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Transdermal drug delivery systems in diabetes management: A review

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 13-25页

作者： li Ching ng Manish Gupta School of Pharmacy Monash University MalaysiaBandar Sunway 47500Malaysia Faculty of Pharmacy DIT UniversityDehradun 248009India

Diabetes mellitus is a chronic disease in which there is an insufficient production of insulin by the pancreas, or the insulin produced is unable to be utilized effectively by the body. Diabetes affects more than 415 million people globally and is estimated to strike about 642 million people in 2040. The WHO reported that diabetes will become the seventh biggest cause of mortality in 2030. Insulin injection and oral hypoglycemic agents remain the primary treatments in diabetes management. These often present with poor patient compliance. However, over the last decade, transdermal systems in diabetes management have gained increasing attention and emerged as a potential hope in diabetes management owing to the advantages that they offer as compared to invasive injection and oral dosage forms. This review presents the recent advances and developments in transdermal research to achieve better diabetes management. Different technologies and approaches have been explored and applied to the transdermal systems to optimize diabetes management. Studies have shown that these transdermal systems demonstrate higher bioavailability compared to oral administration due to the avoidance of first-pass hepatic metabolism and a sustained drug release pattern. Besides that, transdermal systems have the advantage of reducing dosing frequency as drugs are released at a predetermined rate and control blood glucose level over a prolonged time, contributing to better patient compliance. In summary, the transdermal system is a field worth exploring due to its significant advantages over oral route in administration of antidiabetic drugs and biosensing of blood glucose level to ensure better clinical outcomes in diabetes management.

关键词： Transdermal Diabetes Antidiabetic Insulin Drug delivery system

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Solving sparse non-negative tensor equations： algorithms and applications

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Frontiers of Mathematics in China 2015年第3期10卷 649-680页

作者： Xutao li Michael K. ng School of Computer Engineering Nanyang Technological University Singapore 639798 Singapore Centre for Mathematical Imaging and Vision and Department of MathematicsHong Kong Baptist University Hong Kong China

We study iterative methods for solving a set of sparse non-negative tensor equations （multivariate polynomial systems） arising from data mining applications such as information retrieval by query search and community discovery in multi-dimensional networks. By making use of sparse and non-negative tensor structure, we develop Jacobi and Gauss-Seidel methods for solving tensor equations. The multiplication of tensors with vectors are required at each iteration of these iterative methods, the cost per iteration depends on the number of non-zeros in the sparse tensors. We show linear convergence of the Jacobi and Gauss-Seidel methods under suitable conditions, and therefore, the set of sparse non-negative tensor equations can be solved very efficiently. Experimental results on information retrieval by query search and community discovery in multi-dimensional networks are presented to illustrate the application of tensor equations and the effectiveness of the proposed methods.

关键词： Nonnegative tensor multi-dimensional network information retrieval community iterative method multivariate polynomial equation

Design and control of deformable quadrotor with varying length arms

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Science China(Technological Sciences) 2023年第5期66卷 1225-1234页

作者： SUN YiChong XIE MingNa li YeHui ng WingYin ZHAng Heng li Zheng Multi-Scale Medical Robotics Centre The Chinese University of Hong KongHong Kong 999077China Department of Surgery The Chinese University of Hong KongHong Kong 999077China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China College of Optoelectronic Engineering Chongqing UniversityChongqing 400044China

Deformable quadrotors can manipulate their specific structure for specialized tasks or excellent flight performance under diverse *** added deformation mechanism,the quadrotor exhibits higher flexibility;however,this is accompanied by difficulties in modeling analysis and controller design,which are crucial ***,a novel deformable quadrotor that can alter its arm's length is designed by combining the crank-slider mechanism and *** dynamics,including the attitude and position systems,are analyzed and the former is further described as switched linear parameter varying(SLPV)systems from a control-oriented *** addition,a combined SLPV/proportion-integration-differentiation(PID)attitude controller is developed to handle different deformable quadrotor modes,which guarantees the stability of the closed-loop attitude system during the deformation process and achieves attitude ***,together with the cascade PID position controller,the entire flight controller is constructed whose feasibility is verified via fixed-point hovering and trajectory tracking experiments.

关键词： deformable quadrotor mechanics and control LPV systems switched control strategy specialized aerial system

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Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

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Science China Earth Sciences 2025年第1期 11-26页

作者： Man-Hei ng Xiaoping ZHAng Jianwu CHEN Yongqiang SHI Fuchang ZUO Wenxi PEng Weichun FU liansheng li Pengwei LUO Chi-Long TAng Guozheng ZHAng Zhiwu MEI li WAng Cunhui li Jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese Long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. Furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

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Kernel Density Estimation Based Multiphase Fuzzy Region Competition Method for Texture Image Segmentation

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Communications in Computational Physics 2010年第8期8卷 623-641页

作者： Fang li Michael K.ng Department of Mathematics East China Normal UniversityShanghai 200241China Centre for Mathematical Imaging and Vision and Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this paper,we propose a multiphase fuzzy region competition model for texture image *** the functional,each region is represented by a fuzzy membership function and a probability density function that is estimated by a nonparametric kernel density *** overall algorithm is very efficient as both the fuzzy membership function and the probability density function can be implemented *** apply the proposed method to synthetic and natural texture images,and synthetic aperture radar *** experimental results have shown that the proposed method is competitive with the other state-of-the-art segmentation methods.

