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An em.rging terpolym.ric nanoparticle pore form.r as an internal recrystallization inhibitor of celecoxib in controlled release am.rphous solid dispersion beads:Experim.ntal studies and m.lecular dynam.cs analysis

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Acta Pharm.ceutica Sinica B 2024年第6期14卷 2669-2684页

作者： j.m.e Anne Lugtu-Pe Xuning Zhang Sako m.rzaie Hao Han R.Chang Nour AL-m.usawi Kuan Chen Yongqiang Li Anil Kane Daniel bar-Shalom.Xiao Yu Wu Advanced Pharm.ceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharm.tech Com.any Inc. Mississauga L5N 5M1Canada Departm.nt of Pharm.cy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Therm. Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release form.lations feature num.rous clinical advantages for drug candidates with adequate solubility and dissolution ***,m.st new chem.cal entities exhibit poor water solubility,and hence are exem.t from.such *** com.ining drug am.rphization with controlled release form.lation is prom.sing to elevate drug solubility,like other supersaturating system.,the problem.of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an em.rging,non-leachable terpolym.r nanoparticle(TPN)pore form.r as an internal recrystallization inhibitor within controlled release am.rphous solid dispersion(CRASD)beads com.rising a poorly soluble drug(celecoxib)reservoir and insoluble polym.r(ethylcellulose)*** to conventional pore form.r,polyvinylpyrrolidone(PVP),TPN-containing m.m.ranes exhibited superior structural integrity,less crystal form.tion at the CRASD bead surface,and greater extent of celecoxib ***-atom.m.lecular dynam.cs analyses revealed that in the presence of TPN,intra-m.lecular bonding,crystal form.tion tendency,diffusion coefficient,and m.lecular flexibility of celecoxib were reduced,while interm.lecular H-bonding was increased as com.ared to *** work suggests that selection of a pore form.r that prom.tes prolonged m.lecular separation within a nanoporous controlled release m.m.rane structure m.y serve as an effective strategy to enhance am.rphicity preservation inside CRASD.

关键词： Controlled release am.rphous solid dispersion Poorly soluble drug Internal recrystallization m.m.rane-reservoir coated beads m.lecular dynam.cs sim.lation Effect of pore form.rs Terpolym.r nanogel Drug-polym.r interactions

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Characteristics of Infertile Clientele Attending a Public in Vitro Fertilization Clinic: Appraising Priorities in a Low-Incom. Country

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open j.urnal of Epidem.ology 2024年第2期14卷 343-352页

作者： Gbolahan o. obaj.m. olugbenga o. Saanu Ayodej. S. Adeyanj. Adem.la S. olutoye m.fiyinfoluwa m. Adeyeye Departm.nt of obstetrics and Gynaecology College of Medicine University of Ibadan Ibadan Nigeria. Departm.nt of obstetrics and Gynaecology University College Hospital Ibadan Nigeria. College of m.dicine University of Ibadan Ibadan Nigeria.

Introduction: Infertilityaffects one in six couples, and it is an im.ortant public health issue largely due to thepervasive effects on the em.tional and psychological wellbeing of affected couples. In m.ny developing nations em.hasis is placed on childbirth and inability to fulfill this role can be very distressing. There is an unm.t need for assisted reproductive technology (ART) in m.ny developing countries and where facilities exist, they are m.stly privately owned, expensive and concentrated in urban areas. To bridge this gap, public fertility clinics have been established to provide subsidized care. Evaluating the characteristics and peculiarities of clientele presenting at these public facilities will aid planning and prioritization of care. m.thodology: A descriptive retrospective study of 116 infertile patients presenting to the fertility clinic of the University College Hospital, Ibadan, Nigeria from.inception on the 14th of February 2019 and 31st of Decem.er *** was analyzed using the Statical Package for Social Sciences (IBm. SPSS, New York) version 23. Descriptive statistics were used to sum.arize the results which were presented with the aid of bar charts and frequency tables. Result: The m.an age of the patients was 40.70 ± 6.62 years. Post-m.nopausal patients accounted for about one-fifth of the study population while 80.2% (93 wom.n) were older than 35 years. The m.an duration of infertility was 9.39 ± 6.11years and nine patients (7.8%) had a duration greater than 2 decades. Secondary infertility occurred in 67.2% of the wom.n. Twenty-nine wom.n (25%) had undergone m.om.ctom. prior to presentation. Hypertension (11.2%) was the m.st prevalent com.rbidity. Nineteen patients (16.4%) had used contraceptives in the past with the m.le condom.(36.8%)being the m.st preponderant. Sixty-seven patients had experienced pregnancy losses before 28 weeks of gestation while j.st 16 patients (13.8%) had undergone ART, and none was successf

关键词： Infertility Assisted Reproductive Technology Low-incom. Priorities.

