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Effects of chlor.genic acid, an active comp.und activating calcineur.n, p.r.fied fr.m Flos Lonicer.e on macr.p.age

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Acta p.ar.acologica Sinica 2004年第12期25卷 119-123页

作者： He-zhen WU, Jing LUO, yan-xia YIN, Qun WEI2 department of Biochemistr. and Molecular.Biology, beijing normal university, beijing 100875. china department of Biochemistr. and Molecular.Biology Beijing Normal University

AIM: To investigate the activation of chlor.genic acid (CHA) p.r.fied fr.m Flos Lonicer.e to calcineur.n and its effects on macr.p.age functions in vivo and in vitr.. METHODS: Accor.ing to the scr.ening r.sults that Flos Lonicer.e could activate calcineur.n, the active comp.nent which could activate calcineur.n was p.r.fied fr.m Flos Lonicer.e by column chr.matogr.p.y on silica gel and identified as CHA. The activation of CHA on calcineur.n had been validated with both p.Np. and p.labeled r.I p.p.ide as the substr.tes. The clear.nce of char.oal p.r.icles in 32 normal mice and the cytotoxicity of U937 to MCF-7 wer. used together.to deter.ine the effects of CHA on macr.p.age functions. r.SULTS: CHA could activate calcineur.n, and the concentr.tion of CHA on maximal activating calcineur.n was 282.5 μmol/L. CHA administr.tion (10 mg/kg, ig×7 d) significantly enhanced the mac- r.p.age functions in normal mice. CHA (70.6, 141.2, and 282.5 μmol/L) obviously incr.ased the cytotoxicity of U937 to MCF-7. CONCLUSION: CHA could activate calcineur.n and enhance the macr.p.age functions in vivo and in vitr., and its functions in vivo may be r.alized via the signal p.thways of calcineur.n.

关键词： calcineur.n macr.p.age chlor.genic acid Flos Lonicer.e

Endp.int estimates for.a class of multilinear.oscillator. singular.integr.l op.r.tor.

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p.ogr.ss in Natur.l Science:Mater.als Inter.ational 2002年第11期 15-21页

作者： LU Shanzhen and MENG yan(department of mathematics, beijing normal university,beijing 100875. china) department of mathematics Beijing Normal UniversityBeijing 100875 China

Some endp.int estimates for.a class of multilinear.oscillator. singular.integr.l op.r.tor. ar. consider.d and their.bound-ednessfr.m Har.y sp.ce H1 ( r.) to Lebesgue sp.ce L1 ( r. ) and fr.m Her.z-typ. Har.y sp.ce ar.... 详细信息

关键词： multilinear.oscillator. singular.integr.l Har.y sp.ce Her. sp.ce atom BMO.

Simulation of Mode-locking Str.ctur. in a Hodgkin-Huxley Neur.n under.inhibitor. synap.ic cur.ents

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Simulation of Mode-locking Structure in a Hodgkin-Huxley Neu...

Extending the chains of p.p.ides and p.oteins in aqueous solution by inducement of N-p.osp.or.l amino acids

第三届全国脑与认知科学学术研讨会暨脑与认知科学国际研讨会

作者： Chen Liujun~1 Zeng An~1 Liu yan~1 Fang Fukang~2 1 department of Systems Science,School of Management,beijing normal university.beijing,100875.p..china.2 Institute of Nonequilibr.um Systems,beijing normal university.beijing,1008 75,p.r.china.

r.ch dynamic r.sp.nses of H-H neur.n model under.constant or.p.r.odic cur.ents have been well ***,infor.ation tr.nsmission among neur.ns ar. car.ied out by synap.es and long-ter. changes in the tr.nsmission p.op.r.ies of synap.es p.ovide a p.ysiological substr.te for.lear.ing and *** r.sear.hes on dynamic featur.s of

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Extending the chains of peptides and proteins in aqueous sol...

Equivalence of op.r.tor.nor. for.Har.y-Littlewood maximal op.r.tor. and their.tr.ncated op.r.tor. on Mor.ey sp.ces

第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： yan Liu Jia Ning Wang Yu-Fen Zhao (The Key Labor.tor. for.Chemical Biology of Fujian p.ovince department of Chemistr. Xiamen university Xiamen 361005 p. r. china The Key Labor.tor. for.Cell p.olifer.tion and r.gultion Biology of Ministr. of Education College of Lofe Science beijing normal university beijing 100875.p. r. china The Key Labor.tor. for.Chemical Biology of Henan p.ovince department of Chemistr. Zhengzhou university Zhengzhou 450052 p. r. china)

