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Evaluation of the etiology and risk factors for maternal sepsis: A single center study in Guangzhou, China

World Journal of Clinical Cases 2021年第26期9卷 7704-7716页

作者： Lin Lin Lu-Wen Ren Xue-Yuan Li Wen Sun Yan-Hong chen jing-Si chen dun-jin chen Department of Obstetrics and Gynecology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina Key Laboratories for Major Obstetric Diseases of Guangdong Province Guangzhou 510150Guangdong ProvinceChina Department of Fetal Medicine and Prenatal Diagnosis The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina

BACKGROUND Maternal sepsis is a major cause of gestational morbidity and neonatal mortality worldwide and particularly in *** To evaluate the etiology of maternal sepsis and further identify its risk *** In this retrospective study,we evaluated 70698 obstetric patients who were admitted to the Third Affiliated Hospital of Guangzhou Medical University between January 1,2009 and June 30,*** were divided into sepsis group and non-sepsis group based on the incidence of *** about medical history(surgical and obstetric history)and demographic information were *** Mann-Whitney U test was used to compare patient age,gestational age and duration of hospitalization between the two *** and multivariate logistic regression models were used to analyze the etiology and the risk factors for maternal *** and adjusted odds ratios(OR)are *** A total of 561 of 70698 obstetric patients were diagnosed with infection;of the infected patients,492 had non-sepsis associated infection(87.7%),while 69 had sepsis(12.3%).The morbidity rate of maternal sepsis was 9.76/10000;the fatality rate in the sepsis group was 11.6%(8/69).Emergency admission(OR=2.183)or transfer(OR=2.870),irregular prenatal care(OR=2.953),labor induction(OR=4.665),cervical cerclage(OR=14.214),first trimester(OR=6.806)and second trimester(OR=2.09)were significant risk factors for maternal *** Mode of admission,poor prenatal care,labor induction,cervical cerclage,first trimester and second trimester pregnancy were risk factors for maternal *** coli was the most common causative organism for maternal sepsis,and the uterus was the most common site of infection.

关键词： Maternal sepsis Sepsis-3 Infection Risk factors

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Thrombotic pulmonary embolism of inferior vena cava during caesarean section:A case report and review of the literature

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World Journal of Clinical Cases 2022年第13期10卷 4226-4235页

作者： Lan Jiang Wei-Xiang Liang Yi Yan Shou-Ping Wang Li Dai dun-jin chen Department of Medical Ultrasound The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina Department of Cardiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina Department of Anesthesiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510015Guangdong ProvinceChina Department of Obstetrics and Gynecology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510015Guangdong ProvinceChina

BACKGROUND Thrombotic pulmonary embolism(TPE)is one of the most critical diseases in obstetrics but is rarely reported in caesarean section(CS)because TPE patients in CS have a high risk of death and are difficult to *** case report of TPE during CS was recorded by transthoracic echocardiography(TTE)and can provide a reference for the differential diagnosis of critical illnesses in *** SUMMARY A 37-year-old pregnant woman with rheumatic heart disease(RHD),gravida 5 and para 1(G5P1),presented for emergency CS at 33 wk and 3 d of gestation under general anesthesia because of acute heart failure,pulmonary hypertension and *** placental removal during CS,TTE revealed a nascent thrombus in the inferior vena cava(IVC)that elongated,detached and fragmented leading to acute thromboembolic events and acute *** report presents the whole process and details of TPE during CS and successful rescue without any sequelae in the *** case gives us new ideas for the diagnosis of death or cardiovascular accidents during CS in pregnant women with heart disease and the detailed presentation of the rapid development of TPE may also elucidate new ideas for *** case also highlighted the importance of prophylactic anticoagulation in the management of heart disease during *** Pregnancy with heart failure could trigger inferior vena cava(IVC)-origin TPE during *** and timely treatment can avoid serious consequences.