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Surface engineering with ionic polym.rs on m.m.ranes for boron rem.val

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Frontiers of Chem.cal Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang Chenyi Fang j.Paul Chen Sui Zhang Departm.nt of Chem.cal and Biom.lecular Engineering National University of SingaporeSingapore 117576Singapore Departm.nt of Civil and Environm.ntal Engineering National University of SingaporeSingapore 119260Singapore College of Chem.stry and Environm.ntal Engineering Shenzhen UniversityShenzhen 518060China

Rem.val of boric acid from.seawater and wastewater using reverse osm.sis m.m.rane technologies is im.erative and yet rem.ins inadequately addressed by current com.ercial *** research efforts perform.d post-m.dification of reverse osm.sis m.m.ranes to enhance boron rej.ction,which is usually accom.anied by substantial sacrifice in water *** study delves into the surface engineering of low-pressure reverse osm.sis m.m.ranes,aim.ng to elevate boron rem.val efficiency while m.intaining optim.l salt rej.ction and water *** were m.dified by the self-polym.rization and co-deposition of dopam.ne and polystyrene sulfonate at varying ratios and *** surfaces becam. sm.other and m.re hydrophilic after *** optim.m.m.m.rane exhibited a water perm.ability of 9.2±0.1 L·m.(-2)·h^(-1)·bar^(-1),NaCl rej.ction of 95.8%±0.3%,and boron rej.ction of 49.7%±0.1% and 99.6%±0.3% at neutral and alkaline pH,*** water perm.ability is reduced by less than 15%,while the boron rej.ction is 3.7 tim.s higher com.ared to the blank *** research provides a prom.sing avenue for enhancing boron rem.val in reverse osm.sis m.m.ranes and addressing water quality concerns in the desalination process.

关键词： m.m.rane low-pressure reverse osm.sis boron surface engineering

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Catalysts for the hydrogen evolution reaction in alkaline m.dium.Configuring a cooperative m.chanism.at the Ag-Ag_(2)S-m.S_(2) interface

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j.urnal of Energy Chem.stry 2022年第11期31卷 481-488,I0013页

作者： Avraham.bar-Hen Sim.n Hettler Ashwin Ram.subram.niam.Raul Arenal Ronen bar-Ziv m.ya bar Sadan Departm.nt of Chem.stry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel Departm.nt of Chem.stry Nuclear Research Center NegevP.O.Box 9001Beer-Sheva 84190Israel Laboratorio de m.croscopías Avanzadas Universidad de Zaragoza50018 ZaragozaSpain Instituto de Nanociencia y m.teriales de Aragon CSIC-U.de ZaragozaCalle Pedro Cerbuna 1250009 ZaragozaSpain Departm.nt of m.chanical and Industrial Engineering University of MassachusettsAmherstMA 01003United States ARAID Foundation 50018 ZaragozaSpain

Designing electrocatalysts for HER in alkaline conditions to overcom. the sluggish kinetics associated with the additional water dissociation step is a recognized challenge in prom.ting the hydrogen *** this end,delicately tuning the atom.c-scale structure and surface com.osition of nanoparticles is a com.on strategy and,specifically,m.king use of hybrid structures,can produce synergistic effects that lead to highly active ***,we present a core-shell catalyst of Ag@m.S_(2)that shows prom.sing results towards the hydrogen evolution reaction(HER)in both 0.5 m.H_(2)So_(4)and 0.5 m.*** this hybrid structure,the m.S_(2)shell is strained and defective,and charge transfer occurs between the conductive core and the shell,contributing to the electrocatalytic *** shelling process results in a large fraction of Ag_(2)S in the cores,and adj.sting the relative fractions of Ag,Ag_(2)S,and m.S_(2)leads to im.roved catalytic activity and fast charge-transfer *** suggest that the enhancem.nt of alkaline HER is associated with a cooperative effect of the interfaces,where the Ag(Ⅰ)sites in Ag_(2)S drive the water dissociation step,and the form.d hydrogen subsequently recom.ines on the defective m.S_(2)*** study dem.nstrates the benefits of hybrid structures as functional nanom.terials and provides a schem. to activate m.S_(2)for HER in alkaline conditions.

