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马斯克的星舰或使竞争对手彻底停飞

商业周刊（中文版） 2024年第1期 14-16页

作者： loren Grush 永年(译) 不详

2023年11月18日,在辉煌的几分钟里,太空探索技术公司(SpaceX)的庞大“星舰”火箭(Starship)在轰鸣声中启动,以看似完美的状态冲向天空。然后,大约飞行八分钟的火箭在墨西哥湾上空莫名其妙地爆炸了。然而,对于埃隆·马斯克(Elon Musk)的S... 详细信息

2023年11月18日,在辉煌的几分钟里,太空探索技术公司(SpaceX)的庞大“星舰”火箭(Starship)在轰鸣声中启动,以看似完美的状态冲向天空。然后,大约飞行八分钟的火箭在墨西哥湾上空莫名其妙地爆炸了。然而,对于埃隆·马斯克(Elon Musk)的SpaceX公司来说,这只是发展中的又一个小问题。

关键词：太空探索轰鸣声墨西哥湾竞争对手火箭

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马斯克与贝索斯展开新一轮登月竞赛

商业周刊（中文版） 2024年第8期 18-19页

作者： loren Grush 晴川(译) 不详

●SpaceX原本领先Blue Origin一大步,但现在情况有可能发生变化5年前,杰夫·贝索斯(Jeff Bezos)站在华盛顿特区一个黑的讲台上,他身后的平台上罩着黑色的大幕。身穿灰西装和黑衬衫的他向一群记者和太空爱好者讲述了探索月球的好处。“很... 详细信息

●SpaceX原本领先Blue Origin一大步,但现在情况有可能发生变化5年前,杰夫·贝索斯(Jeff Bezos)站在华盛顿特区一个黑的讲台上,他身后的平台上罩着黑色的大幕。身穿灰西装和黑衬衫的他向一群记者和太空爱好者讲述了探索月球的好处。“很近,只要3天时间就到了,”贝索斯说。“你只要愿意,随时可以去月球。”

关键词：华盛顿特区杰夫贝索斯讲台

Crop adaptation to climate change:An evolutionary perspective

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Molecular Plant 2023年第10期16卷 1518-1546页

作者： Lexuan Gao Michael B.Kantar Dylan Moxley Daniel Ortiz-Barrientos loren H.Rieseberg CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Department of Tropical Plant&Soil Sciences University of Hawaii at ManoaHonoluluHIUSA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBCCanada School of Biological Sciences and Australian Research Council Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandBrisbaneQLDAustralia

The disciplines of evolutionary biology and plant and animal breeding have been intertwined throughout their development,with responses to artificial selection yielding insights into the action of natural selection and evolutionary biology providing statistical and conceptual guidance for modern breeding.Here we offer an evolutionary perspective on a grand challenge of the 21st century:feeding humanity in the face of climate change.We first highlight promising strategies currently under way to adapt crops to current and future climate change.These include methods to match crop varieties with current and predicted environments and to optimize breeding goals,management practices,and crop microbiomes to enhance yield and sustainable production.We also describe the promise of crop wild relatives and recent technological innovations such as speed breeding,genomic selection,and genome editing for improving environmental resilience of existing crop varieties or for developing new crops.Next,we discuss how methods and theory from evolutionary biology can enhance these existing strategies and suggest novel approaches.We focus initially on methods for reconstructing the evolutionary history of crops and their pests and symbionts,because such historical information provides an overall framework for crop-improvement efforts.We then describe how evolutionary approaches can be used to detect and mitigate the accumulation of deleterious mutations in crop genomes,identify alleles and mutations that underlie adaptation(and maladaptation)to agricultural environments,mitigate evolutionary trade-offs,and improve critical proteins.Continuing feedback between the evolution and crop biology communities will ensure optimal design of strategies for adapting crops to climate change.