关键词： Caesarean section Pulmonary embolism Thrombosis Heart failure Echocardiography Case report

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Updates on COVID-19 Infection During Pregnancy

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Maternal-Fetal Medicine 2020年第2期2卷 65-67页

作者： chen Wang dun-jin chen Hui-Xia Yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Key Laboratory for Major Obstetric Diseases of Guangdong Province Department of Gynaecology and ObstetricsThird Affiliated Hospital of Guangzhou Medical UniversityGuangdong 510150China

The 2019 coronavirus disease(COVID-19)is a public health emergency in China this *** it was first reported in Wuhan in December 2019,it has been quickly spreading across Hubei Province and the whole country,and even other parts of the *** of February 23,2020,the total number of confirmed cases in China's Mainland has reached 77150.

关键词： mainland fir winter

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Transvaginal 3D Ultrasound Evaluation of Post-Cesarean Section Uterine Diverticulum

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Open Journal of Obstetrics and Gynecology 2015年第12期5卷 698-702页

作者： Cui-Lan Li Xue-Tang Mo Kai-Xuan Deng dun-jin chen Xing-cheng Gao jin-Guo Zhai Yi-Ming Liao Hui-Ru Dai Xiang Cai The Third Affiliated Hospital of Guangzhou Medical University & Key Laboratory for Major Obstetric Diseases of Guangdong Province & Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Guangzhou China Department of Computer Science Hong Kong Baptist University Hong Kong China

Objectives: This study focused on evaluating the value of transvaginal 3D ultrasound for the diagnosis and prognostic assessment of post-cesarean section uterine diverticulum. Materials and Methods: We retrospectively analyzed the data from 32 patients with post-cesarean section uterine diverticulum over three recent years. In all patients, transvaginal 3D ultrasound was used to measure the size of the uterine diverticulum and the thickness of the lower uterine segment (LUS) and myometrium. Patients with a LUS with a myometrial thickness under 4 mm underwent resection and repair surgery;those with a LUS with a myometrial thickness over 4 mm underwent hysteroscopic resection. The postoperative sonograms were compared with preoperative images to evaluate the efficacy of various treatments. Results: The mean length, width and depth of the uterine diverticula were 18.30 ± 2.80 mm, 9.14 ± 3.20 mm and 11.49 ± 2.71 mm, respectively. The average LUS myometrial thickness was 3.40 ± 0.80 mm (with a range of 1.6 mm - 6.3 mm). After surgery, two patients’ sonograms still showed diverticula at the post-cesarean section scar, measuring 6 mm × 7 mm × 6 mm and 6 mm × 8 mm × 4 mm. There were significant differences in the size of uterine diverticula between preoperative and postoperative sonograms (P < 0.05) and the effective rate of surgery was 93.75% (30/32). Conclusions: Transvaginal 3D ultrasound is an accurate method for detecting post-cesarean section uterine diverticulum and is helpful for assessing surgical options and prognosis. The LUS myometrial thickness, which is considered as an optional index of post-cesarean section uterine diverticulum, should be measured routinely.

关键词： Post-Cesarean Section Uterine Diverticulum Transvaginal 3D Ultrasound LUS Myometrial Thickness

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Precision Surgery for Placenta Previa Complicated with Placenta Percreta

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Maternal-Fetal Medicine 2019年第1期1卷 18-24页

作者： Juan-Juan chen Lin Yu Chun-Hong Su Chun-Fang Zhang Yan-Hong chen Yan-Mei Zhou Wen-Jun He Fang He Ting Song Shou-Ping Wang Zhi-Yuan Su Qing-Ping Jiang Zi-Hao Zou Bin Yu Xiao-Ya Shen Xiao-Ming Guan dun-jin chen Key Laboratory for Major Obstetric Diseases of Guangdong Province Department of Gynaecology andObstetricsThird Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510150China Department of Radiology Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Anesthesiology Third Affiliated Hospital ofGuangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Pathology ThirdAffiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510150China Department of Urology Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics&Gynecology Baylor College ofMedicineHoustonUSA

