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In silico Analysis of osr40c1 Promoter Sequence Isolated from Indica Variety Pokkali

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Rice science 2017年第4期24卷 228-234页

作者： W.S.I.deSILVA M.M.N.PERERA K.L.N.S.PERERA A.M.WICKRAMASURIYA G.A.U.jayasekera Department of Plant Sciences Faculty of ScienceUniversity of ColomboColombo 00300Sri Lanka Genetech Molecular Diagnostics and School of Gene Technology Colombo 00800Sri Lanka

The promoter region of a drought and abscisic acid （ABA） inducible gene, osr40c1, was isolated from a salt-tolerant indica rice variety Pokkali, which is 670 bp upstream of the putative translation start codon. In silico promoter analysis of resulted sequence showed that at least 15 types of putative motifs were distributed within the sequence, including two types of common promoter elements, TATA and CAAT boxes. Additionally, several putative cis-acing regulatory elements which may be involved in regulation of osr40c1 expression under different conditions were found in the 5′-upstream region of osr40c1. These are ABA-responsive element, light-responsive elements （ATCT-motif, Box I, G-box, GT1-motif, Gap-box and Sp1）, myeloblastosis oncogene response element （CCAAT-box）, auxin responsive element （TGA-element）, gibberellin-responsive element （GARE-motif） and fungal-elicitor responsive elements （Box E and Box-W1）. A putative regulatory element, required for endosperm-specific pattern of gene expression designated as Skn-1 motif, was also detected in the Pokkali osr40c1 promoter region. In conclusion, the bioinformatic analysis of osr40c1 promoter region isolated from indica rice variety Pokkali led to the identification of several important stress-responsive cis-acting regulatory elements, and therefore, the isolated promoter sequence could be employed in rice genetic transformation to mediate expression of abiotic stress induced genes.

关键词： osr40c1 promoter cis-acting regulatory element rice

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Expanding Treatment Access for Chronic Hepatitis C with Task-shifting in the Era of Direct-acting Antivirals

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 130-133页

作者： Eric R.Yoo Ryan B.Perumpail George Cholankeril Channa R.jayasekera Aijaz Ahmed Department of Medicine University of Illinois College of Medicine Chicago IL USA Division of Gastroenterology and Hepatology Stanford University School of Medicine Stanford CA USA Division of Gastroenterology and Hepatology University of Tennessee Health Sciences Center Memphis TN USA Division of Gastroenterology and Hepatology Stanford University School of Medicine Stanford CA USA Center for Innovation in Global Health Stanford UniversityStanford CA USA

In the United States,the fight to eradicate hepatitis C virus (HCV) infection has been ongoing for many years,but the results have been less than ***,patients with chronic hepatitis C (CHC) were treated with interferon-based regimens,which were associated with frequent adverse effects,suboptimal response rates,and long durations of treatment-of up to 48 *** from specialistphysicians,such as hepatologists and gastroenterologists,was needed to closely follow patients on these medications so as to monitor laboratory values and manage adverse ***,the emergence of direct-acting antiviral (DAA) agents against HCV infection have heralded outstanding progress in terms of safety,tolerability,lack of adverse effects,efficacy,and truncated duration of therapy-12 weeks or less-thereby making the need for close monitoring by specialist-physicians *** the recent approval of DAA agents by the Food and Drug Administration,the treatment model for CHC no longer relies on the limited number of specialist-physicians,which represented a major barrier to treatment access in the past,especially in underserved areas of the United *** propose and share our experiences in adapting a task-shifting treatment model,one that utilizes a relatively larger pool of non-specialist healthcare providers,such as nursing staff (medical assistants,vocational licensed nurses,registered nurses,etc.) and advanced practice providers (nurse practitioners and physician assistants),to perform a variety of important clinical functions in an effort to make DAA-based antiviral therapy widely available against HCV *** recently,task-shifting was implemented by the United States and World Health Organization in the fight against the human immunodeficiency virus and showed encouraging *** on our experiences in implementing this model at our outreach clinics,the majority of HCV-infected patients treated with DAA agents can be easily monitored by