关键词： Texture multiphase region competition kernel density estimation fuzzy membership function total variation

Alternating Minimization Method for Total Variation Based Wavelet Shrinkage Model

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Communications in Computational Physics 2010年第10期8卷 976-994页

作者： Tieyong Zeng Xiaolong li Michael ng Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong KongChina Institute of Computer Science&Technology Peking UniversityBeijing 100871China

In this paper,we introduce a novel hybrid variational model which generalizes the classical total variation method and the wavelet shrinkage *** alternating minimization direction algorithm is then *** also prove that it converges strongly to the minimizer of the proposed hybrid ***,some numerical examples illustrate clearly that the new model outperforms the standard total variation method and wavelet shrinkage method as it recovers better image details and avoids the Gibbs oscillations.

关键词： Alternating minimization convergence Gibbs oscillation wavelet shrinkage total variation

Monitoring of ground deformation in liulin district,China using InSAR approaches

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International Journal of Digital Earth 2018年第3期11卷 264-283页

作者： Zheyuan Du linlin Ge Alex Hay-Man ng Xiaojing li liyuan li Geoscience and Earth Observing System Group(GEOS) School of Civil and Environmental EngineeringUNSW AustraliaSydneyAustralia Department of Surveying Engineering Guangdong University of TechnologyGuangzhouPeople’s Republic of China

Coalbed methane(CBM)exploration generally refers to a technique that extracts natural gas from coal *** development of CBM in liulin,China,has experienced a significantly growth period during the past two *** research mainly focused on the coal geological background or CBM technique itself,while time series InSAR(TS-InSAR)technique was conducted in this work to study the potential land deformation induced by CBM extraction from 2003 to *** total,21 ALOS-1 PALSAR images(acquired from 22 December 2006 to 2 January 2011)and 14 ENVISAT ASAR scenes(captured between 29 October 2003 and 7 November 2007)were *** TS-InSAR outcome revealed that the annual deformation rates were ranging from 15 to−40 mm yr−1 over the study *** the time series deformation evolutions were analysed over 8 CBM sites(No.4 coal seam)out of 20,and the subsidence rates between 1.9 and−6.5 mm yr−1 were *** addition,the average subsidence rate and standard deviation among these eight measurements were−3.0 and 2.6 mm yr−1 respectively,suggesting that these CBM extraction sites were quite stable and no obvious subsidence had been observed during this eight-year period.

关键词： TS-InSAR subsidence measurement CBM

Mapping land subsidence over the eastern Beijing city using satellite radar interferometry

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International Journal of Digital Earth 2018年第5期11卷 504-519页

作者： Zheyuan Du linlin Ge Alex Hay-Man ng li Xiaojing liyuan li Geoscience and Earth Observing System Group(GEOS) School of Civil and Environmental EngineeringUNSW AustraliaSydneyAustralia Department of Surveying Engineering Guangdong University of TechnologyGuangzhouPeople’s Republic of China

Beijing City has suffered from groundwater-induced subsidence since the late 1930s and the over-exploration of groundwater could lead to subsidence as much as−12.0 cm yr−*** studies on the ground deformation at Beijing City mainly focused on the period before the year of 2014 when a mega-engineering project was launched to reduce water shortage in *** study the most recent ground deformation,19 L-band ALOS-1 PALSAR images(June 2007–January 2011),24 C-band Sentinel-1 SAR images(June 2015–November 2016)together with 9 ALOS-2 PALSAR acquisitions(September 2014–February 2017)were analysed in this *** measurements were exploited to verify the ALOS-1-based time series InSAR(TS-InSAR)result while Sentinel-1 and ALOS-2 result were cross-verified with each ***,the whole study area was divided into four sub-zones,and the result indicated that the subsidence rates over five townships,Cuigezhuan,Jinzhan,liyuan,Songzhuang and Yanjiao were accelerating and more attentions should be *** the contrary,the town centre of Douge Zhuang township experienced a decreasing trend between these two ***,the time series measurements with respect to five selected measurement points and the profile line along the subsidence hot spots were analysed.

关键词： Subsidence Beijing groundwater SAR interferometry

Impact of ozone assisted ultrasonication pre-treatment on anaerobic digestibility of sewage sludge

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Journal of Environmental Sciences 2015年第7期27卷 29-38页

作者： Xinbo Tian Antoine Prandota Trzcinski li Leonard lin Wun Jern ng Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research Institute Nanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University Public Utilities Board Water Reclamation (Plants) Department Nanyang Environment and Water Research Institute Nanyang Technological University

Impact of ultrasonication（ULS） and ultrasonication-ozonation（ULS-Ozone） pre-treatment on the anaerobic digestibility of sewage sludge was investigated with semi-continuous anaerobic reactors at solid retention time（SRT） of 10 and 20 days. The control, ULS and ULS-Ozone reactors produced 256, 309 and 348 m L biogas/g CODfedand the volatile solid（VS） removals were 35.6%, 38.3% and 42.1%, respectively at SRT of 10 days. At SRT of20 days, the biogas yields reached 313, 337 and 393 m L biogas/g CODfedand the VS removal rates were 37.3%, 40.9% and 45.3% in the control, ULS and ULS-Ozone reactors, ***-Ozone pre-treatment increased the residual organic amount in the digested *** soluble residual organics were found to contain macromolecules with molecular weights（MW） larger than 500 k Da and smaller polymeric products with MW around 19.4and 7.7 k Da. These compounds were further characterized to be humic acid-like substances with fluorescent spectroscopy analysis.

关键词： Sewage sludge Ultrasound Ozone Pre-treatment Molecular weight Anaerobic digestion

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