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联合图像配准的脑卒中病灶自动分割方法研究

重庆邮电大学学报（自然科学版） 2024年第4期36卷 729-737页

作者：李欣蔚许炜鑫陈勇秦对张冰玉李章勇王伟重庆邮电大学生物医学工程研究中心重庆400065 陆军军医大学第一附属医院医学工程科重庆400038

针对目前慢性脑卒中的病灶分割准确性相对较低的问题,提出了一种联合深度图像配准的慢性脑卒中自动分割方法。采用深度拉普拉斯金字塔图像配准网络,在微分同胚映射的空间内以从粗到细的方式获得大脑分区,以得到病灶位置的解剖先验信息;... 详细信息

针对目前慢性脑卒中的病灶分割准确性相对较低的问题,提出了一种联合深度图像配准的慢性脑卒中自动分割方法。采用深度拉普拉斯金字塔图像配准网络,在微分同胚映射的空间内以从粗到细的方式获得大脑分区,以得到病灶位置的解剖先验信息;将原始磁共振图像和配准阶段的分区结果联合,输入到加入了通道和空间注意力模块的U-Net进行病灶分割。在公开的数据集ATLAS上进行测试表明,提出的方法有效提高了慢性脑卒中病灶分割的准确性,比经典的2D U-Net提升了4.4百分点,证明了基于深度图像配准的大脑分区先验可有效增强模型对病灶的分割性能,更好的组织分割能提高病灶分割准确性。

关键词：慢性脑卒中图像配准病灶分割

Functional Analysis of Nodulin-like Promoter in Transgenic Cotton Plants

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Journal of Integrative Plant Biology 2005年第10期47卷 1254-1259页

作者： Mao-Zhi REN Quan-Jia CHEN li li Rui ZHANG San-dui GUO life Science and Technology College Shanghai Jiaotong University Shanghai 200030 China The Biotechnology Research Institute Chinese Academy of Agricuhural Sciences Beijing 100081 China Agronomy Department of Xinjiang Agricultural University Urumchi 830052 China

For the first time, a nodulin-like gene promoter was isolated from Gossypium hirsutum L. Guo Y 18 by means of inverse PCR. Three plant expression vectors were constructed for functional identification of the promoter. These vectors were different only in promoter regions; three truncations of the nodulinlike promoter took the place of the CaMV35S promoter in the pBI 121 plant expression vector. Then, the three vectors were introduced into cotton plants via the pollen tube pathway. The expression patterns of the gus gene driven by nodulin-like promoter truncations were investigated in the offspring of transgenic cotton plants. Histochemical GUS staining and fluorescence quantitative analysis were performed to achieve this goal. The results showed that the nodulin-like promoter was a strong, highly reproductive organspecific promoter, which demonstrated a much higher driver activity than the CaMV35S promoter did in cotton reproductive organs, but relatively lower activity in vegetation. Identification of the speciality and strength-determining regions of the nodulin-like promoter was also undertaken.

关键词： cotton plant functional identification nodulin-like promoter predominant expression reproductive organ.

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船用柴油机机体组合结构模态分析方法

噪声与振动控制 2012年第2期32卷 132-136页

作者：魏立队段树林吴伋武起立于洪亮大连海事大学轮机工程学院辽宁大连116026

利用数值试验方法验证包括柴油机机座、机架、气缸体、扫气箱、空冷器等有限元模型简化的合理性。通过螺栓连接板件的模态试验验证有限元法模态分析中螺栓连接处理方法韵可靠性。在此基础上建立包括以上各部件的某大型船用6缸柴油机机... 详细信息

利用数值试验方法验证包括柴油机机座、机架、气缸体、扫气箱、空冷器等有限元模型简化的合理性。通过螺栓连接板件的模态试验验证有限元法模态分析中螺栓连接处理方法韵可靠性。在此基础上建立包括以上各部件的某大型船用6缸柴油机机体组合结构有限元模型。通过对整体结构模态分析，找出整机刚度局部薄弱部位和整体固有振型。为大型船用柴油机设计人员在设计阶段，预报和预防整体结构振动提供一较为简便的方法。

关键词：振动与波船用柴油机数值试验模态分析有限元法组合结构

Correlation between single nucleotide polymorphism of rs3811047 in IL-1 F7 gene and rheumatoid arthritis susceptibility among Han population in central plains of China

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Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 73-75页

