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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 17-18页

作者： dupuis o. Silveira R. Dupont C. 王雅楠 U. de Gynecol. obstet . H.opital de la Croix Rousse Lyon France Dr.

A depressed skull fracture is an inward buckling of the calvarial bones and is referred to as a “ ping- pong" fracture. This study aimed to look at differences between “ spontaneous"and "instrument- associated" depressed skull fractures. This retrospective, case- control analysis included every neonate who was admitted with a depressed skull fracture between 1990 and 2000. Cases after a spontaneous vaginal delivery, elective cesarean delivery, or cesarean delivery that was performed during labor without previous instrument use were classified as “ spontaneous"(n = 18 cases). Cases after a delivery in which forceps or a vacuum cup had been used either successfully or unsuccessfully were classified as “ instrument- associated" (n = 50 cases). Continuous data were analyzed with 2- tailed unpaired t tests; χ 2 analysis was used for nominal data. A probability value of onsidered statistically significant. Fifty depressed skull fractures were associated with an instrument delivery, and 18 depressed skull fractures were classified as "spontaneous." The only obstetric parameter that differed significantly between the 2 groups was the length of the active phase. Among the 68 neonates, 15 neonates underwent prolonged second stage, forceps or manual head rotation, or forceps use during elective cesarean delivery. All “ instrument- associated" cases were caused by forceps application or sequential instrument use; depressed skull fractures never occurred after isolated vacuum extraction. Every type of forceps was involved. Intracranial lesions were significantly more frequent in the instrument- associated group (30% vs 0% ; P =. 02). Two infants sustained persistent severe motor disabilities. Depressed skull fractures occur in the setting of spontaneous and operative deliveries, although the incidence is higher in the latter case. Depressed skull fractures that are associated with instrumental deliveries are significantly more likely to be associated with intracranial

关键词：凹陷性颅骨骨折真空吸引器颅内损伤病例对照分析产钳助产第二产程延长阴道分娩颅盖骨吸引术持续性

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维普期刊数据库

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产钳助产和剖宫产决策到分娩的间隔:对产程中出现异常胎心节律的137例患者的调查结果(法)

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 61-61页

作者： dupuis o Dubuisson J Moreau R. 党慧敏 Service d'obsté trique Hpital de la Croix-Rousse 103 grande rue de la Croix-Rousse 69004 Lyon

Aim. Comparison of the decision to delivery interval in cases of forceps delivery and in cases of cesarean sections. Material and method. A retrospective analysis was performed on 137 cases of forceps deliver (n = 63) and cesarean section (n = 74) indicated for abnormal fetal heart rhythm. All cases were observed in a level 3 maternity unit between october 2003 and August 2004. Results. The mean decision-to-delivery interval was significantly shorter in the forceps group (14.84min ± 6.54 versus 29.31 min ± 11.79 p onatal morbidity were comparable. Conclusion. This study suggest that once the fetal head is engaged, forceps delivery can significantly reduced the decision-to-delivery interval.

关键词：产钳助产胎心节律可比性一所

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Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients

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Translational Neurodegeneration 2021年第2期10卷 213-229页

作者： David Bayer Stefano Antonucci Hans-Peter Muller Rami Saad Luc dupuis Volker Rasche Tobias M.Bockers Albert C.Ludolph Jan Kassubek Francesco Roselli Department of Neurology Ulm UniversityUlmGermany CEMMA(Cellular and Molecular Mechanisms in Aging)Research Training Group UlmGermany University of Strasbourg StrasbourgFrance Department of Internal Medicine II Ulm University Medical CentreUlmGermany Institute of Anatomy and Cell Biology Ulm UniversityUlmGermany German Center for Neurodegenerative Diseases-DZNE UlmGermany

Background:Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis(ALS).The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS,but the exact extent of hypothalamic circuit alterations in ALS is yet to be *** we explored the integrity of large-scale cortico-hypothalamic circuits involved in energy homeostasis in murine models and in ALS ***:The rAAV2-based large-scale projection mapping and image analysis pipeline based on Wholebrain and Ilastik software suites were used to identify and quantify projections from the forebrain to the lateral hypothalamus in the SoD1(G93A)ALS mouse model(hypermetabolic)and the FusΔNLS ALS mouse model(normo-metabolic).3 T diffusion tensor imaging(DTI)-magnetic resonance imaging(MRI)was performed on 83 ALS and 65 control cases to investigate cortical projections to the lateral hypothalamus(LHA)in ***:Symptomatic SoD1(G93A)mice displayed an expansion of projections from agranular insula,ventrolateral orbitofrontal and secondary motor cortex to the *** findings were reproduced in an independent cohort by using a different analytic *** contrast,in the FusΔNLS ALS mouse model hypothalamic inputs from insula and orbitofrontal cortex were maintained while the projections from motor cortex were *** DTI-MRI data confirmed the disruption of the orbitofrontal-hypothalamic tract in ALS ***:This study provides converging murine and human data demonstrating the selective structural disruption of hypothalamic inputs in ALS as a promising factor contributing to the origin of the hypermetabolic phenotype.

关键词： rAAV2 Agranular insula orbitofrontal cortex Lateral hypothalamus Hypermetabolism Amyotrophic lateral sclerosis

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