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Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

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Chinese Chemical Letters 2024年第6期35卷 427-432页

作者： Yihan Zhou duo gao Yaying Wang Li Liang Qingyu Zhang Wenwen Han Jie Wang Chunliu Zhu Xinxin Zhang Yong Gan State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

Local delivery of nanoparticles holds promise for colorectal cancer(CRC)***,the presence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby adversely affecting treatment *** is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal ***,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(LMs),worm-like micelles(WLMs),large spherical micelles(LSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal *** found that the carriers exhibited diverse shapes while maintaining comparable physicochemical *** these,WLMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells compared to ***,rectally administrated 10-hydroxycamptothecin-loaded WLMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in *** findings underscore the significance of shape design in overcoming colonic mucosal absorption barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.

关键词： Worm-like micelles Mucus penetration Shape dependent Transmucosal delivery Colorectal cancer

胎儿期Ⅰ型先天性胆总管囊肿的MRI影像特征和肝胆发育的参数测量

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磁共振成像 2024年第8期15卷 139-144,178页

作者：谷磊磊高铎韩学芳耿左军周立霞河北医科大学第二医院医学影像科石家庄050000

目的观察胎儿期Ⅰ型先天性胆总管囊肿(congenital choledochal cyst,CCC)的MRI表现,分析CCC胎儿肺肝比值、肝脏、脾脏、胆囊以及门静脉测量参数与正常胎儿的差异。材料与方法随访分析31例出生后经手术证实的CCC患儿的临床资料以及胎儿期... 详细信息

目的观察胎儿期Ⅰ型先天性胆总管囊肿(congenital choledochal cyst,CCC)的MRI表现,分析CCC胎儿肺肝比值、肝脏、脾脏、胆囊以及门静脉测量参数与正常胎儿的差异。材料与方法随访分析31例出生后经手术证实的CCC患儿的临床资料以及胎儿期的MRI表现,观察CCC病灶的形态、走行方向、是否与胆管或胆囊相连、病灶下缘与肝脏下缘的关系,并测量计算胆总管囊肿的体积。以90例健康胎儿为对照组,比较两组胎儿肺肝比值、肝脏(左右径、上下径、最大截面面积、肝实质表观弥散系数)、脾脏(长径、厚度、最大截面面积)、胆囊(长径、短径、长径与短径比值、最大截面面积)以及门静脉直径的差异。并分析CCC胎儿胆总管囊肿体积与MRI测量指标的相关性。结果31例CCC患儿中,男9例,女22例,男女比率约为1∶2.4;其中26例胆总管囊肿病灶为椭圆形,5例为类圆形;31例病灶上端均可见尖角征;29例胆总管囊肿病灶的下缘未及肝脏下缘,2例病灶下缘超过了肝脏下缘;26例病灶的走行方向为右上-左下。CCC组与对照组胎儿的肺肝比值、肝脏(左右径、上下径、最大截面面积、表观弥散系数)、脾脏(长径、厚度)、胆囊(长径、短径、最大截面面积)的差异没有统计学意义(P>0.05);CCC组与对照组胎儿脾脏的最大截面面积、门静脉直径以及胆囊长径与短径的比值差异有统计学意义(P0.05)。结论CCC多见于女性,胎儿期的MRI表现为:病灶多呈椭圆形,一般不超过肝脏下缘,病灶的走行方向多为右上-左下,病变上端可见尖角征。患儿脾脏增大,门静脉增宽,胆囊长径与短径的比值增大。但病灶体积与胎儿脾脏的最大截面面积、门静脉直径、胆囊长径与短径的比值无相关性。

关键词：肝脏胆囊门静脉产前诊断先天性胆总管囊肿磁共振成像

一株铜绿假单胞菌噬菌体全基因组分析及与抗生素体外联合应用效果

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畜牧兽医学报 2024年第2期55卷 727-738页

作者：王晋宇张凯川王芮杰高铎蒋祺丰贾坤华南农业大学兽医学院广州510642

旨在为解决耐药铜绿假单胞菌感染提供不同方法。以鸡源铜绿假单胞菌为宿主菌,从医院污水中分离纯化出铜绿假单胞菌噬菌体,并进行生物学特性研究与基因组学分析,同时采用棋盘法与三种抗生素联合应用测试其效果。结果显示:从医院污水中分... 详细信息

