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MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids

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Chinese Chemical Letters 2024年第4期35卷 464-468页

作者： Jing Chen Peisi Xie Pengfei Wu Yu He Zian Lin Zongwei cai Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350116China Department of Chemistry State Key Laboratory of Environmental and Biological AnalysisHong Kong Baptist UniversityHong KongChina College of Forestry Nanjing Forestry UniversityNanjing 210018China

Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) to investigate the spatial distribution of endogenous compounds(e.g., lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization(MALDI-2) and trapped ion mobility spectrometry(TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies.

关键词： Matrix-assisted laser desorption/ionization(MALDI) Mass spectrometry imaging MALDI coupled with laser-postionization Trapped ion mobility spectrometry Cancer cell spheroids

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Dynamics of Land Use/Land Cover Considering Ecosystem Services for a Dense-Population Watershed Based on a Hybrid Dual-Subject Agent and Cellular Automaton Modeling Approach

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Engineering 2024年第6期37卷 182-195页

作者： Yutong Li Yanpeng cai Qiang Fu Xiaodong Zhang Hang Wan Zhifeng Yang Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou 510006China School of Water Conservancy and Civil Engineering Northeast Agricultural UniversityHarbin 150030China School of Environmental Science and Engineering Shandong UniversityQingdao 266000China

Land use/land cover represents the interactive and comprehensive influences between human activities and natural conditions,leading to potential conflicts among natural and human-related issues as well as among *** study introduced economic standards for farmers.A hybrid approach(CA-ABM)of cellular automaton(CA)and an agent-based model(ABM)was developed to effectively deal with social and land-use synergic issues to examine human–environment interactions and projections of land-use conversions for a humid basin in south *** attributes and socioeconomic data were used to analyze land use/land cover and its drivers of *** major modules of the CA-ABM are initialization,migration,assets,land suitability,and land-use change *** estimates of the factors influencing the urban land-use conversion probability were captured using parameters based on a spatial logistic regression(SLR)***,multicriteria evaluation(MCE)and Markov models were introduced to obtain empirical estimates of the factors affecting the probability of ecological land *** agent-based CA-SLR-MCE-Markov(ABCSMM)land-use conversion model was proposed to explore the impacts of policies on land-use *** model can reproduce observed land-use patterns and provide links for forest transition and urban expansion to land-use decisions and ecosystem *** results demonstrated land-use simulations under multi-policy scenarios,revealing the usefulness of the model for normative research on land-use management.

关键词： Land use/land cover Human-environment interactions Agent-based model Cellular automaton

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Pulmonary rehabilitation protocols in urgent lung transplantation patients

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World Journal of Emergency Medicine 2024年第1期15卷 47-51页

作者： Fei Zeng Lingyun cai Luyao Guo Meijuan Lan Jiangshuyuan Liang Peipei Gu Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe underlying diseases and complex *** aim of the study was to report the clinical outcomes of patients who received ULTx and followed the perioperative rehabilitation protocol implemented in a lung transplant ***:A retrospective analysis was conducted in ULTx patients who required preoperative invasive mechanical ventilation(IMV)and ECMO between January 2018 and January *** were retrieved from electronic medical records at our lung transplant ***:Fourteen patients(mean age 57.43±10.97 years;12 males,2 females)underwent ULTx with bridging ECMO and *** mean body mass index was 23.94±3.33 kg/m²,and the mean Acute Physiology and Chronic Health Evaluation(APACHE)II score was 21.50±*** Nutritional Risk Screening 2002(NRS 2002)scores were≥*** was performed after an 8.5-day waiting period(interquartile interval[IQR]5.0-26.5 d).Following the surgeries,the average lengths of ECMO and IMV were 1.0(IQR 1.0-2.0)d and 5.0(IQR 3.0-7.3)d,*** total length of hospital stay was 60.1±30.8 d,with an average intensive care unit stay of 38.3±22.9 d and post-operative hospitalization stay of 45.8±26.1 *** patients died within 30 d after ULTx,with a 30-day survival rate of 85.71%.CONCLUSION:Patients receiving ULTx showed an acceptable short-term survival rate,validating the practicality and safety of the treatment protocols implemented in our center.

关键词： Urgent lung transplantation End-stage lung disease Extracorporeal membrane oxygenation Invasive respiratory support Pulmonary rehabilitation.