关键词： Task-shifting Treatment Access Underserved Under-resourced Hepatitis C virus HCV Direct acting antivirals DAAs

Sofosbuvir-based Regimens with Task Shifting Is Cost-effective in Expanding Hepatitis C Treatment Access in the United States

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Journal of Clinical and Translational Hepatology 2017年第1期5卷 16-22页

作者： Channa R.jayasekera Rachel Beckerman Nathaniel Smith Ryan B.Perumpail Robert J.Wong Zobair M.Younossi Aijaz Ahmed Liver Transplant Program Division of Gastroenterology and HepatologyStanford University Medical CenterStanfordCaliforniaUSA Center for Innovation in Global Health Stanford UniversityStanfordCaliforniaUSA Maple Health Group LLCNew YorkNew YorkUSA Division of Gastroenterology and Hepatology Alameda Health SystemHighland HospitalOaklandCaliforniaUSA Department of Medicine Center for Liver DiseasesInova Fairfax HospitalFalls ChurchVirginiaUSA Betty and Guy Beatty Center for Integrated Research Inova Health SystemFalls ChurchVirginiaUSA

Background and Aims:The current paradigm of specialist physician-managed treatment of chronic hepatitis C virus infection(HCV)is inefficient in absorbing the approximately 3 million patients awaiting treatment in the United *** shifting—whereby specialist physicians screen patients for treatment eligibility but on-treatment monitoring is devolved to more abundant non-physician clinicians—achieves non-inferior treatment outcomes with second generation direct-acting antivirals(2^(nd)Gen DAAs),may increase treatment capacity,and may facilitate greater treatment *** determined the cost effectiveness of 2^(nd)Gen DAAs with respect to interferon-based first-generation DAAs(1^(st)Gen DAAs)within a task-shifted treatment ***:Using a previously described decision-analytic Markov structure,we modeled a hypothetical cohort of 1,000 patients with HCV genotype 1 infection over a lifetime horizon,based upon our outreach clinic's HCV treatment ***-naive and treatment-experienced HCV cohorts were modeled separately,based upon our outr8each clinic's *** response to 2^(nd)Gen DAAs was modeled based on our outreach clinic's *** events,utility,costing,and transition probabilities were sourced from the ***:Driven by improved effectiveness and safety,as well as an expected increase in treatment capacity,2^(nd)Gen DAAs treatment monitored by non-physician clinicians was projected to improve health outcomes and be dominant from a cost-effective perspective versus that of 1^(st)Gen *** were consistent across all assessed patient ***:Based on an assumption of increased treatment capacity accompanying a task-shifted treatment model,2^(nd)Gen DAAs-based treatment was cost effective and cost saving as compared to 1^(st)Gen DAAs-based treatment for all HCV patient subgroups assessed.

关键词： Hepatitis C Treatment access Task shifting Cost effectiveness

G6PD deficiency in pathogenesis of Chronic kidney disease(CKD) of unknown aetiology in Sri Lanka

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G6PD deficiency in pathogenesis of Chronic kidney disease(CK...

第八届亚太医学毒理学大会暨全国中毒控制与救治论坛（2009）

作者： jayasekera JMKB Dissanayake AMSDM Abeysekera DTDJ Wazeel M Sivakanesan R Department of Pathology Faculty of MedicineUniversity of PeradeniyaSri Lanka

Introduction: In recent years investigators in Sri Lanka have noticed alarmingly high number of patients with CKD in both North Central(NCP)and Uva Provinces(UP)of the *** performed so far suggest a common,although yet unknown aetiology,leading to marked tubulointestitial fibrosis of the kidneys that finally causes kidney *** literature shows that G6PD deficiency is so far related only to acute renal failure.

