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世界核心医学期刊文摘(眼科学分册) 2006年第3期 51-52页

作者： LabbéA dupas b.hamard p baudouin C. 王静波 Service d’Ophtalmologie III C.H.N.O. des Quinze-Vingts 28 rue de Charenton Paris 75012 FranceDr.

Objective: To analyze bleb structure after filtering surgery at the cellular level using a new generation in vivo confocal microscope. Design: Observational case series. participants: We retrospectively evaluated 17 filtering blebs of 13 patients after trabeculectomy. Methods: Ophthalmologic examinations included slit-lamp examination, applanation tonometry, and in vivo confocal microscopy (Heidelberg Retina Tomograph II, Rostock Cornea Module). Eyes were classified into 3 groups: (1) functioning blebs (6 eyes), (2) nonfunctioning blebs (6 eyes), and (3) functioning blebs after application of mitomycin C (5 eyes). Cellular patterns, morphologic appearance, and functional aspects of functioning and nonfunctio ning blebs were compared in a masked manner. Main Outcome Measures: In vivo confocal microscopy images were analyzed for number of intraepithelialmicrocysts,density of subepithelial connective tissue, presence of blood vessels, or encapsulation. Results: All functioning blebs had numerous intraepithelial opticallyempty microcysts, whereas all nonfunctioning blebs had none or few. Subepithelial con nective tissue was widely spaced in all functioning blebs, whereas the tissue was dense in 83.3%of nonfunctioning blebs. Functioning blebs with mitomycin C had numerous microcysts and loosely arranged subepithelial connective tissue as compared with nonfunctioning blebs. Conclusions: In vivo confocal microscopy study of blebs is an original method that agrees well with ex vivo histologic examination. The number of microcysts and the density of the subepithelial connective tissue observed with in vivo confocal microscopy are correlated with bleb function. by providing details of the structures of filtering blebs at the cellular leve l, in vivo confocal microscopy constitutes a new promising way to understand wound healing mechanisms after filtering surgery.

关键词：滤过泡显微镜非功能性实验设备活体共焦显微

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IN VITRO EFFECTS OF pRESERVED OR pRESERVATIVE -FREE ANTIGLAUCOMA MEDICATIONS ON HUMAN COMpLEMENT SYSTEM

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国际眼科杂志 2003年第1期3卷 85-85页

作者： C.blondin p.hamard b.Cholley N.Haeffner-Cavaillon C.baudouin Department of Ophthalmology Quinze-Vingts National HospitalDepartment of Ophthalmology Quinze-Vingts National HospitalLaboratory of Toxicology Faculty of Pharmacological and Biological Sciences University Paris VINSERM U430 Broussais HospitalINSERM U430 Broussais HospitalDepartment of Ophthalmology Quinze-Vingts National Hospital Ambroise Par Hospital AP-HP Paris and Universities of Paris VI and Ver-sailles France

purpose: Antiglaucoma drugs have been associated with con-junctival and trabecular inflammatory cell infiltrates. However, the underlying mechanisms are still poorly understood. The aim of this study was to assess the... 详细信息

关键词：抗青光眼药物补体系统炎症反应防腐剂

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