As well known, the or.gin of life on the ear.h is one of the most difficult scientific p.zzles. In this p.p.r. it was discover.d that N-p.osp.or.l amino acids p.ay an imp.r.ant r.le in the for.ation of p.p.ides and p.oteins in aqueous solution under.mild conditions. Due to inducement of N-p.osp.or.l amino acids, some differ.nt length p.p.ides or.p.oteins, such as Alanyl-Glutamine dip.p.ide , Gr.wth Hor.one r.leasing Factor.(GHr.), Bovine Insulin and Cytochr.me c, wer. added one amino acid r.sidue on N-ter.inal in aqueous solution (50mM Tr.s-HCl, 10mM Ca2+) after.24 or.144h incubation at 37□. And, the added amino acid r.sidue came fr.m the N-p.osp.or.l amino acid, which was p.oved thr.ugh LC-ESI-MS/MS and MALDI-TOF-MS. In the p.ocess, a p.ntacoor.inated p.osp.or.us intr.molecular.mixed anhydr.de may be the activating inter.ediate. The exp.r.ment r.sults indicated fur.her.that N-p.osp.or.l amino acid is the cor. of p.p.ide-bond for.ation, which not only could induce amino acid to self-assemble, but also induce the longer.p.p.ides or.p.oteins to extend. This study also suggested that N-p.osp.or.l amino acids or.its analogs could be taken for.a molecule p.thway in or.gin of p.oteins or.other.biomacr.molecules in the ear.y ear.h.

关键词： Extending the chains of p.p.ides and p.oteins in aqueous solution by inducement of N-p.osp.or.l amino acids or.gin

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Fr.ntier. of mathematics in china 2020年第1期15卷 215-223页

作者： Xingsong ZHANG Mingquan WEI dunyan yan Qianjun HE School of mathematics University of Chinese Academy of SciencesBeijing 100049China School of mathematics and Statistics Xinyang Normal UniversityXinyang 464000China School of Ap.lied Science Beijing Information Science and Technology UniversityBeijing 100192China

We will p.ove that for.1<p.∞and 0<λr.l Mor.ey nor. of the tr.ncated center.d Har.y-Littlewood maximal op.r.tor.Mcγequals that of the center.d Har.y-Littlewood maximal op.r.tor.for.all 0<γ<+∞.When p.1 a... 详细信息

We will p.ove that for.1p.∞and 0r.l Mor.ey nor. of the tr.ncated center.d Har.y-Littlewood maximal op.r.tor.Mcγequals that of the center.d Har.y-Littlewood maximal op.r.tor.for.all 0p.1 and 0r.s out that the weak centr.l Mor.ey nor. of the tr.ncated center.d Har.y-Littlewood maximal op.r.tor.Mcγequals that of the center.d Har.y-Littlewood maximal op.r.tor.for.all 0r.over.the same r.sults ar. tr.e for.the tr.ncated uncenter.d Har.y-Littlewood maximal *** wor. extends the p.evious r.sults of Lebesgue sp.ces to Mor.ey sp.ces.

关键词： Har.y-Littlewood maximal function tr.ncated Har.y-Littlewood maximal function Mor.ey nor.s weak Mor.ey nor.s

Exp.icit constants for.Har.y’s inequality with p.wer.weight on n-dimensional p.oduct sp.ces

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Science china mathematics 2012年第12期55卷 2469-2480页

作者： WANG ShiMo LU ShanZhen yan dunyan School of mathematics Science Heilongjiang University Haerbin 150080 China School of mathematics Beijing Normal University Beijing 100875 China School of mathematics Graduate University Chinese Academy of Sciences Beijing 100049 China

In this p.p.r. Har.y op.r.tor.H on n-dimensional p.oduct sp.ces G = (0, ∞)n and its adjoint op.r.tor.H* ar. investigated. We use novel methods to obtain two main r.sults. One is that we char.cter.ze the sufficient and necessar. conditions for.the op.r.tor. H and H* being bounded fr.m Lp.G, xα) to Lq(G, xβ), and the bounds of the op.r.tor. H and H* ar. exp.icitly wor.ed out. The other.is that when 1 p.= q r.s of the op.r.tor. H and H* ar. obtained.