作者： li-Pu Shi Ya He Zhi-dui liu Department of Rheumatology People's Hospital of Zhengzhou

Objective:To discuss the association between single nucleotide polymorphism(SNP) of rs3811047 in IL-1 F7 gene and rheumatoid arthritis(RA) susceptibility among the Han population in central plains of ***:A total of 276 RA patients admitted to our hospital from December 2009 to December 2011 together with 276 healthy physical examinees in the same period were chosen as the *** typing for rs3811047 SNP in IL-1 F7 gene was carried out by using ligase detection reaction and polymerase chain reaction *** the frequency of each allele and genotypes distribution was calculated so as to evaluate the association between genotype distribution and RA ***:The frequency of A allele of rs3811047 in IL-1 F7 gene in RA group and control group was 16.27%and 17.68%,respectively,and that of G allele in two groups was 83.73%and 82.32%,*** difference between two groups wasn’t statistical significant(P >0.05).The frequency of genotype AA,AG and GG in RA group was 2.19%,27.84%and 69.97%,respectively,while that in control group was 2.94%,29.78%and 67.28%, *** difference of distribution of three genotypes was not statistically significant (P >0.05).RA patients with A allele were better than those without A allele in joint swelling index, rest pain,HAQ scoring and blood *** was significant difference between two groups in above indexes(Plity among the Han population in central plains of China and rs3811047 SNP inIL-1 F7 gene is ***,A allele of rs3811047 has certain influence on the condition of RA patients.

关键词： Rheumatoid arthritis IL-1 F7 gene Single nucleotide polymorphism Susceptibility

Dietary copper requirement of broilers fed a corn-soybean meal diet during 22—42 d of age

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Animal Nutrition 2024年第1期16卷 96-104页

作者： ling Zhu Wei Wu Bingxin Wu Yun Hu liyang Zhang Weiyun Zhang Tingting li Xiaoyan Cui Feiyu Gao Ding li Xugang Luo Shengchen Wang Poultry Mineral Nutrition Laboratory College of Animal Science and TechnologyYangzhou UniversityYangzhou 225000China Mineral Nutrition Research Division State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

This research was to assess the dietary copper(Cu)requirement of broiler chickens fed a practical cornsoybean meal diet during 22—42 d of age.A total of 288 numbered Arbor Acres male broilers at 22 d of age were randomly allotted 6 treatments with 8 replicate cages(6 broilers per cage)per *** were fed a Cu-unsupplemented corn-soybean meal basal diet(control,containing 7.36 mg Cu/kg)or the basal diet added with 3,6,9,12,or 15 mg Cu/kg from CuSO_(4)·5H_(2)O for 21 ***,asymptotic and broken-line models were fitted and the best fitted models were selected to determine dietary Cu *** results revealed that the contents of Cu in serum and liver,m RNA expression levels of Cu-and zinc-containing superoxide dismutase(CuZnSOD)in liver and monoamine oxidase b(MAO B)in heart,as well as protein expression level of CuZnSOD in liver were affected(Plinearly and quadratically(Pline models(Pliver and MAO B in heart,as well as liver CuZnSOD protein expression level were new specific sensitive biomarkers for estimating dietary Cu requirements,and the dietary Cu requirement was recommended to be 14 mg/kg to support Cu metabolic needs related to key Cucontaining enzymes in broilers fed the corn-soybean meal diet during 22—42 d of age,which was higher than the dietary Cu requirement(8 mg/kg)for broilers at the corresponding stage suggested by the Chinese Feeding Standard of Chicken.

关键词： Copper Copper content Gene expression of copper-containing enzyme Requirement Broiler

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Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo

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Protein & Cell 2010年第5期1卷 478-490页

作者： Yixu Chen Wen dui Zhongsheng Yu Changqing li Jun Ma Renjie Jiao State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of Sciences15 Datun RoadBeijing 100101China Graduate School of the Chinese Academy of Sciences Beijing 100080China Divisions of Biomedical Informatics and Developmental Biology Cincinnati Children’s Hospital Research Foundation3333 Burnet AvenueCincinnatiOH 45229USA

