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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： Nguyen Quang Thu Nguyen Tran Nam Tien Nguyen thi Hai yen Thuc-Huy duong Nguyen Phuoc Long Huy Truong Nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

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Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong duong Duc thien hoang Hai yen Nguyen Anh Duc Trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy thi Thu Phan yen thi hoang Creswell Jacob Dang thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Pthis resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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The Integration of Intemational Chinese Students Into Local Singaporean Community

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Journal of Tourism and Hospitality Management 2016年第2期4卷 73-86页

作者： Tran Nhi Bach Van duong thi hoang yen Xiao Juan Sun Chenhui James Cook University Australia (Singapore Campus) Singapore

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Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts

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Open Journal of Animal Sciences 2024年第3期14卷 194-203页

作者： Van Khanh Nguyen Huong Thu thi Vu Au thi hoang yen Kim thi Pham Giang thi Thanh Nhan Hung Phu Lai Lan Doan Pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam

this study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency.

关键词： Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time Confluence

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奉祀天后圣母的研究--以越南芹苴市华人的天后圣母信仰为例

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妈祖文化研究 2024年第1期 25-33页

作者： [越南]阮福才陈氏金黄 FPT大学越南芹苴26132 坚江师范学院越南坚江83000

本文以芹苴市华人奉祀天后圣母为研究对象,探讨了这一文化的特征、形成原因和社会意义,分析了芹苴市华人奉祀天后圣母的组成要素、内在逻辑和外在表现发现,这一文化是华人社区对中国传统文化的继承和创新,也是对越南多元文化的融入和贡... 详细信息

本文以芹苴市华人奉祀天后圣母为研究对象,探讨了这一文化的特征、形成原因和社会意义,分析了芹苴市华人奉祀天后圣母的组成要素、内在逻辑和外在表现发现,这一文化是华人社区对中国传统文化的继承和创新,也是对越南多元文化的融入和贡献。本文认为,芹苴市华人奉祀天后圣母是华人社会意识的反映,也是华人社会实践的指导,体现了华人对生存环境的适应和改造。同时指出,天后圣母的当地信仰满足了华人的精神需求,增强了华人的社会凝聚力,促进了华人与越南社会的和谐共处。

关键词：越南华人妈祖文化跨文化交流

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Effects of parental age on offspring growth and survival in both wild and domesticated strains of bighead catfish(Clarias macrocephalus Günther,1864)

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Aquaculture and Fisheries 2023年第2期8卷 141-147页

作者： Thuy yen duong Thet Su Win thi Ngoc Tran Nguyen College of Aquaculture and Fisheries Can Tho UniversityCan Tho920000Viet Nam International Master Program in Aquaculture Course 4Can Tho UniversityCan Tho920000Viet Nam

Understanding the relationship between fish parental age and offspring performance over their life cycle is crucial for *** study investigates the effect of parental age for both 1-and 2-year-old fish on the growth and survival rates of their larval to grow-out stages for two wild and domesticated strains of bighead catfish(Clarias macrocephalus).Fish were sampled from the Vietnamese Mekong Delta where wild adult fish were collected from a conservation area in Ca Mau Province and domesticated fish were taken from a hatchery in Can *** offspring treatments of 1-and 2-year-old broodstock strains were reared for 3 successive periods:40 days for fingerling rearing in static tanks with water exchange,60 days for juveniles,and 90 days for grow-out in recirculating *** final weight of fish at 190 days varied from 96.7 to 144.7 *** growth of offspring was not affected by parental age(P>0.05),over the 3 rearing ***,the domesticated fish strain showed significantly better growth rates than the wild fish strain(P<0.05).Feed conversion ratios were comparable across fish *** rates did not differ at the fingerling(21.8%-36.4%)and juvenile(69.0%-73.3%)***,significant differences were found at the grow-out stage(69.3%-84.0%),with offspring from 2-year-old parents of both strains having greater survival ***,1-and 2-year-old fish appear to be suitable for bighead catfish breeders.

关键词： Parental age Clarias catfish Fish growth Strain evaluation Wild broodstock

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A comparative analysis of weight-based machine learning methods for landslide susceptibility mapping in Ha Giang area

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Big Earth Data 2023年第4期7卷 1005-1034页

作者： Thanh Trinh Binh Thanh Luu Trang Ha thi Le duong Huy Nguyen Trong Van Tran thi Hai Van Nguyen Khanh Quoc Nguyen Lien thi Nguyen Faculty of Computer Science Phenikaa UniversityYen NghiaHa DongHanoi 12116Vietnam Phenikaa Research and Technology Institute(PRATI) A&A Green Phoenix Group JSCNo.167 Hoang NganTrung HoaCau GiayHanoi 11313Vietnam Northwestern Geological Division General Department of Geology and Minerals of VietnamHanoiVietnam Youth union office Thuyloi University175 Tay SonDong DaHanoiVietnam Center of Remote Sensing and Geohazards Vietnam Institute of Geosciences and Mineral ResourcesHanoiVietnam