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斯里兰卡橡胶育种与遗传研究的进展

世界热带农业信息 1987年第4期 1-4页

作者： N.E.M.jayasekera 郁如斯里兰卡橡胶研究所

本文回顾了几十年来斯里兰卡橡胶选育种工作的成果。作者把斯里兰卡的橡胶选育种工作划分了三个阶段,并指出了每个阶段的工作重点。作者还介绍了斯里兰卡有关橡胶细胞学研究、人工突变体的诱导、无性系的引进、种质的采集和环境对基因... 详细信息

本文回顾了几十年来斯里兰卡橡胶选育种工作的成果。作者把斯里兰卡的橡胶选育种工作划分了三个阶段,并指出了每个阶段的工作重点。作者还介绍了斯里兰卡有关橡胶细胞学研究、人工突变体的诱导、无性系的引进、种质的采集和环境对基因型的影响等情况。

关键词：橡胶树产量疫病抗白粉病园艺作物无性系无性繁殖系品系(育种) 橡胶研究所选育种斯里兰卡南亚遗传研究植胶

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推荐种植的新无性系RRIC100

世界热带农业信息 1984年第3期 10-12页

作者： N.E.M.jayasekera 王佩珍

1876年斯里兰卡从巴西引进大约1919株橡胶实生苗.是为斯里兰卡橡胶园的基础。自从引进这批橡胶树以来,单位面积产量大约增加了4倍。增产的主要原因是使用了改良的种植材料。在1935—1945年的初期发展阶段,斯里兰卡橡胶育种方案的唯一目... 详细信息

1876年斯里兰卡从巴西引进大约1919株橡胶实生苗.是为斯里兰卡橡胶园的基础。自从引进这批橡胶树以来,单位面积产量大约增加了4倍。增产的主要原因是使用了改良的种植材料。在1935—1945年的初期发展阶段,斯里兰卡橡胶育种方案的唯一目标是增加产量。在此期间培育出了RRIC45和36。

关键词：新无性系 RRIC100 胶园拉特纳普拉

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英国大陆架重质油油田的开发

国外油田工程 2000年第4期16卷 3-4页

作者： A.J.jayasekera S.G.Goodyear 张金莉李维安大庆油田测井公司研究所大庆油田研究院

英国大陆架 (UKCS)的油田所采出的石油大部分为轻质油 ,但也发现了几个重质油油田。本文所述的重质油油田是指原油粘度大于 5cP的油田。UKCS的大部分重质油油田都是在较浅的储集层中形成的 ,而这些储集层又都是由极好的水平渗透率 ( 30 ... 详细信息

英国大陆架 (UKCS)的油田所采出的石油大部分为轻质油 ,但也发现了几个重质油油田。本文所述的重质油油田是指原油粘度大于 5cP的油田。UKCS的大部分重质油油田都是在较浅的储集层中形成的 ,而这些储集层又都是由极好的水平渗透率 ( 30 0 0～ 1 0 0 0 0md)和垂直渗透率 (垂直 /水平渗透率比值为 0 2～ 1 0 )的高孔隙度疏松砂岩所组成的。通常 ,这些油层都位于水下 ,而有些油层还具有原生气顶。

关键词：英国大陆架重质油渗透率粘度稠油油田开发

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英国大陆架重质油油田的开发

石油石化节能与计量 2000年第4期 3-4页

作者： A.J.jayasekera,S.G.Goodyear,张金莉,李维安大庆油田测井公司研究所大庆油田研究院

关键词：英国大陆架重质油渗透率粘度水驱生产能力

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如何打造人气文化区

艺术教育 2018年第12期 9-9页

作者： Kingsley jayasekera

从国际上来说,很多人印象中的中国香港有非常多高层建筑,它的天际线是很美丽的。西九龙文化区作为一块小小的填海区,对于香港来说十分重要。在设计之初,我们要考虑如何保留香港最独特的地方。例如,在这么多高层建筑的下面有什么?有不同... 详细信息

从国际上来说,很多人印象中的中国香港有非常多高层建筑,它的天际线是很美丽的。西九龙文化区作为一块小小的填海区,对于香港来说十分重要。在设计之初,我们要考虑如何保留香港最独特的地方。例如,在这么多高层建筑的下面有什么?有不同的市场,在这里我们可以看到真正的香港是什么样子,市民的生活是怎么样的,他们怎样聊天,怎样玩游戏,怎样享受生活,这才是城市重要的部分。我们要把这种感觉和氛围保留下来,将其带入空间设计当中。

关键词：购物中心