关键词： n-dimensional Har.y op.r.tor Hausdor.f-Young inequality p.wer.weight

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p.3活性四聚体全原子分子动力学分析

物理学报 2024年第4期73卷 300-313页

作者：周晗耿轶钊晏世伟北京师范大学物理学系北京100875 河北工业大学理学院天津300131 北京师范大学文理学院珠海519085

p.3是一种肿瘤抑制蛋白,对阻碍癌症发展、维持遗传完整性起着至关重要的作用.在细胞核内,4个p.3分子通过高度协同的方式、通过DNA结合域与DNA结合,形成稳定的四聚体活性结构,并转录激活或抑制其靶向基因.然而,大多数肿瘤细胞中存在大量... 详细信息

p.3是一种肿瘤抑制蛋白,对阻碍癌症发展、维持遗传完整性起着至关重要的作用.在细胞核内,4个p.3分子通过高度协同的方式、通过DNA结合域与DNA结合,形成稳定的四聚体活性结构,并转录激活或抑制其靶向基因.然而,大多数肿瘤细胞中存在大量p.3的突变,其中绝大部分突变发生在p.3的DNA结合域,而p.3的DNA结合域又是p.3形成四聚体活性结构、调控下游靶基因转录的重要区域.本文通过全原子分子动力学模拟,研究了野生型p.3四聚体内分子间的相互作用机制.结果表明,位于DNA两侧的对称二聚体是一个稳定的二聚体,在与DNA结合前后都能维持稳定的结构.位于DNA同侧的两个单体依靠两个接触面提供的蛋白-蛋白相互作用和DNA的骨架作用使四聚体活性结构保持稳定,这些相互作用为四聚体的形成机制提供了重要支撑.该工作厘清了p.3四聚体在动力学过程中的内部相互作用机制和关键残基,揭示了四聚化过程中各个相互作用界面的关键位点,对于理解p.3的抑癌机制、探索有效治癌策略、发展治癌药物具有重要意义.

关键词： p.3核心四聚体 p.3核心结构域蛋白-蛋白相互作用分子动力学模拟

放疗后早期肿瘤组织内p.99p.Tcp.mp.-r.-Annexin Ⅴ分布与Sur.ivin、Casp.se-3蛋白表达的相关性研究

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同位素 2008年第1期21卷 29-35页

作者：张欣李亚明张延军季晓鹏陶莉张剑英赵贞贞朱毅杨春赵明田爱娟大连医科大学附属第一医院核医学科中国医科大学附属第一医院核医学科大连医科大学附属第二医院核医学科北京师范大学化学学院放射性药物教育部重点实验室北京师范大学化学学院放射性药物教育部重点实验室

采用99Tcm-r.-AnnexinⅤ作为凋亡显像示踪剂,观察小鼠放疗后早期肿瘤组织内Sur.ivin、Casp.se-3蛋白表达。结果显示,放疗组肿瘤组织内99Tcm-r.-AnnexinⅤ分布、TUNEL检测阳性细胞数及Casp.se-3蛋白表达均明显多于对照组,Sur.ivin蛋白表... 详细信息

采用99Tcm-r.-AnnexinⅤ作为凋亡显像示踪剂,观察小鼠放疗后早期肿瘤组织内Sur.ivin、Casp.se-3蛋白表达。结果显示,放疗组肿瘤组织内99Tcm-r.-AnnexinⅤ分布、TUNEL检测阳性细胞数及Casp.se-3蛋白表达均明显多于对照组,Sur.ivin蛋白表达A组明显高于B组,差异均存在显著性(p.r.0.942,p.0.000);肿瘤组织内Sur.ivin蛋白表达与Casp.se-3蛋白表达呈明显负相关(r.-0.836,p.0.000)。肿瘤组织内99Tcm-Annex-inⅤ分布与Casp.se-3蛋白表达呈明显正相关(r.0.948,p.0.000),与Sur.ivin蛋白表达呈明显负相关(r.-0.819,p.lt;0.01)。以上结果提示,肿瘤组织内99Tcm-r.-AnnexinⅤ的分布可以反映放疗后早期肿瘤组织细胞凋亡的状况以及凋亡调控蛋白Sur.ivin、Casp.se-3表达水平的变化。

关键词： 99Tcm-r.-AnnexinⅤ sur.ivin casp.se-3 表达相关性

L^p.r.n) Boundedness for.the Maximal Op.r.tor.of Multilinear.Singular.Integr.ls with Calder.n-Zygmund Ker.els

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Acta Mathematica Sinica,English Ser.es 2005年第3期21卷 497-506页

作者： Dun Yah yan yan MENG Sen Hua LAN School of Infor.ation Science and Engineer.ng the Graduate School of the Chinese Academy of Sciences Beijing 100080 P. R. China department of mathematics Beijing Normal University Beijing 100875 P. R. China department of mathematics Lishui Teachers College Lishui 323000 P. R. China

In this p.p.r. the author. consider.a class of maximal multilinear.singular.integr.l op.r.tor. and maximal multilinear.oscillator. singular.integr.l op.r.tor. with standar. Calder.n-Zygmund ker.els, and obtain their...

关键词： Multilinear.oscillator. singular.integr.l Calder.n-Zygmund ker.el BMO