Landslide susceptibility maps (LSMs) are very crucial for planningpolicies in hazardous areas. However, the accuracy and reliability ofLSMs depend on available data and the selection of suitable *** study is conducted to produce LSMs by combinations of machinelearning methods and weighting techniques for Ha Giang province,Vietnam, where has limited data. In study area, we gather 11 landslideconditioning factors and establish a landslide inventory *** the weights of classes (or factors) is very important toprepare data for machine learning methods to generate LSMs. Wefrst use frequency ratio (FR) and analytic hierarchy process (AHP)techniques to generate the weights. Then, random forest (RF), supportvector machine (SVM), logistic regression (LR), and AHP methods arecombined with FR and AHP weights to yield accurate and reliableLSMs. Finally, the performance of these methods is evaluated by fivestatistical metrics, ROC and R-index. The empirical results have shownthat RF is the best method in terms of R-index and the five metrics, *** rate (0.9661), FP rate (0.0), ACC (0.9835), MAE (0.0046), and RMSE(0.0350) for this study area. this study opens the perspective of weightbasedmachine learning methods for landslide susceptibility mapping.

关键词： Landslide logistic regression random forest SvM Vietnam

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Utilization and Satisfaction with HIV Services at 7 Provinces in Vietnam: A Cross-Sectional Study

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World Journal of AIDS 2022年第2期12卷 65-82页

作者： Le Bao Chau Pham thi Huyen Chang duong Minh Duc hoang Van Minh Luu Quoc Toan Bui thi Tu Quyen Le thi Vui Bui thi Thu Ha Hanoi University of Public Health Hanoi Vietnam

The study was carried out to determine utilization and satisfaction with essential HIV services from HIV individuals and high-risk populations in 7 socioeconomic provinces nationwide. A cross-sectional approach was applied in the study. Data were collected through face-to-face interviews using self-report questionnaires. Findings from 2380 respondents indicated a high percentage of utilization as well as a high level of satisfaction, in particular among men who have sex with men (MSM) and female sex worker (FSW) sub-group. Needle, syringe, and condom programs had lower usage and satisfaction mean scores in comparison with other services. The proportion of people who used drugs (PWID) and participated in the needle and syringe program was 53.6%. HIV counseling and testing uptake proportion of overall respondents in the last 12 months was 82.2% while the rate of antiretroviral treatment among infected PWID was 74.9%. The level of satisfaction with treatment services was found to be higher than preventive interventions (p < 0.05). Analysis using univariable logistic regression suggested an association between some socioeconomic factors such as income, employment, educational attainment, and marital status with subjects’ satisfaction with several HIV services. Preventive services, especially needle, syringe and condom programs should be prioritized to scale up the coverage and effectiveness. Innovative approaches targeting at PWID should be promoted to increase their access to prevention programs as well as HIV care when needed.

关键词： HIV Service Utilization Satisfaction

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Thermodynamic Simulation on the Change in Phase for Carburizing Process

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Computers, Materials & Continua 2021年第7期68卷 1129-1145页

作者： Anh Tuan hoang Xuan Phuong Nguyen Osamah Ibrahim Khalaf thi Xuan Tran Minh Quang Chau thi Minh Hao Dong duong Nam Nguyen Ho Chi Minh city University of Technology(HUTECH) HoVietnam Ho Chi Minh city University of Transport Ho Chi Minh cityVietnam Al-Nahrain University Al-Nahrain Nanorenewable Energy Research CenterBaghdadIraq Hanoi University of Science and Technology HanoiVietnam Industrial University of Ho Chi Minh City(IUH) Ho Chi Minh cityVietnam Vietnam Maritime University HaiphongVietnam

The type of technology used to strengthen the surface structure of machine parts,typically by carbon-permeation,has made a great contribution to the mechanical engineering industry because of its outstanding advantages in corrosion resistance and enhanced mechanical and physical ***,carbon permeation is considered as an optimal method of heat treatment through the diffusion of carbon atoms into the surface of alloy *** study presented research results on the thermodynamic calculation and simulation of the carbon permeability *** Fick’s law,the paper calculated the distribution of carbon concentration in the alloy steel after it is absorbed from the surface into the internal of the *** the SYSWELD software,an analysis was performed on the carbon permeability process to determine the distribution of carbon concentrations in 20CrMo steel that was then followed by a detailed analysis of the microstructure of the sample post the carburizing *** to the calculation results,the surface carbon content was 0.9%and steadily decreased into the *** 3 hours,the depth of the absorbent layer was measured at 0.5 mm for both the cylindrical and cubic *** analyzing the phase,the distribution of martensite phases such as ferrite/pearlite and residual austenite was also determined after the carburizing process.

关键词： Carburizing process 20CrMo steel thermodynamic analysis microstructure formation carbon concentration

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