关键词： abiotic stress resistance climate change crop adaptation Darwinian agriculture evolutionary biology plant breeding

A data-driven framework for medium-term electric vehicle charging demand forecasting

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Energy and AI

Energy and AI 2023年第4期14卷 201-211页

作者： Alexander Orzechowski loren Lugosch Hao Shu Raymond Yang Wei Li Brett H.Meyer McGill University Mcconnell Engineering Building3380 University StMontreal QC H2X 2G6Canada Mogile Technologies 16647 Hymus BlvdKirklandQuebec H9H 4R9Canada

The rapid phase-in of electric vehicles(EV)will cause unprecedented issues with managing the supply of electricity and charging stations.It is in the interest of utility providers and everyday consumers to be able to plan for peak charging times,and related congestion.While past work has been done for localized,short-term forecasting,it has not included longer term forecasting,or considered the relationships between multiple stations.Importantly,past work has also not offered a framework for dataset construction and evaluated different dataset features.We propose a methodology to forecast demand at public EV charging stations,and use it to explore the potential of data-driven models to predict demand up to one week in advance.Our strategy includes selecting parameters for formatting a dataset given a list of charging events,a way to consider flexible prediction horizons,and deployment of deep and supervised learning-based models.To the best of our knowledge,ours is the first study to propose machine learning to forecast medium-term public EV charging demand,to exploit weather and other features at public charging stations,and to forecast demand at multiple stations and the entire network.We validated our approach using data from eleven stations over three years from Scotland,UK.Our method outperforms the benchmark time series method,and predicts network demand with a symmetric mean absolute percentage error(SMAPE)of 5.9%and a mean absolute error(MAE)of 124.7 kWh,or less than twelve percent of average daily demand.

关键词： Public EV charging Forecasting Energy consumption Smart grid Time-series Multi-task learning Deep learning

Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature

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World Journal of Hepatology 2020年第2期12卷 64-71页

作者： Mariano Piazzolla Nicola Castellaneta Antonio Novelli Emanuele Agolini Dario Cocciadiferro Leonardo Resta loren duda Michele Barone Enzo Ierardi Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Laboratory of Medical Genetics Ospedale Pediatrico Bambino GesùRome 00165Italy Section of Pathology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy

BACKGROUND Benign recurrent intrahepatic cholestasis is a genetic disorder with recurrent cholestatic jaundice due to ATP8B1 and ABCB11 gene mutations encoding for hepato-canalicular transporters.Herein,we firstly provide the evidence that a nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygous form is involved in BRIC pathogenesis.CASE SUMMARY A 29-year-old male showed severe jaundice and laboratory tests consistent with intrahepatic cholestasis despite normal gamma-glutamyltranspeptidase.Acute and chronic liver diseases with viral,metabolic and autoimmune etiology were excluded.Normal intra/extra-hepatic bile ducts were demonstrated by magnetic resonance.Liver biopsy showed:Cholestasis in the centrilobular and intermediate zones with bile plugs and intra-hepatocyte pigment,Kupffer’s cell activation/hyperplasia and preserved biliary ducts.Being satisfied benign recurrent intrahepatic cholestasis diagnostic criteria,ATP8B1 and ABCB11 gene analysis was performed.Surprisingly,we found a novel nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygosis.The variant was confirmed by Sanger sequencing following a standard protocol and tested for familial segregation,showing a maternal inheritance.Immunohistochemistry confirmed a significant reduction of mutated gene related protein(familial intrahepatic cholestasis 1).The patient was treated with ursodeoxycholic acid 15 mg/kg per day and colestyramine 8 g daily with total bilirubin decrease and normalization at the 6th and 12th mo.CONCLUSION A genetic abnormality,different from those already known,could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition,thus encouraging further mutation detection in this field.