旨在为解决耐药铜绿假单胞菌感染提供不同方法。以鸡源铜绿假单胞菌为宿主菌,从医院污水中分离纯化出铜绿假单胞菌噬菌体,并进行生物学特性研究与基因组学分析,同时采用棋盘法与三种抗生素联合应用测试其效果。结果显示:从医院污水中分离到一株铜绿假单胞菌噬菌体PaVOB,TEM显示病毒颗粒具有一个平均直径为73.02 nm的二十面体头部和一个平均长度为155.57 nm的长尾部,属于有尾噬菌体目,长尾噬菌体科,具有双链DNA基因组,宿主谱较窄,耐低温(-20℃)并且在37℃达到最适温度,有良好的酸碱耐受性,在pH为3~12时保持活性,最佳MOI为0.001,一步生长曲线显示潜伏期为10 min,爆发量为50 PFU·cell^(-1),吸附性试验表明PaVOB在10 min的吸附率为99.1%。PaVOB基因组全长为72179 bp,(G+C)%含量为54.81%,与VB PaeP FBPa1亲缘关系小于0.1,ORF预测显示,PaVOB包括74个ORF,软件预测均未发现毒力基因、耐药基因和tRNA存在。此外,抗生素联合应用结果显示,PaVOB与头孢曲松联合应用有协同作用,在效价为107 PFU·mL^(-1)时与恩诺沙星产生协同作用,与庆大霉素产生无关作用。铜绿假单胞菌噬菌体PaVOB对环境适应能力强,且基因组信息清晰,能够选择性地与不同抗生素联合应用发挥协同作用,具有治疗临床耐药铜绿假单胞菌感染的可能性。

关键词：铜绿假单胞菌噬菌体生物学特性基因组学抗生素联合应用

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施肥对旱作盐碱地线虫群落与燕麦产量的影响

中国生态农业学报（中英文） 2024年第1期32卷 153-163页

作者：乔月静霍瑞轩赵璐明李青山范雅琦高铎张礼静郭来春山西农业大学农学院晋中030801 白城市农业科学院白城137000

本研究以线虫作为指示生物,探索不同肥料长期施用对旱作盐碱瘠薄土壤微食物网的影响。依托5年定位试验,设置单施醋糟(VR)、有机肥(OM)、菌肥(BM)、化肥(CF)及醋糟/粉煤灰配施(VRF)和有机肥/化肥配施(OCF)、不施肥(CK)7个处理,选取燕麦... 详细信息

本研究以线虫作为指示生物,探索不同肥料长期施用对旱作盐碱瘠薄土壤微食物网的影响。依托5年定位试验,设置单施醋糟(VR)、有机肥(OM)、菌肥(BM)、化肥(CF)及醋糟/粉煤灰配施(VRF)和有机肥/化肥配施(OCF)、不施肥(CK)7个处理,选取燕麦苗期、抽穗期和收获期的耕层土壤样品,分析土壤线虫群落、土壤性状及燕麦产量。结果表明:大部分施肥处理降低了土壤pH和容重,显著提升了有机质、硝态氮含量以及微生物数量(P<0.05)。除BM外,各施肥处理的燕麦均显著增产(P<0.05),增幅为44.5%~92.3%,其中OM和CF显著高于其他施肥处理(P<0.05)。施肥显著提高了土壤线虫的数量和丰富度(P<0.05),OM处理线虫群落达到结构化状态,食物网稳定,但植物寄生线虫占比较高(36.2%);相比其他肥料,CF处理则会显著增加线虫优势属数量,显著降低线虫多样性(P<0.05);而两者配施的OCF一定程度上弥补了各自的不足。VRF和VR处理均显著提高了食微线虫占比(P<0.05),降低了植物寄生性线虫占比,VRF处理自由生活线虫成熟度指数显著最高(P<0.05)。土壤有机质、有效磷和微生物是土壤线虫数量变化的主要因素,土壤pH、EC、容重是燕麦增产的主要限制因素,而土壤线虫数量与燕麦产量无显著相关。有机肥/化肥和醋糟/粉煤灰配施较肥料单施更利于土壤微生态环境的健康稳定。

