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Stem cells as delivery vehicles for regenerative medicinechallenges and perspectives

World Journal of Stem Cells 2018年第5期10卷 43-56页

作者： Luminita Labusca dumitru daniel herea Kaveh Mashayekhi Orthopedics and Traumatology Clinic Emergency County Hospital Saint Spiridon Iasi RomaniaIasi 700000Romania Stem Cell Laboratory National Institute of Research and Development for Technical Physics(NIRDTP)Iasi 700349Romania Systems Bioinformatics and Modelling SBIM Frankfurt 45367Germany

The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications. Stem-cell-mediated delivery of genes, proteins or small molecules takes advantage of the innate capability of stem cells to migrate and home to injury sites. As the native migratory properties are affected by in vitro expansion, the existent methods for enhancing stem cell targeting capabilities(modified culture methods, genetic modification, cell surface engineering) are described. The role of various nanoparticles in eq-uipping stem cells with therapeutic small molecules is revised together with their class-specific advantages and shortcomings. Modalities to circumvent common challenges when designing a stem-cell-mediated targeted delivery system are described as well as future prospects in using this approach for regenerative medicine applications.

关键词： Stem cells Delivery agents Regenerative medicine Nanoparticles Targeted delivery

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Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea Alice dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei daniel Ursescu Stefan Irimiciuc Valentin Craciun Extreme Light Infrastructure-Nuclear Physics(ELI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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Telocytes involvement in recovery after myocardial infarction

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上海大学学报（自然科学版） 2017年第2期23卷 155-160页

作者： BANCIU daniel dumitru CRETOIU Dragos CRETOIU Sanda BANCIU Adela Research Beyond Limits SRL Bucharest 040234 Romania University of Bucharest Bucharest 050107 Romania Carol Davila University of Medicine and Pharmacy Bucharest 020021 Romania National Institute of Research-Development in the Pathology Domain and Biomedical Sciences Victor Babes Bucharest 050096 Romania Constantin Brancusi University Gorj 210135 Romania

Myocardial infarction(MI)is a disorder that lowers the lifespan and quality of *** treatment as early as possible is the most effective solution,with an increased focus on post-MI *** the recovery process after MI,telocytes(TCs)appear to play an important role,which develops a large number of questions awaiting *** possible signaling mechanisms involved in recovery after MI may lead to identification the limits of current therapies,and development of new therapeutic *** words:telocytes;myocardial infarction;stem

关键词： telocytes myocardial infarction stem cell

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Hepatocellular carcinoma in the setting of interferon-free treatment for chronic HCV hepatitis - experience of a single center

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Hepatoma Research 2018年第1期4卷 21-30页

作者： Elena Laura Iliescu Adriana Mercan-Stanciu Letitia Toma Elena Simona Ioanitescu Radu dumitru daniel Rusie Department of Internal Medicine II Fundeni Clinical InstituteBucharest 022328Romania Department of Interventional Radiology Fundeni Clinical InstituteBucharest 022328Romania Department of General Surgery Clinical Emergency HospitalBucharest 014461Romania

Aim: This study aims to analyze the particularities of hepatitis C induced hepatocellular carcinoma (HCC), developed during or after treatment with direct-acting antivirals. Methods: We conducted an observational prospective study on 278 patients, who underwent treatment for hepatitis C related liver cirrhosis and respectively for F3 chronic hepatitis C. Liver status was assessed using biological parameters and imagistic evaluation (ultrasonography, computed tomography scan, magnetic resonance imaging). Results: The follow-up time was 14 months. Before therapy, 69.3% of the cirrhotic patients and 26.7% of those with F3 degree of liver fibrosis had high levels of alpha-fetoprotein, with no imagistic evidence of HCC. During treatment, HCC was confirmed in 5 patients, 2 of them presenting portal vein thrombosis (PVT). Antiviral therapy was not interrupted. Two patients developed HCC at the end of treatment, while 4 of them were diagnosed with HCC after three months of ending the treatment. Excepting the ones with PVT, all patients underwent trans-arterial chemoembolization. Conclusion: All patients acquired sustained virological response. The screening for HCC should not be stopped after achievement of sustained virological response. Patients who develop HCC after antiviral treatment often need to be evaluated by magnetic resonance imaging in order to detect the extensionof the disease.

关键词： Hepatitis C virus direct-acting antiviral therapy hepatocellular carcinoma trans-arterial chemoembolization

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