RecQ5 in mammalian cells has been suggested to suppress inappropriate homologous ***,the specific pathway(s)in which it is involved and the underlining mechanism(s)remain poorly *** took advantage of genetic tools in Drosophila to investigate how Drosophila RecQ5(dRecQ5)functions in vivo in homologous recombination-mediated double strand break(DSB)*** generated null alleles of dRecQ5 using the targeted recombination *** mutant animals are homozygous viable,but with growth retardation during *** mutants are sensitive to both exogenous DSB-inducing treatment,such as gamma-irradiation,and endogenously induced double strand breaks(DSBs)by I-Sce I *** the absence of dRecQ5,single strand annealing(SSA)-mediated DSB repair is compromised with compensatory increases in either inter-homologous gene conversion,or non-homologous end joining(NHEJ)when inter-chromosomal homologous sequence is *** of function of dRecQ5 also leads to genome instability in loss of heterozygosity(LOH)***,our data demonstrate that dRecQ5 functions in SSA-mediated DSB repair to achieve its full efficiency and in suppression of LOH in Drosophila.

关键词： Drosophila RecQ5 double strand break repair homologous recombination nonhomologous end joining single strand annealing RecQ helicase

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基于层次分析法的农家乐发展评价

辽宁农业科学 2019年第3期 26-29页

作者：李堆淑卢豪商洛学院生物医药与食品工程学院陕西商洛726000 商洛学院城乡规划建筑工程学院陕西商洛726000

为了研究农家乐的发展状况,以陕西省蓝田县葛牌镇为研究对象,采用层次分析法(AHP)构建了影响蓝田县葛牌镇农家乐发展的指标体系,以生态环境、文化旅游、基础设施为准则层的3个指标以及指标层选择了森林保护、道路绿化、红色旅游等11个... 详细信息

为了研究农家乐的发展状况,以陕西省蓝田县葛牌镇为研究对象,采用层次分析法(AHP)构建了影响蓝田县葛牌镇农家乐发展的指标体系,以生态环境、文化旅游、基础设施为准则层的3个指标以及指标层选择了森林保护、道路绿化、红色旅游等11个指标。结果表明,准则层中生态环境是蓝田县葛牌镇农家乐发展的主导因素(权重为0.665),其次为基础设施和文化旅游。在指标层中,生态环境的二级指标森林保护的综合权重最高,为0.481,由此可见,在葛牌镇农家乐发展过程中,主要依靠生态环境的保护所获得生态效益,促进自身的发展。

关键词：蓝田县葛牌镇农家乐文化旅游层次分析法

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一种新型松节油系列单组分聚氨酯的研究

三明学院学报 2001年第3期19卷 35-39页

作者：陈健黄力堆黄茂村严良聚陈世江周文富三明高等专科学校化学与生物工程系福建三明365004

文章介绍了萜烯马来酐乙二醇聚氨酯的制备及性能测试。结果表明该聚氨酯具有良好的耐酸、耐水、耐油和耐有机溶剂的性能 ,光泽度高。重点讨论了NCO/OH的配比量、反应温度及催化剂用量对该聚氨酯性能的影响。

关键词：萜烯马来酐乙二醇酯聚氨酯配比量

核桃青皮不同溶剂提取物对烟青虫的防治效果研究

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现代农业科技 2016年第22期 109-110,117页

作者：何念武刘晓阳李堆淑任道远黄金辉商洛学院生物医药与食品工程学院陕西商洛726000 陕西师范大学食品工程与营养科学学院陕西省烟草公司商洛市公司

采用水、乙醇、氯仿、乙酸乙酯及乙醚5种不同极性的溶剂,利用超声波辅助提取法从核桃青皮中提取有效成分,继而研究其对烟青虫的毒杀和拒食活性。结果表明:5种提取物均对烟青虫具有毒杀作用,且呈现良好的剂量效应关系,不同提取物、不同... 详细信息

采用水、乙醇、氯仿、乙酸乙酯及乙醚5种不同极性的溶剂,利用超声波辅助提取法从核桃青皮中提取有效成分,继而研究其对烟青虫的毒杀和拒食活性。结果表明:5种提取物均对烟青虫具有毒杀作用,且呈现良好的剂量效应关系,不同提取物、不同浓度都会影响烟青虫的毒杀活性和拒食活性。5种提取物对烟青虫的杀虫活性顺序依次为乙酸乙酯提取物>氯仿提取物>乙醚提取物>乙醇提取物>水提取物。由此可见,核桃青皮不同溶剂提取物对烟青虫具有一定的毒杀作用,具有开发成生物农药的潜力。

关键词：核桃青皮提取物烟青虫毒杀活性拒食活性