关键词：盐碱地长期施肥肥料类型燕麦土壤线虫土壤理化性状

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Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows

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Animal Nutrition 2023年第2期13卷 401-410页

作者： Yeqianli Wo Fengtao Ma Qiang Shan duo gao Yuhang Jin Peng Sun State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Chromium yeast(CY)supplementation has the potential to alleviate the negative effects of heat stress in dairy cows,but the mechanism remains *** aimed to identify the metabolic mechanisms whereby CY supplementation alleviates the negative effects of heat stress in mid-lactation dairy *** Holstein dairy cows with similar milk yield(24.6±1.5 kg/d),parity(2 or 3)and days in milk(125±8 d)were fed the same basal diet containing 0.09 mg of Cr/kg *** were allocated randomly to 2 groups:a control group(CON,without CY supplementation)and a CY group(CY,administered 0.36 mg Cr/kg DM).The experiment was performed over 8 weeks during a hot summer,in which the mean temperature-humidity index was 79.0±3.13(>72),indicating that the dairy cows were exposed to heat *** yeast supplementation reduced rectal temperature(P=0.032),and increased the lactation performance by increasing the yield of milk(+2.6 kg/d),protein,lactose and total solid,and protein and lactose percentages in the milk of the heat-stressed dairy cows(P1.0,P<0.05),and found to be involved in 6 Kyoto Encyclopedia of Genes and Genomes pathways,including those involved in nicotinate and nicotinamide ***,plasma concentration of nicotinamide was higher after CY supplementation,which might also contribute to the reduction of rectal temperature,the regulation of glucose homeostasis,and an improvement in the lactation performance of heat-stressed dairy *** conclusion,CY supplementation reduces re

关键词： Chromium yeast Heat stress Metabolomics Nicotinamide Dairy cow

Soft chemical synthesis and luminescence properties of red long-lasting phosphors Y_2O_2S:Sm^(3+)

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International Journal of Minerals,Metallurgy and Materials 2013年第10期20卷 972-977页

作者： Yan-juan Li Ming-wen Wang Lu-dan Zhang duo gao Shi-xiang Liu School of Chemistry and Biological Engineering University of Science and Technology Beijing

Sm3＋-activated Y2028 red phosphors were prepared by the combustion method and microemulsion method at the first time. X-ray characterization and electron diffraction show that, Y202S：Sm3＋, Ti4＋, Mg2＋ samples prepared by these two methods are pure hexagonal crystals in structure with a trivial change due to dopants. Scanning electron microscopy （SEM） results show that the product presents an almond-like sheet in uniform size. Under the excitation of 269 nm ultraviolet light, Y202S：Sm3＋ samples fabricated by these two methods exhibit three main groups of red emission lines located at 564, 604, and 656 nm, respectively, which are attributed to the transitions of 4G5/2 →6H5/2, 4G~/2 →6H7/2, 4G5/2 →6H9/2, respectively. The samples prepared by microemulsion are seven times higher in fluorescent emission intensity and half time longer in afterglow time than that prepared by combustion.

关键词： phosphors soft chemical synthesis luminescence combustion microemulsion

Highly reversible Zn anode enabled by anticatalytic carbon layer with suppressed hydrogen evolution

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Rare Metals 2024年第7期43卷 3044-3054页

作者： Wen-duo Zhang Chuang Sun Yu-Xuan Zhu Feng gao Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou221116China