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Wavefield Separation of Distributed Acoustic Sensing Vertical Seismic Profile Data Based on Multichannel Vector Median Filtering

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Journal of Earth Science 2024年第2期35卷 712-716页

作者： Zijuan Ma Jun Lu Feng Zhang Pinbo Ding Zhidong cai Key Laboratory of Intraplate Volcanoes and Earthquakes Ministry of EducationChina University of GeosciencesBeijing 100083China College of Geophysics China University of PetroleumBeijing 102249China New Resources Geophysical Exploration Division BGP Inc.CNPCZhuozhouHebei 072751China

INTRODUCTION Distributed acoustic sensing(DAS)is a novel and popular technology for vertical seismic profile(VSP)data acquisition because of its many advantages,including full vertical coverage,high sampling density,low cost,and resistance to stressors(high temperature and pressure).The current industrial application of DAS in borehole exploration acquires single-mode *** records strain rates,which are then converted to particle velocities by the modem before being written to the disk.

关键词： Seismic Vertical borehole

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Synergic catalysis of W and Ni originating from substitution of trivacant phosphotungstate for the selective oxidation of aniline to azoxybenzene

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Chinese Chemical Letters 2024年第2期35卷 558-563页

作者： Sheng cai Xiao-Yuan Wu Weiming Wu Sa-Sa Wang Can-Zhong Lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Partial substitution of polyoxometalate(POM)is an efficient route to modulate the catalytic property of maternal *** this work,a new Keggin type POM involving{Ni 6}cluster,{[Ni(H_(2) O)_(2)(Dach)_(2)][Ni(Dach)_(2)]_(2)}{[Ni_(6)Cl(μ-OH)_(3)(H_(2) O)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))][Ni_(6)(μ-OH)_(3)(H_(2) O)_(2)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))]}Cl·27H_(2) O,(1,Dach=1,2-diaminocyclohexane)was *** 1 shows excellent catalytic performance in the selective oxidation of aniline to azoxybenzene(AOB)in *** apparently different results from that with the matrix{PW 9 O_(3)_(4)}({PW9})suggest the successful regulation of the catalytic property of{PW9}by the introduction of the{Ni6}cluster into the *** experimental results indicate that the highlighted performance of 1 is contributed by the synergy of W and Ni sites,which are respectively responsible for the oxidation and condensation steps in the production of *** good selectivity to AOB is essentially attributed to the effective modulation of the reaction rates of oxidation and condensation steps by W and Ni sites,respectively.

关键词： Polyoxometalate {Ni6}cluster Modulated catalytic property Aniline oxidation Azoxybenzene

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Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie cai Wen-Wen Fan Yun-Hui Zhong cai-Lan Wen Xiao-Dan Wei Wan-Chen Wei Wan-Yan Xiang Jin-Mao Chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university ***:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical *** data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their *** analysis and logistic regression were used to examine the factors associated with these ***:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular *** insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,Pted with the convergence of positive and negative fusion images at close range(r=-0.321,Pted that gender,age,and the difference in right and binocular SE did not influence the emergence of these ***:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent *** binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

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Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes:a bioinformatics analysis

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1411-1417页

作者： cai-Han Yu cai-Xia Wu Dai Li Lan-Lan Gong Xu-Dong Lyu Jie Yang Department of Ophthalmology Xianning Central HospitalThe First Affiliated Hospital of Hubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100Hubei ProvinceChina School of Optometry Hubei University of Science and TechnologyXianning 430071Hubei ProvinceChina

AIM:To prevent neovascularization in diabetic retinopathy(DR)patients and partially control disease ***:Hypoxia-related differentially expressed genes(DEGs)were identified from the GSE60436 and GSE102485 datasets,followed by gene ontology(GO)functional annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** candidate drugs were screened using the CMap ***,a protein-protein interaction(PPI)network was constructed to identify hypoxia-related hub genes.A nomogram was generated using the rms R package,and the correlation of hub genes was analyzed using the Hmisc R *** clinical significance of hub genes was validated by comparing their expression levels between disease and normal groups and constructing receiver operating characteristic curve(ROC)***,a hypoxia-related miRNA-transcription factor(TF)-Hub gene network was constructed using the NetworkAnalyst online ***:Totally 48 hypoxia-related DEGs and screened 10 potential candidate drugs with interaction relationships to upregulated hypoxia-related genes were identified,such as ruxolitinib,meprylcaine,and *** addition,8 hub genes were also identified:glycogen phosphorylase muscle associated(PYGM),glyceraldehyde-3-phosphate dehydrogenase spermatogenic(GAPDHS),enolase 3(ENO3),aldolase fructose-bisphosphate C(ALDOC),phosphoglucomutase 2(PGM2),enolase 2(ENO2),phosphoglycerate mutase 2(PGAM2),and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3).Based on hub gene predictions,the miRNA-TF-Hub gene network revealed complex interactions between 163 miRNAs,77 TFs,and hub *** results of ROC showed that the except for GAPDHS,the area under curve(AUC)values of the other 7 hub genes were greater than 0.758,indicating their favorable diagnostic ***:PYGM,GAPDHS,ENO3,ALDOC,PGM2,ENO2,PGAM2,and PFKFB3 are hub genes in DR,and hypoxia-related hub genes exhibited favorable diagnostic perform