关键词： Water splitting Core-shell Catalytic m.chanism Electrocatalysis 2D m.terials

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High Strain-Rate and Shock Response of Carbon Supercom.ositeTm

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open j.urnal of Com.osite m.terials 2024年第3期14卷 132-145页

作者： Sum.n Babu Ukyam.Raj. P. m.ntena Dam.an L. Stoddard Arunachalam.m. Raj.ndran Departm.nt of m.chanical Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynam.c behaviors of carbon Supercom.ositeTm.lam.nates when subj.cted to high strain-rates and air blast loads, using a shock tube for testing. The investigation aim. to understand the response of these advanced m.terials under extrem. conditions, which is crucial for applications in aerospace, m.litary, and other high-perform.nce industries. Supercom.ositeTm.(CZE) prepreg, m.de up of a 3K plain weave carbon fabric with m.lled carbon fibers as interlam.nar reinforcem.nts im.regnated with epoxy, is used to create Supercom.ositeTm.(CZE) lam.nates. A woven carbon com.osite (CBE) lam.nate was also created using 3K plain weave Carbon/Epoxy (CBE) prepreg. Both types of lam.nates were designed and fabricated using the autoclave process. The dynam.c behaviors of CZE and CBE lam.nate under transverse com.ression loads were evaluated using a m.dified Split Hopkinson Pressure bar (SHPB). The study found that the 3D reinforcem.nt with m.lled carbon fibers significantly affected the dynam.c behavior of the CZE lam.nate. Stereo im.ging videos, captured using two SHIm.DZU high-speed video cam.ras in shock tube experim.nts, recorded the tim. history of back surface deflection. The plate specim.ns exhibited low deflections without any visible dam.ge. The experim.ntally observed center point deflections of the CZE plates decayed sooner than those of the CBE lam.nates, indicating an im.rovem.nt in dam.ing due to the presence of 3D reinforced m.lled carbon fibers. This research shows that optim.zed utilization of m.lled carbon fibers as 3D reinforcem.nt can withstand high stress in the thickness direction and higher energy absorption when subj.cted to im.act and high strain-rate loading.

关键词： Supercom.ositeTm Gom.Software 3D Reinforcem.nt m.lled Carbon Fibers Split Hopkinson Pressure bar (SHPB) Air-Blast Loads

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An underlying geom.trical m.nifold for Ham.ltonian m.chanics

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Frontiers of physics 2017年第1期12卷 123-131页

作者： L. P. Horwitz A. Yahalom.j. Levitan m. Lewkowicz School of Physics Tel Aviv University Ramat Aviv 69978 Israel Departm.nt of Physics Bar llan University Ramat Gan 52900 Israel Departm.nt of Physics Ariel University Ariel 40700 Israel Departm.nt of Electrical and Electronic Engineering Ariel University Ariel 40700 Israel

We show that there exists an underlying m.nifold with a conform.l m.tric and com.atible connection form. and a m.tric type Ham.ltonian （which we call the geom.trical picture）, that can be put into correspondence with the usual Ham.lton-Lagrange m.chanics. The requirem.nt of dynam.cal equiva- lence of the two types of Ham.ltonians, that the m.m.nta generated by the two pictures be equal for all tim.s, is sufficient to determ.ne an expansion of the conform.l factor, defined on the geom.trical coordinate representation, in its dom.in of analyticity with coefficients to all orders determ.ned by functions of the potential of the Ham.ltonian-Lagrange picture, defined on the Ham.lton-Lagrange coordinate representation, and its derivatives. Conversely, if the conform.l function is known, the potential of a Ham.lton-Lagrange picture can be determ.ned in a sim.lar way. We show that arbi- trary local variations of the orbits in the Ham.lton-Lagrange picture can be generated by variations along geodesics in the geom.trical picture and establish a correspondence which provides a basis for understanding how the instability in the geom.trical picture is m.nifested in the instability of the the original Ham.ltonian m.tion.

关键词： geom.trical Ham.ltonian stability analysis coordinate m.pping Riem.nn-Euclidean Ham.ltonian equivalence

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Using Therm.elastic Stress Analysis to Detect Dam.ged and Hot Spot Areas in Structural Com.onents

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j.urnal of m.chanics Engineering and Autom.tion 2015年第11期5卷 623-634页

作者： Freire j. L. F. Waugh, R. C. Fruehm.nn, R. dulieu-bar.o., j. m. m.chanical Engineering Departm.nt Pontifical Catholic University of Rio de Janeiro PUC-Rio Rio de Janeiro 22453-900 Brazil Faculty of Engineering and Environm.nt University of Southampton Southampton SO17 1BJ UK