Objectives:To investigate whether a precise circular resection of the uterine tissue at the placental attachment part is effective in cases with placenta previa complicated with placenta percreta (PPWPP).Methods:Patients diagnosed with PPWPP were assessed for pregnancy termination at 34-36 weeks of *** the operation,we performed circular resection of the uterine tissue at the placental attachment *** the characteristics of the operation and the follow-ups were ***:During the operation,the vital signs were *** mean intraoperative blood loss,packed red blood cells units transfusion,fresh frozen plasma transfusion,and operation time were 2140 mL,6 U,440 mL,and 179.8 minutes,*** was no bowel,ureter,or bladder *** there was no patient transferred to the ICU after *** mean postoperative blood loss was *** was no fever,infection,intestinal obstruction,or other complications after operation during the *** shape and the blood flow of the uterus were *** the patients were discharged,one had developed cesarean scar *** mean lochia duration was 30 *** menstrual cycle and volume were as *** shape and the blood flow of the uterus and the ovarian were ***:The circular resection following end-to-end anastomosis is an effective precision surgical approach for *** can achieve the purpose of hemostasis while maximizing the protection of organ function and reducing surgical trauma.

关键词： Placenta previa Placenta percreta Precision surgery Circular resection

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假肥大型肌营养不良症的产前基因诊断(英文)

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北京大学学报（医学版） 2006年第1期38卷 53-56页

作者：黎青李少英胡冬贵孙筱放陈敦金张成蒋玮莹广州市第二人民医院广州市妇产科研究所广州510150 中山大学基础医学院

Objective: Duchenne and Becker muscular dystrophy (DMD/BMD) is an X-linked lethal recessive disease caused by mutations in the dystrophy gene. There is no efficient treatment for this serious and disabling disease. We established a combination method to detect carriers and perform prenatal diagnosis. Methods: In our study, from 1994 to 2005, using a different combination of 5 methods, including SRY gene amplification, multiplex PCR, multiplex Fluorescence PCR capillary electrophoresis, multiplex ligation-dependent probe amplification (MLPA) and linkage analysis of short tandem repeats (STR), 36 prenatal diagnosis were performed for pregnancies at risk of having a DMD/BMD baby through amniocentesis. Results: Fourteen out of 21 male fetuses were found to be affected and respective pregnancies were terminated. A combined diagnostic rate of 83% was achieved for 30 cases with deletions, duplications, and non-deletion mutations after tested by more than one method. Conclusion: Using a combined method, we can diagnoses patients and carriers in DMD families, and perform prenatal diagnosis for the risk fetus. MLPA provides a simple, rapid and accurate method for deletions and duplications of all the 79 DMD exons. MLPA method for DMD diagnosis is the first report in our country.

关键词：肌营养不良杜氏产前诊断基因核酸扩增技术假肥大型肌营养不良症基因诊断

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氧浓度测定仪器简介及离子流氧分析仪在果蔬贮运中的应用

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保鲜与加工 2017年第1期17卷 108-111页

作者：董成虎王文生杨敦敦于晋泽陈存坤纪海鹏国家农产品保鲜工程技术研究中心(天津) 农业部农产品贮藏保鲜重点实验室天津市农产品采后生理与贮藏保鲜重点实验室天津300384

介绍了电化学氧分析仪、氧化锆测氧仪、顺磁式测氧仪等几种常用的测氧仪器,并重点介绍了离子流氧分析仪的工作原理和主要优点,对影响离子流氧分析仪测定结果和使用寿命的主要因素进行了研究和分析,并就其在果蔬贮运中的合理应用给出了... 详细信息

介绍了电化学氧分析仪、氧化锆测氧仪、顺磁式测氧仪等几种常用的测氧仪器,并重点介绍了离子流氧分析仪的工作原理和主要优点,对影响离子流氧分析仪测定结果和使用寿命的主要因素进行了研究和分析,并就其在果蔬贮运中的合理应用给出了建议。

关键词：氧浓度测定仪器离子流氧分析仪工作原理应用果蔬贮藏

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The effect of Ti and Zr content on the structure,mechanics and energy-release characteristics of Ti—Zr—Ta alloys

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Defence Technology（防务技术） 2024年第1期31卷 343-350页

作者： Jia-yu Meng jing-zhi He Bin Zhang jin chen Shun Li dun Niu Yu Tang Xi’an Modern Chemistry Research Institute Xi'an710065China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China

Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage *** this work the microstructure,mechanical properties and energy release characteristics of multi-element Ti-Zr-Ta alloys with good casting performance were *** microstructure of the Ti_(x)ZrTa alloys gradually change from BCC+HCP to single BCC structure with the increase of *** the Ti_(2)Zr_(y)Ta alloys was still uniform and single BCC structure with the increase of *** evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti-Zr-Ta *** synergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation *** as Zr content increases,the fracture strain of Ti_(2)Zr_(y)Ta alloys decrease,then the oxidation reaction rate and fragmentation degree gradually *** higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of Ti_(x)ZrTa alloys with low Ti content and Ti_(2)Zr_(y)Ta alloys with high Zr content.

