promoting(PGP)*** on 16S rRNA sequences,the most efficient halotolerant isolates possessing PGP traits were identified as Pseudomonas plecoglossicida(KM 233646),Acinetobacter calcoaceticus(KM 233647),Bacillus flexus(KM 233648),and Bacillus safensis(KM 233652).Application of these isolates as bio-inoculants significantly(P<0.05)increased the growth and bacoside A yield of a medicinal plant,Bacopa monnieri(L.)Nash,grown on natural salt-affected *** phytoremediation of salt-affected soil was evident by the substantial increase in shoot Na^+:K^+ratio of bio-inoculant-treated *** compared to un-inoculated control plants,the soil physico-chemical properties of bio-inoculant-treated plants were *** shoot and root biomass(fresh and dry weights),soil enzymes,and soil nutrient parameters showed significant positive correlations with the shoot Na+:K+***,the halotolerant PGPR screened in this study could be useful for the reclamation of saline soils concomitant with improved plant growth and bacoside A yield.

关键词： bio-inoculant phytoremediation plant productivity soil physico-chemical property soil salinity

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On Some Quality Issues of Component Selection in CBSD

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Journal of Software Engineering and Applications 2010年第6期3卷 556-560页

作者： Jeetendra Pande Raj Kishore Bisht durgesh Pant Vinay kumar Pathak 不详

Component based development offers many potential benefits, viz. software reuse, reduced time-to-market, inter- operability, ease of quality certification etc. However, it is not always that benefits derived from addition of components from a component repository are more than the costs involved in developing the module from scratch. This work evaluates various software quality models and suggests recommendations for enhancing software quality in COTS (component off-the-shelf) based software products by designing software quality metrics that would help in managing and enhancing quality in component-based software development.

关键词： Component Based Software Development (CBSD) Components-off-the-Shelf (COTS) McCall’s Model Dormey’s Model Bohem’s Model

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