关键词： diabetic retinopathy hypoxia-related genes hub genes miRNA-TF-Hub gene drug prediction

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Arbitrary skin metallization by pencil-writing inspired solid-ink rubbing for advanced energy storage and harvesting

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Journal of Energy Chemistry 2024年第1期88卷 592-602,I0013页

作者： Yonghan Zhou Zhongfeng Ji Wenrui cai Xuewei He Ruiying Bao Xuewei Fu Wei Yang Yu Wang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina

The development of a durable metallic coating on diverse substrates is both intriguing and challenging,particularly in the research of metal-conductive materials for applications such as batteries,soft electronics,and ***,by learning from the pencil-writing process,a facile solid-ink rubbing technology(SIR-tech)is invented to address the above *** solid-ink is exampled by rational combination of liquid metal and graphite *** harnessing the synergistic effects between rubbing and adhesion,controllable metallic skin is successfully formed onto metals,woods,ceramics,and plastics without limitation in size and ***,outperforming pure liquid-metal coating,the composite metallic skin by SIR-tech is very robust due to the self-lamination of graphite nanoplate exfoliated by liquid-metal *** critical factors controlling the structures-properties of the composite metallic skin have been systematically investigated as *** applications,the SIR-tech is demonstrated to fabricate high-performance composite current collectors for next-generation batteries without traditional metal ***,advanced skin-electrodes are further demonstrated for stable triboelectricity generation even under temperature fluctuation from-196 to 120℃.This facile and highly-flexible SIR-tech may work as a powerful platform for the studies on functional coatings by liquid metals and beyond.

关键词： Microadhesion guided technology Skin metallization by solid-ink rubbing Liquid metal composites Composite current collector Batteries and triboelectric nanogenerators

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From Digital Human Modeling to Human Digital Twin: Framework and Perspectives in Human Factors

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 1-14页

作者： Qiqi He Li Li Dai Li Tao Peng Xiangying Zhang Yincheng cai Xujun Zhang Renzhong Tang State Key Laboratory of Fluid Power Components and Mechatronic Systems Zhejiang UniversityHangzhou 310027China ZJU-Sunon Joint Research Center for Smart Furniture Zhejiang UniversityHangzhou 310027China PICO-Lab Bytedance Inc.Shanghai 200233China Sunon technology Co. Ltd.Hangzhou 311215China

The human digital twin(HDT)emerges as a promising human-centric technology in Industry 5.0,but challenges remain in human modeling and *** human modeling(DHM)provides solutions for modeling and simulating human physical and cognitive aspects to support ergonomic ***,it has limitations in real-time data usage,personalized services,and timely *** emerging HDT concept offers new possibilities by integrating multi-source data and artificial intelligence for continuous monitoring and ***,this paper reviews the evolution from DHM to HDT and proposes a unified HDT framework from a human factors *** framework comprises the physical twin,the virtual twin,and the linkage between these *** virtual twin integrates human modeling and AI engines to enable model-data-hybrid-enabled *** can potentially upgrade traditional ergonomic methods to intelligent services through real-time analysis,timely feedback,and bidirectional ***,the future perspectives of HDT for industrial applications as well as technical and social challenges are *** general,this study outlines a human factors perspective on HDT for the first time,which is useful for cross-disciplinary research and human factors innovation to enhance the development of HDT in industry.

关键词： Human digital twin Digital human modeling Human factors Human-centric technology

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Granger causal representation learning for groups of time series

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Science China(Information Sciences) 2024年第5期67卷 56-68页

作者： Ruichu cai Yunjin WU Xiaokai HUANG Wei CHEN Tom Z.J.FU Zhifeng HAO School of Computer Science Guangdong University of Technology Peng Cheng Laboratory College of Science Shantou University

Discovering causality from multivariate time series is an important but challenging *** existing methods focus on estimating the Granger causal structures among multivariate time series,while ignoring the prior knowledge of these time series, e.g., the group of the time series. Focusing on discovering the Granger causal structures among groups of time series, we propose a Granger causal representation learning method to solve this problem. First, we use the multiset canonical correlation analysis method to learn the Granger causal representation of each group of time series. Then, we model the Granger causal relationships among the learned Granger causal representations using a recurrent neural network with temporal information. Finally, we formulate the above two stages into one unified optimization problem, which is efficiently solved using the augmented Lagrangian method. We conduct extensive experiments on synthetic and real-world datasets to validate the correctness and effectiveness of the proposed method.

关键词： Granger causal discovery Granger causal representation learning time series data recurrent neural network multiset canonical correlation analysis

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