关键词： Energetic structural materials Ti-Zr-Ta Multi-element alloy Energy release characteristics

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Bifunctional nanozyme activities of layered double hydroxide derived Co-A1-Ce mixed metal oxides for antibacterial application

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Journal of Oceanology and Limnology 2020年第4期38卷 1233-1245页

作者： chen Chao WANG Yi ZHANG dun CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Open Studio for Marine Corrosion and Protection Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Marine biofouling is an expensive problem that needs evolved chemical or physical antifouling ***,most of the current antifouling materials that would damage the environment through metal leaching and bacteria resistance are being *** is one kind of environmental antifouling materials through generating reactive oxygen species(ROS).We prepared various contents of CeO2 that could uniform disperse compounding with Co3 O4 and CoAl2 O4 to form a stable Co-Al-Ce mixed metal oxide(MMO) by a layered double hydroxide derived *** find that coupling with CeO2 can improve the peroxidase(POx) *** the molar ratio of Ce is 2.5% and the calcination temperature is 200℃,the POx activity of Co-Al-Ce MMO is the best caused by the good dispersion of catalytically active components and the high specific area(150.10±4.95 m2/g).This novel Co-Al-Ce MMO also exhibits an antibacterial mode of action Gram-negative bacteria in near-neutral pH solution through generating ROS(mainly ·O2-)in the presence of H2 *** containing MMO can be utilized as potential green marine antifouling material.

关键词： mixed metal oxide ceria enzyme mimic antibacterial marine biofouling

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Dynamic expression of Slit1–3 and Robo1–2 in the mouse peripheral nervous system after injury

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Neural Regeneration Research 2020年第5期15卷 948-958页

作者： Bing chen Lauren Carr Xin-Peng dun Department of Neurology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’anJiangsu ProvinceChina Plymouth University Peninsula Schools of Medicine and Dentistry PlymouthUK The Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo *** we previously reported that Slit1–3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system,how this expression changes after injury has not been well ***,we constructed a peripheral nerve injury mouse model by transecting the right sciatic *** 14 days after injury,quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1–3 and Robo1–2 in L4–5 spinal cord and dorsal root ganglia,as well as the sciatic *** analysis was performed to examine Slit1–3,Robo1–2,neurofilament heavy chain,F4/80,and vimentin in L4–5 spinal cord,L4 dorsal root ganglia,and the sciatic ***-expression of Slit1–3 and Robo1–2 in L4 dorsal root ganglia was detected by in situ *** addition,Slit1–3 and Robo1–2 protein expression in L4–5 spinal cord,L4 dorsal root ganglia,and sciatic nerve were detected by western blot *** results showed no significant changes of Slit1–3 or Robo1–2 mRNA expression in the spinal cord within 14 days after *** the dorsal root ganglion,Slit1–3 and Robo1–2 mRNA expression were initially downregulated within 4 days after injury;however,Robo1–2 mRNA expression returned to the control level,while Slit1–3 mRNA expression remained upregulated during regeneration from 4–14 days after *** the sciatic nerve,Slit1–3 and their receptors Robo1–2 were all expressed in the proximal nerve stump;however,Slit1,Slit2,and Robo2 were barely detectable in the nerve bridge and distal nerve stump within 14 days after ***3 was highly ex-pressed in macrophages surrounding the nerve bridge and slightly downregulated in the distal nerve stump within 14 days after ***1 was upregulated in vimentin-positive cells and migrating S

关键词： dorsal root ganglion nerve regeneration neural regeneration peripheral nerve Robo 1 Robo 2 sciatic nerve Slit1 Slit2 Slit3

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