Aqueous zinc-ion batteries(AZIBs)have emerged as a promising high-efficiency energy storage system due to the high energy density,low-cost and environmental ***,the practical application of AZIBs is severely restricted by the challenges faced by the Zn anode,which include uncontrollable dendrite growth,corrosion and hydrogen evolution ***,a simple and convenient physical vapor deposition(PVD)method is reported for fabricating uniform graphite as a protection layer on the surface of Zn *** high conductivity graphite layer on Zn anode(denoted as Zn@C)not only benefits the uniform distribution of the electric field,but also provides numerous Zn nucleation sites to regulate and navigate Zn-ion stripping/plating ***,the graphite layer with a poor catalytic activity endows the Zn@C anode with a highly suppressed hydrogen ***,a hydrogen and dendrite free anode is achieved with artificial anticatalytic carbon layer on Zn anode,exhibiting a high reversibility and excellent cycling stability over 2600 h at the current density of 5 mA·cm^(-2)with a capacity of 2.5 mAh·cm^(-2)and longtime cycling stability for assembled full *** work strategically designs the properties of the artificial interface layer to effectively address various challenges simultaneously,which presents insights for the future development of high-performance rechargeable AZIBs.

关键词： Zn metal anode Artificial anticatalytic layer Hydrogen suppression Dendrite free

Fabrication of amorphous FeCoNiCuMnP x high-entropy phosphide/carbon composites with a heterostructured fusiform morphology for efficient oxygen evolution reaction

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Journal of Materials Science & Technology 2024年第1期168卷 62-70页

作者： Yifan Zhou Longqing gao Haoyuan Chen Hao Wang Juan Zhang Xiumin Li Fangfang duo Guoqing Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Graduate School of Sustainable Community Studies Hirosaki University1-BunkyochoHirosaki 036-8560Japan Graduate School of Science and Technology Hirosaki University3-BunkyochoHirosaki 036-8561Japan Xinxiang University School of Chemistry&Materials EngineeringXinxiang 453003China Energy Conversion Engineering Laboratory Institute of Regional InnovationHirosaki University3-BunkyochoHirosaki 036-8561Japan

Amorphous high-entropy materials with abundant defects,coordinatively unsaturated sites,and loosely bonded atoms could exhibit excellent electrocatalytic ***,how to fabricate such ma-terials with nanostructure as well as amorphous structure is still full of *** this work,high-entropy metal organic framework(HE-MOF)is employed as the self-sacrificial template to fabricate FeCoNiCuMnP x high-entropy phosphide/carbon(HEP/C)*** obtained composite shows a het-erostructured fusiform morphology,in which the HEP is encapsulated by a carbon layer,revealing high electron conductivity as well as rich catalytic active sites for oxygen evolution reaction(OER).Beside,it is found that there is a short-range ordered crystal structure in the amorphous phase,which is bene-ficial for revealing high OER catalytic activity as well as good *** a result,the optimum HEP/C composite shows an overpotential 239 mV@10 mA cm^(−2)with a small Tafel slope of 72.5 mV dec^(−1) for catalyzing OER in alkaline solution.

关键词： Water electrolysis Oxygen evolution reaction High-entropy MOFs High-entropy phosphides Amorphous structure

Migration law of heavy metal cadmium in soil-root interface systems

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 243-248页

作者： Jin-Xiang YANG Ming-Xu ZHANG Xiao-Long LI Liang-Min gao duo-Xi YAO School of Earth and Environment Anhui University of Science and Technology Huainan 232001 China

The distribution characteristics of heavy metals in soil-root systems have great significance for the research into soil pollution risk assessment and the phytoremediation effect. This paper takes ligustrum lucidum as an example, based on the characteristics of adsorption of heavy metals in soil by woody plants, lays out sampling points, and using software Surer for the Kiging interpolation analysis, and the horizontal migration law of heavy metal cadmium in the soil-root interface system is simulated. Through multi-model statistical regression trend analysis, the horizontal migration mechanism of cadmium in different sections is discussed. The results show that：（1） under horizontal migration law： the migration ability of Cd is weaker near the Ligustrum lucidum root （0 30 cm）; with the root extension, the migration ability of Cd gradually is strengthened, and the main range of the migration ability is 60-90 cm. In addition, its migration law follows the cubic curve mode. （2） under longitudinal migration law： based on the Kriging method, migration models Z（hi） of heavy metal Cd in any depth of hi are constructed and fit the correlation coefficient R^2〉0.95.

关键词： coal mine production safety monitor game