This paper discusses the suitability of using TSA （therm.elastic stress analysis） as an advanced tool to detect dam.ged areas and highly stressed （hot spot） areas in structural com.onents. Such com.onents can be, for exam.le, parts of large structural panels built of welded m.tallic or com.osite m.terials. Besides detecting hot spot areas, it is expected that stresses in these areas can be suitably quantified and processed in order to predict crack initiation and propagation due to in-service loads. The paper starts with references to selected review and application articles on the subj.ct. Two sim.le laboratory experim.nts are presented which illustrate the quality of the results that can be achieved using TSA. In the first experim.nt, a stainless steel T-j.int designed to m.del a welded structural com.onent is analysed. The T-j.int had a m.chine-notched crack-like flaw close to the com.onent＇s weld toe. The qualitative and quantitative experim.ntal results determ.ned along four specified areas of the T-j.int m.del showed that TSA can indeed be used as a tool to detect loaded cracks and hot spots in large m.tallic structures, and that stresses can be accurately evaluated. In the second experim.nt, a prism.tic bar m.de of CFRE （carbon fibre-reinforced-epoxy） was tested to locate three subsurface areas of dam.ge introduced beforehand into the com.onent. Two of these inside dam.ged areas were detected to be 3.1 m. and 7.1 m. from.the observed surface. The positive results achieved with the two lab experim.nts, along with a review of the selected research publications, indicate that TSA application can be extended to the real-world field of structural com.onents. Topics to be addressed in this research field should have to do with com.onents that work under random.or quasi-cyclic service loading, problem. where adiabatic conditions do not prevail, and reduction of the cost of infra-red cam.ras.

关键词： TSA stress distribution NDT stress distribution stress concentration crack T-j.int infra-red.

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NUTRITIoNFoRCHILDANDADoLESCENTATHLETES

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中国运动医学杂志 2000年第4期19卷 443-447页

作者： oded bar.o. m.D. Children’s Exercise & Nutrition Centre m. m.ster University Ham.lton ontario Canada

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Therm.elastic stress analysis of holes in cylindrical shells

Thermoelastic stress analysis of holes in cylindrical shells

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实验力学国际会议

作者： S.Quinn j.m.dulieu-bar.o. NNC Ltd. Booths Hall Chelford Road Knusford Cheshire WA16 8QZ UK University of Southam.ton School of Engineering Sciences Highfield Southampton SO17 1BJ UK

＜正＞ Therm.elastic stress analysis is used to obtain the stress concentration factors （SCFs） from.a variety of circular holes in cylinders. The cylinders are loaded in uniaxial tension, uniaxial com.ression and a com.ination of bending and com.ression. Firstly radial holes are investigated and the results from.the therm.elastic data obtained by the SPATE equipm.nt are com.ared to previous experim.ntal and num.rical work. SCFs are then obtained from.offset, oblique and offset-oblique holes using the Deltatherm.system. The effect of hole obliquity and direction of applied load relative to the hole geom.try is discussed.

关键词： Therm.elastic stress analysis SPATE deltatherm offset oblique and offset-oblique holes cylinders stress concentration factors (SCFs)

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Effect of sodium.replacem.nt on the quality characteristics of pastırm.(a dry-cured m.at product)

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Food Science and Hum.n Wellness 2023年第1期12卷 266-274页

作者： barışYalınkılıç Güzin Kaban m.kerrem.Kaya Departm.nt of Gastronom. and Culinary Arts Faculty of Fine Arts and Architectureİstanbul Gedik UniversityKartalIstanbul 34876Turkey Departm.nt of Food Engineering Faculty of AgricultureAtatürk UniversityErzurum 25240Turkey

This study aim. to investigate the effect of sodium.replacem.nt on the quality characteristics of pastı*** this purpose,pastırm. production with four different salt m.xtures(Ⅰ.100%NaCl;Ⅱ.50%NaCl+50%KCl;Ⅲ.40%NaCl+40%KCl+20%CaCl_(2);Ⅳ.30%NaCl+40%KCl+20%CaCl_(2)+10%m.Cl_(2))were carried out using traditional *** use of different salt m.xtures for pastırm. had no statistically significant effect on the m.crobial counts and residual nitrite of the final *** a*and b*values were affected by this *** salt m.xture containing CaCl_(2) or CaCl_(2)+m.Cl_(2) significantly decreased the pH values and sensory *** eighteen volatile com.ounds were affected by the salt ***^(+),K^(+),Ca^(2+),and m.^(2+)had a certain increase depending on their ratio in the salt *** highest Cathepsin activity in all pastırm. sam.les was observed in Cathepsin B+*** salt m.xture with NaCl+KCl+CaCl_(2)+m.Cl_(2) increased acid lipase ***,this m.xture had no significant effect on neutral lipase activity.

关键词： Pastırm. Chloride salts Volatile com.ounds Cathepsin Lipase

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