关键词： Benign recurrent intrahepatic cholestasis ATP8B1/ABCB11 genes Jaundice Heterozygous variant of ATP8B1 gene(c.1558A>T) Familial inheritance Case report

A new model of speciation

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National Science Review 2019年第2期6卷 289-290页

作者： loren H.Rieseberg Department of Botany and Biodiversity Research Centre University of British Columbia NSR

In the first paragraph of ‘On the origin of species’, Darwin [1]refers to speciation as that ‘mystery of mysteries’. Although the means by which new species arise is no longer mysterious, some puzzles remain. One such puzzle, which is addressed in a recent paper from Chung-I Wu’s group on mangrove speciation [2],concerns the popular allopatric speciation model. In this model,

关键词： HYBRIDIZATION

While neither universally applicable nor practical operationally, the biological species concept continues to offer a compelling framework for studying species and speciation

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National Science Review 2020年第8期7卷 1398-1400页

作者： Lexuan Gao loren H.Rieseberg CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Chinese Academy of Sciences Department of Botany and Biodiversity Research Centre University of British Columbia

Few topics in evolutionary biology have received as much scrutiny and debate as the nature of species and species concepts. This is partly because species are central to many fields of biology(but especially evolution, ecology, systematics, and conservation biology), and there does not appear to be a single concept that can satisfy the needs of these different disciplines [1].

关键词： REPRODUCTIVE ISOLATION GENE FLOW INTROGRESSION BARRIER

A new section of Kaili Formation (Cambrian) and a biostratigraphic study of the boundary interval across the undefined Cambrian Series 2 and Series 3 at Jianshan,Jianhe County,China with a discussion of global correlation based on the first appearance dat

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Progress in Natural Science:Materials International 2008年第12期18卷 1549-1556页

作者： loren E.Babcock School of Earth Sciences Ohio State UniversityColumbusOH 43210USA

A trilobite biostratigraphic study of a new section of the Kaili Formation at Jianshan,Chuandong Village,Jianhe County, Guizhou is reported.Additional occurrences of key species associated with the Ovatoryctocara granulata-Bathynotus holopygus Zone and the overlying Oryctocephalus indicus Zone that were originally defined from the trilobite assemblages at the Wuliu- Zengjiayan section of the Kaili are reported from this new section.The first appearance datum (FAD) of Oryctocephalus indicus occurs at the 44.52 m above the base of the unit.Based on study of abundant specimens (n=800) from the Kaili Formation, we argue that Oryctocephalus indicus is a widespread taxon with a global distribution.O.reticulatus (Lermontova,1940) from the middle part of the Kounamkites Zone of the Amganian Stage in the Molodo River region of Siberia and O.americanus (Sundberg and McCollum,2003) from Nevada,North America are similar to representatives of O.indicus which occur in the O.indicus Zone of the Kaili Formation.O.reticulatus and O.americanus are here synonymized with O.indicus (Reed,1910).This study strengthens the Wuliu-Zengjiayan section of the Kaili Formation as a candidate section for a Global Stratotype for the base of the unnamed Cambrian Series 3.

关键词： Jianshan section Kaili Formation Boundary Cambrian Series 3 Guizhou China

Plant Evolutionary Adaptation

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Plant Communications 2020年第6期1卷 1-3页

作者： loren H.Rieseberg Lexuan Gao Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouver BC V6T1Z4Canada CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

In 1973,evolutionary biologist Theodosius Dobzhansky penned a famous essay titled“Nothing in Biology Makes Sense Except in the Light of Evolution”(Dobzhansky,1973).In the essay,he described how many features of biology,such as the adaptive radiations of Drosophila fruit flies and the similarity of embryo development across animal species,are best explained by evolution.Although Dobzhansky’s examples largely came from the animal kingdom,evolution is also the chief unifying theory in plant biology,linking molecular,cell,and whole organism-level phenomena.Plant Communications is intended to represent all of the plant sciences,and evolution can provide connections between the diverse studies published in the journal.This is illustrated by this special issue on Plant Evolutionary Adaptation,in which evolutionary approaches are employed to explain phenomena ranging from the geographic distribution of genomic variation to patterns of plant dispersal to the success of invasive species.Here we provide background for the topics addressed by these studies and highlight their main conclusions,moving from molecular to organismal-level studies.

关键词： journal linking explain